BRPI0911577A8 - derivados espiro-indol para o tratamento de doenças parasíticas. - Google Patents
derivados espiro-indol para o tratamento de doenças parasíticas. Download PDFInfo
- Publication number
- BRPI0911577A8 BRPI0911577A8 BRPI0911577A BRPI0911577A BRPI0911577A8 BR PI0911577 A8 BRPI0911577 A8 BR PI0911577A8 BR PI0911577 A BRPI0911577 A BR PI0911577A BR PI0911577 A BRPI0911577 A BR PI0911577A BR PI0911577 A8 BRPI0911577 A8 BR PI0911577A8
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- parasitic diseases
- spiroindole
- derivatives
- spiroindole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08155342 | 2008-04-29 | ||
EP08155342.2 | 2008-04-29 | ||
EP09151117 | 2009-01-22 | ||
EP09151117.0 | 2009-01-22 | ||
PCT/EP2009/053902 WO2009132921A1 (en) | 2008-04-29 | 2009-04-01 | Spiro-indole derivatives for the treatment of parasitic diseases |
Publications (4)
Publication Number | Publication Date |
---|---|
BRPI0911577A2 BRPI0911577A2 (pt) | 2016-01-05 |
BRPI0911577A8 true BRPI0911577A8 (pt) | 2018-03-06 |
BRPI0911577B1 BRPI0911577B1 (pt) | 2021-02-23 |
BRPI0911577B8 BRPI0911577B8 (pt) | 2021-05-25 |
Family
ID=40613087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0911577A BRPI0911577B8 (pt) | 2008-04-29 | 2009-04-01 | derivados espiro-indol, seus usos no tratamento de doenças parasíticas, e composição farmacêutica |
Country Status (31)
Country | Link |
---|---|
US (2) | US8053442B2 (pt) |
EP (2) | EP2285808B1 (pt) |
JP (2) | JP5438098B2 (pt) |
KR (1) | KR101390081B1 (pt) |
CN (1) | CN102015711B (pt) |
AR (1) | AR071222A1 (pt) |
AU (1) | AU2009242279B2 (pt) |
BR (1) | BRPI0911577B8 (pt) |
CA (1) | CA2719365C (pt) |
CL (1) | CL2009001007A1 (pt) |
CO (1) | CO6300940A2 (pt) |
CY (1) | CY1114874T1 (pt) |
DK (1) | DK2285808T3 (pt) |
EA (1) | EA019601B1 (pt) |
EC (2) | ECSP10010646A (pt) |
ES (1) | ES2447590T3 (pt) |
HK (1) | HK1149935A1 (pt) |
HR (1) | HRP20140151T1 (pt) |
IL (1) | IL208357A (pt) |
JO (1) | JO2904B1 (pt) |
MA (1) | MA32316B1 (pt) |
MX (1) | MX2010011868A (pt) |
MY (2) | MY156601A (pt) |
NZ (1) | NZ588217A (pt) |
PE (1) | PE20091787A1 (pt) |
PL (1) | PL2285808T3 (pt) |
PT (1) | PT2285808E (pt) |
SI (1) | SI2285808T1 (pt) |
TW (1) | TWI442921B (pt) |
WO (1) | WO2009132921A1 (pt) |
ZA (1) | ZA201006752B (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2285808B1 (en) * | 2008-04-29 | 2013-11-20 | Novartis AG | Spiro-indole derivatives for the treatment of parasitic diseases |
CN102584835B (zh) * | 2011-01-17 | 2014-08-27 | 苏州大学 | 一种含吲哚结构的螺杂环化合物及其制备方法 |
CN104185634B (zh) * | 2012-03-23 | 2017-05-03 | 诺华股份有限公司 | 制备螺旋吲哚酮和其中间体的化学工艺 |
HUE046421T2 (hu) * | 2012-03-23 | 2020-02-28 | Novartis Ag | Kémiai eljárás spiroindolok és intermedierjeik elõállítására |
HUE036985T2 (hu) | 2012-03-23 | 2018-08-28 | Codexis Inc | Biokatalizátor és eljárások triptamin és triptamin-analógok származékainak szintetizálására |
EP3068793B1 (en) | 2013-11-13 | 2021-02-17 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
SG11201703258PA (en) | 2014-11-25 | 2017-05-30 | Codexis Inc | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
CN118005631A (zh) | 2014-12-18 | 2024-05-10 | 豪夫迈·罗氏有限公司 | 四氢-吡啶并[3,4-b]吲哚***受体调节剂及其用途 |
KR102572178B1 (ko) * | 2015-01-23 | 2023-08-28 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 피라졸로[3,4-d]피리미딘 유도체 및 리슈마니아증의 치료를 위한 그의 용도 |
WO2016147205A1 (en) * | 2015-03-13 | 2016-09-22 | Council Of Scientific & Industrial Research | Novel substituted 3-spirophosphoryl pyrazole-2-oxindoles as anti-infectives and process for the synthesis thereof |
US11174267B2 (en) | 2015-06-12 | 2021-11-16 | The Regents Of The University Of California | Spiroindolinones and therapeutic uses thereof |
JP2017024992A (ja) * | 2015-07-15 | 2017-02-02 | 公益財団法人微生物化学研究会 | 化合物の製造方法 |
HUE064542T2 (hu) | 2018-06-21 | 2024-03-28 | Hoffmann La Roche | A 3-((1R,3R)1(2,6-difluoro-4-((1-(3-fluoropropil)azetidin-3-il)amino)fenil)-3-metil-1,3,4,9 -tetrahidro-2H-pirido[3,4-b]indol-2-il)-2,2-difluoropropán-1-ol tartarátsó szilárd formái, eljárás elõállításukra és rákos megbetegedések kezelésében történõ alkalmazási módszereik |
CN110590795B (zh) * | 2019-10-10 | 2021-01-22 | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 一类多并杂环螺羟吲哚类化合物的合成方法 |
US20230132973A1 (en) * | 2020-03-17 | 2023-05-04 | The University Of Buea | DIHYDRO-SPIRO[INDOLINE-3:1'-iSOQUINOLIN]-2-ONES AS ANTIMALARIAL AGENTS |
CN116273188A (zh) * | 2023-03-01 | 2023-06-23 | 岭南师范学院 | 一种负载金属的多孔有机框架材料在催化Pictet-Spengler反应中的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2663935A1 (fr) * | 1990-06-27 | 1992-01-03 | Adir | Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
EP1655302A3 (en) * | 1998-07-14 | 2006-08-23 | Bayer HealthCare AG | Antiparasitic artemisinin derivatives (endoperoxides) |
US7148214B1 (en) | 1998-12-19 | 2006-12-12 | Janssen Pharmaceutica, N.V. | Antihistaminic spiro compounds |
US20050101623A1 (en) * | 2003-07-23 | 2005-05-12 | Pharmacia Corporation | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors |
AR053710A1 (es) | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
CN101547923A (zh) | 2006-12-07 | 2009-09-30 | 弗·哈夫曼-拉罗切有限公司 | 作为via受体拮抗剂的螺环-哌啶衍生物 |
AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
US8324221B2 (en) | 2008-01-09 | 2012-12-04 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
EP2285808B1 (en) * | 2008-04-29 | 2013-11-20 | Novartis AG | Spiro-indole derivatives for the treatment of parasitic diseases |
-
2009
- 2009-04-01 EP EP09737965.5A patent/EP2285808B1/en active Active
- 2009-04-01 CA CA2719365A patent/CA2719365C/en active Active
- 2009-04-01 NZ NZ588217A patent/NZ588217A/xx unknown
- 2009-04-01 SI SI200930847T patent/SI2285808T1/sl unknown
- 2009-04-01 WO PCT/EP2009/053902 patent/WO2009132921A1/en active Application Filing
- 2009-04-01 BR BRPI0911577A patent/BRPI0911577B8/pt active IP Right Grant
- 2009-04-01 AU AU2009242279A patent/AU2009242279B2/en active Active
- 2009-04-01 KR KR1020107026548A patent/KR101390081B1/ko active IP Right Grant
- 2009-04-01 ES ES09737965.5T patent/ES2447590T3/es active Active
- 2009-04-01 EP EP13185962.1A patent/EP2722333A1/en not_active Withdrawn
- 2009-04-01 PL PL09737965T patent/PL2285808T3/pl unknown
- 2009-04-01 MX MX2010011868A patent/MX2010011868A/es active IP Right Grant
- 2009-04-01 MY MYPI2013001071A patent/MY156601A/en unknown
- 2009-04-01 PT PT97379655T patent/PT2285808E/pt unknown
- 2009-04-01 EA EA201001689A patent/EA019601B1/ru not_active IP Right Cessation
- 2009-04-01 CN CN2009801149364A patent/CN102015711B/zh active Active
- 2009-04-01 JP JP2011506638A patent/JP5438098B2/ja active Active
- 2009-04-01 DK DK09737965.5T patent/DK2285808T3/da active
- 2009-04-01 MY MYPI20104473 patent/MY152021A/en unknown
- 2009-04-27 US US12/430,625 patent/US8053442B2/en active Active
- 2009-04-27 AR ARP090101487A patent/AR071222A1/es active IP Right Grant
- 2009-04-28 PE PE2009000577A patent/PE20091787A1/es active IP Right Grant
- 2009-04-28 CL CL2009001007A patent/CL2009001007A1/es unknown
- 2009-04-28 JO JO2009149A patent/JO2904B1/en active
- 2009-04-28 TW TW098114086A patent/TWI442921B/zh active
-
2010
- 2010-09-21 ZA ZA2010/06752A patent/ZA201006752B/en unknown
- 2010-09-21 IL IL208357A patent/IL208357A/en active IP Right Grant
- 2010-11-19 MA MA33365A patent/MA32316B1/fr unknown
- 2010-11-25 CO CO10148514A patent/CO6300940A2/es active IP Right Grant
- 2010-11-29 EC EC2010010646A patent/ECSP10010646A/es unknown
-
2011
- 2011-04-27 HK HK11104203.2A patent/HK1149935A1/xx unknown
- 2011-07-19 US US13/186,035 patent/US8399453B2/en active Active
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2013
- 2013-12-12 JP JP2013257004A patent/JP2014065729A/ja active Pending
-
2014
- 2014-02-18 HR HRP20140151AT patent/HRP20140151T1/hr unknown
- 2014-02-20 CY CY20141100135T patent/CY1114874T1/el unknown
-
2017
- 2017-10-13 EC ECIEPI201768127A patent/ECSP17068127A/es unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/02/2021, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/04/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |