BRPI0807987A2 - Terapia de combinação para tratamento de distúrbios imunes. - Google Patents
Terapia de combinação para tratamento de distúrbios imunes.Info
- Publication number
- BRPI0807987A2 BRPI0807987A2 BRPI0807987-0A2A BRPI0807987A BRPI0807987A2 BR PI0807987 A2 BRPI0807987 A2 BR PI0807987A2 BR PI0807987 A BRPI0807987 A BR PI0807987A BR PI0807987 A2 BRPI0807987 A2 BR PI0807987A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- combination therapy
- immune disorders
- immune
- disorders
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89214207P | 2007-02-28 | 2007-02-28 | |
US94527907P | 2007-06-20 | 2007-06-20 | |
PCT/US2008/002530 WO2008106131A2 (en) | 2007-02-28 | 2008-02-26 | Combination therapy for treatment of immune disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0807987A2 true BRPI0807987A2 (pt) | 2014-06-24 |
Family
ID=39596554
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0807987-0A2A BRPI0807987A2 (pt) | 2007-02-28 | 2008-02-26 | Terapia de combinação para tratamento de distúrbios imunes. |
Country Status (11)
Country | Link |
---|---|
US (3) | US20100135998A1 (pt) |
EP (3) | EP2056838B1 (pt) |
JP (2) | JP5337055B2 (pt) |
CN (2) | CN103933573A (pt) |
AU (1) | AU2008219681A1 (pt) |
BR (1) | BRPI0807987A2 (pt) |
CA (1) | CA2679400A1 (pt) |
MX (1) | MX2009009167A (pt) |
NZ (2) | NZ597915A (pt) |
WO (1) | WO2008106131A2 (pt) |
ZA (1) | ZA200905962B (pt) |
Families Citing this family (27)
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US7910703B2 (en) | 2006-03-10 | 2011-03-22 | Zymogenetics, Inc. | Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use |
WO2007147019A2 (en) | 2006-06-13 | 2007-12-21 | Zymogenetics, Inc. | Il-17 and il-23 antagonists and methods of using the same |
BRPI0819656A2 (pt) * | 2007-11-27 | 2015-06-23 | Ablynx Nv | Seqüências de aminoácidos contras citocinas heterodiméricas e/ou seus receptores e polipeptídeos compreendendo as mesmas |
JP2012508367A (ja) * | 2008-11-06 | 2012-04-05 | アムビト ビオスシエンセス コルポラチオン | リン酸化型fms関連チロシンキナーゼ3バイオマーカーアッセイ |
MY160126A (en) | 2009-05-13 | 2017-02-28 | Genzyme Corp | Anti-human cd52 immunoglobulins |
GB201013975D0 (en) * | 2010-08-20 | 2010-10-06 | Imp Innovations Ltd | Method of treating desease |
US8927693B2 (en) | 2010-02-18 | 2015-01-06 | Bristol-Myers Squibb Company | Fibronectin based scaffold domain proteins that bind IL-23 |
JPWO2011152503A1 (ja) | 2010-06-02 | 2013-08-01 | 大日本住友製薬株式会社 | 自己免疫疾患またはアレルギー疾患の治療剤 |
EP2640745B1 (en) | 2010-09-10 | 2018-11-07 | MedImmune Limited | Bivalent and bispecific anti-il6/anti-il23 antibodies |
CN103282382B (zh) | 2010-11-04 | 2017-11-03 | 勃林格殷格翰国际有限公司 | 抗il‑23抗体 |
AU2012272706B2 (en) | 2011-06-22 | 2017-07-06 | Apellis Pharmaceuticals, Inc. | Methods of treating chronic disorders with complement inhibitors |
SG11201406238UA (en) | 2012-04-05 | 2014-10-30 | Hoffmann La Roche | Bispecific antibodies against human tweak and human il17 and uses thereof |
KR102124758B1 (ko) | 2012-05-03 | 2020-06-19 | 베링거 인겔하임 인터내셔날 게엠베하 | 항-il-23p19 항체 |
EP2866833B1 (en) | 2012-06-27 | 2019-05-15 | Merck Sharp & Dohme Corp. | Crystalline anti-human il-23 antibodies |
AR095199A1 (es) * | 2013-03-15 | 2015-09-30 | Genzyme Corp | Anticuerpos anti-cd52 |
AU2014264951A1 (en) * | 2013-05-10 | 2015-11-12 | Numab Therapeutics AG | Bispecific constructs and their use in the treatment of various diseases |
CN113604543A (zh) | 2014-03-27 | 2021-11-05 | 豪夫迈·罗氏有限公司 | 用于诊断和治疗炎症性肠病的方法 |
JP2017524359A (ja) | 2014-07-24 | 2017-08-31 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Il−23a関連疾患の処置に有用なバイオマーカー |
EA202193002A2 (ru) * | 2014-09-03 | 2022-03-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Соединение, нацеленное на ил-23a и фно-альфа, и его применение |
AR102417A1 (es) * | 2014-11-05 | 2017-03-01 | Lilly Co Eli | Anticuerpos biespecíficos anti-tnf- / anti-il-23 |
EP3368066A1 (en) * | 2015-10-30 | 2018-09-05 | Eli Lilly and Company | Anti-cgrp/anti-il-23 bispecific antibodies and uses thereof |
AU2017241776A1 (en) * | 2016-03-29 | 2018-10-11 | Janssen Biotech, Inc. | Treating psoriasis with increased interval dosing of anti-IL12 and/or -23 antibody |
CN108113999A (zh) * | 2016-11-29 | 2018-06-05 | 浦项工科大学校产学协力团 | 以Th17细胞为有效成分包含的代谢性疾病预防或治疗用细胞治疗剂组合物 |
CN117045784A (zh) * | 2016-12-14 | 2023-11-14 | 比奥拉治疗股份有限公司 | 使用利用可摄入装置释放的il-12/il-23抑制剂治疗胃肠道疾病 |
CN108640997A (zh) * | 2018-05-22 | 2018-10-12 | 蔡毓旻 | 一种双特异性抗体 |
WO2021062267A1 (en) * | 2019-09-26 | 2021-04-01 | Nantbio, Inc. | Primary t-cell expansion |
WO2021146850A1 (en) * | 2020-01-20 | 2021-07-29 | Tsinghua University | A critical role of febrile temperature in regulating interleukin (il) -17 producing cells via smad4 |
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US20080019975A1 (en) | 2006-07-07 | 2008-01-24 | Bioassets Development Corporation | Novel Regimens for Treating Diseases and Disorders |
MX2009001620A (es) | 2006-08-11 | 2009-02-23 | Schering Corp | Anticuerpos para il-17a. |
US7833527B2 (en) * | 2006-10-02 | 2010-11-16 | Amgen Inc. | Methods of treating psoriasis using IL-17 Receptor A antibodies |
-
2008
- 2008-02-26 EP EP08714219.6A patent/EP2056838B1/en active Active
- 2008-02-26 NZ NZ597915A patent/NZ597915A/xx not_active IP Right Cessation
- 2008-02-26 MX MX2009009167A patent/MX2009009167A/es active IP Right Grant
- 2008-02-26 CN CN201410124618.9A patent/CN103933573A/zh active Pending
- 2008-02-26 EP EP11173881A patent/EP2425838A3/en not_active Withdrawn
- 2008-02-26 US US12/527,459 patent/US20100135998A1/en not_active Abandoned
- 2008-02-26 CA CA002679400A patent/CA2679400A1/en not_active Abandoned
- 2008-02-26 CN CN200880013960.4A patent/CN101668531B/zh not_active Expired - Fee Related
- 2008-02-26 AU AU2008219681A patent/AU2008219681A1/en not_active Abandoned
- 2008-02-26 EP EP11173876A patent/EP2417974A1/en not_active Withdrawn
- 2008-02-26 JP JP2009551701A patent/JP5337055B2/ja not_active Expired - Fee Related
- 2008-02-26 BR BRPI0807987-0A2A patent/BRPI0807987A2/pt not_active IP Right Cessation
- 2008-02-26 NZ NZ579297A patent/NZ579297A/en not_active IP Right Cessation
- 2008-02-26 WO PCT/US2008/002530 patent/WO2008106131A2/en active Application Filing
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2009
- 2009-08-27 ZA ZA200905962A patent/ZA200905962B/xx unknown
-
2012
- 2012-02-24 US US13/405,024 patent/US20120156699A1/en not_active Abandoned
- 2012-09-26 JP JP2012212022A patent/JP2012251002A/ja active Pending
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2013
- 2013-06-24 US US13/925,525 patent/US20130287775A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2012251002A (ja) | 2012-12-20 |
US20130287775A1 (en) | 2013-10-31 |
MX2009009167A (es) | 2009-09-04 |
CN101668531B (zh) | 2014-05-07 |
EP2056838B1 (en) | 2013-09-25 |
WO2008106131A2 (en) | 2008-09-04 |
NZ579297A (en) | 2012-03-30 |
JP2010520197A (ja) | 2010-06-10 |
CN101668531A (zh) | 2010-03-10 |
EP2417974A1 (en) | 2012-02-15 |
CN103933573A (zh) | 2014-07-23 |
EP2425838A3 (en) | 2012-05-02 |
NZ597915A (en) | 2013-08-30 |
US20100135998A1 (en) | 2010-06-03 |
WO2008106131A3 (en) | 2008-12-11 |
US20120156699A1 (en) | 2012-06-21 |
CA2679400A1 (en) | 2008-09-04 |
JP5337055B2 (ja) | 2013-11-06 |
ZA200905962B (en) | 2010-05-26 |
EP2425838A2 (en) | 2012-03-07 |
AU2008219681A1 (en) | 2008-09-04 |
EP2056838A2 (en) | 2009-05-13 |
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