PT2285808E - Derivados de espiro-indole para o tratamento de doenças parasitárias - Google Patents

Derivados de espiro-indole para o tratamento de doenças parasitárias Download PDF

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Publication number
PT2285808E
PT2285808E PT97379655T PT09737965T PT2285808E PT 2285808 E PT2285808 E PT 2285808E PT 97379655 T PT97379655 T PT 97379655T PT 09737965 T PT09737965 T PT 09737965T PT 2285808 E PT2285808 E PT 2285808E
Authority
PT
Portugal
Prior art keywords
spiro
treatment
indole derivatives
parasitic diseases
parasitic
Prior art date
Application number
PT97379655T
Other languages
English (en)
Inventor
Shi Hua Ang
Philipp Krastel
Seh Yong Leong
Liying Jocelyn Tan
Wei Lin Josephine Wong
Bryan Ks Yeung
Bin Zou
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40613087&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2285808(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT2285808E publication Critical patent/PT2285808E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT97379655T 2008-04-29 2009-04-01 Derivados de espiro-indole para o tratamento de doenças parasitárias PT2285808E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08155342 2008-04-29
EP09151117 2009-01-22

Publications (1)

Publication Number Publication Date
PT2285808E true PT2285808E (pt) 2014-02-24

Family

ID=40613087

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97379655T PT2285808E (pt) 2008-04-29 2009-04-01 Derivados de espiro-indole para o tratamento de doenças parasitárias

Country Status (31)

Country Link
US (2) US8053442B2 (pt)
EP (2) EP2285808B1 (pt)
JP (2) JP5438098B2 (pt)
KR (1) KR101390081B1 (pt)
CN (1) CN102015711B (pt)
AR (1) AR071222A1 (pt)
AU (1) AU2009242279B2 (pt)
BR (1) BRPI0911577B8 (pt)
CA (1) CA2719365C (pt)
CL (1) CL2009001007A1 (pt)
CO (1) CO6300940A2 (pt)
CY (1) CY1114874T1 (pt)
DK (1) DK2285808T3 (pt)
EA (1) EA019601B1 (pt)
EC (2) ECSP10010646A (pt)
ES (1) ES2447590T3 (pt)
HK (1) HK1149935A1 (pt)
HR (1) HRP20140151T1 (pt)
IL (1) IL208357A (pt)
JO (1) JO2904B1 (pt)
MA (1) MA32316B1 (pt)
MX (1) MX2010011868A (pt)
MY (2) MY152021A (pt)
NZ (1) NZ588217A (pt)
PE (1) PE20091787A1 (pt)
PL (1) PL2285808T3 (pt)
PT (1) PT2285808E (pt)
SI (1) SI2285808T1 (pt)
TW (1) TWI442921B (pt)
WO (1) WO2009132921A1 (pt)
ZA (1) ZA201006752B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010011868A (es) * 2008-04-29 2010-11-26 Novartis Ag Derivados de espiro-indol para el tratamiento de enfermedades parasitarias.
CN102584835B (zh) * 2011-01-17 2014-08-27 苏州大学 一种含吲哚结构的螺杂环化合物及其制备方法
CN104508126B (zh) 2012-03-23 2017-06-30 科德克希思公司 用于合成色胺和色胺类似物的衍生物的生物催化剂和方法
CN104185634B (zh) * 2012-03-23 2017-05-03 诺华股份有限公司 制备螺旋吲哚酮和其中间体的化学工艺
WO2013139987A1 (en) * 2012-03-23 2013-09-26 Novartis Ag Chemical process for preparing spiroindolones and intermediates thereof
JP6643987B2 (ja) 2013-11-13 2020-02-12 コデクシス， インコーポレイテッド ケトン化合物およびアミン化合物の還元的アミノ化のための操作されたイミンレダクターゼおよび方法
HUE053363T2 (hu) 2014-11-25 2021-06-28 Codexis Inc Módosított iminreduktázok és eljárások keton- és aminvegyületek reduktív aminálására
EA032311B1 (ru) 2014-12-18 2019-05-31 Ф. Хоффманн-Ля Рош Аг Тетрагидро-пиридо[3,4-b]индоловые модуляторы эстрогеновых рецепторов и их применение
TWI726861B (zh) * 2015-01-23 2021-05-11 英商葛蘭素史克智慧財產發展有限公司 吡唑并-嘧啶化合物、其鹽及其用途
WO2016147205A1 (en) * 2015-03-13 2016-09-22 Council Of Scientific & Industrial Research Novel substituted 3-spirophosphoryl pyrazole-2-oxindoles as anti-infectives and process for the synthesis thereof
WO2016201440A1 (en) * 2015-06-12 2016-12-15 The Regents Of The University Of California Spiroindolinones and therapeutic uses thereof
JP2017024992A (ja) * 2015-07-15 2017-02-02 公益財団法人微生物化学研究会 化合物の製造方法
ES2951829T3 (es) 2018-06-21 2023-10-25 Hoffmann La Roche Formas sólidas de la sal de tartrato de 3-((1R,3R)-1-(2,6-difluoro-4-((1-(3-fluoropropil)acetidin-3-il)amino)fenil)-3-metil-1,3,4,9-tetrahidro-2H-pirido[3,4-b]indol-2-il)-2,2-difluoropropan-1-ol, proceso para su preparación y procedimientos de su uso en el tratamiento de cánceres
CN110590795B (zh) * 2019-10-10 2021-01-22 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一类多并杂环螺羟吲哚类化合物的合成方法
US20230132973A1 (en) * 2020-03-17 2023-05-04 The University Of Buea DIHYDRO-SPIRO[INDOLINE-3:1'-iSOQUINOLIN]-2-ONES AS ANTIMALARIAL AGENTS

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2663935A1 (fr) * 1990-06-27 1992-01-03 Adir Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
SI1095042T1 (sl) * 1998-07-14 2006-04-30 Bayer Healthcare Ag Antiparazitski artemizininski derivati
UA74537C2 (uk) 1998-12-19 2006-01-16 Янссен Фармацевтика Н.В. Антигістамінні спіросполуки
US20050101623A1 (en) * 2003-07-23 2005-05-12 Pharmacia Corporation Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
AR053710A1 (es) 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
EP2102207B1 (en) 2006-12-07 2010-06-02 F.Hoffmann-La Roche Ag Spiro-piperidine derivatives as via receptor antagonists
AU2008345225A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
CL2009000035A1 (es) 2008-01-09 2009-11-27 Array Biopharma Inc Compuestos derivados 3-espiro-heterociclo-1il-5h-ciclopentan[d]pirimidin-indol, util para inhibir la actividad de akt quinasa; composicion farmaceutica que comprende dichos compuestos; y uso en el tratamiento de enfermedades tal como cancer, fibrosis quistica, diabetes, enfermedad de alzheimer, entre otras.
MX2010011868A (es) * 2008-04-29 2010-11-26 Novartis Ag Derivados de espiro-indol para el tratamiento de enfermedades parasitarias.

Also Published As

Publication number Publication date
NZ588217A (en) 2012-10-26
ECSP10010646A (es) 2010-12-30
KR101390081B1 (ko) 2014-04-29
BRPI0911577B1 (pt) 2021-02-23
BRPI0911577B8 (pt) 2021-05-25
WO2009132921A1 (en) 2009-11-05
CN102015711A (zh) 2011-04-13
CA2719365C (en) 2017-03-07
EA201001689A1 (ru) 2011-08-30
PE20091787A1 (es) 2009-12-14
CN102015711B (zh) 2013-05-01
HK1149935A1 (en) 2011-10-21
HRP20140151T1 (hr) 2014-03-28
MA32316B1 (fr) 2011-05-02
JP5438098B2 (ja) 2014-03-12
US20090275560A1 (en) 2009-11-05
CO6300940A2 (es) 2011-07-21
BRPI0911577A2 (pt) 2016-01-05
JP2011518852A (ja) 2011-06-30
IL208357A (en) 2014-11-30
US8053442B2 (en) 2011-11-08
CY1114874T1 (el) 2016-12-14
EP2285808B1 (en) 2013-11-20
TWI442921B (zh) 2014-07-01
JP2014065729A (ja) 2014-04-17
ES2447590T3 (es) 2014-03-12
IL208357A0 (en) 2010-12-30
CA2719365A1 (en) 2009-11-05
ECSP17068127A (es) 2017-10-31
SI2285808T1 (sl) 2014-03-31
JO2904B1 (en) 2015-09-15
MX2010011868A (es) 2010-11-26
DK2285808T3 (da) 2014-02-03
PL2285808T3 (pl) 2014-04-30
US8399453B2 (en) 2013-03-19
TW200948357A (en) 2009-12-01
AU2009242279A1 (en) 2009-11-05
EP2285808A1 (en) 2011-02-23
AR071222A1 (es) 2010-06-02
EA019601B1 (ru) 2014-04-30
CL2009001007A1 (es) 2010-06-11
US20110275613A1 (en) 2011-11-10
KR20100135320A (ko) 2010-12-24
MY152021A (en) 2014-08-15
MY156601A (en) 2016-03-15
ZA201006752B (en) 2011-05-25
EP2722333A1 (en) 2014-04-23
AU2009242279B2 (en) 2012-08-30
BRPI0911577A8 (pt) 2018-03-06

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