BRPI0821114A2 - Composto, uso de um composto e método para tratar qualquer mamífero afetado por câncer - Google Patents

Composto, uso de um composto e método para tratar qualquer mamífero afetado por câncer

Info

Publication number: BRPI0821114A2
Authority: BR; Brazil
Prior art keywords: compound; cancer; treat; affected mammal; mammal
Prior art date: 2007-12-20

Application number

BRPI0821114-0A

Other languages

English (en)

Inventor

Alberto Rodrígues Vicente

María Garranzo García-Ibarrola

Carmen Murcia Pérez

Francisco Sánchez Sancho

María Del Carmen Cuevas Marchante

Cristina Mateo Urbano

Isabel Digón Juárez

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-20

Filing date

2008-12-19

Publication date

2015-06-16

2008-12-19 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

2015-06-16 Publication of BRPI0821114A2 publication Critical patent/BRPI0821114A2/pt

2021-09-08 Publication of BRPI0821114B1 publication Critical patent/BRPI0821114B1/pt

2021-11-09 Publication of BRPI0821114B8 publication Critical patent/BRPI0821114B8/pt

Links

150000001875 compounds Chemical class 0.000 title abstract 3
206010028980 Neoplasm Diseases 0.000 title abstract 2
201000011510 cancer Diseases 0.000 title abstract 2
241000124008 Mammalia Species 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Dermatology (AREA)
Peptides Or Proteins (AREA)
Steroid Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BRPI0821114A 2007-12-20 2008-12-19 Composto antitumoral, composição farmacêutica, uso de um composto antitumoral, uso de uma composição farmacêutica, e processo para a preparação do referido composto BRPI0821114B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP07123882		2007-12-20
EP07123882.8		2007-12-20
PCT/EP2008/068065 WO2009080769A1 (en)	2007-12-20	2008-12-19	Antitumoral compounds

Publications (3)

Publication Number	Publication Date
BRPI0821114A2 true BRPI0821114A2 (pt)	2015-06-16
BRPI0821114B1 BRPI0821114B1 (pt)	2021-09-08
BRPI0821114B8 BRPI0821114B8 (pt)	2021-11-09

Family

ID=40580474

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BRPI0821116A BRPI0821116B8 (pt)	2007-12-20	2008-12-19	composto, composição farmacêutica que o contem, uso deste e processo para a preparação do mesmo
BRPI0821114A BRPI0821114B8 (pt)	2007-12-20	2008-12-19	Composto antitumoral, composição farmacêutica, uso de um composto antitumoral, uso de uma composição farmacêutica, e processo para a preparação do referido composto

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
BRPI0821116A BRPI0821116B8 (pt)	2007-12-20	2008-12-19	composto, composição farmacêutica que o contem, uso deste e processo para a preparação do mesmo

Country Status (27)

Country	Link
US (4)	US8710264B2 (pt)
EP (3)	EP2231590B9 (pt)
JP (3)	JP5727228B2 (pt)
KR (3)	KR101579553B1 (pt)
CN (4)	CN102190643B (pt)
AT (1)	ATE549313T1 (pt)
AU (2)	AU2008341671B2 (pt)
BR (2)	BRPI0821116B8 (pt)
CA (2)	CA2715203C (pt)
CY (1)	CY1117245T1 (pt)
DK (2)	DK2231633T3 (pt)
ES (3)	ES2442140T3 (pt)
HK (3)	HK1147990A1 (pt)
HR (2)	HRP20120464T1 (pt)
IL (3)	IL206397A (pt)
MX (2)	MX2010006795A (pt)
MY (3)	MY164533A (pt)
NZ (3)	NZ597526A (pt)
PL (2)	PL2231590T3 (pt)
PT (2)	PT2231590E (pt)
RS (2)	RS52343B (pt)
RU (3)	RU2489429C2 (pt)
SG (2)	SG170778A1 (pt)
SI (2)	SI2231590T1 (pt)
UA (3)	UA119963C2 (pt)
WO (2)	WO2009080769A1 (pt)
ZA (3)	ZA201004018B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ597526A (en)	2007-12-20	2012-06-29	Pharma Mar Sa	Antitumoral compounds
JP6180115B2 (ja)	2012-01-05	2017-08-16	花王株式会社	刺激感緩和剤
BR112015026261A8 (pt)	2013-04-16	2017-12-26	Actelion Pharmaceuticals Ltd	Derivados biaromáticos antibacterianos
GB201309807D0 (en) *	2013-05-31	2013-07-17	Pharma Mar Sau	Antibody drug conjugates
CN108467378A (zh) *	2017-02-23	2018-08-31	复旦大学	一种二氢吡喃酮类化合物及其制备方法和用途
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5142056A (en) *	1989-05-23	1992-08-25	Abbott Laboratories	Retroviral protease inhibiting compounds
US4855086A (en)	1982-10-15	1989-08-08	Burroughs Wellcome Co.	Novel pesticides, preparation and use
JPS61109717A (ja)	1984-11-02	1986-05-28	Teruhiko Beppu	抗腫瘍剤
WO1992012140A1 (en) *	1990-12-28	1992-07-23	Georgia Tech Research Corporation	Peptides ketoamides, ketoacids, and ketoesters
JPH0539283A (ja)	1991-01-31	1993-02-19	Suntory Ltd	新規物質Ｓ−５９９１７ａ及びその製造方法
ZA938019B (en)	1992-11-13	1995-04-28	Upjohn Co	Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
US5523456A (en) *	1994-09-29	1996-06-04	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US5681847A (en) *	1995-12-05	1997-10-28	Harbor Branch Oceanographic Institution, Inc.	Methods of using discodermolide compounds
US5834506A (en)	1996-11-01	1998-11-10	Warner-Lambert Company	Dihydropyrones with improved antiviral activity
US5840974A (en) *	1996-12-04	1998-11-24	Britisch Biotech Pharmaceuticals, Ltd.	Metalloproteinase inhibitors
NZ510013A (en)	1998-09-11	2003-11-28	Warner Lambert Co	Dihydropyrones with selected heterocycles replacing the phenyls bearing polar substituents used as HIV protease inhibitors
US6380400B1 (en)	1998-09-11	2002-04-30	Victor Fedij	Methods of making dihydropyrone HIV protease inhibitors
CA2401104A1 (en) *	2000-04-04	2001-10-11	Novartis Ag	Method for treating cells resistant to antineoplastic agents
NZ567758A (en) *	2002-03-04	2009-07-31	Merck Hdac Res Llc	Methods of inducing terminal differentiation using suberoylanilide hydrozmic acid (SAHA)
MXPA06000975A (es) *	2003-07-25	2006-04-11	Novartis Ag	Lactams sustituidos y su uso como agentes anti-cancer.
RU2006142690A (ru) *	2004-06-03	2008-06-10	Козан Байосайенсиз Инкорпорейтед (Us)	Соединения лептомицина
US7446196B2 (en) *	2004-06-03	2008-11-04	Kosan Biosciences, Incorporated	Leptomycin compounds
WO2007014423A1 (en) *	2005-08-02	2007-02-08	Medvet Science Pty, Ltd.	Exercise apparatus
BRPI0722429A2 (pt) *	2006-06-16	2013-11-26	Pharma Mar Sa	Processo para a preparação de um composto de di-hidropiran-2-ona, processo para a preparação de compostos intermediários, e compostos de fragmentos
NZ597526A (en)	2007-12-20	2012-06-29	Pharma Mar Sa	Antitumoral compounds

2008
- 2008-12-19 NZ NZ597526A patent/NZ597526A/en unknown
- 2008-12-19 AT AT08865009T patent/ATE549313T1/de active
- 2008-12-19 KR KR1020107015968A patent/KR101579553B1/ko active IP Right Grant
- 2008-12-19 PL PL08865009T patent/PL2231590T3/pl unknown
- 2008-12-19 JP JP2010538769A patent/JP5727228B2/ja active Active
- 2008-12-19 ES ES08864895.1T patent/ES2442140T3/es active Active
- 2008-12-19 RS RS20120242A patent/RS52343B/en unknown
- 2008-12-19 SG SG201102163-1A patent/SG170778A1/en unknown
- 2008-12-19 SI SI200830644T patent/SI2231590T1/sl unknown
- 2008-12-19 BR BRPI0821116A patent/BRPI0821116B8/pt active IP Right Grant
- 2008-12-19 DK DK08864895.1T patent/DK2231633T3/da active
- 2008-12-19 RU RU2010130253/04A patent/RU2489429C2/ru active
- 2008-12-19 CN CN201110073931.0A patent/CN102190643B/zh active Active
- 2008-12-19 MX MX2010006795A patent/MX2010006795A/es active IP Right Grant
- 2008-12-19 BR BRPI0821114A patent/BRPI0821114B8/pt active IP Right Grant
- 2008-12-19 UA UAA201406894A patent/UA119963C2/uk unknown
- 2008-12-19 CN CN2011100568656A patent/CN102174058A/zh active Pending
- 2008-12-19 RU RU2010130180/04A patent/RU2493147C2/ru active
- 2008-12-19 DK DK08865009.8T patent/DK2231590T3/da active
- 2008-12-19 UA UAA201009035A patent/UA104281C2/ru unknown
- 2008-12-19 CA CA2715203A patent/CA2715203C/en active Active
- 2008-12-19 RU RU2013112003/04A patent/RU2528393C9/ru active
- 2008-12-19 SI SI200831122T patent/SI2231633T1/sl unknown
- 2008-12-19 JP JP2010538765A patent/JP5529038B2/ja active Active
- 2008-12-19 MY MYPI2014002392A patent/MY164533A/en unknown
- 2008-12-19 PT PT08865009T patent/PT2231590E/pt unknown
- 2008-12-19 RS RS20140007A patent/RS53140B/en unknown
- 2008-12-19 EP EP08865009A patent/EP2231590B9/en active Active
- 2008-12-19 MY MYPI2010002591A patent/MY155342A/en unknown
- 2008-12-19 ES ES08865009T patent/ES2384420T3/es active Active
- 2008-12-19 CN CN2008801218410A patent/CN101903337B/zh active Active
- 2008-12-19 CA CA2710087A patent/CA2710087C/en active Active
- 2008-12-19 WO PCT/EP2008/068065 patent/WO2009080769A1/en active Application Filing
- 2008-12-19 AU AU2008341671A patent/AU2008341671B2/en active Active
- 2008-12-19 CN CN200880121840.6A patent/CN101903367B/zh active Active
- 2008-12-19 SG SG201102164-9A patent/SG170779A1/en unknown
- 2008-12-19 WO PCT/EP2008/068049 patent/WO2009080761A1/en active Application Filing
- 2008-12-19 PT PT88648951T patent/PT2231633E/pt unknown
- 2008-12-19 ES ES13154647.5T patent/ES2578606T3/es active Active
- 2008-12-19 NZ NZ586013A patent/NZ586013A/en unknown
- 2008-12-19 MY MYPI2010002590A patent/MY148651A/en unknown
- 2008-12-19 US US12/746,966 patent/US8710264B2/en active Active
- 2008-12-19 NZ NZ586012A patent/NZ586012A/en unknown
- 2008-12-19 UA UAA201009034A patent/UA106967C2/uk unknown
- 2008-12-19 AU AU2008341670A patent/AU2008341670B2/en active Active
- 2008-12-19 MX MX2010006796A patent/MX2010006796A/es active IP Right Grant
- 2008-12-19 US US12/746,974 patent/US9187445B2/en active Active
- 2008-12-19 EP EP08864895.1A patent/EP2231633B1/en active Active
- 2008-12-19 PL PL08864895T patent/PL2231633T3/pl unknown
- 2008-12-19 EP EP13154647.5A patent/EP2597091B1/en active Active
- 2008-12-19 KR KR1020107015965A patent/KR101541436B1/ko active IP Right Grant
- 2008-12-19 KR KR1020157016575A patent/KR101639772B1/ko active IP Right Grant
2010
- 2010-06-04 ZA ZA2010/04018A patent/ZA201004018B/en unknown
- 2010-06-04 ZA ZA2010/04017A patent/ZA201004017B/en unknown
- 2010-06-15 IL IL206397A patent/IL206397A/en active IP Right Grant
- 2010-06-15 IL IL206396A patent/IL206396A/en active IP Right Grant
2011
- 2011-03-01 HK HK11102050.0A patent/HK1147990A1/xx unknown
- 2011-03-01 HK HK11102052.8A patent/HK1147998A1/xx unknown
- 2011-03-01 HK HK13107821.5A patent/HK1180678A1/zh unknown
- 2011-08-31 ZA ZA2011/06371A patent/ZA201106371B/en unknown
2012
- 2012-06-01 HR HRP20120464AT patent/HRP20120464T1/hr unknown
2013
- 2013-11-24 IL IL229594A patent/IL229594A/en active IP Right Grant
2014
- 2014-01-08 HR HRP20140015AT patent/HRP20140015T1/hr unknown
- 2014-01-27 CY CY20141100069T patent/CY1117245T1/el unknown
- 2014-04-10 JP JP2014080887A patent/JP5860088B2/ja active Active
2015
- 2015-08-12 US US14/824,690 patent/US9750759B2/en active Active
- 2015-08-12 US US14/824,699 patent/US9827257B2/en active Active

Also Published As

Publication number	Publication date
CN101903367A (zh)	2010-12-01
ZA201106371B (en)	2013-05-29
RU2528393C1 (ru)	2014-09-20
NZ586012A (en)	2011-11-25
US20100280108A1 (en)	2010-11-04
RU2528393C9 (ru)	2015-01-10
ES2578606T3 (es)	2016-07-28
US9187445B2 (en)	2015-11-17
SG170779A1 (en)	2011-05-30
BRPI0821116B1 (pt)	2020-02-18
UA104281C2 (ru)	2014-01-27
PL2231633T3 (pl)	2014-03-31
RS52343B (en)	2012-12-31
BRPI0821114B1 (pt)	2021-09-08
US20150344454A1 (en)	2015-12-03
IL206396A0 (en)	2010-12-30
CN101903337B (zh)	2013-12-18
CA2710087A1 (en)	2009-07-02
PT2231633E (pt)	2014-01-20
WO2009080769A1 (en)	2009-07-02
EP2231633A1 (en)	2010-09-29
MY155342A (en)	2015-10-15
CN101903367B (zh)	2015-08-05
IL206396A (en)	2014-05-28
BRPI0821114B8 (pt)	2021-11-09
JP2011506578A (ja)	2011-03-03
WO2009080761A1 (en)	2009-07-02
MX2010006795A (es)	2010-10-26
US20120041063A2 (en)	2012-02-16
HK1147990A1 (en)	2011-08-26
ES2442140T3 (es)	2014-02-25
IL206397A0 (en)	2010-12-30
JP2011506575A (ja)	2011-03-03
CN102190643B (zh)	2015-02-25
CN101903337A (zh)	2010-12-01
BRPI0821116A2 (pt)	2015-08-11
KR101639772B1 (ko)	2016-07-15
SI2231590T1 (sl)	2012-10-30
EP2231590A1 (en)	2010-09-29
EP2597091B1 (en)	2016-04-20
DK2231633T3 (da)	2014-01-20
HRP20140015T1 (hr)	2014-02-14
RU2013112003A (ru)	2014-08-20
MY148651A (en)	2013-05-15
IL229594A (en)	2016-02-29
EP2231590B9 (en)	2012-08-15
EP2231590B1 (en)	2012-03-14
EP2231633B1 (en)	2013-10-30
IL229594A0 (en)	2014-01-30
CA2715203A1 (en)	2009-07-02
KR20100100979A (ko)	2010-09-15
NZ597526A (en)	2012-06-29
KR20150076265A (ko)	2015-07-06
CN102190643A (zh)	2011-09-21
AU2008341670B2 (en)	2012-04-19
AU2008341671B2 (en)	2012-07-26
JP5860088B2 (ja)	2016-02-16
US9827257B2 (en)	2017-11-28
US8710264B2 (en)	2014-04-29
NZ586013A (en)	2012-02-24
HRP20120464T1 (hr)	2012-07-31
JP2014133752A (ja)	2014-07-24
KR101579553B1 (ko)	2015-12-22
RU2489429C2 (ru)	2013-08-10
PL2231590T3 (pl)	2012-09-28
KR101541436B1 (ko)	2015-08-03
JP5727228B2 (ja)	2015-06-03
RU2493147C2 (ru)	2013-09-20
DK2231590T3 (da)	2012-07-09
AU2008341670A1 (en)	2009-07-02
US9750759B2 (en)	2017-09-05
SG170778A1 (en)	2011-05-30
MY164533A (en)	2017-12-29
CA2715203C (en)	2015-09-08
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