WO2010149688A3 - Antitumoral compounds - Google Patents

Antitumoral compounds Download PDF

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Publication number
WO2010149688A3
WO2010149688A3 PCT/EP2010/058879 EP2010058879W WO2010149688A3 WO 2010149688 A3 WO2010149688 A3 WO 2010149688A3 EP 2010058879 W EP2010058879 W EP 2010058879W WO 2010149688 A3 WO2010149688 A3 WO 2010149688A3
Authority
WO
WIPO (PCT)
Prior art keywords
antitumoral compounds
antitumoral
compounds
cancer
compound
Prior art date
Application number
PCT/EP2010/058879
Other languages
French (fr)
Other versions
WO2010149688A2 (en
Inventor
María GARRANZO GARCÍA-IBARROLA
Carmen MURCIA PÉREZ
Alberto RODRÍGUEZ VICENTE
María Cristina MATEO URBANO
Francisco SÁNCHEZ SANCHO
Andrés FRANCESCH SOLLOSO
María del Carmen CUEVAS MARCHANTE
Original Assignee
Pharma Mar, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar, S.A. filed Critical Pharma Mar, S.A.
Publication of WO2010149688A2 publication Critical patent/WO2010149688A2/en
Publication of WO2010149688A3 publication Critical patent/WO2010149688A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A compound of general formula (I), wherein Y, W, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and the dashed lines take various meanings, for use in the treatment of cancer.
PCT/EP2010/058879 2009-06-24 2010-06-23 Antitumoral compounds WO2010149688A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09382102 2009-06-24
EP09382102.3 2009-06-24

Publications (2)

Publication Number Publication Date
WO2010149688A2 WO2010149688A2 (en) 2010-12-29
WO2010149688A3 true WO2010149688A3 (en) 2011-08-25

Family

ID=43126885

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/058879 WO2010149688A2 (en) 2009-06-24 2010-06-23 Antitumoral compounds

Country Status (1)

Country Link
WO (1) WO2010149688A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201309807D0 (en) * 2013-05-31 2013-07-17 Pharma Mar Sau Antibody drug conjugates
CN108467378A (en) * 2017-02-23 2018-08-31 复旦大学 A kind of dihydropyran ketone compound and its preparation method and application
JOP20190254A1 (en) 2017-04-27 2019-10-27 Pharma Mar Sa Antitumoral compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005021558A2 (en) * 2003-08-14 2005-03-10 Cephalon, Inc. Proteasome inhibitors and methods of using the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0713031B8 (en) 2006-06-16 2021-05-25 Pharma Mar Sa dihydro-pyran-2-one compound, pharmaceutical composition, and use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005021558A2 (en) * 2003-08-14 2005-03-10 Cephalon, Inc. Proteasome inhibitors and methods of using the same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KOSHINO H ET AL: "The structure of enopeptins A and B, novel depsipeptide antibiotics", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 32, no. 52, 1 January 1991 (1991-01-01), pages 7707 - 7710, XP002248559, ISSN: 0040-4039, DOI: DOI:10.1016/0040-4039(91)80571-M *
PHOON C W ET AL: "Isolation and total synthesis of gymnastatin N, a POLO-like kinase 1 active constituent from the fungus Arachniotus punctatus", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 60, no. 50, 6 December 2004 (2004-12-06), pages 11619 - 11628, XP004628624, ISSN: 0040-4020, DOI: DOI:10.1016/J.TET.2004.09.046 *
SCHMIDT U ET AL: "Synthesis of Enopeptin B from Streptomyces sp RK-1051", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, WILEY VCH VERLAG, WEINHEIM, vol. 36, no. 10, 1 January 1997 (1997-01-01), pages 1110 - 1112, XP002248558, ISSN: 1433-7851, DOI: DOI:10.1002/ANIE.199711101 *

Also Published As

Publication number Publication date
WO2010149688A2 (en) 2010-12-29

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