DK2231633T3 - Antitumorale forbindelser - Google Patents

Antitumorale forbindelser

Info

Publication number
DK2231633T3
DK2231633T3 DK08864895.1T DK08864895T DK2231633T3 DK 2231633 T3 DK2231633 T3 DK 2231633T3 DK 08864895 T DK08864895 T DK 08864895T DK 2231633 T3 DK2231633 T3 DK 2231633T3
Authority
DK
Denmark
Prior art keywords
antitumoral
relations
cancer
compound
treatment
Prior art date
Application number
DK08864895.1T
Other languages
English (en)
Inventor
Vicente Alberto Rodriguez
Garcia-Ibarrola Maria Garranzo
Perez Carmen Murcia
Sancho Francisco Sanchez
Marchante Maria Del Carmen Cuevas
Urbano Cristina Mateo
Juarez Isabel Digon
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Application granted granted Critical
Publication of DK2231633T3 publication Critical patent/DK2231633T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/51Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/695Silicon compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/366Lactones having six-membered rings, e.g. delta-lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30Oxygen atoms, e.g. delta-lactones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DK08864895.1T 2007-12-20 2008-12-19 Antitumorale forbindelser DK2231633T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07123882 2007-12-20
PCT/EP2008/068049 WO2009080761A1 (en) 2007-12-20 2008-12-19 Antitumoral compounds

Publications (1)

Publication Number Publication Date
DK2231633T3 true DK2231633T3 (da) 2014-01-20

Family

ID=40580474

Family Applications (2)

Application Number Title Priority Date Filing Date
DK08865009.8T DK2231590T3 (da) 2007-12-20 2008-12-19 Antitumorforbindelser
DK08864895.1T DK2231633T3 (da) 2007-12-20 2008-12-19 Antitumorale forbindelser

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK08865009.8T DK2231590T3 (da) 2007-12-20 2008-12-19 Antitumorforbindelser

Country Status (27)

Country Link
US (4) US9187445B2 (da)
EP (3) EP2231633B1 (da)
JP (3) JP5529038B2 (da)
KR (3) KR101639772B1 (da)
CN (4) CN102190643B (da)
AT (1) ATE549313T1 (da)
AU (2) AU2008341670B2 (da)
BR (2) BRPI0821116B8 (da)
CA (2) CA2710087C (da)
CY (1) CY1117245T1 (da)
DK (2) DK2231590T3 (da)
ES (3) ES2384420T3 (da)
HK (3) HK1180678A1 (da)
HR (2) HRP20120464T1 (da)
IL (3) IL206396A (da)
MX (2) MX2010006796A (da)
MY (3) MY148651A (da)
NZ (3) NZ586013A (da)
PL (2) PL2231590T3 (da)
PT (2) PT2231633E (da)
RS (2) RS52343B (da)
RU (3) RU2528393C9 (da)
SG (2) SG170778A1 (da)
SI (2) SI2231590T1 (da)
UA (3) UA104281C2 (da)
WO (2) WO2009080761A1 (da)
ZA (3) ZA201004018B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2231590T3 (da) 2007-12-20 2012-07-09 Pharma Mar Sa Antitumorforbindelser
JP6180115B2 (ja) * 2012-01-05 2017-08-16 花王株式会社 刺激感緩和剤
PL2986607T3 (pl) 2013-04-16 2017-11-30 Idorsia Pharmaceuticals Ltd Przeciwbakteryjne pochodne biaromatyczne
GB201309807D0 (en) * 2013-05-31 2013-07-17 Pharma Mar Sau Antibody drug conjugates
CN108467378A (zh) * 2017-02-23 2018-08-31 复旦大学 一种二氢吡喃酮类化合物及其制备方法和用途
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142056A (en) * 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
US4855086A (en) * 1982-10-15 1989-08-08 Burroughs Wellcome Co. Novel pesticides, preparation and use
JPS61109717A (ja) 1984-11-02 1986-05-28 Teruhiko Beppu 抗腫瘍剤
EP0564561A4 (en) * 1990-12-28 1994-08-10 Georgia Tech Res Inst Peptides ketoamides, ketoacids, and ketoesters
JPH0539283A (ja) 1991-01-31 1993-02-19 Suntory Ltd 新規物質S−59917a及びその製造方法
ZA938019B (en) 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
US5523456A (en) * 1994-09-29 1996-06-04 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5681847A (en) * 1995-12-05 1997-10-28 Harbor Branch Oceanographic Institution, Inc. Methods of using discodermolide compounds
US5834506A (en) 1996-11-01 1998-11-10 Warner-Lambert Company Dihydropyrones with improved antiviral activity
US5840974A (en) * 1996-12-04 1998-11-24 Britisch Biotech Pharmaceuticals, Ltd. Metalloproteinase inhibitors
AU773567B2 (en) 1998-09-11 2004-05-27 Warner-Lambert Company HIV protease inhibitors
US6380400B1 (en) 1998-09-11 2002-04-30 Victor Fedij Methods of making dihydropyrone HIV protease inhibitors
CA2401104A1 (en) * 2000-04-04 2001-10-11 Novartis Ag Method for treating cells resistant to antineoplastic agents
EP2082737B1 (en) * 2002-03-04 2014-12-31 Merck HDAC Research, LLC Methods of inducing terminal differentiation
AU2004263287B2 (en) 2003-07-25 2009-02-12 Novartis Ag Substituted lactams and their use as anti-cancer agents
US7446196B2 (en) 2004-06-03 2008-11-04 Kosan Biosciences, Incorporated Leptomycin compounds
RU2006142690A (ru) * 2004-06-03 2008-06-10 Козан Байосайенсиз Инкорпорейтед (Us) Соединения лептомицина
WO2007014423A1 (en) * 2005-08-02 2007-02-08 Medvet Science Pty, Ltd. Exercise apparatus
NZ573706A (en) 2006-06-16 2011-09-30 Pharma Mar Sa Antitumoral dihydropyran-2-one compounds
DK2231590T3 (da) 2007-12-20 2012-07-09 Pharma Mar Sa Antitumorforbindelser

Also Published As

Publication number Publication date
ZA201004018B (en) 2011-12-28
EP2231590B1 (en) 2012-03-14
IL206396A0 (en) 2010-12-30
US8710264B2 (en) 2014-04-29
RU2013112003A (ru) 2014-08-20
CN102190643A (zh) 2011-09-21
PT2231633E (pt) 2014-01-20
WO2009080769A1 (en) 2009-07-02
HRP20140015T1 (hr) 2014-02-14
MY155342A (en) 2015-10-15
ES2384420T3 (es) 2012-07-04
US20110034549A1 (en) 2011-02-10
ZA201004017B (en) 2011-12-28
PT2231590E (pt) 2012-06-25
SI2231590T1 (sl) 2012-10-30
RU2010130180A (ru) 2012-01-27
CY1117245T1 (el) 2017-04-05
KR101579553B1 (ko) 2015-12-22
RU2489429C2 (ru) 2013-08-10
UA106967C2 (uk) 2014-11-10
US20150342972A1 (en) 2015-12-03
JP2011506575A (ja) 2011-03-03
IL206396A (en) 2014-05-28
IL206397A0 (en) 2010-12-30
AU2008341670B2 (en) 2012-04-19
US20120041063A2 (en) 2012-02-16
EP2597091B1 (en) 2016-04-20
EP2231590A1 (en) 2010-09-29
PL2231633T3 (pl) 2014-03-31
IL206397A (en) 2014-01-30
US9750759B2 (en) 2017-09-05
RS52343B (en) 2012-12-31
IL229594A (en) 2016-02-29
SG170779A1 (en) 2011-05-30
PL2231590T3 (pl) 2012-09-28
SI2231633T1 (sl) 2014-02-28
CA2710087A1 (en) 2009-07-02
MX2010006795A (es) 2010-10-26
ES2578606T3 (es) 2016-07-28
UA119963C2 (uk) 2019-09-10
MY148651A (en) 2013-05-15
BRPI0821114B1 (pt) 2021-09-08
BRPI0821116B1 (pt) 2020-02-18
BRPI0821114B8 (pt) 2021-11-09
CN101903367A (zh) 2010-12-01
BRPI0821116A2 (pt) 2015-08-11
JP5529038B2 (ja) 2014-06-25
JP2011506578A (ja) 2011-03-03
KR101639772B1 (ko) 2016-07-15
ZA201106371B (en) 2013-05-29
JP5860088B2 (ja) 2016-02-16
US9827257B2 (en) 2017-11-28
CN102190643B (zh) 2015-02-25
KR101541436B1 (ko) 2015-08-03
RS53140B (en) 2014-06-30
EP2231590B9 (en) 2012-08-15
RU2528393C1 (ru) 2014-09-20
HRP20120464T1 (hr) 2012-07-31
BRPI0821114A2 (pt) 2015-06-16
RU2010130253A (ru) 2012-01-27
ATE549313T1 (de) 2012-03-15
CA2715203C (en) 2015-09-08
EP2231633B1 (en) 2013-10-30
JP2014133752A (ja) 2014-07-24
NZ586013A (en) 2012-02-24
AU2008341671B2 (en) 2012-07-26
MY164533A (en) 2017-12-29
SG170778A1 (en) 2011-05-30
BRPI0821116B8 (pt) 2021-05-25
CN102174058A (zh) 2011-09-07
HK1180678A1 (zh) 2013-10-25
CN101903367B (zh) 2015-08-05
KR20150076265A (ko) 2015-07-06
HK1147998A1 (en) 2011-08-26
CA2715203A1 (en) 2009-07-02
US9187445B2 (en) 2015-11-17
RU2493147C2 (ru) 2013-09-20
JP5727228B2 (ja) 2015-06-03
AU2008341670A1 (en) 2009-07-02
NZ586012A (en) 2011-11-25
US20100280108A1 (en) 2010-11-04
CN101903337B (zh) 2013-12-18
DK2231590T3 (da) 2012-07-09
EP2597091A1 (en) 2013-05-29
ES2442140T3 (es) 2014-02-25
AU2008341671A1 (en) 2009-07-02
CA2710087C (en) 2015-06-02
US20150344454A1 (en) 2015-12-03
KR20100125226A (ko) 2010-11-30
MX2010006796A (es) 2010-10-26
KR20100100979A (ko) 2010-09-15
NZ597526A (en) 2012-06-29
IL229594A0 (en) 2014-01-30
UA104281C2 (ru) 2014-01-27
WO2009080761A1 (en) 2009-07-02
CN101903337A (zh) 2010-12-01
HK1147990A1 (en) 2011-08-26
EP2231633A1 (en) 2010-09-29
RU2528393C9 (ru) 2015-01-10

Similar Documents

Publication Publication Date Title
NL300936I2 (nl) Semaglutide
EA200801428A1 (ru) Производные пиридиазинона для лечения опухолей
GEP20125702B (en) Benzimidazole derivatives
IL229594A0 (en) Materials and preparations for the treatment of tumors
NO20081292L (no) Pentasykliske kinaseinhibitorer
EA200901179A1 (ru) Замещённые тетрагидрохинолины
MY159479A (en) Herbicides
WO2010149688A3 (en) Antitumoral compounds
HRP20120434T1 (en) 4-oxadiazolyl-piperidine compounds and use thereof
GB0620005D0 (en) Compounds