BRPI0815557A2 - Atividaores de glicocinase - Google Patents

Atividaores de glicocinase

Info

Publication number
BRPI0815557A2
BRPI0815557A2 BRPI0815557-7A2A BRPI0815557A BRPI0815557A2 BR PI0815557 A2 BRPI0815557 A2 BR PI0815557A2 BR PI0815557 A BRPI0815557 A BR PI0815557A BR PI0815557 A2 BRPI0815557 A2 BR PI0815557A2
Authority
BR
Brazil
Prior art keywords
gluckinase
activators
gluckinase activators
Prior art date
Application number
BRPI0815557-7A2A
Other languages
English (en)
Inventor
Feng Tian
Qun Dang
G Sridhar Prasad
Wenyu Li
Brett C Bookser
Nicholas Brian Raffaele
Mark D Erion
Original Assignee
Metabasis Therapeuticas Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabasis Therapeuticas Inc filed Critical Metabasis Therapeuticas Inc
Publication of BRPI0815557A2 publication Critical patent/BRPI0815557A2/pt

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    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
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    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
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    • C07F9/40—Esters thereof
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BRPI0815557-7A2A 2007-08-13 2008-08-13 Atividaores de glicocinase BRPI0815557A2 (pt)

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EP2185570A2 (en) 2010-05-19
US8940927B2 (en) 2015-01-27
JP5572549B2 (ja) 2014-08-13
CA2695583A1 (en) 2009-02-19
CN101821276B (zh) 2016-08-31
EP2185570B1 (en) 2014-03-19
US10174062B2 (en) 2019-01-08
US9522926B2 (en) 2016-12-20
CN101821276A (zh) 2010-09-01
EP2185570A4 (en) 2011-02-09
WO2009023718A3 (en) 2009-04-16
JP2010536773A (ja) 2010-12-02
US20110294758A1 (en) 2011-12-01
WO2009023718A2 (en) 2009-02-19
US20170096440A1 (en) 2017-04-06
MX2010001784A (es) 2010-03-15
US20150119365A1 (en) 2015-04-30

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