BRPI0713923B8 - compostos de ciclopentanos de pirimidila hidroxilados e metoxilados, composição farmacêutica compreendendo os referidos compostos, método de preparação de um composto, e uso dos mesmos - Google Patents
compostos de ciclopentanos de pirimidila hidroxilados e metoxilados, composição farmacêutica compreendendo os referidos compostos, método de preparação de um composto, e uso dos mesmosInfo
- Publication number
- BRPI0713923B8 BRPI0713923B8 BRPI0713923A BRPI0713923A BRPI0713923B8 BR PI0713923 B8 BRPI0713923 B8 BR PI0713923B8 BR PI0713923 A BRPI0713923 A BR PI0713923A BR PI0713923 A BRPI0713923 A BR PI0713923A BR PI0713923 B8 BRPI0713923 B8 BR PI0713923B8
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- compounds
- hydroxylated
- preparing
- compound
- pharmaceutical composition
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Biomedical Technology (AREA)
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- Pulmonology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
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Abstract
compostos de ciclopentanos de pirimidila hidroxilados e metoxilados, composição farmacêutica compreendendo os referidos compostos, método de preparação de um composto, e uso dos mesmos. a presente invenção refere-se a compostos, incluindo enantiômeros resolvidos, diastereômeros resolvidos, solvatos e sais farmaceuticamente aceitáveis destes, compreendendo a fórmula i: são também fornecidos métodos de utilização dos compostos desta invenção como inibidores de akt proteína quinase e para o tratamento de doenças hiperproliferativas tais como câncer.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR122013028005A BR122013028005B8 (pt) | 2006-07-06 | 2007-07-05 | compostos de ciclopentanos de pirimidila hidroxilados e metoxilados, composição farmacêutica, kit e forma de dosagem oral compreendendo os referidos compostos, uso das referidas composições, bem como processo de preparação dos referidos compostos |
BR122013028012A BR122013028012B8 (pt) | 2006-07-06 | 2007-07-05 | composto de ciclopentano de pirimidila hidroxilado e metoxilado, sua composição farmacêutica e seu método de preparação |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81871806P | 2006-07-06 | 2006-07-06 | |
US60/818,718 | 2006-07-06 | ||
PCT/US2007/072885 WO2008006040A1 (en) | 2006-07-06 | 2007-07-05 | Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0713923A2 BRPI0713923A2 (pt) | 2013-07-02 |
BRPI0713923B1 BRPI0713923B1 (pt) | 2020-09-29 |
BRPI0713923B8 true BRPI0713923B8 (pt) | 2021-05-25 |
Family
ID=38686743
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR122013028005A BR122013028005B8 (pt) | 2006-07-06 | 2007-07-05 | compostos de ciclopentanos de pirimidila hidroxilados e metoxilados, composição farmacêutica, kit e forma de dosagem oral compreendendo os referidos compostos, uso das referidas composições, bem como processo de preparação dos referidos compostos |
BR122013028012A BR122013028012B8 (pt) | 2006-07-06 | 2007-07-05 | composto de ciclopentano de pirimidila hidroxilado e metoxilado, sua composição farmacêutica e seu método de preparação |
BRPI0713923A BRPI0713923B8 (pt) | 2006-07-06 | 2007-07-05 | compostos de ciclopentanos de pirimidila hidroxilados e metoxilados, composição farmacêutica compreendendo os referidos compostos, método de preparação de um composto, e uso dos mesmos |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR122013028005A BR122013028005B8 (pt) | 2006-07-06 | 2007-07-05 | compostos de ciclopentanos de pirimidila hidroxilados e metoxilados, composição farmacêutica, kit e forma de dosagem oral compreendendo os referidos compostos, uso das referidas composições, bem como processo de preparação dos referidos compostos |
BR122013028012A BR122013028012B8 (pt) | 2006-07-06 | 2007-07-05 | composto de ciclopentano de pirimidila hidroxilado e metoxilado, sua composição farmacêutica e seu método de preparação |
Country Status (35)
Country | Link |
---|---|
EP (4) | EP2966065A3 (pt) |
JP (4) | JP5266216B2 (pt) |
KR (5) | KR101578877B1 (pt) |
CN (2) | CN101578273B (pt) |
AR (3) | AR061842A1 (pt) |
AT (1) | ATE524447T1 (pt) |
AU (1) | AU2007269060B2 (pt) |
BR (3) | BR122013028005B8 (pt) |
CA (2) | CA2836316A1 (pt) |
CL (1) | CL2007001993A1 (pt) |
CO (1) | CO6150161A2 (pt) |
CR (1) | CR10600A (pt) |
CY (1) | CY1112117T1 (pt) |
DK (2) | DK2402325T3 (pt) |
ES (3) | ES2372774T3 (pt) |
HK (3) | HK1160638A1 (pt) |
HR (1) | HRP20110908T1 (pt) |
HU (1) | HUE026237T2 (pt) |
IL (2) | IL196028A (pt) |
IN (1) | IN2014KN02886A (pt) |
MA (1) | MA31655B1 (pt) |
MX (4) | MX366319B (pt) |
MY (1) | MY147364A (pt) |
NO (1) | NO342346B1 (pt) |
NZ (3) | NZ610633A (pt) |
PL (2) | PL2402325T3 (pt) |
PT (1) | PT2049501E (pt) |
RS (1) | RS52212B (pt) |
RU (2) | RU2478632C2 (pt) |
SG (4) | SG184706A1 (pt) |
SI (2) | SI2402325T1 (pt) |
TW (2) | TWI402266B (pt) |
UA (1) | UA95641C2 (pt) |
WO (1) | WO2008006040A1 (pt) |
ZA (1) | ZA200900070B (pt) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA95641C2 (en) * | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
US8063050B2 (en) * | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
US8329701B2 (en) | 2006-07-06 | 2012-12-11 | Array Biopharma Inc. | Dihydrofuro pyrimidines as AKT protein kinase inhibitors |
KR101527232B1 (ko) | 2006-07-06 | 2015-06-09 | 어레이 바이오파마 인크. | Akt 단백질 키나제 억제제로서의 시클로펜타〔d〕피리미딘 |
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