BRPI0713252B8 - processo para a recuperação de fator de crescimento endotelial vascular (vegf) recombinante reenovelado - Google Patents
processo para a recuperação de fator de crescimento endotelial vascular (vegf) recombinante reenoveladoInfo
- Publication number
- BRPI0713252B8 BRPI0713252B8 BRPI0713252A BRPI0713252A BRPI0713252B8 BR PI0713252 B8 BRPI0713252 B8 BR PI0713252B8 BR PI0713252 A BRPI0713252 A BR PI0713252A BR PI0713252 A BRPI0713252 A BR PI0713252A BR PI0713252 B8 BRPI0713252 B8 BR PI0713252B8
- Authority
- BR
- Brazil
- Prior art keywords
- vegf
- growth factor
- vascular endothelial
- endothelial growth
- recovered recombinant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
Abstract
processos para a recuperação de uma proteína recombinante reenovelada e método para purificar uma proteína recombinante. são fornecidos processos para a recuperação e purificação de proteínas recombinantes reenoveladas produzidas em células hospedeiras heteróloga, que inclui a etapa de reenovelamento da proteína em um tampão de ph elevado.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83083106P | 2006-07-14 | 2006-07-14 | |
US60/830,831 | 2006-07-14 | ||
PCT/US2007/073496 WO2008008975A2 (en) | 2006-07-14 | 2007-07-13 | Refolding of recombinant proteins |
Publications (4)
Publication Number | Publication Date |
---|---|
BRPI0713252A2 BRPI0713252A2 (pt) | 2012-04-10 |
BRPI0713252B1 BRPI0713252B1 (pt) | 2018-12-18 |
BRPI0713252B8 true BRPI0713252B8 (pt) | 2019-04-09 |
BRPI0713252C1 BRPI0713252C1 (pt) | 2021-05-25 |
Family
ID=38722613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0713252A BRPI0713252C1 (pt) | 2006-07-14 | 2007-07-13 | processo para a recuperação de fator de crescimento endotelial vascular (vegf) recombinante reenovelado |
Country Status (18)
Country | Link |
---|---|
US (4) | US20080125580A1 (pt) |
EP (1) | EP2041154B1 (pt) |
JP (2) | JP5566104B2 (pt) |
KR (1) | KR101520105B1 (pt) |
CN (1) | CN101506222B (pt) |
AR (1) | AR062069A1 (pt) |
AU (1) | AU2007272412B2 (pt) |
BR (1) | BRPI0713252C1 (pt) |
CA (1) | CA2656835C (pt) |
IL (1) | IL196004A (pt) |
MX (1) | MX2009000278A (pt) |
MY (1) | MY169472A (pt) |
NZ (1) | NZ573639A (pt) |
RU (1) | RU2439076C2 (pt) |
SG (1) | SG162834A1 (pt) |
TW (1) | TWI476207B (pt) |
WO (1) | WO2008008975A2 (pt) |
ZA (1) | ZA200900229B (pt) |
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AU2009284113B2 (en) | 2008-08-21 | 2015-05-14 | Octapharma Ag | Recombinantly produced human factor VIII and IX |
KR101063347B1 (ko) | 2009-04-06 | 2011-09-07 | 인하대학교 산학협력단 | 이온성 액체를 이용한 이황화 결합을 포함하는 단백질의 재접힘 방법 |
US8067201B2 (en) * | 2009-04-17 | 2011-11-29 | Bristol-Myers Squibb Company | Methods for protein refolding |
CN102482321B (zh) | 2009-06-22 | 2015-06-17 | 安姆根有限公司 | 使用化学控制的氧化还原态重折叠蛋白质 |
AU2010266093B2 (en) | 2009-06-25 | 2013-06-27 | Amgen Inc. | Capture purification processes for proteins expressed in a non-mammalian system |
KR20130140010A (ko) * | 2010-10-20 | 2013-12-23 | 메디뮨 엘엘씨 | 봉입체의 가공처리 방법 |
WO2012147965A1 (ja) * | 2011-04-28 | 2012-11-01 | 独立行政法人理化学研究所 | 生物材料を透明化する方法、及びその利用 |
CN103562702A (zh) | 2011-05-20 | 2014-02-05 | 独立行政法人理化学研究所 | 生物材料用透明化试剂、及其利用 |
CN102443055B (zh) * | 2011-10-26 | 2017-07-28 | 浙江海正药业股份有限公司 | 一种重组人肿瘤坏死因子相关凋亡诱导配体的纯化工艺 |
RU2492177C2 (ru) * | 2011-12-15 | 2013-09-10 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП ГосНИИгенетика) | СПОСОБ ВЫДЕЛЕНИЯ И ОЧИСТКИ РЕКОМБИНАНТНОГО ГОРМОНА РОСТА ЧЕЛОВЕКА, СЕКРЕТИРУЕМОГО ДРОЖЖАМИ Saccharomyces cerevisiae |
CA2866753C (en) * | 2012-03-27 | 2020-09-22 | Genentech, Inc. | Improved harvest operations for recombinant proteins |
CN103588871B (zh) * | 2012-08-16 | 2016-08-03 | 深圳新鹏生物工程有限公司 | 一种rhTRAIL菌体的分离纯化方法 |
ES2710314T3 (es) * | 2012-12-20 | 2019-04-24 | Medimmune Llc | Métodos de producción de inmunoconjugados |
US10065987B2 (en) * | 2013-02-12 | 2018-09-04 | Bristol-Myers Squibb Company | High pH protein refolding methods |
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US9982012B2 (en) | 2013-03-29 | 2018-05-29 | Dr. Reddy's Laboratories Limited | Refolding of granulocyte colony stimulating factor |
JP6433901B2 (ja) | 2013-08-14 | 2018-12-05 | 国立研究開発法人理化学研究所 | 光透過性に優れた生物材料を調製するための組成物およびその利用 |
CN103694339B (zh) * | 2013-12-04 | 2017-10-13 | 珠海联邦制药股份有限公司 | 一种甘精胰岛素前体的复性方法 |
KR101651330B1 (ko) * | 2014-07-28 | 2016-08-25 | 가톨릭대학교 산학협력단 | 세포투과성이 우수한 tat-a20 융합단백질의 제조방법 및 이의 용도 |
WO2016081288A1 (en) * | 2014-11-18 | 2016-05-26 | Merck Sharp & Dohme Corp. | Process for refolding recombinant chymotrypsin |
EP3221448B1 (en) | 2014-11-18 | 2021-01-06 | Merck Sharp & Dohme Corp. | Process for producing recombinant trypsin |
AU2015371341B2 (en) | 2014-12-22 | 2021-05-20 | Ucb Biopharma Sprl | Method of protein manufacture |
CA2969574A1 (en) * | 2014-12-23 | 2016-06-30 | Armo Biosciences, Inc. | Methods of improving yield in recombinant protein production |
DK3337820T3 (da) * | 2015-08-17 | 2021-01-18 | Lupin Ltd | Forbedret fremgangsmåde til genfoldning af fragmenter af antistoffer |
CN106008702B (zh) * | 2016-07-22 | 2019-11-26 | 江苏江山聚源生物技术有限公司 | 一种规模化分离纯化重组人源胶原蛋白的方法 |
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JP2022529811A (ja) * | 2019-04-24 | 2022-06-24 | タンベックス バイオファーマ ユーエスエー,インコーポレイティド | 顆粒球コロニー刺激因子を調製するためのプロセス |
KR20230066318A (ko) * | 2020-06-26 | 2023-05-15 | 트레포일 테라퓨틱스, 인크. | 재조합 변형된 섬유모세포 성장 인자 및 이의 치료적 용도 |
CN111848774B (zh) * | 2020-08-05 | 2022-05-10 | 武汉海特生物制药股份有限公司 | 一种美曲普汀的制备方法 |
WO2023017540A1 (en) * | 2021-08-11 | 2023-02-16 | Tata Institute For Genetics And Society | Methods for refolding a solubilized recombinant protein and implementation thereof |
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2007
- 2007-07-13 CN CN2007800318084A patent/CN101506222B/zh active Active
- 2007-07-13 KR KR1020097002959A patent/KR101520105B1/ko active IP Right Grant
- 2007-07-13 MX MX2009000278A patent/MX2009000278A/es active IP Right Grant
- 2007-07-13 TW TW096125690A patent/TWI476207B/zh active
- 2007-07-13 AR ARP070103137A patent/AR062069A1/es active IP Right Grant
- 2007-07-13 AU AU2007272412A patent/AU2007272412B2/en active Active
- 2007-07-13 RU RU2009105080/10A patent/RU2439076C2/ru active
- 2007-07-13 SG SG201004640-7A patent/SG162834A1/en unknown
- 2007-07-13 CA CA2656835A patent/CA2656835C/en active Active
- 2007-07-13 WO PCT/US2007/073496 patent/WO2008008975A2/en active Application Filing
- 2007-07-13 EP EP07812919.4A patent/EP2041154B1/en active Active
- 2007-07-13 NZ NZ573639A patent/NZ573639A/en unknown
- 2007-07-13 US US11/777,997 patent/US20080125580A1/en not_active Abandoned
- 2007-07-13 BR BRPI0713252A patent/BRPI0713252C1/pt active IP Right Grant
- 2007-07-13 ZA ZA200900229A patent/ZA200900229B/xx unknown
- 2007-07-13 MY MYPI20090074A patent/MY169472A/en unknown
- 2007-07-13 JP JP2009520923A patent/JP5566104B2/ja active Active
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2008
- 2008-12-17 IL IL196004A patent/IL196004A/en active IP Right Grant
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2011
- 2011-08-02 US US13/196,680 patent/US20110294990A1/en not_active Abandoned
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2012
- 2012-11-02 US US13/668,182 patent/US9200030B2/en active Active
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2013
- 2013-02-06 JP JP2013021750A patent/JP6120356B2/ja active Active
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2015
- 2015-10-26 US US14/922,802 patent/US9994612B2/en active Active
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