BRPI0608886B8 - derivados de n-sulfonilpirróis e seus usos - Google Patents

derivados de n-sulfonilpirróis e seus usos

Info

Publication number
BRPI0608886B8
BRPI0608886B8 BRPI0608886A BRPI0608886A BRPI0608886B8 BR PI0608886 B8 BRPI0608886 B8 BR PI0608886B8 BR PI0608886 A BRPI0608886 A BR PI0608886A BR PI0608886 A BRPI0608886 A BR PI0608886A BR PI0608886 B8 BRPI0608886 B8 BR PI0608886B8
Authority
BR
Brazil
Prior art keywords
sulfonylpyrroles
derivatives
compounds
description
meanings indicated
Prior art date
Application number
BRPI0608886A
Other languages
English (en)
Inventor
Zimmermann Astrid
Schneider Siegfried
Beckers Thomas
Bär Thomas
Maier Thomas
Gekeler Volker
Original Assignee
Nycomed Gmbh
Takeda Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Gmbh, Takeda Gmbh filed Critical Nycomed Gmbh
Publication of BRPI0608886A2 publication Critical patent/BRPI0608886A2/pt
Publication of BRPI0608886B1 publication Critical patent/BRPI0608886B1/pt
Publication of BRPI0608886B8 publication Critical patent/BRPI0608886B8/pt

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

n-sulfonilpirróis e seu uso como inibidores de histona deacetilase. a presente invenção refere-se a compostos de uma certa fórmula i, em que r1, r2, r3, r4, r5, r6 e r7 têm os significados indicados na descrição, que são inibidores de hdag eficazes.
BRPI0608886A 2005-03-15 2006-03-14 derivados de n-sulfonilpirróis e seus usos BRPI0608886B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05102019 2005-03-15
EP05102019.6 2005-03-15
EP05108735.1 2005-09-21
EP05108735 2005-09-21
PCT/EP2006/060712 WO2006097474A1 (en) 2005-03-15 2006-03-14 N-sulphonylpyrroles and their use as histone deacetylase inhibitors

Publications (3)

Publication Number Publication Date
BRPI0608886A2 BRPI0608886A2 (pt) 2010-02-02
BRPI0608886B1 BRPI0608886B1 (pt) 2020-11-17
BRPI0608886B8 true BRPI0608886B8 (pt) 2021-05-25

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BRPI0608886A BRPI0608886B8 (pt) 2005-03-15 2006-03-14 derivados de n-sulfonilpirróis e seus usos

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EP (1) EP1861365B1 (pt)
JP (1) JP5119143B2 (pt)
KR (1) KR101194510B1 (pt)
CN (1) CN101137623B (pt)
AT (1) ATE435203T1 (pt)
AU (1) AU2006224553B2 (pt)
BR (1) BRPI0608886B8 (pt)
CA (1) CA2599538C (pt)
CY (1) CY1109414T1 (pt)
DE (1) DE602006007558D1 (pt)
DK (1) DK1861365T3 (pt)
EA (2) EA015533B1 (pt)
ES (1) ES2327269T3 (pt)
HK (1) HK1125359A1 (pt)
HR (1) HRP20090402T1 (pt)
IL (1) IL185275A (pt)
MX (1) MX2007010561A (pt)
NO (1) NO340622B1 (pt)
NZ (1) NZ560267A (pt)
PL (1) PL1861365T3 (pt)
PT (1) PT1861365E (pt)
RS (1) RS51151B (pt)
SI (1) SI1861365T1 (pt)
TW (1) TWI321562B (pt)
WO (1) WO2006097474A1 (pt)

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AU2006298881A1 (en) 2005-09-21 2007-04-12 4Sc Ag Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors
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