BRPI0608840B8 - composição farmacêutica compreendendo uma difenil uréia substituída por ômega-carboxiarila, e seu processo de preparação - Google Patents

composição farmacêutica compreendendo uma difenil uréia substituída por ômega-carboxiarila, e seu processo de preparação

Info

Publication number
BRPI0608840B8
BRPI0608840B8 BRPI0608840A BRPI0608840A BRPI0608840B8 BR PI0608840 B8 BRPI0608840 B8 BR PI0608840B8 BR PI0608840 A BRPI0608840 A BR PI0608840A BR PI0608840 A BRPI0608840 A BR PI0608840A BR PI0608840 B8 BRPI0608840 B8 BR PI0608840B8
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
omega
substituted diphenyl
preparation process
diphenyl urea
Prior art date
Application number
BRPI0608840A
Other languages
English (en)
Inventor
Wollenschläger Axel
Schückler Fritz
Original Assignee
Batyer Healthcare Ag
Bayer Healthcare Llc
Bayer Ip Gmbh
Bayer Pharma AG
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36507604&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0608840(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Batyer Healthcare Ag, Bayer Healthcare Llc, Bayer Ip Gmbh, Bayer Pharma AG, Bayer Schering Pharma Ag filed Critical Batyer Healthcare Ag
Publication of BRPI0608840A2 publication Critical patent/BRPI0608840A2/pt
Publication of BRPI0608840B1 publication Critical patent/BRPI0608840B1/pt
Publication of BRPI0608840B8 publication Critical patent/BRPI0608840B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2813—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

composição farmacêutica compreendendo uma difenil uréia substituída por ômega - carboxiarila para o tratamento de câncer. a presente invenção refere-se a uma composição farmacêutica compreendendo o composto de fórmula (1) em uma alta concentração e pelo menos um excipiente farmaceuticamente aceitável, ao uso da composição para o tratamento de doenças hiperproliferativas tais como câncer, tanto como um agente único ou em combinação com outras terapias anticâncer, e ao processo de preparação da referida composição.
BRPI0608840A 2005-03-07 2006-02-22 composição farmacêutica compreendendo uma difenil uréia substituída por ômega-carboxiarila, e seu processo de preparação BRPI0608840B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65882705P 2005-03-07 2005-03-07
PCT/EP2006/001574 WO2006094626A1 (en) 2005-03-07 2006-02-22 Pharmaceutical composition comprising an omega- carboxyaryl substituted diphenyl urea for the treatment of cancer

Publications (3)

Publication Number Publication Date
BRPI0608840A2 BRPI0608840A2 (pt) 2010-02-02
BRPI0608840B1 BRPI0608840B1 (pt) 2020-04-14
BRPI0608840B8 true BRPI0608840B8 (pt) 2021-05-25

Family

ID=36507604

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0608840A BRPI0608840B8 (pt) 2005-03-07 2006-02-22 composição farmacêutica compreendendo uma difenil uréia substituída por ômega-carboxiarila, e seu processo de preparação

Country Status (38)

Country Link
US (2) US9737488B2 (pt)
EP (1) EP1868579B1 (pt)
JP (1) JP5304241B2 (pt)
KR (1) KR101335932B1 (pt)
CN (2) CN104688697A (pt)
AR (1) AR054234A1 (pt)
AT (1) ATE482693T1 (pt)
AU (1) AU2006222365B2 (pt)
BR (1) BRPI0608840B8 (pt)
CA (1) CA2601955C (pt)
CR (1) CR9348A (pt)
CU (1) CU23821A3 (pt)
CY (1) CY1111065T1 (pt)
DE (1) DE602006017188D1 (pt)
DK (1) DK1868579T3 (pt)
DO (1) DOP2006000057A (pt)
ES (1) ES2351612T3 (pt)
GT (1) GT200600096A (pt)
HK (2) HK1118019A1 (pt)
HN (1) HN2006009702A (pt)
HR (1) HRP20100674T1 (pt)
IL (1) IL185517A (pt)
MA (1) MA29378B1 (pt)
MX (1) MX2007010856A (pt)
MY (1) MY162319A (pt)
NO (1) NO343834B1 (pt)
NZ (1) NZ561178A (pt)
PE (1) PE20061345A1 (pt)
PL (1) PL1868579T3 (pt)
PT (1) PT1868579E (pt)
SG (1) SG160364A1 (pt)
SI (1) SI1868579T1 (pt)
TN (1) TNSN07341A1 (pt)
TW (1) TWI324928B (pt)
UA (1) UA93673C2 (pt)
UY (1) UY29410A1 (pt)
WO (1) WO2006094626A1 (pt)
ZA (1) ZA200707638B (pt)

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