PL1819698T3 - Pochodne 1-[(6-podstawione alkoksychinoksalinylo)aminokarbonylo]-4-(hetero)arylopiperazyny - Google Patents
Pochodne 1-[(6-podstawione alkoksychinoksalinylo)aminokarbonylo]-4-(hetero)arylopiperazynyInfo
- Publication number
- PL1819698T3 PL1819698T3 PL05809031T PL05809031T PL1819698T3 PL 1819698 T3 PL1819698 T3 PL 1819698T3 PL 05809031 T PL05809031 T PL 05809031T PL 05809031 T PL05809031 T PL 05809031T PL 1819698 T3 PL1819698 T3 PL 1819698T3
- Authority
- PL
- Poland
- Prior art keywords
- aminocarbonyl
- hetero
- arylpiperazine derivatives
- alkoxyquinoxalinyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020040094233A KR100739233B1 (ko) | 2004-11-17 | 2004-11-17 | 1-[(3-알콕시-6-치환-퀴녹살린-2-일)아미노카르보닐]-4-(헤테로)아릴피페라진 유도체 |
KR1020040094232A KR20060053788A (ko) | 2004-11-17 | 2004-11-17 | 1-[(2-알콕시-6-치환-퀴녹살린-3-일)아미노카르보닐]-4-(헤테로)아릴피페라진 유도체 |
PCT/KR2005/003463 WO2006054830A1 (en) | 2004-11-17 | 2005-10-18 | 1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives |
EP05809031A EP1819698B1 (en) | 2004-11-17 | 2005-10-18 | 1-[(6-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
PL1819698T3 true PL1819698T3 (pl) | 2011-08-31 |
Family
ID=36407350
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL05809031T PL1819698T3 (pl) | 2004-11-17 | 2005-10-18 | Pochodne 1-[(6-podstawione alkoksychinoksalinylo)aminokarbonylo]-4-(hetero)arylopiperazyny |
Country Status (12)
Country | Link |
---|---|
US (2) | US8314100B2 (pl) |
EP (1) | EP1819698B1 (pl) |
JP (1) | JP6097946B2 (pl) |
CN (1) | CN103524436B (pl) |
AT (1) | ATE499366T1 (pl) |
AU (1) | AU2005307209B2 (pl) |
BR (1) | BRPI0517734A (pl) |
CA (1) | CA2587891C (pl) |
DE (1) | DE602005026557D1 (pl) |
MX (1) | MX2007005863A (pl) |
PL (1) | PL1819698T3 (pl) |
WO (1) | WO2006054830A1 (pl) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2587891C (en) | 2004-11-17 | 2010-08-31 | Rexhan Pharmaceuticals, Inc. | 1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)alylpiperazine derivatives |
KR101140133B1 (ko) | 2010-02-17 | 2012-05-02 | 한국화학연구원 | 1-(6,7-다이플루오르-3-메톡시퀴녹살린-2-일)-3-[1-(헤테로아릴메틸)피페리딘-4-일] 우레아 유도체, 그 제조방법 및 그의 용도 |
US9744167B2 (en) | 2013-06-28 | 2017-08-29 | Rexahn Pharmaceuticals, Inc. | Nanoparticulate compositions and formulations of piperazine compounds |
HUE046316T2 (hu) * | 2014-12-08 | 2020-02-28 | Lsk Nrdo Co Ltd | Új 4- (aril) -N- (2-alkoxi-tieno [3,2-B] pirazin-3-il) -piperazin-1-karboxamid-származék és annak antiproliferatív hatása |
US9969698B2 (en) * | 2015-09-04 | 2018-05-15 | Rexahn Pharmaceuticals, Inc. | Quinoxalinyl-piperazinamide methods of use |
WO2017213452A1 (ko) * | 2016-06-09 | 2017-12-14 | 동국대학교 산학협력단 | 신규한 4-(아릴)-n-(3-알콕시퓨로[2,3-b]피라진-2-일)-피페라진-1-카복스아미드 유도체 및 이의 항증식 효과 |
KR101872645B1 (ko) * | 2016-06-09 | 2018-08-03 | 동국대학교 산학협력단 | 신규한 4-(아릴)-N-(3-알콕시퓨로[2,3-b]피라진-2-일)-피페라진-1-카복스아미드 유도체 및 이의 항증식 효과 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL59104A (en) * | 1979-02-09 | 1984-02-29 | Roussel Uclaf | Heterotricyclic derivatives,process for their preparation and pharmaceutical compositions incorporating them |
FR2448541A1 (fr) * | 1979-02-09 | 1980-09-05 | Roussel Uclaf | Nouveaux derives de l'oxoimidazoquinoxaline et leurs sels, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
US6071697A (en) * | 1992-08-03 | 2000-06-06 | Max-Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. | Method for testing the differentiation status in pancreatic cells of a mammal |
CZ59398A3 (cs) * | 1996-06-29 | 1998-07-15 | Samjin Pharmaceutical Co., Ltd. | Piperazinové deriváty a způsob jejich přípravy |
JP3422486B2 (ja) | 1999-03-03 | 2003-06-30 | サムジン ファーマシューティカル カンパニー リミテッド | ピペラジン誘導体及びその製造方法 |
WO2001095856A2 (en) * | 2000-06-15 | 2001-12-20 | Chaconne Nsi Co., Ltd. | Urea derivative useful as an anti-cancer agent and process for preparing same |
AR043059A1 (es) * | 2002-11-12 | 2005-07-13 | Bayer Pharmaceuticals Corp | Derivados de indolil pirazinona utiles para el tratamiento de trastornos hiper-proliferativos |
ATE390422T1 (de) * | 2003-04-16 | 2008-04-15 | Astrazeneca Ab | Quinazolin-derivate für die behandling von krebs |
CA2587891C (en) | 2004-11-17 | 2010-08-31 | Rexhan Pharmaceuticals, Inc. | 1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)alylpiperazine derivatives |
-
2005
- 2005-10-18 CA CA2587891A patent/CA2587891C/en not_active Expired - Fee Related
- 2005-10-18 AT AT05809031T patent/ATE499366T1/de active
- 2005-10-18 WO PCT/KR2005/003463 patent/WO2006054830A1/en active Application Filing
- 2005-10-18 US US11/667,923 patent/US8314100B2/en active Active
- 2005-10-18 AU AU2005307209A patent/AU2005307209B2/en not_active Ceased
- 2005-10-18 EP EP05809031A patent/EP1819698B1/en not_active Not-in-force
- 2005-10-18 JP JP2007542886A patent/JP6097946B2/ja not_active Expired - Fee Related
- 2005-10-18 CN CN201310540633.7A patent/CN103524436B/zh not_active Expired - Fee Related
- 2005-10-18 BR BRPI0517734-0A patent/BRPI0517734A/pt not_active Application Discontinuation
- 2005-10-18 PL PL05809031T patent/PL1819698T3/pl unknown
- 2005-10-18 DE DE602005026557T patent/DE602005026557D1/de active Active
- 2005-10-18 MX MX2007005863A patent/MX2007005863A/es active IP Right Grant
-
2012
- 2012-10-26 US US13/661,975 patent/US8598173B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE602005026557D1 (de) | 2011-04-07 |
US20130053390A1 (en) | 2013-02-28 |
JP6097946B2 (ja) | 2017-03-22 |
CA2587891C (en) | 2010-08-31 |
EP1819698B1 (en) | 2011-02-23 |
ATE499366T1 (de) | 2011-03-15 |
US8314100B2 (en) | 2012-11-20 |
JP2008520653A (ja) | 2008-06-19 |
US8598173B2 (en) | 2013-12-03 |
EP1819698A1 (en) | 2007-08-22 |
CN103524436A (zh) | 2014-01-22 |
AU2005307209A1 (en) | 2006-05-26 |
AU2005307209B2 (en) | 2009-11-19 |
BRPI0517734A (pt) | 2008-10-21 |
MX2007005863A (es) | 2007-10-19 |
WO2006054830A1 (en) | 2006-05-26 |
CN103524436B (zh) | 2015-09-23 |
US20080318963A1 (en) | 2008-12-25 |
CA2587891A1 (en) | 2006-05-26 |
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