BRPI0516497A - oligonucleotìdeos imunoestimuladores semi-macios de classe c - Google Patents

oligonucleotìdeos imunoestimuladores semi-macios de classe c

Info

Publication number
BRPI0516497A
BRPI0516497A BRPI0516497-4A BRPI0516497A BRPI0516497A BR PI0516497 A BRPI0516497 A BR PI0516497A BR PI0516497 A BRPI0516497 A BR PI0516497A BR PI0516497 A BRPI0516497 A BR PI0516497A
Authority
BR
Brazil
Prior art keywords
semi
class
soft
immunostimulatory oligonucleotides
oligonucleotides
Prior art date
Application number
BRPI0516497-4A
Other languages
English (en)
Inventor
Arthur M Krieg
Ulrike Samulowitz
Jorg Vollmer
Eugen Uhlmann
Original Assignee
Coley Pharm Group Inc
Coley Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coley Pharm Group Inc, Coley Pharm Gmbh filed Critical Coley Pharm Group Inc
Publication of BRPI0516497A publication Critical patent/BRPI0516497A/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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Abstract

OLIGONUCLEOTìDEOS IMUNOESTIMULADORES SEMI-MACIOS DE CLASSE C. A invenção se relaciona a oligonucleotídeos imuno-estimuladores específicos semi-macios da Classe-C que são úteis para a estimulação da resposta imune. Em particular, os oligonucleotídeos são úteis para tratar alergias, tais como rinite alérgica e asma, câncer e doenças infecciosas, tais como hepatite B e hepatite C.
BRPI0516497-4A 2004-10-20 2005-10-20 oligonucleotìdeos imunoestimuladores semi-macios de classe c BRPI0516497A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62075904P 2004-10-20 2004-10-20
PCT/US2005/037731 WO2006135434A2 (en) 2004-10-20 2005-10-20 Semi-soft c-class immunostimulatory oligonucleotides

Publications (1)

Publication Number Publication Date
BRPI0516497A true BRPI0516497A (pt) 2008-09-09

Family

ID=37507656

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0516497-4A BRPI0516497A (pt) 2004-10-20 2005-10-20 oligonucleotìdeos imunoestimuladores semi-macios de classe c

Country Status (28)

Country Link
US (3) US7566703B2 (pt)
EP (1) EP1802757B1 (pt)
JP (1) JP2008516634A (pt)
KR (1) KR20070065392A (pt)
CN (1) CN101084310A (pt)
AR (1) AR051462A1 (pt)
AT (1) ATE527355T1 (pt)
AU (1) AU2005332970A1 (pt)
BR (1) BRPI0516497A (pt)
CA (1) CA2578844A1 (pt)
CR (1) CR9131A (pt)
ES (1) ES2375071T3 (pt)
GT (1) GT200500294A (pt)
IL (1) IL182470A0 (pt)
MA (1) MA29028B1 (pt)
MY (1) MY159370A (pt)
NO (1) NO20072526L (pt)
NZ (1) NZ554753A (pt)
PA (1) PA8650101A1 (pt)
PE (1) PE20061045A1 (pt)
RS (1) RS20070164A (pt)
RU (1) RU2393223C2 (pt)
SV (1) SV2006002279A (pt)
TN (1) TNSN07150A1 (pt)
TW (1) TW200626720A (pt)
UY (1) UY29173A1 (pt)
WO (1) WO2006135434A2 (pt)
ZA (2) ZA200703609B (pt)

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