BRPI0512681A - derivados de uréia cìclica de amino, preparação destes e emprego farmacêutico destes como inibidores de cinase - Google Patents

derivados de uréia cìclica de amino, preparação destes e emprego farmacêutico destes como inibidores de cinase

Info

Publication number
BRPI0512681A
BRPI0512681A BRPI0512681-9A BRPI0512681A BRPI0512681A BR PI0512681 A BRPI0512681 A BR PI0512681A BR PI0512681 A BRPI0512681 A BR PI0512681A BR PI0512681 A BRPI0512681 A BR PI0512681A
Authority
BR
Brazil
Prior art keywords
alkyl
heteroaryl
alkynyl
cycloalkyl
alkenyl
Prior art date
Application number
BRPI0512681-9A
Other languages
English (en)
Inventor
Hartmut Strobel
Sven Ruf
Dominique Lesuisse
Conception Nemecek
Youssef El-Ahmad
Stefan Guessregen
Anne Lebrum
Kurt Ritter
Didier Benard
Augustin Hittinger
Herve Bouchard
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34931289&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0512681(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of BRPI0512681A publication Critical patent/BRPI0512681A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

DERIVADOS DE URéIA CìCLICA DE AMINO, PREPARAçãO DESTES E EMPREGO FARMACêUTICO DESTES COMO INIBIDORES DE CINASE A invenção refere-se a produtos de fórmula (I): em que p = 0,1 e 2; A = arila, heteroarila, carbociclo ou heterociclo; X = ligação única; -N(R)-; - NH-alk-; alquileno; -O-; -S(O)n-: -N(R6)-C(O)-; -NH-CO-alk-; -N(R6)-C(O)- N(R6<39>)-; .-N(R6)-C(S)-N(R6<39>)-; -N(R6)-C(O)O-; -N(R6)-SO2-; -N(R6)-SO2-N(R6<39>)-; -C(O)-N(R6)-; -SO2-NR6-; e -C(O)O-; L1 = ligação única, alquileno, alquenileno, alquinileno, cicloalquileno, fenileno, heteroarileno; todos opcionalmente substituídos: R1 = hidrogênio, alquila, alquenila, alquinila ou cicloalquila, arila, heteroarila, arilalquila, heteroarilalquila; -SO2R9, -C(O)R9; -C(O)OR9, -C(O)NR10R11, -C(S)NR10R11, -SO2NR10R11; R2 = hidrogênio, alquila, alquenila, alquinila, cicloalquila, ou R1 e R2 com N, ou NR1R2 com L1 podem formar heterociclo saturado ou insaturado possivelmente contendo O, N, S; R3 = hidrogênio; halogênio; alquila, alquenila, alquinila, cicloalquila, alcóxi, alquilenodióxi, heterociclo, arila e heteroarila, todos opcionalmente substituídos; S(O)n-alquila, amino, alquilamino, dialquilamino, com dialquilamino opcionalmente formando com N um ciclo, todos opcionalmente substituídos; R4, R4<39> e R4'' = hidrogênio, halogênio, alquila, alquenila, alquinila, cicloalquila, arila, heteroarila, oxo; com dois dentre R4, R4' e R4'' possivelmente formando com C um anel possivelmente contendo O, N ou S; L2 = ligação única, alquileno,alquenileno, alquinileno, cicloalquileno, -O-, -NR7-, -C(O)-, SO2; Y = N-heterociclo possivelmente contendo O, N ou S; R5 = hidrogênio, halogênio, alquila, alquenila, alquinila, cicloalquila, arila, arilalquila, heteroarila, heteroarilalquila; todos estes radicais sendo opcionalmente substituídos, estes produtos sendo em todas formas isoméricas e os sais, como produtos medicinais.
BRPI0512681-9A 2004-07-27 2005-07-25 derivados de uréia cìclica de amino, preparação destes e emprego farmacêutico destes como inibidores de cinase BRPI0512681A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04291904A EP1621536A1 (en) 2004-07-27 2004-07-27 Amino cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
PCT/EP2005/008720 WO2006010641A2 (en) 2004-07-27 2005-07-25 Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0512681A true BRPI0512681A (pt) 2008-04-01

Family

ID=34931289

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512681-9A BRPI0512681A (pt) 2004-07-27 2005-07-25 derivados de uréia cìclica de amino, preparação destes e emprego farmacêutico destes como inibidores de cinase

Country Status (20)

Country Link
US (1) US7759379B2 (pt)
EP (2) EP1621536A1 (pt)
JP (1) JP2008508228A (pt)
KR (1) KR20070038529A (pt)
CN (1) CN101031559A (pt)
AR (1) AR050269A1 (pt)
AT (1) ATE498618T1 (pt)
AU (1) AU2005266460A1 (pt)
BR (1) BRPI0512681A (pt)
CA (1) CA2571323A1 (pt)
DE (1) DE602005026395D1 (pt)
EA (1) EA011088B1 (pt)
IL (1) IL180286A0 (pt)
MA (1) MA28732B1 (pt)
MX (1) MX2007001024A (pt)
NO (1) NO20071067L (pt)
PE (1) PE20060383A1 (pt)
TW (1) TW200616973A (pt)
UY (1) UY29039A1 (pt)
WO (1) WO2006010641A2 (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7354933B2 (en) * 2003-01-31 2008-04-08 Aventis Pharma Sa Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621539A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Heterocycle -substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621535A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
FR2896503B1 (fr) * 2006-01-23 2012-07-13 Aventis Pharma Sa Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
FR2896504B1 (fr) 2006-01-23 2012-07-13 Aventis Pharma Sa Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
DK2368550T3 (da) 2006-03-27 2013-09-30 Univ California Androgenreceptormodulator til behandlingen af prostatakræft og androgenreceptor-associerede sygdomme
EP2125750B1 (en) * 2007-02-26 2014-05-21 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2697147A1 (en) * 2007-07-26 2009-02-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
US8440658B2 (en) 2007-12-11 2013-05-14 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
JP5490020B2 (ja) * 2008-01-24 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター
WO2009102428A2 (en) * 2008-02-11 2009-08-20 Vitae Pharmaceuticals, Inc. 1,3-OXAZEPAN-2-ONE AND 1,3-DIAZEPAN-2-ONE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1
WO2009102460A2 (en) * 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2718264A1 (en) * 2008-03-18 2009-09-24 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
CA2722427A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5696037B2 (ja) 2008-05-01 2015-04-08 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
EP2291373B1 (en) * 2008-05-01 2013-09-11 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5538365B2 (ja) 2008-05-01 2014-07-02 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
CA2729998A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
RU2539979C2 (ru) 2008-07-25 2015-01-27 Вайтаи Фармасьютиклз, Инк. Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1
WO2010127237A2 (en) * 2009-04-30 2010-11-04 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2744946A1 (en) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
JP5656986B2 (ja) 2009-06-11 2015-01-21 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １，３−オキサジナン−２−オン構造に基づく１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
EP2448928B1 (en) 2009-07-01 2014-08-13 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2011041584A2 (en) 2009-09-30 2011-04-07 President And Fellows Of Harvard College Methods for modulation of autophagy through the modulation of autophagy-enhancing gene products
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
EP2585444B1 (en) 2010-06-25 2014-10-22 Boehringer Ingelheim International GmbH Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
CA2813671A1 (en) 2010-11-02 2012-05-10 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of metabolic disorders
ES2836424T3 (es) 2012-09-26 2021-06-25 Aragon Pharmaceuticals Inc Antiandrógenos para tratar el cáncer de próstata no metastásico y resistente a la castración
MA52308A (fr) * 2014-09-29 2021-02-24 Chemocentryx Inc Procédés et intermédiaires pour la préparation d'antagonistes c5ar
AU2019387367A1 (en) 2018-11-30 2021-06-10 Nuvation Bio Inc. Diarylhydantoin compounds and methods of use thereof
WO2021057696A1 (zh) * 2019-09-27 2021-04-01 隆泰申医药科技(南京)有限公司 一种杂芳基类化合物及其应用
CN114591335B (zh) * 2021-03-29 2023-06-27 浙江大学 吲唑类化合物及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2476087A1 (fr) * 1980-02-18 1981-08-21 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2671348B1 (fr) 1991-01-09 1993-03-26 Roussel Uclaf Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
US5411981A (en) * 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
DE19540027A1 (de) * 1995-10-27 1997-04-30 Gruenenthal Gmbh Substituierte Imidazolidin-2,4-dion-Verbindungen als pharmazeutische Wirkstoffe
DE19732928C2 (de) * 1997-07-31 2000-05-18 Gruenenthal Gmbh Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel
FR2796945B1 (fr) * 1999-07-30 2002-06-28 Sod Conseils Rech Applic Nouveaux derives d'hydantoines, de thiohydantoines, de pyrimidinediones et de thioxopyrimidinones, leurs procedes de preparation et leur application a titre de medicaments
US6114365A (en) * 1999-08-12 2000-09-05 Pharmacia & Upjohn S.P.A. Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
AU2002951247A0 (en) * 2002-09-06 2002-09-19 Alchemia Limited Compounds that interact with kinases
US7354933B2 (en) * 2003-01-31 2008-04-08 Aventis Pharma Sa Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
FR2850652B1 (fr) * 2003-01-31 2008-05-30 Aventis Pharma Sa Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
US7256208B2 (en) 2003-11-13 2007-08-14 Bristol-Myers Squibb Company Monocyclic N-Aryl hydantoin modulators of androgen receptor function
EP1621539A1 (en) 2004-07-27 2006-02-01 Aventis Pharma S.A. Heterocycle -substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621535A1 (en) 2004-07-27 2006-02-01 Aventis Pharma S.A. Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors

Also Published As

Publication number Publication date
UY29039A1 (es) 2006-02-24
ATE498618T1 (de) 2011-03-15
PE20060383A1 (es) 2006-06-06
TW200616973A (en) 2006-06-01
AR050269A1 (es) 2006-10-11
CN101031559A (zh) 2007-09-05
EA200700141A1 (ru) 2007-08-31
CA2571323A1 (en) 2006-01-02
IL180286A0 (en) 2007-07-04
US7759379B2 (en) 2010-07-20
WO2006010641A3 (en) 2006-10-26
EA011088B1 (ru) 2008-12-30
KR20070038529A (ko) 2007-04-10
EP1773808A2 (en) 2007-04-18
NO20071067L (no) 2007-04-26
EP1773808B1 (en) 2011-02-16
WO2006010641A2 (en) 2006-02-02
MX2007001024A (es) 2007-04-16
US20080004300A1 (en) 2008-01-03
AU2005266460A1 (en) 2006-02-02
MA28732B1 (fr) 2007-07-02
DE602005026395D1 (de) 2011-03-31
JP2008508228A (ja) 2008-03-21
EP1621536A1 (en) 2006-02-01

Similar Documents

Publication Publication Date Title
BRPI0512681A (pt) derivados de uréia cìclica de amino, preparação destes e emprego farmacêutico destes como inibidores de cinase
PE20070115A1 (es) Derivados de [1,3,5]-triazina como inhibidores de aspartil proteasas
BRPI0610030B8 (pt) Composto, composição farmacêutica, e, uso de um composto
AR054102A1 (es) Derivados de fenil-piperazina-metanona. procesos de obtencion y composiciones farmaceuticas
BR0108679A (pt) Novos compostos
PE20080769A1 (es) Derivados de biaril-sulfonamida
AR038863A1 (es) Uso de un inhibidor de garft y/o de aicarft y de un agente antitoxico para preparar un medicamento para destruir selectivamente celulas mtap-deficientes de un mamifero
PE20020366A1 (es) Derivados de piperazina como ligandos del receptor 5ht2
AR047496A1 (es) Derivados de diaril-urea en el tratamiento de enfermedades dependientes de la quinasa de proteina
UY26957A1 (es) Nuevos agentes anticolinérgicos que se pueden emplear como medicamentos así como procedimiento para su preparación
AR037647A1 (es) Derivados de diarilurea utiles para el tratamiento de enfermedades dependientes de la cinasa de proteina
AR055774A1 (es) Fenilacetamidas apropiadas como inhibidores de proteina quinasa
HUP0400963A2 (hu) Antidiarrheás és perifériális analgetikus hatású helyettesített ciklohexán-1,4-diamin-származékok felhasználása gyógyszerkészítmények előállítására
EA200600480A1 (ru) Имидазопиридинзамещённые тропановые производные, обладающие активностью антагониста ccr5 рецептора, для лечения вируса иммунодефицита человека (вич) и воспаления
UY27592A1 (es) Nuevo uso
UY27752A1 (es) Derivados del tropano útiles en terapia
ECSP066948A (es) Benzoxazinas para el tratamiento de enfermedades de las vías respiratorias
HUP0401481A2 (hu) Kinolinszármazékok, mint neuropeptid Y antagonisták, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
BRPI0408767A (pt) inibidores de transcriptase reversa não-nucleosìdeos i para o tratamento de doenças mediadas pelo hiv
BRPI0512073A (pt) composto, composição farmacêutica, e, uso da mesma
BR0307894A (pt) Heterocìclos tricìclicos fundidos úteis para o tratamento de distúrbios hiperproliferativos
UY28377A1 (es) Agentes terapeuticos
AR039111A1 (es) Tiopirimidinas e isotiazolpirimidinas inhibidoras de quinasas
AR059490A1 (es) Cmpuestos antivirales heterociclicos
HUP0201475A2 (hu) Heteroarilamidin-, metilamidin- és guanidinszármazékok, előállításuk és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.