BRPI0508080A - emprego de derivados de amida de metileno em distúrbios cardiovasculares - Google Patents
emprego de derivados de amida de metileno em distúrbios cardiovascularesInfo
- Publication number
- BRPI0508080A BRPI0508080A BRPI0508080-0A BRPI0508080A BRPI0508080A BR PI0508080 A BRPI0508080 A BR PI0508080A BR PI0508080 A BRPI0508080 A BR PI0508080A BR PI0508080 A BRPI0508080 A BR PI0508080A
- Authority
- BR
- Brazil
- Prior art keywords
- amide derivatives
- cardiovascular disorders
- methylene amide
- prevention
- formula
- Prior art date
Links
- WDWDWGRYHDPSDS-UHFFFAOYSA-N methanimine Chemical class N=C WDWDWGRYHDPSDS-UHFFFAOYSA-N 0.000 title abstract 3
- 208000024172 Cardiovascular disease Diseases 0.000 title abstract 2
- 206010019280 Heart failures Diseases 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 206010048554 Endothelial dysfunction Diseases 0.000 abstract 1
- 230000008694 endothelial dysfunction Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
"EMPREGO DE DERIVADOS DE AMIDA DE METILENO EM DISTúRBIOS CARDIOVASCULARES". A presente invenção refere-se ao uso de derivados de amida de metileno substituído de Fórmula (I) para o tratamento e/ou prevenção de distúrbios cardiovasculares tais como obstrução de coronária e insuficiência cardíaca. Em particular, a presente invenção refere-se ao uso de derivados de amida de metileno substituído de Fórmula (I) em particular para o tratamento e/ou prevenção de disfunção endotelial em insuficiência cardíaca.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04100778 | 2004-02-27 | ||
PCT/EP2005/050823 WO2005082347A1 (en) | 2004-02-27 | 2005-02-25 | Use of methylene amide derivatives in cardiovascular disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0508080A true BRPI0508080A (pt) | 2007-07-17 |
Family
ID=34896106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0508080-0A BRPI0508080A (pt) | 2004-02-27 | 2005-02-25 | emprego de derivados de amida de metileno em distúrbios cardiovasculares |
Country Status (24)
Country | Link |
---|---|
US (1) | US20070185118A1 (pt) |
EP (1) | EP1732534B1 (pt) |
JP (1) | JP5001138B2 (pt) |
KR (1) | KR101188940B1 (pt) |
CN (1) | CN1933827B (pt) |
AT (1) | ATE401877T1 (pt) |
AU (1) | AU2005216649B2 (pt) |
BR (1) | BRPI0508080A (pt) |
CA (1) | CA2554919C (pt) |
CY (1) | CY1108252T1 (pt) |
DE (1) | DE602005008412D1 (pt) |
DK (1) | DK1732534T3 (pt) |
EA (1) | EA011811B1 (pt) |
ES (1) | ES2308458T3 (pt) |
HK (1) | HK1098073A1 (pt) |
HR (1) | HRP20080367T3 (pt) |
IL (1) | IL177494A (pt) |
NO (1) | NO20064295L (pt) |
PL (1) | PL1732534T3 (pt) |
PT (1) | PT1732534E (pt) |
RS (1) | RS50596B (pt) |
SI (1) | SI1732534T1 (pt) |
UA (1) | UA84453C2 (pt) |
WO (1) | WO2005082347A1 (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100410236C (zh) * | 2002-01-29 | 2008-08-13 | 雪兰诺实验室有限公司 | 作为蛋白酪氨酸磷酸酶调节剂的取代亚甲基酰胺衍生物 |
ATE455772T1 (de) | 2003-07-21 | 2010-02-15 | Merck Serono Sa | Alkinylarylcarbonsäureamide |
EP2072498A4 (en) * | 2006-10-12 | 2012-07-18 | Inst Med Molecular Design Inc | N-PHENYLOXAMIDE ACID DERIVATIVE |
US8633245B2 (en) * | 2008-04-11 | 2014-01-21 | Institute Of Medicinal Molecular Design, Inc. | PAI-1 inhibitor |
JP2014529627A (ja) | 2011-08-29 | 2014-11-13 | ティコナ・エルエルシー | 芳香族アミド化合物 |
WO2013032975A1 (en) | 2011-08-29 | 2013-03-07 | Ticona Llc | Thermotropic liquid crystalline polymer with improved low shear viscosity |
CN103764793B (zh) | 2011-08-29 | 2016-09-14 | 提克纳有限责任公司 | 高流动液晶聚合物组合物 |
WO2013032967A1 (en) | 2011-08-29 | 2013-03-07 | Ticona Llc | Cast molded parts formed form a liquid crystalline polymer |
CN103764794B (zh) | 2011-08-29 | 2016-05-18 | 提克纳有限责任公司 | 高流动液晶聚合物组合物 |
US8669341B2 (en) | 2011-08-29 | 2014-03-11 | Ticona Llc | Solid-state polymerization of a liquid crystalline polymer |
JP2014525499A (ja) | 2011-08-29 | 2014-09-29 | ティコナ・エルエルシー | 低い融解温度をもつ耐熱性液晶ポリマー組成物 |
US8852730B2 (en) | 2011-08-29 | 2014-10-07 | Ticona Llc | Melt-extruded substrate for use in thermoformed articles |
JP2014525500A (ja) | 2011-08-29 | 2014-09-29 | ティコナ・エルエルシー | 低溶融粘度液晶ポリマーの溶融重合 |
US20150337212A1 (en) | 2012-12-17 | 2015-11-26 | Shell Oil Company | Integrated gas-to-liquids condensate process |
WO2014130275A2 (en) | 2013-02-22 | 2014-08-28 | Ticona Llc | High performance polymer composition with improved flow properties |
JP6625050B2 (ja) | 2013-06-07 | 2019-12-25 | ティコナ・エルエルシー | 高強度サーモトロピック液晶ポリマー |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001019830A1 (en) * | 1999-09-10 | 2001-03-22 | Novo Nordisk A/S | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) |
US6627767B2 (en) * | 2000-08-29 | 2003-09-30 | Abbott Laboratories | Amino(oxo) acetic acid protein tyrosine phosphatase inhibitors |
DE10117823A1 (de) * | 2001-04-10 | 2002-10-17 | Merck Patent Gmbh | Oxalsäurederivate |
AR034374A1 (es) * | 2001-06-07 | 2004-02-18 | Wyeth Corp | Combinacion de un inhibidor de ptpasa y un inhibidor de ace |
US20030022896A1 (en) * | 2001-06-07 | 2003-01-30 | Wyeth | PTPase inhibitors for improving cardiovascular risk profile |
CN100410236C (zh) * | 2002-01-29 | 2008-08-13 | 雪兰诺实验室有限公司 | 作为蛋白酪氨酸磷酸酶调节剂的取代亚甲基酰胺衍生物 |
-
2005
- 2005-02-25 JP JP2007500226A patent/JP5001138B2/ja not_active Expired - Fee Related
- 2005-02-25 RS RSP-2008/0353A patent/RS50596B/sr unknown
- 2005-02-25 PT PT05716814T patent/PT1732534E/pt unknown
- 2005-02-25 KR KR1020067019715A patent/KR101188940B1/ko not_active IP Right Cessation
- 2005-02-25 AU AU2005216649A patent/AU2005216649B2/en not_active Ceased
- 2005-02-25 DK DK05716814T patent/DK1732534T3/da active
- 2005-02-25 WO PCT/EP2005/050823 patent/WO2005082347A1/en active Application Filing
- 2005-02-25 SI SI200530349T patent/SI1732534T1/sl unknown
- 2005-02-25 AT AT05716814T patent/ATE401877T1/de active
- 2005-02-25 BR BRPI0508080-0A patent/BRPI0508080A/pt not_active IP Right Cessation
- 2005-02-25 CA CA2554919A patent/CA2554919C/en not_active Expired - Fee Related
- 2005-02-25 EP EP05716814A patent/EP1732534B1/en active Active
- 2005-02-25 DE DE602005008412T patent/DE602005008412D1/de active Active
- 2005-02-25 US US10/590,808 patent/US20070185118A1/en not_active Abandoned
- 2005-02-25 ES ES05716814T patent/ES2308458T3/es active Active
- 2005-02-25 CN CN2005800087220A patent/CN1933827B/zh not_active Expired - Fee Related
- 2005-02-25 PL PL05716814T patent/PL1732534T3/pl unknown
- 2005-02-25 EA EA200601511A patent/EA011811B1/ru not_active IP Right Cessation
- 2005-02-25 UA UAA200609879A patent/UA84453C2/ru unknown
-
2006
- 2006-08-15 IL IL177494A patent/IL177494A/en not_active IP Right Cessation
- 2006-09-22 NO NO20064295A patent/NO20064295L/no not_active Application Discontinuation
-
2007
- 2007-05-28 HK HK07105603.1A patent/HK1098073A1/xx not_active IP Right Cessation
-
2008
- 2008-07-24 HR HR20080367T patent/HRP20080367T3/xx unknown
- 2008-08-11 CY CY20081100844T patent/CY1108252T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
KR101188940B1 (ko) | 2012-10-08 |
AU2005216649A1 (en) | 2005-09-09 |
PL1732534T3 (pl) | 2008-12-31 |
IL177494A (en) | 2011-06-30 |
JP5001138B2 (ja) | 2012-08-15 |
CN1933827A (zh) | 2007-03-21 |
CY1108252T1 (el) | 2014-02-12 |
NO20064295L (no) | 2006-09-22 |
KR20060129066A (ko) | 2006-12-14 |
SI1732534T1 (sl) | 2008-10-31 |
CA2554919C (en) | 2013-04-16 |
WO2005082347A1 (en) | 2005-09-09 |
IL177494A0 (en) | 2006-12-31 |
DE602005008412D1 (de) | 2008-09-04 |
EA200601511A1 (ru) | 2007-02-27 |
CN1933827B (zh) | 2011-07-27 |
EA011811B1 (ru) | 2009-06-30 |
HK1098073A1 (en) | 2007-07-13 |
US20070185118A1 (en) | 2007-08-09 |
RS50596B (sr) | 2010-05-07 |
DK1732534T3 (da) | 2008-11-17 |
EP1732534A1 (en) | 2006-12-20 |
PT1732534E (pt) | 2008-08-08 |
ATE401877T1 (de) | 2008-08-15 |
EP1732534B1 (en) | 2008-07-23 |
JP2007524701A (ja) | 2007-08-30 |
ES2308458T3 (es) | 2008-12-01 |
HRP20080367T3 (en) | 2008-09-30 |
UA84453C2 (ru) | 2008-10-27 |
AU2005216649B2 (en) | 2010-09-09 |
CA2554919A1 (en) | 2005-09-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: LABORATOIRES SERONO S.A. (CH) Free format text: TRANSFERIDO DE: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. |
|
B25D | Requested change of name of applicant approved |
Owner name: MERCK SERONO S.A. (CH) |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 11A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2364 DE 26-04-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |