BRPI0418078A8 - composto ou um seu sal, solvato, tautômero ou n-óxido, uso de um composto, métodos para a profilaxia ou tratamento de um estado ou condição doentia mediada pela proteína quinase b e mediada pela proteína quinase a, para tratar uma doença ou condição, para inibir uma proteína quinase b e uma proteína quinase a, para modular um processo celular, para tratar um distúrbio imune em um mamífero e para induzir apoptose em uma célula cancerosa, composição farmacêutica, e, processo para a preparação de um composto - Google Patents
composto ou um seu sal, solvato, tautômero ou n-óxido, uso de um composto, métodos para a profilaxia ou tratamento de um estado ou condição doentia mediada pela proteína quinase b e mediada pela proteína quinase a, para tratar uma doença ou condição, para inibir uma proteína quinase b e uma proteína quinase a, para modular um processo celular, para tratar um distúrbio imune em um mamífero e para induzir apoptose em uma célula cancerosa, composição farmacêutica, e, processo para a preparação de um compostoInfo
- Publication number
- BRPI0418078A8 BRPI0418078A8 BRPI0418078A BRPI0418078A BRPI0418078A8 BR PI0418078 A8 BRPI0418078 A8 BR PI0418078A8 BR PI0418078 A BRPI0418078 A BR PI0418078A BR PI0418078 A BRPI0418078 A BR PI0418078A BR PI0418078 A8 BRPI0418078 A8 BR PI0418078A8
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- BR
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- Prior art keywords
- protein kinase
- compound
- condition
- treat
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- Prior art date
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- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Abstract
"composto ou um seu sal, solvato, tautômero ou nóxido, uso de um composto, métodos para a profilaxia ou tratamento de um estado ou condição doentia mediada pela proteína quinase b e mediada pela proteína quinase a, para tratar uma doença ou condição, para inibir uma proteína quinase b e uma proteína quinase a, para modular um processo celular, para tratar um distúrbio imune em um mamífero e para induzir apoptose em uma célula cancerosa, composição farmacêutica, e, processo para a preparação de um compostos". a invenção provê compostos de fórmula: tendo atividade inibidora da proteina quinase b: em que a é um grupo ligador de hidrocarboneto saturado, contendo de 1 a 7 átomos de carbono, o grupo ligador tendo um comprimento de cadeia máximo de 5 átomos, estendendo-se entre r^ 1^ e nr^ 2^r^ 3^ e um comprimento máximo de cadela de 4 átomos, estendendo-se entre e e nr^ 2^r^ 3^, em que um dos átomos de carbono do grupo ligador pode opcionalmente ser substituído com um átomo de oxigênio ou nitrogênio; e em que os átomos de carbono do grupo ligador a podem opcionalmente conter um ou mais substituintes selecionados de oxo, flúor e hidróxi, desde que o grupo hidróxi, quando presente, não seja localizado em um átomo de carbono com respeito ao grupo nr^ 2^r^ 3^ e desde que o grupo oxo, quando presente, seja localizado em um átomo de carbono com respeito ao grupo nr^ 2^r^ 3^; e é um grupo monocíclico ou bicíclico carbocíclico ou heterocíclico; r^ 1^ é um grupo arila ou heteroarila; e r^ 2^, r^ 3^, r^ 4^ e r^ 5^ são como definidos nas reivindicações. são também providas composições farmacêuticas contendo os compostos, métodos para preparar os compostos e seu uso como agentes anti-câncer.
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US53219903P | 2003-12-23 | 2003-12-23 | |
GB0329617A GB0329617D0 (en) | 2003-12-23 | 2003-12-23 | Pharmaceutical compounds |
US57784304P | 2004-06-08 | 2004-06-08 | |
PCT/GB2004/005464 WO2005061463A1 (en) | 2003-12-23 | 2004-12-23 | Pyrazole derivatives as protein kinase modulators |
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BRPI0418078A BRPI0418078A (pt) | 2007-04-17 |
BRPI0418078A8 true BRPI0418078A8 (pt) | 2018-01-02 |
Family
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Application Number | Title | Priority Date | Filing Date |
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BRPI0418078A BRPI0418078A8 (pt) | 2003-12-23 | 2004-12-23 | composto ou um seu sal, solvato, tautômero ou n-óxido, uso de um composto, métodos para a profilaxia ou tratamento de um estado ou condição doentia mediada pela proteína quinase b e mediada pela proteína quinase a, para tratar uma doença ou condição, para inibir uma proteína quinase b e uma proteína quinase a, para modular um processo celular, para tratar um distúrbio imune em um mamífero e para induzir apoptose em uma célula cancerosa, composição farmacêutica, e, processo para a preparação de um composto |
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AU (1) | AU2004303602C1 (pt) |
BR (1) | BRPI0418078A8 (pt) |
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UY (1) | UY28946A1 (pt) |
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- 2004-12-23 MX MXPA06007326A patent/MXPA06007326A/es active IP Right Grant
- 2004-12-23 CA CA2548374A patent/CA2548374C/en not_active Expired - Fee Related
- 2004-12-23 WO PCT/GB2004/005464 patent/WO2005061463A1/en active Application Filing
- 2004-12-23 JP JP2006546339A patent/JP4928949B2/ja not_active Expired - Fee Related
- 2004-12-23 US US10/596,788 patent/US8247576B2/en not_active Expired - Fee Related
- 2004-12-23 PL PL04806258T patent/PL1706385T3/pl unknown
- 2004-12-23 KR KR1020067014742A patent/KR101164258B1/ko not_active IP Right Cessation
- 2004-12-23 EP EP04806258A patent/EP1706385B1/en active Active
- 2004-12-23 EP EP10168024A patent/EP2228369A1/en not_active Withdrawn
- 2004-12-23 BR BRPI0418078A patent/BRPI0418078A8/pt active Search and Examination
- 2004-12-23 NZ NZ547696A patent/NZ547696A/en not_active IP Right Cessation
-
2005
- 2005-06-08 UY UY28946A patent/UY28946A1/es not_active Application Discontinuation
-
2006
- 2006-06-08 NO NO20062633A patent/NO20062633L/no not_active Application Discontinuation
- 2006-06-19 IL IL176400A patent/IL176400A/en not_active IP Right Cessation
-
2007
- 2007-04-03 HK HK07103603.6A patent/HK1097543A1/xx not_active IP Right Cessation
-
2010
- 2010-12-07 HR HR20100675T patent/HRP20100675T1/hr unknown
-
2011
- 2011-01-03 CY CY20111100002T patent/CY1111493T1/el unknown
-
2012
- 2012-06-28 US US13/536,174 patent/US8691806B2/en not_active Expired - Fee Related
-
2014
- 2014-02-14 US US14/180,440 patent/US9283226B2/en not_active Expired - Fee Related
-
2016
- 2016-01-29 US US15/010,831 patent/US20160250187A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
HK1097543A1 (en) | 2007-06-29 |
KR101164258B1 (ko) | 2012-07-11 |
JP2007516272A (ja) | 2007-06-21 |
AU2004303602B2 (en) | 2008-12-18 |
US8247576B2 (en) | 2012-08-21 |
US20140271662A1 (en) | 2014-09-18 |
US8691806B2 (en) | 2014-04-08 |
HRP20100675T1 (hr) | 2011-01-31 |
US20130005702A1 (en) | 2013-01-03 |
AU2004303602A1 (en) | 2005-07-07 |
IL176400A (en) | 2011-10-31 |
EP1706385B1 (en) | 2010-10-06 |
UY28946A1 (es) | 2006-01-31 |
US20160250187A1 (en) | 2016-09-01 |
CA2548374A1 (en) | 2005-07-07 |
US20110144080A1 (en) | 2011-06-16 |
WO2005061463A1 (en) | 2005-07-07 |
IL176400A0 (en) | 2006-10-05 |
BRPI0418078A (pt) | 2007-04-17 |
MXPA06007326A (es) | 2007-01-26 |
KR20060130621A (ko) | 2006-12-19 |
EP2228369A1 (en) | 2010-09-15 |
EP1706385A1 (en) | 2006-10-04 |
AU2004303602C1 (en) | 2009-05-28 |
CY1111493T1 (el) | 2015-08-05 |
JP4928949B2 (ja) | 2012-05-09 |
PL1706385T3 (pl) | 2011-03-31 |
US9283226B2 (en) | 2016-03-15 |
NO20062633L (no) | 2006-07-20 |
NZ547696A (en) | 2009-12-24 |
CA2548374C (en) | 2014-05-27 |
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