MXPA05007352A - Compuestos triciclicos inhibidores de proteina quinasa para mejorar la eficacia de agentes antineoplasicos y terapia de radiacion. - Google Patents

Compuestos triciclicos inhibidores de proteina quinasa para mejorar la eficacia de agentes antineoplasicos y terapia de radiacion.

Info

Publication number
MXPA05007352A
MXPA05007352A MXPA05007352A MXPA05007352A MXPA05007352A MX PA05007352 A MXPA05007352 A MX PA05007352A MX PA05007352 A MXPA05007352 A MX PA05007352A MX PA05007352 A MXPA05007352 A MX PA05007352A MX PA05007352 A MXPA05007352 A MX PA05007352A
Authority
MX
Mexico
Prior art keywords
kinase inhibitors
diazepinoindole
derivatives
compounds
neoplastic
Prior art date
Application number
MXPA05007352A
Other languages
English (en)
Inventor
Jinjiang Zhu
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MXPA05007352A publication Critical patent/MXPA05007352A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Abstract

Proteina quinasas, tales como CHK-1, que inhiben compuestos triciclicos de la siguiente formula (en la que R2, R3 y R4 son como se han definido en la memoria descriptiva) (ver formula) composiciones farmaceuticas que contienen cantidades eficaces de dichos compuestos o sus sales son utiles como un unico agente o en combinacion con un agente anti-neoplasico o radiacion terapeutica que tienen un efecto antineoplasico para tratar enfermedades o afecciones tales como canceres.
MXPA05007352A 2003-01-09 2004-01-05 Compuestos triciclicos inhibidores de proteina quinasa para mejorar la eficacia de agentes antineoplasicos y terapia de radiacion. MXPA05007352A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43939603P 2003-01-09 2003-01-09
PCT/IB2004/000026 WO2004063198A1 (en) 2003-01-09 2004-01-05 Diazepinoindole derivatives as kinase inhibitors

Publications (1)

Publication Number Publication Date
MXPA05007352A true MXPA05007352A (es) 2006-02-17

Family

ID=32713475

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05007352A MXPA05007352A (es) 2003-01-09 2004-01-05 Compuestos triciclicos inhibidores de proteina quinasa para mejorar la eficacia de agentes antineoplasicos y terapia de radiacion.

Country Status (35)

Country Link
US (3) US6967198B2 (es)
EP (2) EP1585749B1 (es)
JP (1) JP3990718B2 (es)
KR (1) KR100697746B1 (es)
CN (1) CN1759118B (es)
AP (1) AP2048A (es)
AT (1) ATE404564T1 (es)
AU (1) AU2004203977B2 (es)
BR (1) BRPI0406701A (es)
CA (1) CA2512683C (es)
CR (1) CR7899A (es)
CY (1) CY1108408T1 (es)
DE (1) DE602004015724D1 (es)
DK (1) DK1585749T3 (es)
EA (1) EA009337B1 (es)
EC (1) ECSP055911A (es)
ES (1) ES2309484T3 (es)
GE (1) GEP20084367B (es)
HK (1) HK1086257A1 (es)
HR (1) HRP20050624A2 (es)
IL (1) IL169082A (es)
IS (1) IS7884A (es)
MA (1) MA27703A1 (es)
MX (1) MXPA05007352A (es)
NO (1) NO20053775L (es)
NZ (1) NZ540638A (es)
OA (1) OA13017A (es)
PL (1) PL378372A1 (es)
PT (1) PT1585749E (es)
RS (1) RS20050522A (es)
SI (1) SI1585749T1 (es)
TN (1) TNSN05176A1 (es)
UA (1) UA80733C2 (es)
WO (1) WO2004063198A1 (es)
ZA (1) ZA200504674B (es)

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JP2010510222A (ja) * 2006-11-17 2010-04-02 シェーリング コーポレイション 増殖性障害に対する併用療法
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US8211901B2 (en) 2009-05-22 2012-07-03 Shenzhen Chipscreen Biosciences Ltd. Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors
CN101906076B (zh) 2009-06-04 2013-03-13 深圳微芯生物科技有限责任公司 作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用
AU2012253759B2 (en) 2011-05-06 2016-01-21 Zafgen Inc. Tricyclic sulfonamide compounds and methods of making and using same
WO2013096687A1 (en) * 2011-12-22 2013-06-27 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs in combination with chk1 inhibitors for treating cancer
SG11201403538TA (en) 2011-12-31 2014-09-26 Beigene Ltd Fused tetra or penta-cyclic pyridophthalazinones as parp inhibitors
CA2856309C (en) 2011-12-31 2016-06-07 Beigene, Ltd. Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as parp inhibitors
CN102746211B (zh) * 2012-06-27 2015-05-27 上海泰坦化学有限公司 一种取代吲哚-3-甲醛类化合物的制备方法
TWI633107B (zh) * 2013-05-22 2018-08-21 開曼群島商百濟神州生物科技有限公司 作為ｐａｒｐ抑制劑的稠合四或五環二氫二氮呯并咔唑酮
CN112472699A (zh) 2013-07-26 2021-03-12 种族肿瘤学公司 改善比生群及衍生物的治疗益处的组合方法
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EA037366B1 (ru) * 2015-08-25 2021-03-18 Бейджин, Лтд. Способ получения ингибитора parp, кристаллические формы и их применения
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CN110392687B (zh) 2017-02-28 2022-08-02 百济神州(苏州)生物科技有限公司 稠合的四环或五环二氢二氮杂䓬并咔唑酮的盐的结晶形式及其用途
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Also Published As

Publication number Publication date
IS7884A (is) 2005-06-09
ECSP055911A (es) 2005-11-22
KR100697746B1 (ko) 2007-03-22
UA80733C2 (en) 2007-10-25
JP3990718B2 (ja) 2007-10-17
AP2048A (en) 2009-09-24
CN1759118A (zh) 2006-04-12
ATE404564T1 (de) 2008-08-15
US6967198B2 (en) 2005-11-22
AP2005003353A0 (en) 2005-09-30
AU2004203977B2 (en) 2010-06-17
NZ540638A (en) 2007-12-21
EP1585749A1 (en) 2005-10-19
KR20050092397A (ko) 2005-09-21
DK1585749T3 (da) 2008-09-22
RS20050522A (en) 2007-12-31
NO20053775D0 (no) 2005-08-08
PL378372A1 (pl) 2006-04-03
EA200500893A1 (ru) 2006-02-24
ES2309484T3 (es) 2008-12-16
CA2512683A1 (en) 2004-07-29
OA13017A (en) 2006-11-10
US20070135415A1 (en) 2007-06-14
CN1759118B (zh) 2010-12-08
EA009337B1 (ru) 2007-12-28
PT1585749E (pt) 2008-10-23
AU2004203977A1 (en) 2004-07-29
EP1585749B1 (en) 2008-08-13
SI1585749T1 (sl) 2008-10-31
US7462713B2 (en) 2008-12-09
US7132533B2 (en) 2006-11-07
US20050075499A1 (en) 2005-04-07
HK1086257A1 (en) 2006-09-15
CA2512683C (en) 2010-03-16
HRP20050624A2 (en) 2006-02-28
IL169082A (en) 2011-02-28
TNSN05176A1 (fr) 2007-06-11
JP2006516274A (ja) 2006-06-29
CR7899A (es) 2005-08-05
US20060004052A1 (en) 2006-01-05
ZA200504674B (en) 2006-07-26
CY1108408T1 (el) 2014-02-12
EP1947102A1 (en) 2008-07-23
BRPI0406701A (pt) 2005-12-20
NO20053775L (no) 2005-09-16
MA27703A1 (fr) 2006-01-02
GEP20084367B (en) 2008-05-13
WO2004063198A1 (en) 2004-07-29
DE602004015724D1 (de) 2008-09-25

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