PT1501507E - Tetrahidropiranil ciclopentil tetrahidropiridopiridinas moduladoras da actividade dos receptores de quimioquinas - Google Patents

Tetrahidropiranil ciclopentil tetrahidropiridopiridinas moduladoras da actividade dos receptores de quimioquinas Download PDF

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Publication number
PT1501507E
PT1501507E PT03724241T PT03724241T PT1501507E PT 1501507 E PT1501507 E PT 1501507E PT 03724241 T PT03724241 T PT 03724241T PT 03724241 T PT03724241 T PT 03724241T PT 1501507 E PT1501507 E PT 1501507E
Authority
PT
Portugal
Prior art keywords
chemokine receptor
receptor activity
modulators
tetrahydropyranyl cyclopentyl
tetrahydropyranyl
Prior art date
Application number
PT03724241T
Other languages
English (en)
Inventor
Richard Jiao
Gregori Morriello
Lihu Yang
Stephen D Goble
Sander G Mills
Alexander Pasternak
Changyou Zhou
Gabor Butora
Shankaran Kothandaraman
Deodialsingh Guiadeen
Cheng Tang
Christopher Moyes
Original Assignee
Merck Sharp & Dohme
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme, Merck & Co Inc filed Critical Merck Sharp & Dohme
Publication of PT1501507E publication Critical patent/PT1501507E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT03724241T 2002-04-29 2003-04-25 Tetrahidropiranil ciclopentil tetrahidropiridopiridinas moduladoras da actividade dos receptores de quimioquinas PT1501507E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37618002P 2002-04-29 2002-04-29

Publications (1)

Publication Number Publication Date
PT1501507E true PT1501507E (pt) 2008-08-12

Family

ID=29401316

Family Applications (1)

Application Number Title Priority Date Filing Date
PT03724241T PT1501507E (pt) 2002-04-29 2003-04-25 Tetrahidropiranil ciclopentil tetrahidropiridopiridinas moduladoras da actividade dos receptores de quimioquinas

Country Status (15)

Country Link
US (1) US6812234B2 (pt)
EP (1) EP1501507B1 (pt)
JP (1) JP3780291B2 (pt)
AT (1) ATE396993T1 (pt)
AU (1) AU2003231114B8 (pt)
CA (1) CA2483752C (pt)
CY (1) CY1110399T1 (pt)
DE (1) DE60321333D1 (pt)
DK (1) DK1501507T3 (pt)
ES (1) ES2306867T3 (pt)
NZ (1) NZ536477A (pt)
PT (1) PT1501507E (pt)
SI (1) SI1501507T1 (pt)
WO (1) WO2003092586A2 (pt)
ZA (1) ZA200407940B (pt)

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MY129850A (en) 2002-04-29 2007-05-31 Merck Sharp & Dohme Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
RU2355679C2 (ru) 2002-11-27 2009-05-20 Инсайт Корпорейшн Производные 3-аминопирролидина в качестве модуляторов рецепторов хемокинов
JP2007524590A (ja) * 2003-03-18 2007-08-30 メルク　エンド　カムパニー　インコーポレーテッド ケモカイン受容体活性の調節剤であるテトラヒドロピラニルシクロペンチル複素環アミド
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CN100384856C (zh) * 2003-04-17 2008-04-30 麦克公司 趋化因子受体活性调节剂杂环基环戊基四氢异喹啉和杂环基环戊基四氢吡啶并吡啶
WO2004110376A2 (en) * 2003-06-06 2004-12-23 Merck & Co., Inc. Ccr-2 antagonists for treatment of neuropathic pain
CN1870998B (zh) * 2003-10-27 2010-10-20 默沙东公司 Ccr-2拮抗剂盐
AR045875A1 (es) * 2003-10-27 2005-11-16 Merck & Co Inc Procedimiento para la preparacion del antagonista ccr-2
MXPA06007000A (es) 2003-12-18 2006-08-31 Incyte Corp Derivados de 3-cicloalquilaminopirrolidina como moduladores de receptores de quimiocina.
US20070117797A1 (en) * 2004-01-02 2007-05-24 Goble Stephen D Alkylamino, arylamino, and sulfonamido cyclopentyl amide modulators of chemokine receptor activity
EP1718152A4 (en) * 2004-01-28 2009-09-16 Merck & Co Inc AMINOCYCLOPENTYL MODULATORS PYRIDOPYRAZINONE OF CHEMOKINE RECEPTOR ACTIVITY
EP1742915A4 (en) * 2004-04-26 2009-12-02 Merck & Co Inc TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKIN RECEPTOR ACTIVITY
US20070299104A1 (en) * 2004-04-26 2007-12-27 Merck & Co., Inc. Tetrahydropyranyl Cyclopentyl 1-Substituted and 1,1-Disubstituted Tetrahydroisoquinoline Modulators of Chemokine Receptor Activity
CA2564561A1 (en) 2004-04-28 2005-11-10 Merck & Co., Inc. 3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity
BRPI0510665A (pt) * 2004-05-11 2007-12-04 Incyte Corp 3-(4-heteroarilcicloexilamino) ciclopentano-carboxiamidas como moduladores de receptores de quimiocinas
AU2005260013A1 (en) 2004-06-28 2006-01-12 Incyte Corporation 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
TWI366458B (en) * 2004-06-28 2012-06-21 Incyte Corp 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
US20070238723A1 (en) * 2004-10-15 2007-10-11 Goble Stephen D Benzoxazinyl-amidocyclopentyl-heterocyclic modulators of chemokine receptors
AU2006204038A1 (en) * 2005-01-06 2006-07-13 Merck & Co., Inc. Drug combination therapy and pharmaceutical compositions for treating inflammatory disorders
WO2006098959A1 (en) * 2005-03-11 2006-09-21 Merck & Co., Inc. Process for the preparation of (r)-4,4-dialkoxy-pyran-3-ols such as (r)-4,4-dimethoxy-pyran-3-ol
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
WO2007053499A2 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
DK2370442T5 (da) * 2008-11-26 2013-09-23 Pfizer 3-aminocyclopentancarboxamider som chemokinreceptor modulatorer
CA2747677C (en) 2008-12-19 2017-05-09 Boehringer Ingelheim International Gmbh Cyclic pyrimidin-4-carboxamides as ccr2 receptor antagonists for treatment of inflammation, asthma and copd
MY160471A (en) 2009-12-17 2017-03-15 Centrexion Therapeutics Corp New ccr2 receptor antagonists and uses thereof
MX2012007253A (es) 2009-12-22 2012-07-17 Cephalon Inc Derivados triciclicos y sus usos y composiciones farmaceuticas.
US9040526B2 (en) 2010-02-09 2015-05-26 Bristol-Myers Squibb Company Benzylpyrrolidinone derivatives as modulators of chemokine receptor activity
EP2576542B1 (en) * 2010-05-25 2015-04-22 Boehringer Ingelheim International GmbH Cyclic amide derivatives of pyridazine-3-carboxylic acids and their use in the treatment of pulmonary, pain, immune related and cardiovascular diseases
EP2685978A2 (en) * 2011-03-17 2014-01-22 Merck Sharp & Dohme Corp. Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists
US8822460B2 (en) * 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
US9579309B2 (en) 2013-02-28 2017-02-28 Santen Pharmaceutical Co., Ltd. Prophylactic or therapeutic agent for posterior ocular disease containing tetrahydropyranylaminocyclopentylcarbonyltetrahydropyridopyridine derivative as effective ingredient
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MX2017017177A (es) 2015-07-02 2018-11-09 Centrexion Therapeutics Corp Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidi n-1-il)(5-metil-6-(((2r,6s)-6-(p-tolil)tetrahidro-2h-piran-2-il)m etilamino)pirimidin-4il) metanona.
WO2018134731A1 (en) 2017-01-17 2018-07-26 Glaxosmithkline Intellectual Property Development Limited Non peptidic heterobivalent molecules for treating inflammatory diseases
US11304952B2 (en) 2017-09-25 2022-04-19 Chemocentryx, Inc. Combination therapy using a chemokine receptor 2 (CCR2) antagonist and a PD-1/PD-L1 inhibitor
US11154556B2 (en) 2018-01-08 2021-10-26 Chemocentryx, Inc. Methods of treating solid tumors with CCR2 antagonists
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US3772308A (en) 1972-06-02 1973-11-13 Lilly Co Eli Cyclopentanecetamides and cyclopentaneacetonitriles
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MY129850A (en) * 2002-04-29 2007-05-31 Merck Sharp & Dohme Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity

Also Published As

Publication number Publication date
ATE396993T1 (de) 2008-06-15
NZ536477A (en) 2005-05-27
DK1501507T3 (da) 2008-09-29
WO2003092586A3 (en) 2004-09-16
EP1501507B1 (en) 2008-05-28
ZA200407940B (en) 2006-06-28
AU2003231114A1 (en) 2003-11-17
CA2483752C (en) 2011-03-29
JP3780291B2 (ja) 2006-05-31
ES2306867T3 (es) 2008-11-16
CY1110399T1 (el) 2014-04-09
EP1501507A4 (en) 2006-05-17
AU2003231114B8 (en) 2008-08-14
EP1501507A2 (en) 2005-02-02
WO2003092586A2 (en) 2003-11-13
SI1501507T1 (sl) 2008-12-31
CA2483752A1 (en) 2003-11-13
US20040167156A1 (en) 2004-08-26
DE60321333D1 (de) 2008-07-10
US6812234B2 (en) 2004-11-02
AU2003231114B2 (en) 2008-07-24
JP2005523929A (ja) 2005-08-11

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