BRPI0415855A - processo para preparação de ésteres de ácido 2-dihalogenacil-3-amino-acrìlico e ésteres de ácido 3-dihalogeno-metil-pirazol-4-carboxìlico - Google Patents

processo para preparação de ésteres de ácido 2-dihalogenacil-3-amino-acrìlico e ésteres de ácido 3-dihalogeno-metil-pirazol-4-carboxìlico

Info

Publication number
BRPI0415855A
BRPI0415855A BRPI0415855-5A BRPI0415855A BRPI0415855A BR PI0415855 A BRPI0415855 A BR PI0415855A BR PI0415855 A BRPI0415855 A BR PI0415855A BR PI0415855 A BRPI0415855 A BR PI0415855A
Authority
BR
Brazil
Prior art keywords
acid esters
sup
preparing
dihalogenacyl
dihalogen
Prior art date
Application number
BRPI0415855-5A
Other languages
English (en)
Inventor
Reinhard Lantzsch
Wolfgang Joerges
Sergiy Pazenok
Original Assignee
Bayer Cropscience Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Cropscience Ag filed Critical Bayer Cropscience Ag
Publication of BRPI0415855A publication Critical patent/BRPI0415855A/pt
Publication of BRPI0415855B1 publication Critical patent/BRPI0415855B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE éSTERES DE áCIDO 2-DIHALOGENACIL-3-AMINO-ACRìLICO E éSTERES DE áCIDO 3-DIHALOGENO-METIL-PIRAZOL-4-CARBOXìLICO". A presente invenção refere-se a um método para preparação de ésteres de ácido 2-dihaloacil-3-amino-acrílico de fórmula (I), caracterizado pelo fato de reagir-se halogeneto ácido de fórmula (II) com ésteres de ácido dialquilaminoacrílico de fórmula (III), na qual R, R¬ 1¬, R¬ 2¬, X¬ 1¬, X¬ 2¬ e Hal na descrição têm o significado indicado, em um solvente orgânico não miscível com água, na presença de uma base, os novos ésteres de ácido 2-dihalogenacil-3-amino-acrílico de fórmula (I) eles próprios, seu emprego para preparação de 3-dihalogenometil-pirazolas, um processo para preparação de 3-dihalogenometil-pirazolas, assim como novas 3-dihalogenometil-pirazolas.
BRPI0415855-5B1A 2003-10-23 2004-10-12 Processo para preparação de ésteres de ácido 2-dihalogenacil-3-amino-acrílico e ésteres de ácido 3-dihalogeno-metil-pirazol-4-carboxílico BRPI0415855B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10349500A DE10349500A1 (de) 2003-10-23 2003-10-23 Verfahren zum Herstellen von 2-Dihalogenacyl-3-amino-acrylsäureestern und 3-Dihalogenmethyl-pyrazol-4-carbonsäureestern
PCT/EP2004/011376 WO2005042468A1 (de) 2003-10-23 2004-10-12 Verfahren zum herstellen von 2-dihalogenacyl-3-amino-acrylsäureestern und 3-dihalogenmethyl-pyrazol-4-carbonsäureestern

Publications (2)

Publication Number Publication Date
BRPI0415855A true BRPI0415855A (pt) 2007-01-09
BRPI0415855B1 BRPI0415855B1 (pt) 2013-11-05

Family

ID=34529740

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415855-5B1A BRPI0415855B1 (pt) 2003-10-23 2004-10-12 Processo para preparação de ésteres de ácido 2-dihalogenacil-3-amino-acrílico e ésteres de ácido 3-dihalogeno-metil-pirazol-4-carboxílico

Country Status (14)

Country Link
US (1) US7358387B2 (pt)
EP (1) EP1678119B1 (pt)
JP (1) JP4725977B2 (pt)
KR (1) KR101116686B1 (pt)
CN (1) CN100422141C (pt)
AT (1) ATE494274T1 (pt)
BR (1) BRPI0415855B1 (pt)
DE (2) DE10349500A1 (pt)
DK (1) DK1678119T3 (pt)
IL (1) IL175024A (pt)
IN (1) IN2006DE01793A (pt)
MX (1) MXPA06004339A (pt)
TW (1) TWI363050B (pt)
WO (1) WO2005042468A1 (pt)

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EP2072497A1 (de) 2007-12-21 2009-06-24 Bayer CropScience AG Verfahren zum Herstellen von 2-Fluoracyl-3-amino-acrylsäure-Derivaten
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CN103951643B (zh) 2008-07-25 2015-12-09 盐野义制药株式会社 用作hiv整合酶抑制剂的化合物
JP5228817B2 (ja) * 2008-11-12 2013-07-03 セントラル硝子株式会社 ピラゾール化合物の製造方法
KR101847887B1 (ko) 2008-12-11 2018-04-11 시오노기세야쿠 가부시키가이샤 카르바모일피리돈 ｈｉｖ 인테그라제 억제제 및 중간체의 합성
US8552187B2 (en) 2008-12-11 2013-10-08 Shionogi & Co., Ltd. Processes and intermediates for carbamoylpyridone HIV integrase inhibitors
TWI518084B (zh) 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 哌喃酮與吡啶酮衍生物之製造方法
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EP2999694B1 (en) 2013-05-22 2017-05-17 Bayer CropScience Aktiengesellschaft Process for preparing 3,5-bis(fluoroalkyl)pyrazole derivatives from alpha,alpha -dihaloamines
TWI647215B (zh) * 2013-11-11 2019-01-11 德商拜耳作物科學股份有限公司 自α,α－二鹵胺製備３,５－雙鹵烷基吡唑衍生物之方法
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BR112016021874B1 (pt) * 2014-03-24 2021-03-23 Bayer Cropscience Aktiengesellschaft Processo para preparar derivados de 3,5-bis(haloalquil)pirazol a partir de alfa,alfa-dihaloaminas e cetiminas e compostos
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CN104529899A (zh) * 2014-12-19 2015-04-22 浙江泰达作物科技有限公司 高区域选择性制备1-烷基-3-卤代烷基吡唑衍生物的方法
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CN111372908A (zh) 2017-09-04 2020-07-03 索尔维公司 用于制造二氟乙酰氯的方法和中间体
CN111116364B (zh) * 2019-12-30 2022-11-11 浙江本立科技股份有限公司 2-多卤代乙酰基-3-烷氧基丙烯酸酯的制备方法
CN113912541A (zh) * 2021-10-29 2022-01-11 南通宝凯药业有限公司 一种3-二氟甲基-1-甲基-1h-吡唑-4-羧酸的制备方法
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CN117447401B (zh) * 2023-12-26 2024-04-19 山东国邦药业有限公司 一种二氟吡唑酸的合成方法

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Also Published As

Publication number Publication date
DE502004012095D1 (de) 2011-02-17
TW200526550A (en) 2005-08-16
IL175024A0 (en) 2006-08-20
IN2006DE01793A (pt) 2007-08-10
CN1871204A (zh) 2006-11-29
DE10349500A1 (de) 2005-06-02
EP1678119B1 (de) 2011-01-05
WO2005042468A1 (de) 2005-05-12
TWI363050B (en) 2012-05-01
JP4725977B2 (ja) 2011-07-13
US20060252944A1 (en) 2006-11-09
CN100422141C (zh) 2008-10-01
JP2007509850A (ja) 2007-04-19
MXPA06004339A (es) 2006-06-05
EP1678119A1 (de) 2006-07-12
ATE494274T1 (de) 2011-01-15
IL175024A (en) 2011-05-31
BRPI0415855B1 (pt) 2013-11-05
KR101116686B1 (ko) 2012-02-22
DK1678119T3 (da) 2011-05-02
US7358387B2 (en) 2008-04-15
KR20060109901A (ko) 2006-10-23

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