BRPI0307550B8 - composição farmacêutica em gel tópica, de adapaleno 0,3% - Google Patents

composição farmacêutica em gel tópica, de adapaleno 0,3%

Info

Publication number
BRPI0307550B8
BRPI0307550B8 BRPI0307550A BR0307550A BRPI0307550B8 BR PI0307550 B8 BRPI0307550 B8 BR PI0307550B8 BR PI0307550 A BRPI0307550 A BR PI0307550A BR 0307550 A BR0307550 A BR 0307550A BR PI0307550 B8 BRPI0307550 B8 BR PI0307550B8
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
adapalene
topical gel
topical
gel
Prior art date
Application number
BRPI0307550A
Other languages
English (en)
Other versions
BR0307550A (pt
BR0307550B1 (pt
Inventor
Czernielewski Janusz
Graeber Michael
Original Assignee
Galderma Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27806678&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0307550(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR0203070A external-priority patent/FR2837101B1/fr
Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev
Publication of BR0307550A publication Critical patent/BR0307550A/pt
Publication of BR0307550B1 publication Critical patent/BR0307550B1/pt
Publication of BRPI0307550B8 publication Critical patent/BRPI0307550B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/362—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/008—Preparations for oily skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

"uso do ácido 6-[3-(1-adamantil)-4-metoxifenil]-2-naftanóico e composição farmacêutica". a presente invenção trata do uso do ácido 6-[3-(1-adamantil)-4metoxifenil]-2-naftanóico (adapaleno) ou de seus sais para a fabricação de uma composição farmacêutica destinada ao tratamento das afecções dermatológicas com componente inflamatório ou proliferativo, caracterizada pelo fato de compreender 0,3% em peso de adapaleno em relação ao peso total da composição.
BRPI0307550A 2002-03-12 2003-03-12 composição farmacêutica em gel tópica, de adapaleno 0,3% BRPI0307550B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0203070A FR2837101B1 (fr) 2002-03-12 2002-03-12 Utilisation de l'acide 6-[1-adamantyl)-4-methoxyphenyl]-2- naphthoique pour le traitement de desordres dermatologiques
US37022302P 2002-04-08 2002-04-08
PCT/EP2003/003246 WO2003075908A1 (en) 2002-03-12 2003-03-12 Use of adapalene for the treatment of dermatological disorders

Publications (3)

Publication Number Publication Date
BR0307550A BR0307550A (pt) 2005-01-04
BR0307550B1 BR0307550B1 (pt) 2018-01-09
BRPI0307550B8 true BRPI0307550B8 (pt) 2021-05-25

Family

ID=27806678

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0307550A BRPI0307550B8 (pt) 2002-03-12 2003-03-12 composição farmacêutica em gel tópica, de adapaleno 0,3%

Country Status (19)

Country Link
US (17) US7579377B2 (pt)
EP (2) EP1485080B1 (pt)
JP (2) JP2005526063A (pt)
CN (1) CN1642538B (pt)
AT (2) ATE432072T1 (pt)
AU (2) AU2003216898B2 (pt)
BR (1) BRPI0307550B8 (pt)
CA (1) CA2478237C (pt)
CY (2) CY1108868T1 (pt)
DE (2) DE60327745D1 (pt)
DK (2) DK1532974T3 (pt)
ES (2) ES2327508T3 (pt)
HK (1) HK1073996A1 (pt)
MX (1) MXPA04008684A (pt)
PL (1) PL216763B1 (pt)
PT (2) PT1532974E (pt)
RU (2) RU2332208C2 (pt)
SI (2) SI1485080T1 (pt)
WO (1) WO2003075908A1 (pt)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7820186B2 (en) 2001-12-21 2010-10-26 Galderma Research & Development Gel composition for once-daily treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt
DK1532974T3 (da) 2002-03-12 2009-05-11 Galderma Res & Dev Sammensætning, der omfatter 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthsyre, til behandling af dermatologiske lidelser
US20060128808A1 (en) * 2004-10-20 2006-06-15 Galderma Research & Development, S.N.C. Method of using adapalene in acne maintenance therapy
US20080161273A1 (en) * 2004-10-20 2008-07-03 Galderma Research & Development Method of Using Adapalene in Acne Maintenance Therapy
KR20070091613A (ko) * 2004-11-08 2007-09-11 그렌마크 파머수티칼스 엘티디. 항여드름 화합물 및 항생제 화합물을 함유하는 국소적 제약조성물
FR2879459B1 (fr) * 2004-12-22 2007-02-16 Galderma Res & Dev Composition comprenant de l'adapalene solubilise avec des cyclodextrines
EP2540290B1 (en) * 2005-01-26 2018-05-16 Galderma Research & Development Adapalene for the long-term treatment of acne vulgaris
ITRM20050248A1 (it) * 2005-05-20 2006-11-21 Sigma Tau Ind Farmaceuti Uso acido adamantil metossidifenil propenoico per il trattamento di patologie cutanee.
ES2378085T3 (es) 2005-06-17 2012-04-04 Medichem, S.A. Procedimiento para la preparación de adapaleno y compuestos relacionados
AU2006290364B2 (en) * 2005-09-16 2012-07-05 Galderma Research & Development Composition comprising at least one naphthoic acid derivative and at least one compound of polyurethane polymer type or derivatives thereof, preparation processes therefor and uses thereof
FR2890861B1 (fr) * 2005-09-16 2010-05-28 Galderma Res & Dev Compositions comprenant au moins un derive de l'acide naphtoique et au moins un compose de type polymeres de polyurethanes ou des derives de celui-ci, leurs procede de preparation, et leur utilisation
FR2894821B1 (fr) * 2005-12-15 2008-02-29 Galderma Res & Dev Compositions comprenant au moins un compose retinoide et au moins un compose anti-irritant et leurs utilisations
CN1989956B (zh) * 2005-12-29 2010-09-01 北京德众万全医药科技有限公司 一种阿达帕林凝胶组合物及其制备方法
FR2901701B1 (fr) * 2006-05-31 2010-10-29 Galderma Res & Dev Compostions comprenant au moins un derive de l'acide naphtoique et au moins un agent filmogene, leurs procedes de preparation, et leurs utilisations
WO2008062135A1 (fr) * 2006-11-20 2008-05-29 Galderma Research & Development Utilisation d'adapalène pour moduler l'expression de l'il-1ra.
FR2909000B1 (fr) * 2006-11-28 2009-02-06 Galderma Res & Dev S N C Snc Compositions comprenant du peroxyde de benzoyle, au moins un derive de l'acide naphtoique et au moins un compose de type polymeres de polyurethane ou des derives de celui-ci, et leurs utilisations.
MY150444A (en) * 2006-12-15 2014-01-30 Colgate Palmolive Co Liquid detergent composition
FR2910321B1 (fr) 2006-12-21 2009-07-10 Galderma Res & Dev S N C Snc Gel creme comprenant au moins un retinoide et du peroxyde de benzole
FR2910320B1 (fr) 2006-12-21 2009-02-13 Galderma Res & Dev S N C Snc Emulsion comprenant au moins un retinoide et du peroxyde de benzole
JP5125122B2 (ja) * 2007-01-31 2013-01-23 大正製薬株式会社 アダパレン含有外用剤組成物
JP5670008B2 (ja) * 2007-01-31 2015-02-18 大正製薬株式会社 アダパレン含有外用剤組成物
JP5338030B2 (ja) * 2007-01-31 2013-11-13 大正製薬株式会社 アダパレン含有外用剤組成物
JPWO2008111296A1 (ja) 2007-03-09 2010-06-24 国立大学法人京都大学 角化の亢進に起因する皮膚疾患の予防及び治療のための医薬
EP2065032A1 (en) * 2007-11-27 2009-06-03 Galderma Research & Development A method for producing adapalene gels
US20110117182A1 (en) * 2009-07-30 2011-05-19 Allergan, Inc. Combination of dapsone with other anti-acne agents
US20130203850A1 (en) * 2010-04-29 2013-08-08 Galderma Research & Development Method for treating scars with adapalene 0.3%
US10758630B2 (en) 2010-08-13 2020-09-01 The Johns Hopkins University Topical compositions and methods of detection and treatment
DE102010063825A1 (de) * 2010-12-22 2012-06-28 Beiersdorf Ag Kosmetische oder dermatologische wasserfeste Lichtschutzzubereitungen umfassend eine Kombination aus Polyacrylat- und Polyacrylamidverdicker
FR2969492B1 (fr) * 2010-12-23 2013-07-05 Galderma Res & Dev Mousses dermatologiques obtenues a partir d'un gel ou d'une suspension contenant de l'adapalene
EP2679242B1 (en) * 2011-02-25 2020-09-09 Hisamitsu Pharmaceutical Co., Inc. Adjuvant for transdermal or transmucosal administration and pharmaceutical preparation containing same
US10787177B2 (en) 2011-06-29 2020-09-29 SMR Patents S.à.r.l. Exterior rearview device with illumination functions and autonomous vehicles using same
US10137823B2 (en) 2011-06-29 2018-11-27 SMR Patents S.à.r.l. Exterior rearview device with illumination functions
US9206381B2 (en) 2011-09-21 2015-12-08 Ecolab Usa Inc. Reduced misting alkaline cleaners using elongational viscosity modifiers
FR2991175B1 (fr) * 2012-06-01 2014-12-19 Galderma Res & Dev Compositions pharmaceutiques topiques de type emulsion h/e contenant un retinoide
RU2538680C2 (ru) * 2013-03-12 2015-01-10 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Фармацевтическая композиция для лечения атопического дерматита и способ ее получения
JP5980171B2 (ja) * 2013-06-05 2016-08-31 大正製薬株式会社 アダパレン含有外用剤組成物
CN105979969B (zh) 2013-08-08 2020-09-11 诺万公司 局部用组合物和使用所述组合物的方法
JP2015081244A (ja) * 2013-10-23 2015-04-27 第一三共ヘルスケア株式会社 ニキビ治療用医薬組成物
WO2015064710A1 (ja) 2013-10-31 2015-05-07 久光製薬株式会社 アジュバント組成物、これを含むアジュバント製剤、及びキット
US9637708B2 (en) 2014-02-14 2017-05-02 Ecolab Usa Inc. Reduced misting and clinging chlorine-based hard surface cleaner
US10322082B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
KR20170035916A (ko) 2014-07-25 2017-03-31 갈데르마 리써어치 앤드 디벨로프먼트 중증 여드름의 치료를 위한 아다팔렌 및 벤조일 퍼옥시드의 조합
JP6753312B2 (ja) * 2014-12-26 2020-09-09 ニプロ株式会社 医療用皮膚外用剤
EP3719107A1 (en) 2016-05-23 2020-10-07 Ecolab USA Inc. Reduced misting acidic cleaning, sanitizing, and disinfecting compositions via the use of high molecular weight water-in-oil emulsion polymers
ES2808999T3 (es) 2016-05-23 2021-03-02 Ecolab Usa Inc Composiciones de limpieza antisépticas y desinfectantes alcalinas y neutras con reducción de la formación de neblina a través del uso de polímeros de emulsión de agua en aceite de alto peso molecular
CN110392528A (zh) 2017-03-01 2019-10-29 埃科莱布美国股份有限公司 通过高分子量聚合物减少吸入危险的消毒剂和杀菌剂
US20190381178A1 (en) * 2017-03-02 2019-12-19 Duke University Methods for the treatment of cancer and benign lesions by ablation
US9987239B1 (en) 2017-03-14 2018-06-05 Rey Ventures, LLC Pharmaceutical retinoid preparation for topical use
EP3700504A4 (en) * 2017-10-24 2021-07-28 Glenmark Pharmaceuticals Limited TOPICAL PHARMACEUTICAL COMPOSITION OF ADAPALENE AND MINOCYCLINE
WO2019240290A1 (ja) * 2018-06-16 2019-12-19 ロート製薬株式会社 外用組成物
US20200222358A1 (en) 2019-01-15 2020-07-16 Derma Research Group Inc. Topical dermatologic acne treatment cream composition and method of manufacture
WO2021011451A1 (en) 2019-07-12 2021-01-21 Ecolab Usa Inc. Reduced mist alkaline cleaner via the use of alkali soluble emulsion polymers

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU85849A1 (fr) * 1985-04-11 1986-11-05 Cird Derives benzonaphtaleniques,leur procede de preparation et leur application dans les domaines pharmaceutiques et cosmetiques
DE69118327T2 (de) 1990-11-26 1996-08-29 Bayer Ag Topisch anzuwendende Niclosamid enthaltende Lotion
JP2697999B2 (ja) * 1992-06-29 1998-01-19 株式会社 フィルインターナショナル 化粧品
US5306486A (en) * 1993-03-01 1994-04-26 Elizabeth Arden Co., Division Of Conopco, Inc. Cosmetic sunscreen composition containing green tea and a sunscreen
FR2710854B1 (fr) 1993-10-08 1995-12-01 Oreal Emulsion huile-dans-eau utilisable pour l'obtention d'une crème.
US6133326A (en) * 1994-08-31 2000-10-17 Pfizer Inc Compositions and methods for decreasing sebum production
FR2730930B1 (fr) 1995-02-27 1997-04-04 Oreal Utilisation d'inhibiteurs de no-synthase pour diminuer l'effet irritant cutane de produits utilises dans le domaine cosmetique ou pharmaceutique
US6413536B1 (en) * 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
US5665364A (en) * 1995-07-24 1997-09-09 The Procter & Gamble Company Compositions for topical delivery of active ingredients
JPH10114648A (ja) * 1996-10-11 1998-05-06 Kao Corp 皮膚外用組成物
KR20010012464A (ko) * 1997-05-12 2001-02-15 세이지 파마슈티칼스, 인크. 화상 치료 및 감염 방지를 위한 국소 분무
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
JP2001097847A (ja) * 1999-09-29 2001-04-10 Pola Chem Ind Inc ゲル組成物の製造法
CN1379667A (zh) * 1999-10-19 2002-11-13 宝洁公司 预防和治疗感冒和流感样症状的组合物和它们的使用方法
US6967023B1 (en) * 2000-01-10 2005-11-22 Foamix, Ltd. Pharmaceutical and cosmetic carrier or composition for topical application
US6383505B1 (en) 2000-11-09 2002-05-07 Steris Inc Fast-acting antimicrobial lotion with enhanced efficacy
BRPI0101486B1 (pt) 2001-04-17 2017-09-19 Cristália Produtos Químicos Farmacêuticos Ltda. Pharmaceutical composition for topic use containing heparin for the treatment of skin or mucosal injuries caused by burns
DK1532974T3 (da) 2002-03-12 2009-05-11 Galderma Res & Dev Sammensætning, der omfatter 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthsyre, til behandling af dermatologiske lidelser
EP2540290B1 (en) 2005-01-26 2018-05-16 Galderma Research & Development Adapalene for the long-term treatment of acne vulgaris
JP4962858B2 (ja) * 2007-06-21 2012-06-27 スズキ株式会社 インストルメントパネル

Also Published As

Publication number Publication date
JP2011032287A (ja) 2011-02-17
CA2478237C (en) 2009-05-12
RU2332208C2 (ru) 2008-08-27
JP5722598B2 (ja) 2015-05-20
RU2377981C1 (ru) 2010-01-10
RU2004130308A (ru) 2005-04-10
MXPA04008684A (es) 2004-12-06
ATE417610T1 (de) 2009-01-15
SI1485080T1 (sl) 2009-10-31
CY1108868T1 (el) 2014-07-02
SI1532974T1 (sl) 2009-04-30
BR0307550A (pt) 2005-01-04
US20120231062A1 (en) 2012-09-13
ES2327508T3 (es) 2009-10-30
US20140249232A1 (en) 2014-09-04
US20110027204A1 (en) 2011-02-03
AU2003216898B2 (en) 2008-04-24
US7737181B2 (en) 2010-06-15
PT1485080E (pt) 2009-07-31
US7834060B2 (en) 2010-11-16
US20110027367A1 (en) 2011-02-03
HK1073996A1 (en) 2005-10-28
US7868044B2 (en) 2011-01-11
DK1485080T3 (da) 2009-08-31
CA2478237A1 (en) 2003-09-18
EP1485080A1 (en) 2004-12-15
DE60325379D1 (de) 2009-01-29
US20110130461A1 (en) 2011-06-02
ES2319778T3 (es) 2009-05-12
US20090281188A1 (en) 2009-11-12
ATE432072T1 (de) 2009-06-15
US20180104203A1 (en) 2018-04-19
DE60327745D1 (de) 2009-07-09
US20080293817A1 (en) 2008-11-27
CY1109307T1 (el) 2014-07-02
PT1532974E (pt) 2009-02-23
US7579377B2 (en) 2009-08-25
WO2003075908A1 (en) 2003-09-18
BR0307550B1 (pt) 2018-01-09
RU2008118056A (ru) 2009-11-10
AU2003216898A1 (en) 2003-09-22
DK1532974T3 (da) 2009-05-11
US9387187B2 (en) 2016-07-12
US20140308223A1 (en) 2014-10-16
US8921423B2 (en) 2014-12-30
CN1642538B (zh) 2010-05-26
US9901556B2 (en) 2018-02-27
PL372317A1 (en) 2005-07-11
CN1642538A (zh) 2005-07-20
US9872842B2 (en) 2018-01-23
AU2008203279B2 (en) 2011-06-30
US9381179B2 (en) 2016-07-05
AU2008203279A1 (en) 2008-08-14
EP1532974A3 (en) 2005-12-14
JP2005526063A (ja) 2005-09-02
EP1485080B1 (en) 2009-05-27
US9622994B2 (en) 2017-04-18
US20150045440A1 (en) 2015-02-12
EP1532974B1 (en) 2008-12-17
US7838558B2 (en) 2010-11-23
US20170181991A1 (en) 2017-06-29
US20110070176A1 (en) 2011-03-24
US20050059740A1 (en) 2005-03-17
US20100273882A1 (en) 2010-10-28
US8729127B2 (en) 2014-05-20
US20160361282A1 (en) 2016-12-15
US8653140B2 (en) 2014-02-18
US20070043119A1 (en) 2007-02-22
EP1532974A2 (en) 2005-05-25
US20170049732A1 (en) 2017-02-23
PL216763B1 (pl) 2014-05-30
US8703820B2 (en) 2014-04-22

Similar Documents

Publication Publication Date Title
BRPI0307550B8 (pt) composição farmacêutica em gel tópica, de adapaleno 0,3%
ITMI20020756A1 (it) Composizioni farmaceutiche topiche per il trattamento delle dermatiti
LTC1620113I2 (lt) Ivermektino topinė kompozicija, skirta dermatologinių susirgimų gydymui
CO6640250A2 (es) Formulación tópica que comprende (r)-3-ciclopentil-3-(4-(7h-pirrolo(2,3-d)pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo o una sal farmaceúticamente aceptable del mismo y una emulsión de aceite en agua
WO2007092312A3 (en) Topical skin treating compositions
BR0308429A (pt) Aroilpiridinonas monocìclicas como agentes antiinflamatórios
DE602006009259D1 (de) Pharmazeutische zusammensetzung mit einem organopoirkstoff
NO20074780L (no) Heterocyklylamidsubstituerte imidazoler
BR0318343A (pt) composição tópica para administração transdérmica
ATE420089T1 (de) Substituierte azachinazoline mit antiviraler wirkung
ATE256392T1 (de) Verwendung von polyaminosäurederivate als konservierungsmittel
BRPI0914462A2 (pt) "composição tópica, método de prevenção ou redução da ocorrência de tratamento de acne e uso de uma composição"
EA200602002A1 (ru) Применение спинозинов для заживления ран
BRPI0603258A (pt) composições para uso na pele
BRPI0800753A2 (pt) composiÇÕes contendo retinàide e derivados do Ácido beta-aminoisobutÍrico
DE602004031964D1 (de) Ndlung von dermatologischen erkrankungen
BR112012000410B8 (pt) uso de benzidamina ou dos sais de adição de ácido, e, composição farmacêutica
DE602006003848D1 (de) Formulierung zur verzögerten Freisetzung von Valproinsäure und deren Derivate
ATE531698T1 (de) 4-aminocarbonylamino-substitutierte imidazolverbindungen mit antiviraler wirkung
CY1114473T1 (el) Συνδυασμος αδαπαλενης και υπεροξειδιου του βενζοϋλιου για την αγωγη των φλεγμονωδων βλαβων της ακμης

Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: GALDERMA RESEARCH AND DEVELOPMENT (FR)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 018070033204/SP DE 25/05/2007.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM OS ARTIGOS 8O, 11 E 13 DA LPI.

B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 12/03/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 12/03/2023