BRPI0211844B8 - composto de ácido fenóxi-acético ou um de seus sais farmaceuticamente aceitáveis, e, composição farmacêutica - Google Patents

composto de ácido fenóxi-acético ou um de seus sais farmaceuticamente aceitáveis, e, composição farmacêutica

Info

Publication number
BRPI0211844B8
BRPI0211844B8 BR0211844A BR0211844A BRPI0211844B8 BR PI0211844 B8 BRPI0211844 B8 BR PI0211844B8 BR 0211844 A BR0211844 A BR 0211844A BR 0211844 A BR0211844 A BR 0211844A BR PI0211844 B8 BRPI0211844 B8 BR PI0211844B8
Authority
BR
Brazil
Prior art keywords
compound
alkyl
phenoxy
pharmaceutically acceptable
pharmaceutical composition
Prior art date
Application number
BR0211844A
Other languages
English (en)
Other versions
BR0211844A (pt
BRPI0211844B1 (pt
Inventor
Masui Seiichiro
Sakuma Shogo
Kanda Takashi
Yamakawa Tomio
Original Assignee
Nippon Chemiphar Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co filed Critical Nippon Chemiphar Co
Publication of BR0211844A publication Critical patent/BR0211844A/pt
Publication of BRPI0211844B1 publication Critical patent/BRPI0211844B1/pt
Publication of BRPI0211844B8 publication Critical patent/BRPI0211844B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/62—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems having two or more ring systems containing condensed 1,3-oxazole rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms

Abstract

"composto e ativador de receptor delta ativado por proliferador de peroxissoma". um composto representado pela seguinte fórmula geral (i): (em que r^ 1^ representa fenila, etc, que pode ter substituintes selecionado dentre o grupo consistindo de alquila c~ 1-8~ alquila c~ 1-8~ tendo halogênio, halogênio, hidroxila, etc., r^ 2^ representa alquila c~ 1-8~, etc.; a representa oxigênio, enxofre, etc;, x representa cadeia alquileno c~ 1-8~, etc; y representa c(=o), ch=ch, etc.; r^ 3^, r^ 4^, e r^ 5^ cada representa hidrogênio, alquila c~ 1-8~, etc; b representa ch ou nitrogênio; z representa oxigênio ou enxofre; r^ 6^ e r^ 7^ representa, cada, hidrogênio, alquila c~ 1-8~, etc.; e r^ 8^ representa hidrogênio ou alquila c~ 1-8~, desde que pelo menos um dentre r^ 3^, r^ 4^ e r^ 5^ não é hidrogênio) ou um sal do composto; e um ativador de ppar-<sym> que contém o composto ou sal como o ingrediente ativo.
BR0211844A 2001-08-10 2002-08-02 composto de ácido fenóxi-acético ou um de seus sais farmaceuticamente aceitáveis, e, composição farmacêutica BRPI0211844B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001243734 2001-08-10
PCT/JP2002/007897 WO2003016291A1 (fr) 2001-08-10 2002-08-02 Activateur du recepteur $g(d) sensible au proliferateur de peroxysome

Publications (3)

Publication Number Publication Date
BR0211844A BR0211844A (pt) 2004-08-31
BRPI0211844B1 BRPI0211844B1 (pt) 2019-08-27
BRPI0211844B8 true BRPI0211844B8 (pt) 2021-05-25

Family

ID=19073779

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0211844A BRPI0211844B8 (pt) 2001-08-10 2002-08-02 composto de ácido fenóxi-acético ou um de seus sais farmaceuticamente aceitáveis, e, composição farmacêutica

Country Status (16)

Country Link
US (3) US7265137B2 (pt)
EP (1) EP1424330B1 (pt)
JP (3) JP4421895B2 (pt)
KR (1) KR100901683B1 (pt)
CN (1) CN1330641C (pt)
AT (1) ATE526319T1 (pt)
AU (1) AU2002323776B2 (pt)
BR (1) BRPI0211844B8 (pt)
CA (1) CA2457054C (pt)
CY (1) CY1112130T1 (pt)
DK (1) DK1424330T3 (pt)
ES (1) ES2372813T3 (pt)
IL (2) IL160304A0 (pt)
MX (1) MXPA04001258A (pt)
PT (1) PT1424330E (pt)
WO (1) WO2003016291A1 (pt)

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Also Published As

Publication number Publication date
JP4421895B2 (ja) 2010-02-24
EP1424330B1 (en) 2011-09-28
JP5097180B2 (ja) 2012-12-12
EP1424330A1 (en) 2004-06-02
CN1568316A (zh) 2005-01-19
DK1424330T3 (da) 2012-01-16
ATE526319T1 (de) 2011-10-15
KR20040023741A (ko) 2004-03-18
WO2003016291A1 (fr) 2003-02-27
US20080009631A1 (en) 2008-01-10
US20050054674A1 (en) 2005-03-10
US20080009525A1 (en) 2008-01-10
IL160304A (en) 2010-12-30
US7265137B2 (en) 2007-09-04
CN1330641C (zh) 2007-08-08
BR0211844A (pt) 2004-08-31
JP2009280622A (ja) 2009-12-03
PT1424330E (pt) 2011-12-22
JPWO2003016291A1 (ja) 2004-12-02
BRPI0211844B1 (pt) 2019-08-27
ES2372813T3 (es) 2012-01-26
KR100901683B1 (ko) 2009-06-08
CY1112130T1 (el) 2015-11-04
MXPA04001258A (es) 2005-06-06
US7648999B2 (en) 2010-01-19
EP1424330A4 (en) 2004-10-27
US7652045B2 (en) 2010-01-26
CA2457054A1 (en) 2003-02-27
CA2457054C (en) 2011-10-11
AU2002323776B2 (en) 2008-07-31
JP2009102442A (ja) 2009-05-14
IL160304A0 (en) 2004-07-25

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