BR9912556A - Triazolpiridinas para o tratamento de distúrbios trombóticos - Google Patents

Triazolpiridinas para o tratamento de distúrbios trombóticos

Info

Publication number
BR9912556A
BR9912556A BR9912556-0A BR9912556A BR9912556A BR 9912556 A BR9912556 A BR 9912556A BR 9912556 A BR9912556 A BR 9912556A BR 9912556 A BR9912556 A BR 9912556A
Authority
BR
Brazil
Prior art keywords
thrombotic disorders
triazolpyridines
treatment
triazolpyridine
gpiib
Prior art date
Application number
BR9912556-0A
Other languages
English (en)
Inventor
William J Hoekstra
Edward C Lawson
Bruce E Maryanoff
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of BR9912556A publication Critical patent/BR9912556A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Patente de Invenção: "TRIAZOLPIRIDINAS PARA O TRATAMENTO DE DISTúRBIOS TROMBóTICOS". A invenção refere-se a novos derivados de triazolpiridina que são úteis como antagonistas de GPIIb/IIIa. Também são apresentadas composições farmacêuticas compreendendo os derivados de triazolpiridina da presente invenção, métodos de tratamento de condições mediadas por GPIIb/IIIa (por exemplo, métodos para tratamento de distúrbios trombóticos mediados por plaquetas) junto com processos para fazer os compostos e os novos intermediários.
BR9912556-0A 1998-07-27 1999-07-21 Triazolpiridinas para o tratamento de distúrbios trombóticos BR9912556A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9423198P 1998-07-27 1998-07-27
US09/354,032 US6303625B1 (en) 1998-07-27 1999-07-15 Triazolopyridines for the treatment of thrombosis disorders
PCT/US1999/016572 WO2000006570A1 (en) 1998-07-27 1999-07-21 Triazolopyridines for the treatment of thrombosis disorders

Publications (1)

Publication Number Publication Date
BR9912556A true BR9912556A (pt) 2002-01-15

Family

ID=22243910

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9912556-0A BR9912556A (pt) 1998-07-27 1999-07-21 Triazolpiridinas para o tratamento de distúrbios trombóticos

Country Status (21)

Country Link
US (1) US6303625B1 (pt)
EP (1) EP1102766B1 (pt)
JP (1) JP2003527306A (pt)
KR (1) KR20010079576A (pt)
CN (1) CN1320125A (pt)
AR (1) AR019477A1 (pt)
AT (1) ATE263169T1 (pt)
AU (1) AU757512B2 (pt)
BR (1) BR9912556A (pt)
CA (1) CA2338654A1 (pt)
CZ (1) CZ2001347A3 (pt)
DE (1) DE69916073T2 (pt)
ES (1) ES2219042T3 (pt)
HU (1) HUP0103832A3 (pt)
ID (1) ID27214A (pt)
MX (1) MXPA01001099A (pt)
NO (1) NO20010456L (pt)
PL (1) PL345769A1 (pt)
SK (1) SK1342001A3 (pt)
WO (1) WO2000006570A1 (pt)
ZA (1) ZA200100783B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306909B1 (en) 1997-03-12 2001-10-23 Queen's University At Kingston Anti-epileptogenic agents
GEP20063956B (en) * 1999-08-13 2006-11-10 Biogen Idec Inc Cell adhesion inhibitors
TWI290136B (en) 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
EP1397136A1 (en) * 2001-05-25 2004-03-17 Queen's University At Kingston Heterocyclic beta-aminoacids and their use as anti-epileptogenic agents
US7365205B2 (en) 2001-06-20 2008-04-29 Daiichi Sankyo Company, Limited Diamine derivatives
EP1781655A2 (en) * 2004-08-18 2007-05-09 Pharmacia & Upjohn Company LLC Triazolopyridine compounds useful for the treatment of inflammation
WO2006052962A2 (en) * 2004-11-10 2006-05-18 Janssen Pharmaceutica, N.V. Bicyclic triazole a4 integrin inhibitors
WO2007032498A1 (ja) * 2005-09-16 2007-03-22 Daiichi Sankyo Company, Limited 光学活性なジアミン誘導体およびその製造方法
ATE542818T1 (de) * 2006-10-11 2012-02-15 Amgen Inc Imidazo- und triazolopyridinverbindungen und verfahren zu deren anwendung
EP2417135A1 (en) * 2009-04-07 2012-02-15 Schering Corporation Substituted triazolopyridines and analogs thereof
US8871760B2 (en) * 2009-09-21 2014-10-28 Roche Palo Alto Llc [1,2,4]triazolo[3,4-C][1,4]oxazines as P2X7 modulators
EP2755976B1 (en) 2011-09-15 2018-07-18 Novartis AG 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridines as c-met tyrosine kinase inhibitors
US20160108039A1 (en) * 2013-06-03 2016-04-21 Bayer Pharma Aktiengesellschaft Triazolopyridines as thrombin inhibitors for the treatment of thromboembolic diseases
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3050525A (en) 1960-12-14 1962-08-21 John B Bicking Certain derivatives of s-triazolo [4, 3-a]-pyridine
WO1994018981A1 (en) 1993-02-22 1994-09-01 Merck & Co., Inc. Fibrinogen receptor antagonists
DE4326758A1 (de) * 1993-08-10 1995-02-16 Basf Ag [1,3,4]Triazolo[1,5-a]pyridine
CA2134192A1 (en) 1993-11-12 1995-05-13 Michael L. Denney 5, 6-bicyclic glycoprotein iib/iiia antagonists

Also Published As

Publication number Publication date
ATE263169T1 (de) 2004-04-15
JP2003527306A (ja) 2003-09-16
HUP0103832A3 (en) 2002-12-28
PL345769A1 (en) 2002-01-02
AU5221899A (en) 2000-02-21
ID27214A (id) 2001-03-08
ES2219042T3 (es) 2004-11-16
CA2338654A1 (en) 2000-02-10
AR019477A1 (es) 2002-02-20
KR20010079576A (ko) 2001-08-22
MXPA01001099A (es) 2002-04-24
AU757512B2 (en) 2003-02-20
CN1320125A (zh) 2001-10-31
WO2000006570A1 (en) 2000-02-10
EP1102766B1 (en) 2004-03-31
EP1102766A1 (en) 2001-05-30
NO20010456D0 (no) 2001-01-26
CZ2001347A3 (cs) 2001-12-12
DE69916073T2 (de) 2004-12-30
DE69916073D1 (de) 2004-05-06
NO20010456L (no) 2001-03-26
ZA200100783B (en) 2002-01-28
HUP0103832A2 (hu) 2002-04-29
SK1342001A3 (en) 2002-04-04
US6303625B1 (en) 2001-10-16

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT.CL: C07D 471/04, A61K 31/437, C07D 487/04, C07D 211/34, A61P 7/02, A61P 9/10, A61P7/00, A61P 9/00

Ipc: C07D 471/04 (2009.01), A61K 31/437 (2009.01), C07D

B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements