DE60229530D1 - Substituierte piperazine als modulatoren des melanocortinrezeptors - Google Patents

Substituierte piperazine als modulatoren des melanocortinrezeptors

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Publication number
DE60229530D1
DE60229530D1 DE60229530T DE60229530T DE60229530D1 DE 60229530 D1 DE60229530 D1 DE 60229530D1 DE 60229530 T DE60229530 T DE 60229530T DE 60229530 T DE60229530 T DE 60229530T DE 60229530 D1 DE60229530 D1 DE 60229530D1
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Germany
Prior art keywords
substituted piperazine
compounds
melanocortinreceptor
modulators
prophylaxis
Prior art date
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Expired - Lifetime
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DE60229530T
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English (en)
Inventor
Christopher H Fotsch
Premilla Arasasingham
Yunxin Bo
Ning Chen
Martin H Goldberg
Nianhe Han
Feng-Yin Hsieh
Michael G Kelly
Qingyian Liu
Mark H Norman
Duncan M Smith
Markian Stec
Nuria Tamayo
Ning Xi
Shimin Xu
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Amgen Inc
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Amgen Inc
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Publication of DE60229530D1 publication Critical patent/DE60229530D1/de
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE60229530T 2001-07-25 2002-07-25 Substituierte piperazine als modulatoren des melanocortinrezeptors Expired - Lifetime DE60229530D1 (de)

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CA2454903A1 (en) 2003-02-06
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EP1417190B1 (de) 2008-10-22
US20070265248A1 (en) 2007-11-15
EP1417190A1 (de) 2004-05-12
WO2003009850A1 (en) 2003-02-06
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