HUP0103832A2 - Trombózisos rendellenességek kezelésére alkalmas triazolopiridin-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás ezek előállítására - Google Patents

Trombózisos rendellenességek kezelésére alkalmas triazolopiridin-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás ezek előállítására

Info

Publication number
HUP0103832A2
HUP0103832A2 HU0103832A HUP0103832A HUP0103832A2 HU P0103832 A2 HUP0103832 A2 HU P0103832A2 HU 0103832 A HU0103832 A HU 0103832A HU P0103832 A HUP0103832 A HU P0103832A HU P0103832 A2 HUP0103832 A2 HU P0103832A2
Authority
HU
Hungary
Prior art keywords
group
formula
preparation
treatment
piperidin
Prior art date
Application number
HU0103832A
Other languages
English (en)
Inventor
William J. Hoekstra
Edward C. Lawson
Bruce E. Maryanoff
Original Assignee
Ortho-Mcneil Pharmaceutical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho-Mcneil Pharmaceutical, Inc. filed Critical Ortho-Mcneil Pharmaceutical, Inc.
Publication of HUP0103832A2 publication Critical patent/HUP0103832A2/hu
Publication of HUP0103832A3 publication Critical patent/HUP0103832A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

A tal lm ny új (I) és (II) ltal nos képletű triazolopiridinszrmazékokra vonatkozik, a képletben M jelentése -(CH2)m-, -CH=CH-, -CH=CF-, -CF=CH-, vagy -CC- képletű csoport; m értéke 1, 2 vagy 3; nértéke 0, 1 vagy 2; A jelentése pipreidin-2-il-, piperidin-3-il-,piperidin-4-il-, piperazin-1-il-, pirolidin-2-il-, pirolidin-3-il-csoport vagy -NHR2 képletű csoport vagy (a) ltal nos képletű csoport,R10 jelentése hidrogénatom vagy -C(O)N(R1)YZ ltal nos képletű csoport,ahol R5 jelentése -C(O)NHQ(CHW)rCO2R8 ltal nos képletű csoport, R15jelentése hidrogénatom vagy alkilcsoport; és gyógy szatilagelfogadható sóik. A tal lm ny szerinti vegyületek GPIIb/IIIaantagonistaként haszn lhatók. A tal lm ny kiterjed a fentitriazolopiridin-sz rmazékokat tartalmazó, vérlemezke ltal k"zvetítetttrombózis rendellenességek kezelésére alkalmasgyógyszerkészítményekre, tov bb a gyógyszerkészítmények elő llít s ra. Ó
HU0103832A 1998-07-27 1999-07-21 Triazolopyridines for the treatment of thrombosis disorders, pharmaceutical compositions containing the same and process for preparation thereof HUP0103832A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9423198P 1998-07-27 1998-07-27
PCT/US1999/016572 WO2000006570A1 (en) 1998-07-27 1999-07-21 Triazolopyridines for the treatment of thrombosis disorders

Publications (2)

Publication Number Publication Date
HUP0103832A2 true HUP0103832A2 (hu) 2002-04-29
HUP0103832A3 HUP0103832A3 (en) 2002-12-28

Family

ID=22243910

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103832A HUP0103832A3 (en) 1998-07-27 1999-07-21 Triazolopyridines for the treatment of thrombosis disorders, pharmaceutical compositions containing the same and process for preparation thereof

Country Status (21)

Country Link
US (1) US6303625B1 (hu)
EP (1) EP1102766B1 (hu)
JP (1) JP2003527306A (hu)
KR (1) KR20010079576A (hu)
CN (1) CN1320125A (hu)
AR (1) AR019477A1 (hu)
AT (1) ATE263169T1 (hu)
AU (1) AU757512B2 (hu)
BR (1) BR9912556A (hu)
CA (1) CA2338654A1 (hu)
CZ (1) CZ2001347A3 (hu)
DE (1) DE69916073T2 (hu)
ES (1) ES2219042T3 (hu)
HU (1) HUP0103832A3 (hu)
ID (1) ID27214A (hu)
MX (1) MXPA01001099A (hu)
NO (1) NO20010456L (hu)
PL (1) PL345769A1 (hu)
SK (1) SK1342001A3 (hu)
WO (1) WO2000006570A1 (hu)
ZA (1) ZA200100783B (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306909B1 (en) 1997-03-12 2001-10-23 Queen's University At Kingston Anti-epileptogenic agents
CZ2002518A3 (cs) * 1999-08-13 2002-05-15 Biogen, Inc. Inhibitory buněčné adheze a farmaceutické prostředky, které je obsahují
TWI290136B (en) * 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
JP2004536071A (ja) * 2001-05-25 2004-12-02 クイーンズ　ユニバーシティ　アット　キングストン 複素環ベータアミノ酸およびそれらの抗癲癇誘発剤としての使用
WO2003000657A1 (fr) 2001-06-20 2003-01-03 Daiichi Pharmaceutical Co., Ltd. Derives de diamine
WO2006018727A2 (en) * 2004-08-18 2006-02-23 Pharmacia & Upjohn Company Llc Triazolopyridine compounds useful for the treatment of inflammation
US7618983B2 (en) * 2004-11-10 2009-11-17 Janssen Pharmaceutica, N.V. Bicyclic triazole α4 integrin inhibitors
HUE029336T2 (hu) * 2005-09-16 2017-02-28 Daiichi Sankyo Co Ltd Optikailag aktív diamin-származék és eljárás elõállítására
WO2008045393A2 (en) * 2006-10-11 2008-04-17 Amgen Inc. Imidazo- and triazolo-pyridine compounds and methods of use therof
EP2417135A1 (en) * 2009-04-07 2012-02-15 Schering Corporation Substituted triazolopyridines and analogs thereof
US8871760B2 (en) * 2009-09-21 2014-10-28 Roche Palo Alto Llc [1,2,4]triazolo[3,4-C][1,4]oxazines as P2X7 modulators
MX339302B (es) 2011-09-15 2016-05-19 Novartis Ag 3-(quinolin-6-il-tio)-[1,2,4]-triazolo-[4,3-a]-piridinas 6-sustituidas como cinasas de tirosina.
EP3004095A1 (de) * 2013-06-03 2016-04-13 Bayer Pharma Aktiengesellschaft Triazolopyridine als thrombininhibitoren zur behandlung von thromboembolischen erkrankungen
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3050525A (en) 1960-12-14 1962-08-21 John B Bicking Certain derivatives of s-triazolo [4, 3-a]-pyridine
NZ262664A (en) 1993-02-22 1997-04-24 Merck & Co Inc Heterocyclic substituted derivatives, and medicaments thereof
DE4326758A1 (de) * 1993-08-10 1995-02-16 Basf Ag [1,3,4]Triazolo[1,5-a]pyridine
CA2134192A1 (en) 1993-11-12 1995-05-13 Michael L. Denney 5, 6-bicyclic glycoprotein iib/iiia antagonists

Also Published As

Publication number Publication date
JP2003527306A (ja) 2003-09-16
EP1102766A1 (en) 2001-05-30
WO2000006570A1 (en) 2000-02-10
ES2219042T3 (es) 2004-11-16
AU5221899A (en) 2000-02-21
PL345769A1 (en) 2002-01-02
HUP0103832A3 (en) 2002-12-28
CZ2001347A3 (cs) 2001-12-12
US6303625B1 (en) 2001-10-16
ZA200100783B (en) 2002-01-28
NO20010456D0 (no) 2001-01-26
SK1342001A3 (en) 2002-04-04
ID27214A (id) 2001-03-08
DE69916073D1 (de) 2004-05-06
NO20010456L (no) 2001-03-26
CN1320125A (zh) 2001-10-31
DE69916073T2 (de) 2004-12-30
CA2338654A1 (en) 2000-02-10
AR019477A1 (es) 2002-02-20
AU757512B2 (en) 2003-02-20
ATE263169T1 (de) 2004-04-15
MXPA01001099A (es) 2002-04-24
EP1102766B1 (en) 2004-03-31
KR20010079576A (ko) 2001-08-22
BR9912556A (pt) 2002-01-15

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