BR9808923B1 - processos para fazer compostos inibidores de ciclooxigenase-2, e, compostos intermediÁrios para fazer inibidores de ciclooxigenase-2. - Google Patents

processos para fazer compostos inibidores de ciclooxigenase-2, e, compostos intermediÁrios para fazer inibidores de ciclooxigenase-2.

Info

Publication number
BR9808923B1
BR9808923B1 BRPI9808923-4A BR9808923A BR9808923B1 BR 9808923 B1 BR9808923 B1 BR 9808923B1 BR 9808923 A BR9808923 A BR 9808923A BR 9808923 B1 BR9808923 B1 BR 9808923B1
Authority
BR
Brazil
Prior art keywords
cyclooxygenase
making
compounds
inhibitors
processes
Prior art date
Application number
BRPI9808923-4A
Other languages
English (en)
Other versions
BR9808923A (pt
Inventor
Philip J Pye
Ashok Maliakal
Kai Rossen
Ralph P Volante
Jess Sager
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9709686.1A external-priority patent/GB9709686D0/en
Application filed filed Critical
Publication of BR9808923A publication Critical patent/BR9808923A/pt
Publication of BR9808923B1 publication Critical patent/BR9808923B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/52—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BRPI9808923-4A 1997-04-18 1998-04-14 processos para fazer compostos inibidores de ciclooxigenase-2, e, compostos intermediÁrios para fazer inibidores de ciclooxigenase-2. BR9808923B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4564297P 1997-04-18 1997-04-18
GBGB9709686.1A GB9709686D0 (en) 1997-05-13 1997-05-13 Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors
PCT/US1998/008312 WO1998047871A1 (en) 1997-04-18 1998-04-14 Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors

Publications (2)

Publication Number Publication Date
BR9808923A BR9808923A (pt) 2000-08-01
BR9808923B1 true BR9808923B1 (pt) 2010-08-24

Family

ID=26311530

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9808923-4A BR9808923B1 (pt) 1997-04-18 1998-04-14 processos para fazer compostos inibidores de ciclooxigenase-2, e, compostos intermediÁrios para fazer inibidores de ciclooxigenase-2.

Country Status (22)

Country Link
EP (1) EP0975596B1 (pt)
JP (1) JP3300369B2 (pt)
KR (1) KR20010006546A (pt)
CN (1) CN1182117C (pt)
AT (1) ATE270275T1 (pt)
AU (1) AU729730B2 (pt)
BR (1) BR9808923B1 (pt)
CA (1) CA2287482C (pt)
CZ (1) CZ293246B6 (pt)
DE (1) DE69824839T2 (pt)
EA (1) EA002190B1 (pt)
ES (1) ES2223128T3 (pt)
HK (1) HK1023771A1 (pt)
HR (1) HRP980206B1 (pt)
HU (1) HU226999B1 (pt)
NZ (1) NZ500390A (pt)
PL (1) PL190265B1 (pt)
RS (1) RS49901B (pt)
SK (1) SK285037B6 (pt)
TW (1) TW492959B (pt)
UA (1) UA66792C2 (pt)
WO (1) WO1998047871A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA01007169A (es) 1999-01-14 2003-06-06 Lonza Ag 1-(6-metilpiridin-3-il)-2-(4-(metilsulfonil)fenil)etanona y metodo para su elaboracion.
HUP0105124A3 (en) * 1999-01-14 2002-05-28 Merck & Co Inc 1-(6-methylpyridine-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone and method for its preparation
DK1198455T3 (da) * 1999-07-27 2004-04-05 Lonza Ag Fremgangsmåde til fremstilling af 1-(6-methylpyridin-3-yl)-2-[(4-(methylsulfonyl)phenyl]ethanon
US6566527B1 (en) 1999-07-27 2003-05-20 Merck & Co., Inc. Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-methylsulphonyl)-phenyl]ethanone
US6649629B2 (en) 1999-12-23 2003-11-18 Nitromed, Inc. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
JP2001261647A (ja) * 2000-03-22 2001-09-26 Sankio Chemical Co Ltd ピリジン誘導体の製造方法
ATE366569T1 (de) 2000-07-20 2007-08-15 Lauras As Verwendung von cox-2 inhibitoren als immunostimulantien zur behandlung von hiv oder aids
ES2683125T3 (es) * 2010-06-16 2018-09-25 Glenmark Generics Limited Proceso para la preparación de piridinas 2,3-diaril-5-sustituidas y sus compuestos intermedios
WO2012066570A2 (en) * 2010-11-15 2012-05-24 Virdev Intermediates Pvt. Ltd. A process for cyclooxygenase-2 selective inhibitor
CN103204803A (zh) 2012-01-13 2013-07-17 阿尔弗雷德·E·蒂芬巴赫尔有限责任两合公司 用于合成依托考昔的方法
WO2014114352A1 (en) * 2013-01-25 2014-07-31 Synthon Bv Process for making etoricoxib
WO2015036550A1 (en) 2013-09-13 2015-03-19 Synthon B.V. Process for making etoricoxib

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH561718A5 (pt) * 1971-05-10 1975-05-15 Ciba Geigy Ag
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5686470A (en) * 1995-02-10 1997-11-11 Weier; Richard M. 2, 3-substituted pyridines for the treatment of inflammation
WO1996025405A1 (en) * 1995-02-13 1996-08-22 G.D. Searle & Co. Substituted isoxazoles for the treatment of inflammation
US5643933A (en) * 1995-06-02 1997-07-01 G. D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US5677318A (en) * 1996-07-11 1997-10-14 Merck Frosst Canada, Inc. Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents
IL127441A (en) * 1996-07-18 2003-02-12 Merck Frosst Canada Inc Substituted pyridines, pharmaceutical compositions comprising them and their use in the preparation of anti-inflammatory medicaments or as selective cyclooxygenase-2 inhibitors

Also Published As

Publication number Publication date
ATE270275T1 (de) 2004-07-15
HK1023771A1 (en) 2000-09-22
HRP980206A2 (en) 1998-12-31
NZ500390A (en) 2001-08-31
CN1182117C (zh) 2004-12-29
AU729730B2 (en) 2001-02-08
TW492959B (en) 2002-07-01
PL336298A1 (en) 2000-06-19
EA002190B1 (ru) 2002-02-28
EP0975596A1 (en) 2000-02-02
ES2223128T3 (es) 2005-02-16
WO1998047871A1 (en) 1998-10-29
PL190265B1 (pl) 2005-11-30
SK285037B6 (sk) 2006-05-04
EP0975596B1 (en) 2004-06-30
RS49901B (sr) 2008-08-07
CA2287482C (en) 2004-02-17
HUP0003155A3 (en) 2002-01-28
CZ293246B6 (cs) 2004-03-17
HUP0003155A2 (hu) 2001-06-28
CZ369099A3 (cs) 2000-04-12
BR9808923A (pt) 2000-08-01
EA199900948A1 (ru) 2000-04-24
HRP980206B1 (en) 2002-02-28
SK143699A3 (en) 2000-07-11
JP3300369B2 (ja) 2002-07-08
YU53699A (sh) 2001-12-26
CN1260782A (zh) 2000-07-19
HU226999B1 (en) 2010-04-28
CA2287482A1 (en) 1998-10-29
UA66792C2 (uk) 2004-06-15
DE69824839D1 (de) 2004-08-05
JP2000513018A (ja) 2000-10-03
KR20010006546A (ko) 2001-01-26
DE69824839T2 (de) 2005-07-07
AU7257198A (en) 1998-11-13

Similar Documents

Publication Publication Date Title
YU64100A (sh) Postupak za sintetizovanje cox-2 inhibitora
BR9812837A (pt) Processo para fazer um composto, e, composto
PT971713E (pt) Utilizacao de inibidores da colinesterase para tratamento de desordens da atencao
UA49809C2 (uk) Спосіб одержання фенільних гетероциклів, які використовуються як інгібітори цог-2, а також сполуки, одержані цим способом
WO2002030353A3 (en) NF-λB INHIBITORS
TW200510397A (en) Conjugated complement cascade inhibitors
BR0008625A (pt) Processo para tratamento de asma induzida por exercìcio
BR9808923B1 (pt) processos para fazer compostos inibidores de ciclooxigenase-2, e, compostos intermediÁrios para fazer inibidores de ciclooxigenase-2.
AU2001260880A1 (en) Pharmaceutical compounds for treating copd
ATE193526T1 (de) Alkylierte styrole als prodrugs zu cox-2- inhibitoren
DK0996435T3 (da) Aminosyrederivater anvendelige til behandling af slagtilfælde
DE69715173T2 (de) Bisarylcyclobutenderivate als cyclooxygenasehemmer
NO983511D0 (no) Difenylstilbener som pro-legemidler for COX-2-inhibitorer
BR9709264A (pt) Processo para produzir e composto
DE69930844D1 (de) Inhibitoren von mycobakterien
ATE267194T1 (de) Medikamente geeignet zur behandlung von proliferativen erkrankungen
DK1042288T3 (da) Tripeptidyl-peptidase inhibitorer
ATE409066T1 (de) Einzeldosis aromatase hemmer zur behandlung von unfruchtbarkeit
MY140504A (en) Statin-mmp inhibitor combinations
DK1366033T3 (da) Kemiske forbindelser
WO1999025327A3 (en) Small molecule intervention in hiv-1 replication
BR9807920A (pt) Processos para tratamento de uma demência em um sujeito e para prevenção de uma demência
PT1315491E (pt) Utilizacao de pirazoles substituidos para o fabrico de um medicamento para o tratamento de alergias
BR9607577A (pt) Método para inibir catepsina k

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/08/2010, OBSERVADAS AS CONDICOES LEGAIS.

B25D Requested change of name of applicant approved

Owner name: MERCK SHARP AND DOHME CORP. (US)

Free format text: NOME ALTERADO DE: MERCK AND CO., INC.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE AS 15A, 16A E 17A ANUIDADES.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.