BR9712959A - Compostos ou suas composições, e, uso de compostos ou de composições. - Google Patents
Compostos ou suas composições, e, uso de compostos ou de composições.Info
- Publication number
- BR9712959A BR9712959A BR9712959-3A BR9712959A BR9712959A BR 9712959 A BR9712959 A BR 9712959A BR 9712959 A BR9712959 A BR 9712959A BR 9712959 A BR9712959 A BR 9712959A
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- compounds
- analapril
- medicaments
- residue
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 5
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229960004605 timolol Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI002368A IT1295694B1 (it) | 1996-11-14 | 1996-11-14 | Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica |
PCT/EP1997/006311 WO1998021193A1 (en) | 1996-11-14 | 1997-11-12 | Antithrombotic organic nitrates |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9712959A true BR9712959A (pt) | 2000-02-01 |
BR9712959B1 BR9712959B1 (pt) | 2010-06-01 |
Family
ID=11375213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9712959-3A BR9712959B1 (pt) | 1996-11-14 | 1997-11-12 | nitratos orgánicos anti-trombóticos de inibidores da ace. |
Country Status (18)
Country | Link |
---|---|
US (1) | US6242432B1 (pt) |
EP (1) | EP0941218B1 (pt) |
JP (1) | JP4264137B2 (pt) |
KR (1) | KR100504122B1 (pt) |
CN (1) | CN1094931C (pt) |
AT (1) | ATE226199T1 (pt) |
AU (1) | AU729423B2 (pt) |
BR (1) | BR9712959B1 (pt) |
CA (1) | CA2272063C (pt) |
DE (1) | DE69716461T2 (pt) |
DK (1) | DK0941218T3 (pt) |
ES (1) | ES2186013T3 (pt) |
HU (1) | HUP0000667A3 (pt) |
IL (1) | IL129768A (pt) |
IT (1) | IT1295694B1 (pt) |
PT (1) | PT941218E (pt) |
RU (1) | RU2190594C2 (pt) |
WO (1) | WO1998021193A1 (pt) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9801398D0 (en) | 1998-01-22 | 1998-03-18 | Anggard Erik E | Chemical compounds |
IT1301759B1 (it) * | 1998-06-19 | 2000-07-07 | Nicox Sa | Sali nitrati di farmaci antiipertensivi |
IT1311923B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
IE20000052A1 (en) * | 1999-04-29 | 2000-11-29 | Russinsky Ltd | Nitric acid salts of B-blockers |
IT1314184B1 (it) | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
AU7365900A (en) | 1999-09-08 | 2001-04-10 | Nitromed, Inc. | Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate |
AU780261B2 (en) | 1999-10-29 | 2005-03-10 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
US7235237B2 (en) | 1999-10-29 | 2007-06-26 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
US7708989B2 (en) | 1999-10-29 | 2010-05-04 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
US7537785B2 (en) * | 1999-10-29 | 2009-05-26 | Nitromed, Inc. | Composition for treating vascular diseases characterized by nitric oxide insufficiency |
WO2001045703A1 (en) * | 1999-12-23 | 2001-06-28 | Nitromed, Inc. | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
EP1257668B1 (en) | 2000-02-16 | 2008-10-29 | Illumina, Inc. | Parallel genotyping of multiple patient samples |
WO2001098286A1 (en) | 2000-06-22 | 2001-12-27 | Nitromed, Inc. | Nitrosated and nitrosylated taxanes, compositions and methods of use |
AU5939901A (en) * | 2000-10-27 | 2002-05-06 | Nitromed Inc | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
EP1219306A1 (en) | 2000-12-29 | 2002-07-03 | Nicox S.A. | Compositions comprising cyclodextrins and NO- releasing drugs |
EP1406608B1 (en) | 2001-05-02 | 2009-07-29 | Nitromed, Inc. | Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use |
GB0111872D0 (en) * | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
US20080026984A1 (en) * | 2002-02-04 | 2008-01-31 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
US7968605B2 (en) * | 2002-02-04 | 2011-06-28 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
WO2003066067A2 (en) * | 2002-02-04 | 2003-08-14 | Alfama - Investigaçao E Desenvolvimento De Produtos Farmaceuticos Lda. | Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases |
JP2006501161A (ja) * | 2002-06-11 | 2006-01-12 | ニトロメッド インク. | ニトロソ化および/またはニトロシル化シクロオキシゲナーゼ−2選択的阻害剤、組成物ならびに使用方法 |
US20060247216A1 (en) * | 2002-10-25 | 2006-11-02 | Haj-Yehia Abdullah I | Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments |
GB2395432B (en) * | 2002-11-20 | 2005-09-14 | Northwick Park Inst For Medica | Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs |
AU2003283789A1 (en) * | 2002-11-22 | 2004-06-18 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Beta-blockers having antioxidant and nitric oxide-donor activity |
EP1578413A2 (en) * | 2002-11-29 | 2005-09-28 | Yissum Research Development Company of The Hebrew University of Jerusalem | Ace-inhibitors having antioxidant and no-donor activity |
US7166638B2 (en) | 2003-05-27 | 2007-01-23 | Nicox S.A. | Statin derivatives |
US7169805B2 (en) * | 2003-05-28 | 2007-01-30 | Nicox S.A. | Captopril derivatives |
EP1635816B1 (en) * | 2003-06-19 | 2009-03-04 | NicOx S.A. | Enalapril-nitroxyderivatives derivatives and related compounds as ace inhibitors for the treatment of cardiovascular diseases |
CA2536173A1 (en) * | 2003-08-20 | 2005-03-03 | Nitromed, Inc. | Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use |
US20070060586A1 (en) * | 2003-12-02 | 2007-03-15 | Del Soldato Piero | Nitrooxyderivatives of antihypertensive drugs |
US7825263B2 (en) * | 2003-12-02 | 2010-11-02 | Nicox S.A. | Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive |
EP1704141B1 (en) | 2004-01-05 | 2016-02-24 | Nicox S.A. | Prostaglandin nitrooxyderivatives |
CA2573562A1 (en) * | 2004-07-16 | 2006-02-23 | Nitromed, Inc. | Compositions and methods related to heart failure |
EP1786814B1 (en) | 2004-08-25 | 2010-03-31 | Actelion Pharmaceuticals Ltd. | Bicyclononene derivatives as renin inhibitors |
US20080300292A1 (en) * | 2004-11-08 | 2008-12-04 | Nitromed, Inc | Nitrosated and Nitrosylated Compounds, Compositions and Methods for the Treatment of Ophthalmic Disorders |
EP1846380A4 (en) * | 2005-01-21 | 2010-02-17 | Nicox Sa | HETEROCYCLIC NITROGEN MONOXIDE DONOR COMPOSITIONS CONTAINING CARDIOVASCULAR COMPOUNDS, AND METHODS OF USING THE SAME |
US20100028439A1 (en) * | 2005-05-23 | 2010-02-04 | Elan Pharma International Limited | Nanoparticulate stabilized anti-hypertensive compositions |
JP4297972B2 (ja) * | 2005-05-27 | 2009-07-15 | アクテリオン ファーマシューティカルズ リミテッド | 新規なピペリジンカルボン酸アミド誘導体 |
EP1899295A2 (en) * | 2005-06-29 | 2008-03-19 | Pfizer, Inc. | Prostaglandin derivatives |
US20080274171A1 (en) * | 2005-10-18 | 2008-11-06 | Nicoletta Almirante | Renin Inhibitors Nitroderivatives |
WO2007073226A1 (en) * | 2005-12-20 | 2007-06-28 | Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda | Method for treating a mammal by administration of a compound having the ability to release co |
GB0601394D0 (en) | 2006-01-24 | 2006-03-01 | Hemocorm Ltd | Therapeutic delivery of carbon monoxide |
EP1981847A1 (en) | 2006-02-02 | 2008-10-22 | Actelion Pharmaceuticals Ltd. | Secondary amines as renin inhibitors |
EP1984010A4 (en) * | 2006-02-17 | 2010-09-08 | Nitromed Inc | METHOD FOR USE OF HYDRALAZIN COMPOUNDS AND ISOSORBIDE DINITRATE OR ISOSORBIDE MONONITRATE |
CN101395149A (zh) * | 2006-03-08 | 2009-03-25 | 埃科特莱茵药品有限公司 | 新颖胺类 |
JP2007275193A (ja) * | 2006-04-04 | 2007-10-25 | Fujifilm Corp | 光プローブおよび光断層画像化装置 |
US20090306081A1 (en) * | 2006-05-16 | 2009-12-10 | Letts L Gordon | Solid Dosage Formulations of Hydralazine Compounds and Nitric Oxide Donor Compounds |
TW200831079A (en) * | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Angiotensin II receptor antagonists |
FR2921365B1 (fr) * | 2007-09-21 | 2012-10-12 | Servier Lab | Nouveaux sels d'addition d'inhibiteurs d'enzyme de conversion de l'angiotensine a des acides donneurs de no, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
JP4790871B2 (ja) * | 2008-05-05 | 2011-10-12 | メルク フロスト カナダ リミテツド | レニン阻害剤としての3,4−置換ピペリジン誘導体 |
WO2010116270A1 (en) | 2009-04-10 | 2010-10-14 | Pfizer Inc. | Ep2/4 agonists |
WO2011160974A2 (en) | 2010-06-21 | 2011-12-29 | Nicox S.A. | Statin derivatives |
EP2699242B1 (en) | 2011-04-19 | 2017-11-01 | Alfama, Inc. | Carbon monoxide releasing molecules and uses thereof |
EP2734235B1 (en) | 2011-07-21 | 2017-03-22 | Alfama, Inc. | Ruthenium carbon monoxide releasing molecules and uses thereof |
CA2897571C (en) | 2013-01-21 | 2018-12-18 | Apparao Satyam | Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group |
JP7055802B2 (ja) | 2016-11-08 | 2022-04-18 | ボシュ・アンド・ロム・インコーポレイテッド | 正常眼圧緑内障を処置するための一酸化窒素放出プロスタグランジン誘導体 |
MX2022000133A (es) | 2019-07-01 | 2022-04-27 | Tonix Pharma Ltd | Anticuerpos anti-cd154 y usos de los mismos. |
US20240059781A1 (en) | 2021-01-06 | 2024-02-22 | Tonix Pharma Limited | Methods of inducing immune tolerance with modified anti-cd154 antibodies |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1256345B (it) | 1992-08-20 | 1995-12-01 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione | |
IT1256450B (it) | 1992-11-26 | 1995-12-05 | Soldato Piero Del | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione |
ES2065291B1 (es) * | 1993-07-30 | 1995-10-01 | Prodesfarma Sa | "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente" |
HU218923B (hu) | 1993-10-06 | 2000-12-28 | Nicox S.A. | Gyulladásgátló és/vagy fájdalomcsillapító hatású nitrát-észterek, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására |
CA2190087C (en) * | 1994-05-10 | 2005-08-02 | Piero Del Soldato | Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities |
AU2230897A (en) * | 1996-03-01 | 1997-09-16 | Sankyo Company Limited | Thiazolidine derivatives |
-
1996
- 1996-11-14 IT IT96MI002368A patent/IT1295694B1/it active IP Right Grant
-
1997
- 1997-11-12 IL IL12976897A patent/IL129768A/en not_active IP Right Cessation
- 1997-11-12 BR BRPI9712959-3A patent/BR9712959B1/pt not_active IP Right Cessation
- 1997-11-12 RU RU99112517/04A patent/RU2190594C2/ru not_active IP Right Cessation
- 1997-11-12 DK DK97951890T patent/DK0941218T3/da active
- 1997-11-12 AT AT97951890T patent/ATE226199T1/de active
- 1997-11-12 DE DE69716461T patent/DE69716461T2/de not_active Expired - Lifetime
- 1997-11-12 HU HU0000667A patent/HUP0000667A3/hu unknown
- 1997-11-12 CN CN97181245A patent/CN1094931C/zh not_active Expired - Fee Related
- 1997-11-12 US US09/297,933 patent/US6242432B1/en not_active Expired - Fee Related
- 1997-11-12 ES ES97951890T patent/ES2186013T3/es not_active Expired - Lifetime
- 1997-11-12 KR KR10-1999-7004229A patent/KR100504122B1/ko not_active IP Right Cessation
- 1997-11-12 PT PT97951890T patent/PT941218E/pt unknown
- 1997-11-12 WO PCT/EP1997/006311 patent/WO1998021193A1/en active IP Right Grant
- 1997-11-12 EP EP97951890A patent/EP0941218B1/en not_active Expired - Lifetime
- 1997-11-12 JP JP52217998A patent/JP4264137B2/ja not_active Expired - Fee Related
- 1997-11-12 AU AU55519/98A patent/AU729423B2/en not_active Ceased
- 1997-11-12 CA CA002272063A patent/CA2272063C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IL129768A0 (en) | 2000-02-29 |
ITMI962368A1 (it) | 1998-05-14 |
RU2190594C2 (ru) | 2002-10-10 |
DE69716461T2 (de) | 2003-06-26 |
ES2186013T3 (es) | 2003-05-01 |
EP0941218A1 (en) | 1999-09-15 |
BR9712959B1 (pt) | 2010-06-01 |
EP0941218B1 (en) | 2002-10-16 |
CN1242768A (zh) | 2000-01-26 |
CA2272063C (en) | 2008-05-27 |
DK0941218T3 (da) | 2003-02-17 |
KR20000053251A (ko) | 2000-08-25 |
CA2272063A1 (en) | 1998-05-22 |
HUP0000667A3 (en) | 2000-08-28 |
CN1094931C (zh) | 2002-11-27 |
DE69716461D1 (de) | 2002-11-21 |
WO1998021193A1 (en) | 1998-05-22 |
ATE226199T1 (de) | 2002-11-15 |
KR100504122B1 (ko) | 2005-07-27 |
ITMI962368A0 (it) | 1996-11-14 |
AU5551998A (en) | 1998-06-03 |
IT1295694B1 (it) | 1999-05-27 |
JP2001507676A (ja) | 2001-06-12 |
HUP0000667A2 (en) | 2000-07-28 |
IL129768A (en) | 2004-02-19 |
AU729423B2 (en) | 2001-02-01 |
US6242432B1 (en) | 2001-06-05 |
JP4264137B2 (ja) | 2009-05-13 |
PT941218E (pt) | 2003-03-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25G | Requested change of headquarter approved |
Owner name: NICOX S.A. (FR) Free format text: ANOTADAS AS ALTERACOES DE SEDE SOLICITADAS NA PETICAO NO 020050046572/RJ DE 06/06/2005. |
|
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