DK0941218T3 - Antithrombotiske organiske nitrater - Google Patents

Antithrombotiske organiske nitrater

Info

Publication number
DK0941218T3
DK0941218T3 DK97951890T DK97951890T DK0941218T3 DK 0941218 T3 DK0941218 T3 DK 0941218T3 DK 97951890 T DK97951890 T DK 97951890T DK 97951890 T DK97951890 T DK 97951890T DK 0941218 T3 DK0941218 T3 DK 0941218T3
Authority
DK
Denmark
Prior art keywords
antithrombotic
organic nitrates
compounds
analapril
timolol
Prior art date
Application number
DK97951890T
Other languages
English (en)
Inventor
Soldato Piero Del
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Application granted granted Critical
Publication of DK0941218T3 publication Critical patent/DK0941218T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DK97951890T 1996-11-14 1997-11-12 Antithrombotiske organiske nitrater DK0941218T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI002368A IT1295694B1 (it) 1996-11-14 1996-11-14 Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
PCT/EP1997/006311 WO1998021193A1 (en) 1996-11-14 1997-11-12 Antithrombotic organic nitrates

Publications (1)

Publication Number Publication Date
DK0941218T3 true DK0941218T3 (da) 2003-02-17

Family

ID=11375213

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97951890T DK0941218T3 (da) 1996-11-14 1997-11-12 Antithrombotiske organiske nitrater

Country Status (18)

Country Link
US (1) US6242432B1 (da)
EP (1) EP0941218B1 (da)
JP (1) JP4264137B2 (da)
KR (1) KR100504122B1 (da)
CN (1) CN1094931C (da)
AT (1) ATE226199T1 (da)
AU (1) AU729423B2 (da)
BR (1) BR9712959B1 (da)
CA (1) CA2272063C (da)
DE (1) DE69716461T2 (da)
DK (1) DK0941218T3 (da)
ES (1) ES2186013T3 (da)
HU (1) HUP0000667A3 (da)
IL (1) IL129768A (da)
IT (1) IT1295694B1 (da)
PT (1) PT941218E (da)
RU (1) RU2190594C2 (da)
WO (1) WO1998021193A1 (da)

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US7537785B2 (en) * 1999-10-29 2009-05-26 Nitromed, Inc. Composition for treating vascular diseases characterized by nitric oxide insufficiency
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US7285384B2 (en) 2000-02-16 2007-10-23 Illuminia, Inc. Parallel genotyping of multiple patient samples
DE60131537T2 (de) 2000-06-22 2008-10-23 Nitromed, Inc., Lexington Nitrosierte und nitrosylierte taxane, zubereitungen und methoden der verwendung
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US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
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US7220749B2 (en) 2002-06-11 2007-05-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
EP1562975A2 (en) * 2002-10-25 2005-08-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
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WO2004047837A2 (en) * 2002-11-22 2004-06-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Beta-blockers having antioxidant and nitric oxide-donor activity
US20060166894A1 (en) * 2002-11-29 2006-07-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ace-inhibitors having antioxidant and no-donor activity
US7166638B2 (en) 2003-05-27 2007-01-23 Nicox S.A. Statin derivatives
US7169805B2 (en) * 2003-05-28 2007-01-30 Nicox S.A. Captopril derivatives
CN1809345A (zh) * 2003-06-19 2006-07-26 尼科克斯公司 依那普利－硝基衍生物和相关化合物作为ace抑制剂用于治疗心血管疾病
WO2005018561A2 (en) * 2003-08-20 2005-03-03 Nitromed, Inc. Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use
ATE423107T1 (de) * 2003-12-02 2009-03-15 Nicox Sa Nitrooxyderivate von blutdrucksenkenden arzneimitteln
KR20060120677A (ko) 2003-12-02 2006-11-27 니콕스 에스. 에이. 항고혈압제로서의 카베디롤의 니트로옥시유도체 및 다른베타차단제들
EP1704141B1 (en) * 2004-01-05 2016-02-24 Nicox S.A. Prostaglandin nitrooxyderivatives
EP1778267A4 (en) * 2004-07-16 2010-01-06 Nitromed Inc COMPOSITIONS AND METHODS ASSOCIATED WITH HEART FAILURE
US8138340B2 (en) 2004-08-25 2012-03-20 Actelion Pharmaceuticals Ltd. Bicyclononene derivatives
US20080300292A1 (en) * 2004-11-08 2008-12-04 Nitromed, Inc Nitrosated and Nitrosylated Compounds, Compositions and Methods for the Treatment of Ophthalmic Disorders
WO2006078995A1 (en) * 2005-01-21 2006-07-27 Nitromed, Inc. Cardiovascular compounds comprising heterocyclic nitric oxide donor group compositions and methods of use
US20100028439A1 (en) * 2005-05-23 2010-02-04 Elan Pharma International Limited Nanoparticulate stabilized anti-hypertensive compositions
US7799805B2 (en) * 2005-05-27 2010-09-21 Actelion Pharmaceuticals Ltd. Piperidine carboxylic acid amide derivatives
CA2613748A1 (en) * 2005-06-29 2007-01-04 Pfizer Inc. Prostaglandin derivatives
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WO2007073226A1 (en) * 2005-12-20 2007-06-28 Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda Method for treating a mammal by administration of a compound having the ability to release co
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EP1984010A4 (en) * 2006-02-17 2010-09-08 Nitromed Inc METHOD FOR USE OF HYDRALAZIN COMPOUNDS AND ISOSORBIDE DINITRATE OR ISOSORBIDE MONONITRATE
JP2009529033A (ja) * 2006-03-08 2009-08-13 アクテリオン ファーマシューティカルズ リミテッド 新規アミン
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US20090306081A1 (en) * 2006-05-16 2009-12-10 Letts L Gordon Solid Dosage Formulations of Hydralazine Compounds and Nitric Oxide Donor Compounds
TW200831079A (en) * 2006-12-13 2008-08-01 Merck & Co Inc Angiotensin II receptor antagonists
FR2921365B1 (fr) * 2007-09-21 2012-10-12 Servier Lab Nouveaux sels d'addition d'inhibiteurs d'enzyme de conversion de l'angiotensine a des acides donneurs de no, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2009135299A1 (en) 2008-05-05 2009-11-12 Merck Frosst Canada Ltd. 3, 4 - substituted piperidine derivatives as renin inhibitors
WO2010116270A1 (en) 2009-04-10 2010-10-14 Pfizer Inc. Ep2/4 agonists
WO2011160974A2 (en) 2010-06-21 2011-12-29 Nicox S.A. Statin derivatives
ES2656237T3 (es) 2011-04-19 2018-02-26 Alfama, Inc. Moléculas liberadoras de monóxido de carbono y usos de las mismas
JP6134710B2 (ja) 2011-07-21 2017-05-24 アルファーマ インコーポレイテッドＡｌｆａｍａ，Ｉｎｃ． 一酸化ルテニウム放出分子およびその使用
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
BR112019009330A2 (pt) 2016-11-08 2019-07-30 Bausch & Lomb composto
BR112021026410A2 (pt) 2019-07-01 2022-02-08 Tonix Pharma Ltd Anticorpos anti-cd154 e usos dos mesmos
US20240059781A1 (en) 2021-01-06 2024-02-22 Tonix Pharma Limited Methods of inducing immune tolerance with modified anti-cd154 antibodies

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Publication number Priority date Publication date Assignee Title
IT1256345B (it) 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
ES2065291B1 (es) * 1993-07-30 1995-10-01 Prodesfarma Sa "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente"
WO1995009831A1 (en) 1993-10-06 1995-04-13 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
RU2145595C1 (ru) 1994-05-10 2000-02-20 Никокс С.А. Нитроксисоединения и фармацевтическая композиция на их основе, имеющие противовоспалительную, анальгетическую и антитромбоцитарную активности
AU2230897A (en) * 1996-03-01 1997-09-16 Sankyo Company Limited Thiazolidine derivatives

Also Published As

Publication number Publication date
BR9712959A (pt) 2000-02-01
CA2272063A1 (en) 1998-05-22
CN1242768A (zh) 2000-01-26
KR100504122B1 (ko) 2005-07-27
ITMI962368A0 (it) 1996-11-14
KR20000053251A (ko) 2000-08-25
EP0941218A1 (en) 1999-09-15
CA2272063C (en) 2008-05-27
JP4264137B2 (ja) 2009-05-13
HUP0000667A2 (en) 2000-07-28
AU5551998A (en) 1998-06-03
ES2186013T3 (es) 2003-05-01
RU2190594C2 (ru) 2002-10-10
HUP0000667A3 (en) 2000-08-28
IL129768A (en) 2004-02-19
AU729423B2 (en) 2001-02-01
DE69716461T2 (de) 2003-06-26
DE69716461D1 (de) 2002-11-21
BR9712959B1 (pt) 2010-06-01
JP2001507676A (ja) 2001-06-12
ATE226199T1 (de) 2002-11-15
EP0941218B1 (en) 2002-10-16
ITMI962368A1 (it) 1998-05-14
US6242432B1 (en) 2001-06-05
IL129768A0 (en) 2000-02-29
PT941218E (pt) 2003-03-31
CN1094931C (zh) 2002-11-27
WO1998021193A1 (en) 1998-05-22
IT1295694B1 (it) 1999-05-27

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