ITMI962368A0 - Nuovi prodotti ad attivita' antitrombotica - Google Patents

Nuovi prodotti ad attivita' antitrombotica

Info

Publication number
ITMI962368A0
ITMI962368A0 IT96MI002368A ITMI962368A ITMI962368A0 IT MI962368 A0 ITMI962368 A0 IT MI962368A0 IT 96MI002368 A IT96MI002368 A IT 96MI002368A IT MI962368 A ITMI962368 A IT MI962368A IT MI962368 A0 ITMI962368 A0 IT MI962368A0
Authority
IT
Italy
Prior art keywords
new products
antithrombotic activity
antithrombotic
activity
products
Prior art date
Application number
IT96MI002368A
Other languages
English (en)
Inventor
Soldato Piero Del
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of ITMI962368A0 publication Critical patent/ITMI962368A0/it
Priority to IT96MI002368A priority Critical patent/IT1295694B1/it
Priority to US09/297,933 priority patent/US6242432B1/en
Priority to JP52217998A priority patent/JP4264137B2/ja
Priority to HU0000667A priority patent/HUP0000667A3/hu
Priority to BRPI9712959-3A priority patent/BR9712959B1/pt
Priority to DE69716461T priority patent/DE69716461T2/de
Priority to PT97951890T priority patent/PT941218E/pt
Priority to ES97951890T priority patent/ES2186013T3/es
Priority to SI9730450T priority patent/SI0941218T1/xx
Priority to RU99112517/04A priority patent/RU2190594C2/ru
Priority to CN97181245A priority patent/CN1094931C/zh
Priority to AT97951890T priority patent/ATE226199T1/de
Priority to CA002272063A priority patent/CA2272063C/en
Priority to EP97951890A priority patent/EP0941218B1/en
Priority to IL12976897A priority patent/IL129768A/en
Priority to KR10-1999-7004229A priority patent/KR100504122B1/ko
Priority to DK97951890T priority patent/DK0941218T3/da
Priority to PCT/EP1997/006311 priority patent/WO1998021193A1/en
Priority to AU55519/98A priority patent/AU729423B2/en
Publication of ITMI962368A1 publication Critical patent/ITMI962368A1/it
Application granted granted Critical
Publication of IT1295694B1 publication Critical patent/IT1295694B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
IT96MI002368A 1996-11-14 1996-11-14 Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica IT1295694B1 (it)

Priority Applications (19)

Application Number Priority Date Filing Date Title
IT96MI002368A IT1295694B1 (it) 1996-11-14 1996-11-14 Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
CN97181245A CN1094931C (zh) 1996-11-14 1997-11-12 抗血栓有机硝酸酯
CA002272063A CA2272063C (en) 1996-11-14 1997-11-12 Antithrombotic organic nitrates
HU0000667A HUP0000667A3 (en) 1996-11-14 1997-11-12 Antithrombotic organic nitrates
BRPI9712959-3A BR9712959B1 (pt) 1996-11-14 1997-11-12 nitratos orgánicos anti-trombóticos de inibidores da ace.
DE69716461T DE69716461T2 (de) 1996-11-14 1997-11-12 Antithrombotische organische nitrate
PT97951890T PT941218E (pt) 1996-11-14 1997-11-12 Nitratos organicos antitromboticos
ES97951890T ES2186013T3 (es) 1996-11-14 1997-11-12 Nitratos organicos con actividad antitrombotica.
SI9730450T SI0941218T1 (en) 1996-11-14 1997-11-12 Antithrombotic organic nitrates
RU99112517/04A RU2190594C2 (ru) 1996-11-14 1997-11-12 Органические нитраты и фармацевтическая композиция, обладающая ингибирующей агрегацию тромбоцитов активностью, на их основе
US09/297,933 US6242432B1 (en) 1996-11-14 1997-11-12 Antithrombotic organic nitrates
AT97951890T ATE226199T1 (de) 1996-11-14 1997-11-12 Antithrombotische organische nitrate
JP52217998A JP4264137B2 (ja) 1996-11-14 1997-11-12 抗血栓性有機硝酸塩
EP97951890A EP0941218B1 (en) 1996-11-14 1997-11-12 Antithrombotic organic nitrates
IL12976897A IL129768A (en) 1996-11-14 1997-11-12 Organic nitrates and anticoagulants containing them
KR10-1999-7004229A KR100504122B1 (ko) 1996-11-14 1997-11-12 항혈전성 유기질산염
DK97951890T DK0941218T3 (da) 1996-11-14 1997-11-12 Antithrombotiske organiske nitrater
PCT/EP1997/006311 WO1998021193A1 (en) 1996-11-14 1997-11-12 Antithrombotic organic nitrates
AU55519/98A AU729423B2 (en) 1996-11-14 1997-11-12 Antithrombotic organic nitrates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI002368A IT1295694B1 (it) 1996-11-14 1996-11-14 Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica

Publications (3)

Publication Number Publication Date
ITMI962368A0 true ITMI962368A0 (it) 1996-11-14
ITMI962368A1 ITMI962368A1 (it) 1998-05-14
IT1295694B1 IT1295694B1 (it) 1999-05-27

Family

ID=11375213

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96MI002368A IT1295694B1 (it) 1996-11-14 1996-11-14 Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica

Country Status (18)

Country Link
US (1) US6242432B1 (it)
EP (1) EP0941218B1 (it)
JP (1) JP4264137B2 (it)
KR (1) KR100504122B1 (it)
CN (1) CN1094931C (it)
AT (1) ATE226199T1 (it)
AU (1) AU729423B2 (it)
BR (1) BR9712959B1 (it)
CA (1) CA2272063C (it)
DE (1) DE69716461T2 (it)
DK (1) DK0941218T3 (it)
ES (1) ES2186013T3 (it)
HU (1) HUP0000667A3 (it)
IL (1) IL129768A (it)
IT (1) IT1295694B1 (it)
PT (1) PT941218E (it)
RU (1) RU2190594C2 (it)
WO (1) WO1998021193A1 (it)

Families Citing this family (58)

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GB9801398D0 (en) 1998-01-22 1998-03-18 Anggard Erik E Chemical compounds
IT1301759B1 (it) * 1998-06-19 2000-07-07 Nicox Sa Sali nitrati di farmaci antiipertensivi
IT1311923B1 (it) 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IE20000052A1 (en) * 1999-04-29 2000-11-29 Russinsky Ltd Nitric acid salts of B-blockers
IT1314184B1 (it) 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
AU7365900A (en) 1999-09-08 2001-04-10 Nitromed, Inc. Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate
AU780261B2 (en) 1999-10-29 2005-03-10 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7235237B2 (en) 1999-10-29 2007-06-26 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7708989B2 (en) 1999-10-29 2010-05-04 Nitromed, Inc. Methods of treating vascular diseases characterized by nitric oxide insufficiency
US7537785B2 (en) * 1999-10-29 2009-05-26 Nitromed, Inc. Composition for treating vascular diseases characterized by nitric oxide insufficiency
WO2001045703A1 (en) * 1999-12-23 2001-06-28 Nitromed, Inc. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
EP1257668B1 (en) 2000-02-16 2008-10-29 Illumina, Inc. Parallel genotyping of multiple patient samples
WO2001098286A1 (en) 2000-06-22 2001-12-27 Nitromed, Inc. Nitrosated and nitrosylated taxanes, compositions and methods of use
AU5939901A (en) * 2000-10-27 2002-05-06 Nitromed Inc Methods of treating vascular diseases characterized by nitric oxide insufficiency
EP1219306A1 (en) 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
EP1406608B1 (en) 2001-05-02 2009-07-29 Nitromed, Inc. Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
WO2003066067A2 (en) * 2002-02-04 2003-08-14 Alfama - Investigaçao E Desenvolvimento De Produtos Farmaceuticos Lda. Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases
JP2006501161A (ja) * 2002-06-11 2006-01-12 ニトロメッド インク． ニトロソ化および／またはニトロシル化シクロオキシゲナーゼ−２選択的阻害剤、組成物ならびに使用方法
US20060247216A1 (en) * 2002-10-25 2006-11-02 Haj-Yehia Abdullah I Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
AU2003283789A1 (en) * 2002-11-22 2004-06-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Beta-blockers having antioxidant and nitric oxide-donor activity
EP1578413A2 (en) * 2002-11-29 2005-09-28 Yissum Research Development Company of The Hebrew University of Jerusalem Ace-inhibitors having antioxidant and no-donor activity
US7166638B2 (en) 2003-05-27 2007-01-23 Nicox S.A. Statin derivatives
US7169805B2 (en) * 2003-05-28 2007-01-30 Nicox S.A. Captopril derivatives
EP1635816B1 (en) * 2003-06-19 2009-03-04 NicOx S.A. Enalapril-nitroxyderivatives derivatives and related compounds as ace inhibitors for the treatment of cardiovascular diseases
CA2536173A1 (en) * 2003-08-20 2005-03-03 Nitromed, Inc. Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use
US20070060586A1 (en) * 2003-12-02 2007-03-15 Del Soldato Piero Nitrooxyderivatives of antihypertensive drugs
US7825263B2 (en) * 2003-12-02 2010-11-02 Nicox S.A. Nitrooxyderivatives of carvedilol and other beta blockers as antihypertensive
EP1704141B1 (en) 2004-01-05 2016-02-24 Nicox S.A. Prostaglandin nitrooxyderivatives
CA2573562A1 (en) * 2004-07-16 2006-02-23 Nitromed, Inc. Compositions and methods related to heart failure
EP1786814B1 (en) 2004-08-25 2010-03-31 Actelion Pharmaceuticals Ltd. Bicyclononene derivatives as renin inhibitors
US20080300292A1 (en) * 2004-11-08 2008-12-04 Nitromed, Inc Nitrosated and Nitrosylated Compounds, Compositions and Methods for the Treatment of Ophthalmic Disorders
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US20100028439A1 (en) * 2005-05-23 2010-02-04 Elan Pharma International Limited Nanoparticulate stabilized anti-hypertensive compositions
JP4297972B2 (ja) * 2005-05-27 2009-07-15 アクテリオン ファーマシューティカルズ リミテッド 新規なピペリジンカルボン酸アミド誘導体
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JP4790871B2 (ja) * 2008-05-05 2011-10-12 メルク フロスト カナダ リミテツド レニン阻害剤としての３，４−置換ピペリジン誘導体
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EP2734235B1 (en) 2011-07-21 2017-03-22 Alfama, Inc. Ruthenium carbon monoxide releasing molecules and uses thereof
CA2897571C (en) 2013-01-21 2018-12-18 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
JP7055802B2 (ja) 2016-11-08 2022-04-18 ボシュ・アンド・ロム・インコーポレイテッド 正常眼圧緑内障を処置するための一酸化窒素放出プロスタグランジン誘導体
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US20240059781A1 (en) 2021-01-06 2024-02-22 Tonix Pharma Limited Methods of inducing immune tolerance with modified anti-cd154 antibodies

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
IT1256345B (it) 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
ES2065291B1 (es) * 1993-07-30 1995-10-01 Prodesfarma Sa "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente"
HU218923B (hu) 1993-10-06 2000-12-28 Nicox S.A. Gyulladásgátló és/vagy fájdalomcsillapító hatású nitrát-észterek, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására
CA2190087C (en) * 1994-05-10 2005-08-02 Piero Del Soldato Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities
AU2230897A (en) * 1996-03-01 1997-09-16 Sankyo Company Limited Thiazolidine derivatives

Also Published As

Publication number Publication date
IL129768A0 (en) 2000-02-29
ITMI962368A1 (it) 1998-05-14
RU2190594C2 (ru) 2002-10-10
DE69716461T2 (de) 2003-06-26
ES2186013T3 (es) 2003-05-01
EP0941218A1 (en) 1999-09-15
BR9712959B1 (pt) 2010-06-01
EP0941218B1 (en) 2002-10-16
CN1242768A (zh) 2000-01-26
CA2272063C (en) 2008-05-27
DK0941218T3 (da) 2003-02-17
KR20000053251A (ko) 2000-08-25
CA2272063A1 (en) 1998-05-22
HUP0000667A3 (en) 2000-08-28
CN1094931C (zh) 2002-11-27
DE69716461D1 (de) 2002-11-21
WO1998021193A1 (en) 1998-05-22
ATE226199T1 (de) 2002-11-15
KR100504122B1 (ko) 2005-07-27
AU5551998A (en) 1998-06-03
IT1295694B1 (it) 1999-05-27
JP2001507676A (ja) 2001-06-12
HUP0000667A2 (en) 2000-07-28
IL129768A (en) 2004-02-19
BR9712959A (pt) 2000-02-01
AU729423B2 (en) 2001-02-01
US6242432B1 (en) 2001-06-05
JP4264137B2 (ja) 2009-05-13
PT941218E (pt) 2003-03-31

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