BR9709982A - Derivados de indolina úteis como antagonistas do receptor 5-ht-2c - Google Patents

Derivados de indolina úteis como antagonistas do receptor 5-ht-2c

Info

Publication number
BR9709982A
BR9709982A BR9709982A BR9709982A BR9709982A BR 9709982 A BR9709982 A BR 9709982A BR 9709982 A BR9709982 A BR 9709982A BR 9709982 A BR9709982 A BR 9709982A BR 9709982 A BR9709982 A BR 9709982A
Authority
BR
Brazil
Prior art keywords
receptor antagonists
derivatives useful
indoline derivatives
indoline
useful
Prior art date
Application number
BR9709982A
Other languages
English (en)
Inventor
Steven Mark Bromidge
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of BR9709982A publication Critical patent/BR9709982A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
BR9709982A 1996-06-20 1997-06-16 Derivados de indolina úteis como antagonistas do receptor 5-ht-2c BR9709982A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9612885.5A GB9612885D0 (en) 1996-06-20 1996-06-20 Novel compounds
PCT/EP1997/003157 WO1997048700A1 (en) 1996-06-20 1997-06-16 Indoline derivatives useful as 5-ht-2c receptor antagonists

Publications (1)

Publication Number Publication Date
BR9709982A true BR9709982A (pt) 1999-08-10

Family

ID=10795577

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9709982A BR9709982A (pt) 1996-06-20 1997-06-16 Derivados de indolina úteis como antagonistas do receptor 5-ht-2c

Country Status (28)

Country Link
US (2) US6313145B1 (pt)
EP (1) EP0912556B1 (pt)
JP (1) JP2000512644A (pt)
KR (1) KR20040101563A (pt)
CN (1) CN1147485C (pt)
AR (1) AR008244A1 (pt)
AT (1) ATE196766T1 (pt)
AU (1) AU718000B2 (pt)
BR (1) BR9709982A (pt)
CA (1) CA2258559A1 (pt)
CO (1) CO4870758A1 (pt)
CZ (1) CZ289799B6 (pt)
DE (1) DE69703242T2 (pt)
DK (1) DK0912556T3 (pt)
ES (1) ES2152682T3 (pt)
GB (1) GB9612885D0 (pt)
GR (1) GR3034847T3 (pt)
HK (1) HK1019744A1 (pt)
HU (1) HUP9903480A3 (pt)
IL (1) IL127304A (pt)
NO (1) NO316756B1 (pt)
NZ (1) NZ332840A (pt)
PL (1) PL186885B1 (pt)
PT (1) PT912556E (pt)
TR (1) TR199802552T2 (pt)
TW (1) TW360650B (pt)
WO (1) WO1997048700A1 (pt)
ZA (1) ZA975416B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9710523D0 (en) * 1997-05-23 1997-07-16 Smithkline Beecham Plc Novel compounds
WO1999043650A2 (en) * 1998-02-25 1999-09-02 Smithkline Beecham Plc Process(es) for the preparation of 6-trifluoromethyl-indoline derivatives
GB0019950D0 (en) * 2000-08-12 2000-09-27 Smithkline Beecham Plc Compounds
US20030008880A1 (en) * 2001-05-02 2003-01-09 Pfizer Inc. 4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity
MXPA04005151A (es) 2001-11-28 2004-08-11 Upjohn Co Compuestos terapeuticos.
GB0200283D0 (en) * 2002-01-08 2002-02-20 Smithkline Beecham Plc Compounds
EP1485386A2 (en) 2002-03-04 2004-12-15 PHARMACIA & UPJOHN COMPANY Pyridinyloxy derivatives as 5-ht receptor ligands
US20050203079A1 (en) * 2002-04-19 2005-09-15 Glaxo Group Limited Compounds having affinity at 5ht2C receptor and use thereof in therapy
GB0305024D0 (en) * 2003-03-05 2003-04-09 Glaxo Group Ltd Compounds
GB0305553D0 (en) * 2003-03-11 2003-04-16 Glaxo Group Ltd Compounds
KR101062376B1 (ko) * 2008-04-10 2011-09-06 한국화학연구원 신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물
CN102348798A (zh) 2009-01-16 2012-02-08 麻省理工学院 孤独症谱系障碍的诊断和治疗

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ254785A (en) 1992-08-20 1995-09-26 Smithkline Beecham Plc Heterocyclically-condensed indoles and medicaments
GB9313913D0 (en) 1993-07-06 1993-08-18 Smithkline Beecham Plc Novel compounds
CZ294097B6 (cs) 1995-02-02 2004-10-13 Smithklineábeechamáplc Indolový derivátŹ způsob jeho přípravy a farmaceutická kompozice s jeho obsahem
JPH10513443A (ja) 1995-02-02 1998-12-22 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５ＨＴ▲下２ｃ▼レセプターアンタゴニスト活性を有する複素環化合物
GB9607219D0 (en) 1996-04-04 1996-06-12 Smithkline Beecham Plc Novel compounds
US6028055A (en) 1996-10-22 2000-02-22 Genetech, Inc. Receptor selective BNP

Also Published As

Publication number Publication date
PL330708A1 (en) 1999-05-24
JP2000512644A (ja) 2000-09-26
PL186885B1 (pl) 2004-03-31
TR199802552T2 (xx) 1999-02-22
ES2152682T3 (es) 2001-02-01
IL127304A0 (en) 1999-09-22
PT912556E (pt) 2001-02-28
CN1222152A (zh) 1999-07-07
US20020035134A1 (en) 2002-03-21
CO4870758A1 (es) 1999-12-27
EP0912556B1 (en) 2000-10-04
DK0912556T3 (da) 2001-01-22
AU718000B2 (en) 2000-04-06
NO985970D0 (no) 1998-12-18
CA2258559A1 (en) 1997-12-24
CN1147485C (zh) 2004-04-28
AU3339697A (en) 1998-01-07
HK1019744A1 (en) 2000-02-25
ZA975416B (en) 1999-01-25
AR008244A1 (es) 1999-12-29
HUP9903480A2 (en) 2000-07-28
NZ332840A (en) 2000-05-26
EP0912556A1 (en) 1999-05-06
CZ289799B6 (cs) 2002-04-17
IL127304A (en) 2003-07-06
ATE196766T1 (de) 2000-10-15
GB9612885D0 (en) 1996-08-21
CZ420498A3 (cs) 1999-05-12
DE69703242T2 (de) 2001-03-08
WO1997048700A1 (en) 1997-12-24
NO316756B1 (no) 2004-04-26
DE69703242D1 (de) 2000-11-09
GR3034847T3 (en) 2001-02-28
KR20040101563A (ko) 2004-12-02
NO985970L (no) 1998-12-18
HUP9903480A3 (en) 2002-12-28
US6313145B1 (en) 2001-11-06
TW360650B (en) 1999-06-11

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 36 DA LPI