BR9509236A - Compostos purina e guanina como inibidores de pnp - Google Patents

Compostos purina e guanina como inibidores de pnp

Info

Publication number: BR9509236A
Authority: BR; Brazil
Prior art keywords: purine; pnp inhibitors; guanine compounds; guanine; compounds
Prior art date: 1994-10-05

Application number

BR9509236A

Other languages

English (en)

Inventor

Steven Collin Beasley

Alan Findlay Haughan

John Montana

Robert John Watson

Original Assignee

Chiroscience Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-05

Filing date

1995-10-05

Publication date

1997-10-21

1994-10-05 Priority claimed from GB9420127A external-priority patent/GB9420127D0/en

1994-10-05 Priority claimed from GB9420093A external-priority patent/GB9420093D0/en

1994-10-05 Priority claimed from GB9420045A external-priority patent/GB9420045D0/en

1995-10-05 Application filed by Chiroscience Ltd filed Critical Chiroscience Ltd

1997-10-21 Publication of BR9509236A publication Critical patent/BR9509236A/pt

Links

KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 title 2
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Diabetes (AREA)
Oncology (AREA)
Emergency Medicine (AREA)
Transplantation (AREA)
Pulmonology (AREA)
Virology (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BR9509236A 1994-10-05 1995-10-05 Compostos purina e guanina como inibidores de pnp BR9509236A (pt)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB9420127A GB9420127D0 (en)	1994-10-05	1994-10-05	Compounds
GB9420093A GB9420093D0 (en)	1994-10-05	1994-10-05	Compounds
GB9420045A GB9420045D0 (en)	1994-10-05	1994-10-05	Compounds
PCT/GB1995/002363 WO1996011200A1 (en)	1994-10-05	1995-10-05	Purine and guanine compounds as inhibitors of pnp

Publications (1)

Publication Number	Publication Date
BR9509236A true BR9509236A (pt)	1997-10-21

Family

ID=27267411

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9509236A BR9509236A (pt)	1994-10-05	1995-10-05	Compostos purina e guanina como inibidores de pnp

Country Status (14)

Country	Link
US (1)	US5736549A (pt)
EP (1)	EP0784624A1 (pt)
JP (1)	JPH10507171A (pt)
CN (1)	CN1045088C (pt)
AU (1)	AU695032B2 (pt)
BR (1)	BR9509236A (pt)
CA (1)	CA2201773A1 (pt)
CZ (1)	CZ99797A3 (pt)
FI (1)	FI971413A0 (pt)
HU (1)	HUT77436A (pt)
MX (1)	MX9702488A (pt)
NO (1)	NO971538L (pt)
PL (1)	PL319485A1 (pt)
WO (1)	WO1996011200A1 (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR9510327A (pt) *	1994-10-22	1998-11-10	Chong Kun Dang Corp	Derivados de nucleosídeos e seu processo de preparo
CN1501928A (zh) *	2000-11-02	2004-06-02	斯隆-凯特林癌症研究所	结合hsp90的小分子组合物
AU2003233667A1 (en) *	2002-05-23	2003-12-12	Biocryst Pharmaceuticals, Inc.	Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof
DK1539783T3 (da) *	2002-08-21	2011-06-20	Einstein Coll Med	Inhibitorer af nucleosidphosphorylaser og nucleosidaser
US20070219178A1 (en) *	2003-12-04	2007-09-20	Eisai Co., Ltd.	Preventive or therapeutic agents for multiple sclerosis
ES2563952T3 (es)	2004-03-26	2016-03-16	Sumitomo Dainippon Pharma Co., Ltd.	Compuesto de 8-oxoadenina 9-sustituido
US20110104186A1 (en)	2004-06-24	2011-05-05	Nicholas Valiante	Small molecule immunopotentiators and assays for their detection
TW200801003A (en) *	2005-09-16	2008-01-01	Astrazeneca Ab	Novel compounds
TW200745114A (en) *	2005-09-22	2007-12-16	Astrazeneca Ab	Novel compounds
US20090192153A1 (en) *	2005-09-22	2009-07-30	Dainippon Sumitomo Pharma Co., Ltd. a corporation of Japan	Novel adenine compound
WO2007034817A1 (ja) *	2005-09-22	2007-03-29	Dainippon Sumitomo Pharma Co., Ltd.	新規アデニン化合物
JPWO2007034882A1 (ja) *	2005-09-22	2009-03-26	大日本住友製薬株式会社	新規アデニン化合物
EP1939200A4 (en) *	2005-09-22	2010-06-16	Dainippon Sumitomo Pharma Co	NEW ADENINE CONNECTION
EP1975149B1 (en)	2005-12-26	2012-02-15	Nissan Chemical Industries, Ltd.	1,3-bis(substituted phenyl)-3-hydroxypropan-1-one or 2-propen-1-one compound, and salt thereof
EP2041135A4 (en) *	2006-07-05	2010-12-01	Astrazeneca Ab	As TLR7 MODULATORS, 8-OXOADENINE DERIVATIVES WORK
TW200831105A (en) *	2006-12-14	2008-08-01	Astrazeneca Ab	Novel compounds
JP5329444B2 (ja) *	2007-03-19	2013-10-30	アストラゼネカ・アクチエボラーグ	Ｔｏｌｌ様受容体（ｔｌｒ７）モジュレーターとしての９−置換−８−オキソ−アデニン化合物
JP5480637B2 (ja) *	2007-03-19	2014-04-23	アストラゼネカ・アクチエボラーグ	Ｔｏｌｌ様受容体（ｔｌｒ７）モジュレーターとしての９−置換−８−オキソ−アデニン化合物
PE20081887A1 (es) *	2007-03-20	2009-01-16	Dainippon Sumitomo Pharma Co	Nuevo compuesto de adenina
EP2138497A4 (en) *	2007-03-20	2012-01-04	Dainippon Sumitomo Pharma Co	NEW ADENINE CONNECTION
US8436178B2 (en) *	2007-05-08	2013-05-07	Astrazeneca Ab	Imidazoquinolines with immuno-modulating properties
PE20091236A1 (es) *	2007-11-22	2009-09-16	Astrazeneca Ab	Derivados de pirimidina como immunomoduladores de tlr7
UA104579C2 (uk) *	2007-12-10	2014-02-25	Байокрист Фармасьютикалз, Инк.	Спосіб лікування раку кровотворної системи із застосуванням фородезину у комбінації з ритуксимабом
UY31531A1 (es)	2007-12-17	2009-08-03		Sales derivadas de 8-oxoadenina composiciones farmacéuticas que las contienen y su uso en terapia como moduladores de receptor tipo toll (tlr)
EP2246353A4 (en)	2008-01-17	2011-04-20	Dainippon Sumitomo Pharma Co	PROCESS FOR PREPARING AN ADENINE COMPOUND
JPWO2009091031A1 (ja) *	2008-01-17	2011-05-26	大日本住友製薬株式会社	アデニン化合物の製造方法
GB0908772D0 (en) *	2009-05-21	2009-07-01	Astrazeneca Ab	New salts 756
WO2010133885A1 (en)	2009-05-21	2010-11-25	Astrazeneca Ab	Novel pyrimidine derivatives and their use in the treatment of cancer and further diseases
WO2011068233A1 (en) *	2009-12-03	2011-06-09	Dainippon Sumitomo Pharma Co., Ltd.	Imidazoquinolines which act via toll - like receptors (tlr)
JP5978225B2 (ja)	2010-12-16	2016-08-24	大日本住友製薬株式会社	治療に有用なイミダゾ［４，５−ｃ］キノリン−１−イル誘導体
EP2651943B1 (en)	2010-12-17	2017-03-22	Sumitomo Dainippon Pharma Co., Ltd.	Purine derivatives
KR101708761B1 (ko) *	2012-04-13	2017-02-21	주식회사 머쉬메드	퓨린 유도체 또는 그의 염을 포함하는 아토피성 피부염의 예방 또는 치료용 조성물
CA2871589C (en)	2012-05-18	2020-12-22	Seiji Hori	Pyrimidine carboxylic acid derivatives and their use as tlr7 agonists

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4241063A (en) *	1979-08-06	1980-12-23	Bristol-Myers Company	Purine derivatives and their use as bronchodilators
FI802401A (fi) *	1979-08-06	1981-02-07	Bristol Myers Co	Bronkutvidgande purin
US4748177A (en) *	1984-03-26	1988-05-31	Warner-Lambert Company	Guanine derivatives
EP0182024B1 (en) *	1984-09-20	1991-04-03	Beecham Group Plc	Purine derivatives and their pharmaceutical use
IL76546A (en) *	1984-10-12	1988-12-30	Warner Lambert Co	9-(heteroarylalkyl)-6-purine(thi)one derivatives,their preparation and pharmaceutical compositions containing them
EP0193454A1 (en) *	1985-02-25	1986-09-03	Merck & Co. Inc.	8-Substituted-9-hydroxyalkyl and hydroxyalkoxymethyl-guanines and pharmaceutical compositions containing them
CA1293727C (en) *	1986-08-26	1991-12-31	Catherine Rose Kostlan	9-deazaguanines
EP0302644B1 (en) *	1987-08-01	1997-01-29	Beecham Group Plc	Purine compounds and their preparation
US4996308A (en) *	1988-03-25	1991-02-26	Merrell Dow Pharmaceuticals Inc.	Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group
WO1991006548A1 (en) *	1989-10-31	1991-05-16	Biocryst, Inc.	Inhibitors of purine nucleoside phosphorylase
US4985434A (en) *	1989-10-31	1991-01-15	Biocryst, Inc.	7-substituted derivatives of 2-amino-3H,5H-pyrrolo(3,2-d)pyrimidin-4-ones and pharamceutical uses and compositions containing the same
NL9300058A (nl) *	1992-06-18	1994-01-17	Stichting Rega V Z W	1,5-anhydrohexitol nucleoside analoga en farmaceutisch gebruik daarvan.
US5314893A (en) *	1993-01-25	1994-05-24	Bristol-Myers Squibb Co.	Antiviral tetrahydropyrans
WO1995022330A1 (en) *	1994-02-17	1995-08-24	Commonwealth Scientific And Industrial Research Organisation	Antiviral agents

1995
- 1995-10-05 PL PL95319485A patent/PL319485A1/xx unknown
- 1995-10-05 WO PCT/GB1995/002363 patent/WO1996011200A1/en not_active Application Discontinuation
- 1995-10-05 CZ CZ97997A patent/CZ99797A3/cs unknown
- 1995-10-05 CN CN95195541A patent/CN1045088C/zh not_active Expired - Fee Related
- 1995-10-05 AU AU36128/95A patent/AU695032B2/en not_active Ceased
- 1995-10-05 EP EP95933490A patent/EP0784624A1/en not_active Withdrawn
- 1995-10-05 US US08/539,568 patent/US5736549A/en not_active Expired - Fee Related
- 1995-10-05 MX MX9702488A patent/MX9702488A/es unknown
- 1995-10-05 CA CA002201773A patent/CA2201773A1/en not_active Abandoned
- 1995-10-05 BR BR9509236A patent/BR9509236A/pt not_active Application Discontinuation
- 1995-10-05 JP JP8512417A patent/JPH10507171A/ja active Pending
- 1995-10-05 HU HU9701935A patent/HUT77436A/hu unknown
1997
- 1997-04-04 FI FI971413A patent/FI971413A0/fi unknown
- 1997-04-04 NO NO971538A patent/NO971538L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO1996011200A1 (en)	1996-04-18
EP0784624A1 (en)	1997-07-23
CN1045088C (zh)	1999-09-15
FI971413A (fi)	1997-04-04
NO971538L (no)	1997-06-04
CA2201773A1 (en)	1996-04-18
JPH10507171A (ja)	1998-07-14
HUT77436A (hu)	1998-04-28
AU3612895A (en)	1996-05-02
NO971538D0 (no)	1997-04-04
AU695032B2 (en)	1998-08-06
PL319485A1 (en)	1997-08-04
CN1160402A (zh)	1997-09-24
US5736549A (en)	1998-04-07
MX9702488A (es)	1998-04-30
CZ99797A3 (en)	1997-09-17
FI971413A0 (fi)	1997-04-04

Legal Events

Date	Code	Title	Description
2000-06-06	TC	Change of name
2000-06-27	PC	Transfer	Free format text: DARWIN DISCOVERY LIMITED (GB)
2004-09-08	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2005-03-08	B11B	Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements

Publication	Publication Date	Title
BR9509236A (pt)	1997-10-21	Compostos purina e guanina como inibidores de pnp
BR9709643A (pt)	1999-08-10	Compostos antivirais
NO973326D0 (no)	1997-07-18	Guaninderivater
DE69515355D1 (de)	2000-04-13	Mehrfacharbitrierungsschema
DE29611736U1 (de)	1996-09-05	Kugelschreiber
ID19490A (id)	1998-07-16	Kombinasi-kombinasi antiviral
FI953127A0 (fi)	1995-06-22	Puriinijohdannaisia
NO992103L (no)	1999-04-30	Dihydropyroner med forbedret antiviral aktivitet
FI943744A0 (fi)	1994-08-15	Hopfaellbart staell foer baerbar mikrodator i bil
BR9709432A (pt)	1999-08-10	Composto antivirais
DE69528623T2 (de)	2003-07-31	Leitgerät
BR9709528A (pt)	1999-08-10	Compostos antivirais
DE69501440T2 (de)	1998-04-23	Schreiberhalterung
BR9510418A (pt)	1998-05-19	Derivados tienoxazinona úteis como agentes antivirais
FI964468A (fi)	1996-11-06	Adenosiinijohdannaisia
ID18739A (id)	1998-05-07	Kombinasi-kombinasi antiviral
KR970018486U (ko)	1997-05-26	냉각펜
DE29708468U1 (de)	1997-07-10	Werkzeug-Gestell
DE29617672U1 (de)	1996-11-21	Schreibstift
KR960004335U (ko)	1996-02-14	펜촉
DE29600851U1 (de)	1997-05-15	Schreibstift
DE29618934U1 (de)	1997-01-09	Kugelschreiber
DE29605613U1 (de)	1996-06-20	Fingerschreibgerät
SE9600614D0 (sv)	1996-02-16	Antiviral compounds
SE9602566D0 (sv)	1996-06-26	Antiviral compounds