MA42622B1 - Agents de liaison à tigit et leurs utilisations - Google Patents

Agents de liaison à tigit et leurs utilisations

Info

Publication number
MA42622B1
MA42622B1 MA42622A MA42622A MA42622B1 MA 42622 B1 MA42622 B1 MA 42622B1 MA 42622 A MA42622 A MA 42622A MA 42622 A MA42622 A MA 42622A MA 42622 B1 MA42622 B1 MA 42622B1
Authority
MA
Morocco
Prior art keywords
tigit
agents
liaisons
relates
antibodies
Prior art date
Application number
MA42622A
Other languages
English (en)
Other versions
MA42622A (fr
Inventor
Austin Gurney
Ming-Hong Xie
Original Assignee
Mereo Biopharma 5 Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mereo Biopharma 5 Inc filed Critical Mereo Biopharma 5 Inc
Publication of MA42622A publication Critical patent/MA42622A/fr
Publication of MA42622B1 publication Critical patent/MA42622B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

L'invention concerne des agents qui se lient spécifiquement à tigit. Les agents de liaison à tigit peuvent comprendre des polypeptides, des anticorps et/ou des agents bispécifiques. L'invention concerne également des procédés d'utilisation de ces agents pour améliorer la réponse immunitaire et/ou pour le traitement de maladies telles que le cancer.
MA42622A 2015-05-28 2016-05-27 Agents de liaison à tigit et leurs utilisations MA42622B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562167582P 2015-05-28 2015-05-28
US201562205279P 2015-08-14 2015-08-14
US201662313487P 2016-03-25 2016-03-25
PCT/US2016/034549 WO2016191643A2 (fr) 2015-05-28 2016-05-27 Agents de liaison à tigit et leurs utilisations

Publications (2)

Publication Number Publication Date
MA42622A MA42622A (fr) 2018-06-20
MA42622B1 true MA42622B1 (fr) 2021-11-30

Family

ID=57393726

Family Applications (1)

Application Number Title Priority Date Filing Date
MA42622A MA42622B1 (fr) 2015-05-28 2016-05-27 Agents de liaison à tigit et leurs utilisations

Country Status (29)

Country Link
US (2) US10112997B2 (fr)
EP (2) EP3303379B1 (fr)
JP (2) JP6875295B2 (fr)
KR (1) KR20180014050A (fr)
CN (2) CN109071620B (fr)
AU (1) AU2016267577B2 (fr)
BR (1) BR112017025529A2 (fr)
CA (1) CA2987607A1 (fr)
CL (1) CL2017003021A1 (fr)
CO (1) CO2017012342A2 (fr)
CY (1) CY1125260T1 (fr)
DK (1) DK3303379T3 (fr)
EC (1) ECSP17083779A (fr)
ES (1) ES2902150T3 (fr)
HR (1) HRP20211948T1 (fr)
HU (1) HUE057087T2 (fr)
IL (1) IL255577B (fr)
LT (1) LT3303379T (fr)
MA (1) MA42622B1 (fr)
MD (1) MD3303379T2 (fr)
MX (1) MX2017014955A (fr)
NZ (1) NZ738008A (fr)
PL (1) PL3303379T3 (fr)
PT (1) PT3303379T (fr)
RS (1) RS62815B1 (fr)
SA (1) SA517390370B1 (fr)
SI (1) SI3303379T1 (fr)
TW (1) TWI715587B (fr)
WO (1) WO2016191643A2 (fr)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE036780T2 (hu) 2008-04-09 2018-07-30 Genentech Inc Új kompozíciók és eljárások immunológiai vonatkozású betegségek kezelésére
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
AP2017009765A0 (en) 2014-08-19 2017-02-28 Merck Sharp & Dohme Anti-tigit antibodies
KR102644115B1 (ko) 2014-12-23 2024-03-05 브리스톨-마이어스 스큅 컴퍼니 Tigit에 대한 항체
US10550173B2 (en) 2015-02-19 2020-02-04 Compugen, Ltd. PVRIG polypeptides and methods of treatment
HUE049791T2 (hu) 2015-02-19 2020-10-28 Compugen Ltd PVRIG elleni antitestek és alkalmazási eljárások
TWI715587B (zh) 2015-05-28 2021-01-11 美商安可美德藥物股份有限公司 Ｔｉｇｉｔ結合劑和彼之用途
WO2017037707A1 (fr) 2015-09-02 2017-03-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Anticorps spécifiques contre le domaine d'immunoglobuline de lymphocyte t et itim (tigit)
AR109625A1 (es) 2015-10-01 2019-01-09 Potenza Therapeutics Inc Proteínas de unión a antígenos (abp) que se unen selectivamente a tigit y métodos para el uso de las mismas
KR102355950B1 (ko) 2016-03-04 2022-01-26 제이엔 바이오사이언시즈 엘엘씨 Tigit에 대한 항체
US10894823B2 (en) 2016-03-24 2021-01-19 Gensun Biopharma Inc. Trispecific inhibitors for cancer treatment
WO2017181152A2 (fr) 2016-04-15 2017-10-19 Alpine Immune Sciences, Inc. Protéines immunomodulatrices à variants de cd80 et leurs utilisations
CA3024508A1 (fr) 2016-05-27 2017-11-30 Agenus Inc. Anticorps anti-tim-3 et leurs methodes d'utilisation
WO2017220989A1 (fr) 2016-06-20 2017-12-28 Kymab Limited Anti-pd-l1 et cytokines il-2
US9567399B1 (en) 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
US11834490B2 (en) 2016-07-28 2023-12-05 Alpine Immune Sciences, Inc. CD112 variant immunomodulatory proteins and uses thereof
US11471488B2 (en) 2016-07-28 2022-10-18 Alpine Immune Sciences, Inc. CD155 variant immunomodulatory proteins and uses thereof
KR20230044038A (ko) 2016-08-09 2023-03-31 키맵 리미티드 항-icos 항체
MY194032A (en) * 2016-08-17 2022-11-09 Compugen Ltd Anti-tigit antibodies, anti-pvrig antibodies and combinations thereof
MA46529A (fr) 2016-10-11 2019-08-21 Agenus Inc Anticorps anti-lag-3 et leurs procédés d'utilisation
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
JP7126269B2 (ja) 2016-11-30 2022-08-26 メレオ バイオファーマ ５ インコーポレイテッド Ｔｉｇｉｔ結合物質を含む、がんの処置のための方法
WO2018102746A1 (fr) * 2016-12-02 2018-06-07 Rigel Pharmaceuticals, Inc. Molécules de liaison à l'antigène destinées à la tigit
CN109071656B (zh) * 2017-01-05 2021-05-18 璟尚生物制药公司 检查点调节物拮抗剂
WO2018129346A1 (fr) * 2017-01-06 2018-07-12 Nantkwest, Inc. Cellules nk-92 génétiquement modifiées à expression réduite de cd96/tigit
MX2019010206A (es) * 2017-02-28 2019-12-11 Seattle Genetics Inc Anticuerpos anti inmunorreceptor de linfocitos t con dominios de motivo de inactivación basado en tirosina de inmunorreceptor e inmunoglobulina (tigit).
BR112019018747A2 (pt) 2017-03-16 2020-05-05 Alpine Immune Sciences Inc proteínas imunomoduladoras variantes de cd80 e usos das mesmas
AU2018235835A1 (en) 2017-03-16 2019-09-05 Alpine Immune Sciences, Inc. PD-L2 variant immunomodulatory proteins and uses thereof
JOP20190203A1 (ar) * 2017-03-30 2019-09-03 Potenza Therapeutics Inc بروتينات رابطة لمولد ضد مضادة لـ tigit وطرق استخدامها
WO2018187191A1 (fr) 2017-04-03 2018-10-11 Jounce Therapeutics, Inc Compositions et procédés de traitement du cancer
EP3615070A1 (fr) 2017-04-26 2020-03-04 Bristol-Myers Squibb Company Procédés de production d'anticorps qui réduisent au minimum la réduction de liaison disulfure
PL3618863T3 (pl) * 2017-05-01 2023-11-06 Agenus Inc. Przeciwciała anty- tigit i sposoby ich zastosowania
JP7348072B2 (ja) 2017-06-01 2023-09-20 コンピュジェン リミテッド 三重併用抗体療法
WO2018229163A1 (fr) 2017-06-14 2018-12-20 King's College London Méthodes d'activation des lymphocytes t v delta 2 négatifs gamma delta
GB201709808D0 (en) 2017-06-20 2017-08-02 Kymab Ltd Antibodies
MA49652A (fr) * 2017-07-17 2020-05-27 Janssen Biotech Inc Régions de liaison à un antigène dirigées contre les domaines de la fibronectine de type iii et leurs procédés d'utilisation
BE1025333B1 (fr) * 2017-07-27 2019-01-23 Iteos Therapeutics S.A. Anticorps anti-tigit
CA3070791A1 (fr) * 2017-07-27 2019-01-31 Iteos Therapeutics Sa Anticorps anti-tigit
WO2019023504A1 (fr) 2017-07-27 2019-01-31 Iteos Therapeutics Sa Anticorps anti-tigit
CN111051347B (zh) 2017-09-29 2021-12-21 江苏恒瑞医药股份有限公司 Tigit抗体、其抗原结合片段及医药用途
CA3198255A1 (fr) 2017-10-10 2019-04-18 Alpine Immune Sciences, Inc. Proteines immunomodulatrices de variants de ctla-4 et leurs utilisations
AU2018351000B2 (en) 2017-10-18 2023-11-30 Alpine Immune Sciences, Inc. Variant ICOS Ligand immunomodulatory proteins and related compositions and methods
EP3697435A1 (fr) * 2017-10-20 2020-08-26 Fred Hutchinson Cancer Research Center Compositions et procédés d'immunothérapie ciblant tigit et/ou cd112r ou comprenant la surexpression de cd226
WO2019122882A1 (fr) 2017-12-19 2019-06-27 Kymab Limited Anticorps bispécifique pour icos et pd-l1
KR20200109313A (ko) * 2018-01-15 2020-09-22 난징 레전드 바이오테크 씨오., 엘티디. Tigit에 대한 항체 및 이의 변이체
TW202011984A (zh) 2018-04-18 2020-04-01 美商山可爾股份有限公司 IL-15/IL-15Rα異二聚體Fc融合蛋白及其用途
KR20210010862A (ko) 2018-04-18 2021-01-28 젠코어 인코포레이티드 IL-15/IL-15Rα Fc-융합 단백질 및 PD-1 항원 결합 도메인을 함유하는 PD-1 표적화 이종이량체 융합 단백질 및 이의 용도
EP3813880A4 (fr) 2018-06-29 2022-07-13 Gensun Biopharma Inc. Antagonistes des régulateurs de points de contrôle immunitaires antitumoraux
TWI754157B (zh) 2018-07-25 2022-02-01 大陸商信達生物製藥（蘇州）有限公司 抗ｔｉｇｉｔ抗體及其用途
CN112638944A (zh) 2018-08-23 2021-04-09 西进公司 抗tigit抗体
JP2022503959A (ja) 2018-10-03 2022-01-12 ゼンコア インコーポレイテッド Ｉｌ－１２ヘテロ二量体ｆｃ－融合タンパク質
WO2020077276A2 (fr) 2018-10-12 2020-04-16 Xencor, Inc. Protéines de fusion fc d'il-15/il-15ralpha ciblant pd-1 et utilisations dans des polythérapies faisant intervenir celles-ci
WO2020132646A1 (fr) 2018-12-20 2020-06-25 Xencor, Inc. PROTÉINES DE FUSION FC HÉTÉRODIMÈRES CIBLÉES CONTENANT LES IL-15/IL-15Rα ET DES DOMAINES DE LIAISON À L'ANTIGÈNE NKG2D
KR20210108978A (ko) 2018-12-21 2021-09-03 오제 이뮈노테라프틱스 이작용성 항-pd-1/il-7 분자
JP2022516351A (ja) * 2019-01-07 2022-02-25 アイテオス ベルジャム エスエイ 抗ｔｉｇｉｔ抗体
WO2020165374A1 (fr) 2019-02-14 2020-08-20 Ose Immunotherapeutics Molécule bifonctionnelle comprenant il-15ra
US20220146500A1 (en) * 2019-02-27 2022-05-12 Yale University Compositions and methods for enhancing mucosal immunity
WO2020185739A1 (fr) 2019-03-11 2020-09-17 Jounce Therapeutics, Inc. Anticorps anti-icos pour le traitement du cancer
CN109734806B (zh) * 2019-03-15 2022-07-01 安徽安科生物工程（集团）股份有限公司 一种全人源抗huTIGIT单克隆抗体及其应用
TWI760751B (zh) 2019-05-29 2022-04-11 美商美國禮來大藥廠 Tigit及pd-1/tigit-結合分子
AU2020290916A1 (en) * 2019-06-13 2021-11-04 Green Cross Corporation Antibody to TIGIT and use thereof
CA3143995A1 (fr) * 2019-06-21 2020-12-24 Single Cell Technology, Inc. Anticorps anti-tigit
CN114007646A (zh) * 2019-06-25 2022-02-01 南京金斯瑞生物科技有限公司 抗cd47/抗tigit双特异抗体及其制备方法和应用
WO2020263312A1 (fr) 2019-06-28 2020-12-30 Gensun Biopharma, Inc. ANTAGONISTE ANTITUMORAL COMPOSÉ D'UN DOMAINE EXTRACELLULAIRE TGFβ1 - RII MUTÉ ET D'UN ÉCHAFAUDAGE D'IMMUNOGLOBULINE
WO2021024020A1 (fr) 2019-08-06 2021-02-11 Astellas Pharma Inc. Polythérapie impliquant des anticorps dirigés contre la claudine 18.2 et inhibiteurs de point de contrôle immunitaire pour le traitement du cancer
CN110669139A (zh) * 2019-09-18 2020-01-10 沣潮医药科技（上海）有限公司 二聚体免疫粘附素、药物组合物和用途
US11667709B2 (en) 2019-09-24 2023-06-06 Industrial Technology Research Institute Anti-TIGIT antibodies and methods of use
WO2021062332A1 (fr) * 2019-09-27 2021-04-01 Icahn School Of Medicine At Mount Sinai Association d'inhibiteurs de la signalisation de l'il4 et de points de contrôle immunitaires pour le traitement du cancer
AU2020358979A1 (en) 2019-10-03 2022-04-21 Xencor, Inc. Targeted IL-12 heterodimeric Fc-fusion proteins
TW202128757A (zh) 2019-10-11 2021-08-01 美商建南德克公司 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白
US20220378909A1 (en) 2019-11-05 2022-12-01 Jounce Therapeutics, Inc. Methods of Treating Cancer with Anti-PD-1 Antibodies
CN111018999B (zh) * 2019-12-05 2022-07-12 沣潮医药科技（上海）有限公司 二聚体免疫融合蛋白、药物组合物和用途
TW202136287A (zh) 2019-12-17 2021-10-01 法商Ｏｓｅ免疫治療公司 包含il-7變體之雙官能分子
CN112409450B (zh) * 2020-03-29 2023-01-24 郑州大学 TIGIT-IgV的亲和剂及其应用
CN113563470B (zh) 2020-04-29 2023-02-10 广州昂科免疫生物技术有限公司 结合tigit抗原的抗体及其制备方法与应用
JP2023525082A (ja) 2020-05-07 2023-06-14 アンスティテュ・クリー 免疫抑制線維芽細胞集団のバイオマーカーとしてのａｎｔｘｒ１及び免疫療法に対する応答を予測するためのその使用
IL298111A (en) 2020-06-02 2023-01-01 Arcus Biosciences Inc Antibodies to tigit
WO2021258337A1 (fr) * 2020-06-24 2021-12-30 Huahui Health Ltd. Anticorps monoclonaux humains dirigés contre tigit pour des maladies immunitaires
JP2023532768A (ja) 2020-07-07 2023-07-31 バイオエヌテック エスエー Ｈｐｖ陽性癌の治療用ｒｎａ
CN111763660A (zh) * 2020-08-07 2020-10-13 南京大学 一种重组溶瘤痘苗病毒及其制备方法和应用
CN115708865A (zh) * 2020-08-25 2023-02-24 沣潮医药科技（上海）有限公司 Tigit免疫粘附素在制备调节血管生成产品中的应用
WO2022089392A1 (fr) * 2020-10-26 2022-05-05 中山康方生物医药有限公司 Anticorps anti-tigit, composition pharmaceutique et utilisation correspondante
AU2021376218A1 (en) 2020-11-08 2023-06-15 Seagen Inc. Combination Therapy
WO2022112198A1 (fr) 2020-11-24 2022-06-02 Worldwide Innovative Network Procédé de sélection des thérapies optimales par points de contrôle immunitaire
WO2022111612A1 (fr) * 2020-11-26 2022-06-02 信达生物制药(苏州)有限公司 Préparation comprenant un anticorps bispécifique anti-tigit/pd-1, son procédé de préparation et son utilisation
TW202245808A (zh) 2020-12-21 2022-12-01 德商拜恩迪克公司 用於治療癌症之治療性ｒｎａ
WO2022135666A1 (fr) 2020-12-21 2022-06-30 BioNTech SE Programme de traitement faisant intervenir des protéines cytokines
WO2022135667A1 (fr) 2020-12-21 2022-06-30 BioNTech SE Arn thérapeutique pour le traitement du cancer
WO2022148781A1 (fr) 2021-01-05 2022-07-14 Institut Curie Association d'activateurs de mcoln et d'inhibiteurs de point de contrôle immunitaire
WO2022217026A1 (fr) 2021-04-09 2022-10-13 Seagen Inc. Méthodes de traitement du cancer à l'aide d'anticorps anti-tigit
WO2022214653A1 (fr) 2021-04-09 2022-10-13 Ose Immunotherapeutics Nouvel échafaudage pour molécules bifonctionnelles présentant des propriétés améliorées
EP4320156A1 (fr) 2021-04-09 2024-02-14 Ose Immunotherapeutics Échafaudage pour molécules bifonctionnelles comprenant des domaines de liaison pd-1 ou cd28 et sirp
CN115925967A (zh) 2021-04-22 2023-04-07 广东菲鹏制药股份有限公司 双特异性多功能融合多肽
AR125753A1 (es) 2021-05-04 2023-08-09 Agenus Inc Anticuerpos anti-tigit, anticuerpos anti-cd96 y métodos de uso de estos
BR112023023453A8 (pt) 2021-05-10 2024-02-15 Medimabbio Inc Anticorpo anti-tigit ou um fragmento de ligação ao antígeno deste, composições farmacêuticas e usos do referido anticorpo anti-tigit ou um fragmento de ligação ao antígeno deste
IL309831A (en) 2021-07-13 2024-02-01 BioNTech SE Multispecific binding agents against CD40 and CD137 in combined cancer therapy
CA3226242A1 (fr) * 2021-07-23 2023-01-26 Zhongmin Wang Composition pharmaceutique et son utilisation
CN115838424A (zh) * 2021-09-22 2023-03-24 上海康岱生物医药技术股份有限公司 靶向tigit的单克隆抗体
TW202333802A (zh) 2021-10-11 2023-09-01 德商拜恩迪克公司 用於肺癌之治療性rna(二)
CN116284390A (zh) * 2021-12-21 2023-06-23 广东安普泽生物医药股份有限公司 人tigit抗体及其应用
WO2023149977A1 (fr) * 2022-02-04 2023-08-10 Mereo Biopharma 5, Inc. Méthodes de traitement du cancer
WO2023178192A1 (fr) 2022-03-15 2023-09-21 Compugen Ltd. Anticorps antagonistes de l'il-18bp et leur utilisation en monothérapie et polythérapie dans le traitement du cancer
WO2023215719A1 (fr) 2022-05-02 2023-11-09 Arcus Biosciences, Inc. Anticorps anti-tigit et leurs utilisations
WO2023234748A1 (fr) * 2022-06-03 2023-12-07 메디맵바이오 주식회사 Anticorps anti-tigit et leurs utilisations
WO2024003360A1 (fr) 2022-07-01 2024-01-04 Institut Curie Biomarqueurs et leurs utilisations pour le traitement du neuroblastome
WO2024028386A1 (fr) 2022-08-02 2024-02-08 Ose Immunotherapeutics Molécule multifonctionnelle dirigée contre cd28

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080050809A1 (en) 1999-09-28 2008-02-28 Alejandro Abuin Novel human kinases and polynucleotides encoding the same
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
CU23007A1 (es) 2001-04-06 2004-12-17 Ct De Inmunologia Molecular Ct De Inmunologia Mole Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos
US20040185040A1 (en) * 2001-11-21 2004-09-23 Celltech R & D Limited Modulating immune responses
JP2005535290A (ja) 2002-02-22 2005-11-24 ジェネンテック・インコーポレーテッド 免疫関連疾患の治療のための組成物と方法
US7193069B2 (en) 2002-03-22 2007-03-20 Research Association For Biotechnology Full-length cDNA
WO2004024068A2 (fr) 2002-09-11 2004-03-25 Genentech, Inc. Nouvelles composition et methodes servant au traitement de maladies associees au systeme immunitaire
US8003108B2 (en) 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
WO2006124667A2 (fr) 2005-05-12 2006-11-23 Zymogenetics, Inc. Compositions et procedes permettant de moduler des reponses immunitaires
JP5129149B2 (ja) 2005-10-31 2013-01-23 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 癌を処置および診断するための組成物および方法
PL2066694T3 (pl) 2006-09-29 2016-04-29 Oncomed Pharm Inc Kompozycje i sposoby diagnozowania i leczenia nowotworu
HUE036780T2 (hu) 2008-04-09 2018-07-30 Genentech Inc Új kompozíciók és eljárások immunológiai vonatkozású betegségek kezelésére
AU2011215685B2 (en) 2010-02-12 2015-08-20 Oncomed Pharmaceuticals, Inc. Methods for identifying and isolating cells expressing a polypeptide
WO2012113813A1 (fr) * 2011-02-23 2012-08-30 F. Hoffmann-La Roche Ag Anticorps contre il33r humain et ses utilisations
CN116637183A (zh) 2012-12-03 2023-08-25 百时美施贵宝公司 强化免疫调变性Fc融合蛋白的抗癌活性
BR112015013127A2 (pt) 2012-12-04 2017-09-26 Oncomed Pharm Inc imunoterapia com agentes de ligação
CN103073644B (zh) 2012-12-31 2014-03-12 中国科学技术大学 特异性抗小鼠tigit的单克隆抗体及其制备方法、鉴定及应用
US9062104B2 (en) * 2013-03-14 2015-06-23 Alderbio Holdings Llc Therapeutic use of antibodies to HGF
BR112016000853A2 (pt) * 2013-07-16 2017-12-12 Genentech Inc métodos para tratar ou retardar, reduzir ou inibir a recidiva ou a progressão do câncer e a progressão de uma doença imune-relacionada em um indivíduo, para aumentar, melhorar ou estimular uma resposta ou função imune em um indivíduo e kit
KR20230097209A (ko) 2014-03-12 2023-06-30 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 Cns의 질환 및 손상을 치료하기 위한 전신적 조절 t 세포 수준 또는 활성의 감소
WO2015143343A2 (fr) 2014-03-21 2015-09-24 The Brigham And Women's Hospital, Inc. Procédés et compositions pour le traitement de maladies immunitaires ou de troubles et/ou la surveillance thérapeutique
JP2017522311A (ja) 2014-07-16 2017-08-10 ジェネンテック， インコーポレイテッド Ｔｉｇｉｔ阻害剤及び抗癌剤を使用する癌の治療方法
AP2017009765A0 (en) 2014-08-19 2017-02-28 Merck Sharp & Dohme Anti-tigit antibodies
US11344620B2 (en) 2014-09-13 2022-05-31 Novartis Ag Combination therapies
WO2016054555A2 (fr) 2014-10-03 2016-04-07 Novartis Ag Polythérapies
JP2017534633A (ja) 2014-11-06 2017-11-24 ジェネンテック， インコーポレイテッド Ｏｘ４０結合アゴニスト及びｔｉｇｉｔ阻害剤を含む組み合わせ療法
EP3233918A1 (fr) 2014-12-19 2017-10-25 Novartis AG Polythérapies
KR102644115B1 (ko) * 2014-12-23 2024-03-05 브리스톨-마이어스 스큅 컴퍼니 Tigit에 대한 항체
JP2018503373A (ja) 2014-12-30 2018-02-08 ジェネンテック， インコーポレイテッド がんの予後診断及び治療のための方法及び組成物
TWI715587B (zh) 2015-05-28 2021-01-11 美商安可美德藥物股份有限公司 Ｔｉｇｉｔ結合劑和彼之用途
JO3620B1 (ar) 2015-08-05 2020-08-27 Amgen Res Munich Gmbh مثبطات نقطة فحص مناعية للاستخدام في علاج سرطانات محمولة عبر الدم
CN115925931A (zh) 2015-08-14 2023-04-07 默沙东公司 抗tigit抗体
WO2017037707A1 (fr) 2015-09-02 2017-03-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Anticorps spécifiques contre le domaine d'immunoglobuline de lymphocyte t et itim (tigit)
CA2998589A1 (fr) 2015-09-14 2017-03-23 Compass Therapeutics Llc Compositions et methodes de traitement du cancer au moyen de l'antagonimisme du parcours cd155/tigit et tgf-beta
CR20180225A (es) 2015-09-25 2018-07-09 Genentech Inc Anticuerpo anti-tigit y métodos de uso
AR109625A1 (es) 2015-10-01 2019-01-09 Potenza Therapeutics Inc Proteínas de unión a antígenos (abp) que se unen selectivamente a tigit y métodos para el uso de las mismas
KR102355950B1 (ko) 2016-03-04 2022-01-26 제이엔 바이오사이언시즈 엘엘씨 Tigit에 대한 항체
JP7126269B2 (ja) 2016-11-30 2022-08-26 メレオ バイオファーマ ５ インコーポレイテッド Ｔｉｇｉｔ結合物質を含む、がんの処置のための方法

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