MX2023008000A - Conjugados de anticuerpo dirigido a b7-h4 y farmaco, y metodos de uso de los mismos. - Google Patents

Conjugados de anticuerpo dirigido a b7-h4 y farmaco, y metodos de uso de los mismos.

Info

Publication number
MX2023008000A
MX2023008000A MX2023008000A MX2023008000A MX2023008000A MX 2023008000 A MX2023008000 A MX 2023008000A MX 2023008000 A MX2023008000 A MX 2023008000A MX 2023008000 A MX2023008000 A MX 2023008000A MX 2023008000 A MX2023008000 A MX 2023008000A
Authority
MX
Mexico
Prior art keywords
methods
drug conjugates
targeted antibody
conjugates
antibody
Prior art date
Application number
MX2023008000A
Other languages
English (en)
Inventor
Timothy B Lowinger
Dorin Toader
Marc I Damelin
Chen - Ni Chin
Original Assignee
Mersana Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mersana Therapeutics Inc filed Critical Mersana Therapeutics Inc
Publication of MX2023008000A publication Critical patent/MX2023008000A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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  • Reproductive Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente divulgación se refiere, en líneas generales, a conjugados anticuerpo-fármaco que comprenden anticuerpos monoclonales que se unen específicamente a B7-4 humana en forma soluble, o unidos a la membrana (es decir, cuando se expresan sobre una superficie celular) y a métodos de uso de estos conjugados como agentes terapéuticos y/o de diagnóstico.
MX2023008000A 2021-01-04 2022-01-04 Conjugados de anticuerpo dirigido a b7-h4 y farmaco, y metodos de uso de los mismos. MX2023008000A (es)

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