BR112022022608A2 - Compostos como inibidores de bcl-2 - Google Patents
Compostos como inibidores de bcl-2Info
- Publication number
- BR112022022608A2 BR112022022608A2 BR112022022608A BR112022022608A BR112022022608A2 BR 112022022608 A2 BR112022022608 A2 BR 112022022608A2 BR 112022022608 A BR112022022608 A BR 112022022608A BR 112022022608 A BR112022022608 A BR 112022022608A BR 112022022608 A2 BR112022022608 A2 BR 112022022608A2
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitors
- bcl
- compounds
- compounded
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
COMPOSTO COMO INIBIDORES DE BCL-2. A presente invenção refere-se a certos inibidores de Bcl2, composições farmacêuticas dos mesmos e métodos de uso dos mesmos.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063021816P | 2020-05-08 | 2020-05-08 | |
US202063115471P | 2020-11-18 | 2020-11-18 | |
US202163146601P | 2021-02-06 | 2021-02-06 | |
PCT/CN2021/092104 WO2021223736A1 (en) | 2020-05-08 | 2021-05-07 | Compounds as bcl-2 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022022608A2 true BR112022022608A2 (pt) | 2023-05-02 |
Family
ID=78468646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022022608A BR112022022608A2 (pt) | 2020-05-08 | 2021-05-07 | Compostos como inibidores de bcl-2 |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230159527A1 (pt) |
EP (1) | EP4146649A1 (pt) |
JP (1) | JP2023525748A (pt) |
KR (1) | KR20230051125A (pt) |
CN (1) | CN115843297A (pt) |
AU (1) | AU2021268845A1 (pt) |
BR (1) | BR112022022608A2 (pt) |
CA (1) | CA3177906A1 (pt) |
MX (1) | MX2022014007A (pt) |
TW (1) | TW202200576A (pt) |
WO (1) | WO2021223736A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114478520A (zh) * | 2020-10-28 | 2022-05-13 | 杭州和正医药有限公司 | Bcl-2蛋白凋亡诱导剂及应用 |
WO2022143602A1 (en) * | 2020-12-28 | 2022-07-07 | Ascentage Pharma (Suzhou) Co., Ltd. | Methods of treating multiple sclerosis |
CN117616023A (zh) * | 2021-04-13 | 2024-02-27 | 爱新医药科技(香港)有限公司 | Bcl-2或bcl-2/bcl-xl调节剂及其用途 |
WO2023088167A1 (en) * | 2021-11-20 | 2023-05-25 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2 inhibitors |
WO2023104043A1 (zh) * | 2021-12-06 | 2023-06-15 | 杭州和正医药有限公司 | 一种抗凋亡蛋白bcl-2抑制剂、药物组合物及其应用 |
WO2023231777A1 (en) * | 2022-06-01 | 2023-12-07 | Fochon Pharmaceuticals, Ltd. | Compounds as bcl-2 inhibitors |
WO2024032776A1 (en) * | 2022-08-12 | 2024-02-15 | Fochon Biosciences, Ltd. | Compounds as bcl-2 inhibitors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG192126A1 (en) * | 2011-01-25 | 2013-09-30 | Univ Michigan | Bcl-2/bcl-xl inhibitors and therapeutic methods using the same |
CN106749233B (zh) * | 2016-11-24 | 2020-04-21 | 中山大学 | 一类磺酰胺衍生物及其应用 |
EP3788042A4 (en) * | 2018-04-29 | 2022-01-26 | BeiGene, Ltd. | BCL-2 INHIBITORS |
WO2020140005A2 (en) * | 2018-12-29 | 2020-07-02 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
CN114929689A (zh) * | 2019-10-28 | 2022-08-19 | 百济神州有限公司 | Bcl-2抑制剂 |
WO2021110102A1 (en) * | 2019-12-02 | 2021-06-10 | Beigene, Ltd. | Methods of cancer treatment using bcl-2 inhibitor |
-
2021
- 2021-05-07 KR KR1020227042843A patent/KR20230051125A/ko unknown
- 2021-05-07 MX MX2022014007A patent/MX2022014007A/es unknown
- 2021-05-07 WO PCT/CN2021/092104 patent/WO2021223736A1/en unknown
- 2021-05-07 TW TW110116647A patent/TW202200576A/zh unknown
- 2021-05-07 US US17/998,234 patent/US20230159527A1/en active Pending
- 2021-05-07 EP EP21800220.2A patent/EP4146649A1/en active Pending
- 2021-05-07 BR BR112022022608A patent/BR112022022608A2/pt unknown
- 2021-05-07 CN CN202180033746.0A patent/CN115843297A/zh active Pending
- 2021-05-07 JP JP2022567822A patent/JP2023525748A/ja active Pending
- 2021-05-07 AU AU2021268845A patent/AU2021268845A1/en active Pending
- 2021-05-07 CA CA3177906A patent/CA3177906A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
MX2022014007A (es) | 2023-02-09 |
KR20230051125A (ko) | 2023-04-17 |
CA3177906A1 (en) | 2021-11-11 |
JP2023525748A (ja) | 2023-06-19 |
US20230159527A1 (en) | 2023-05-25 |
TW202200576A (zh) | 2022-01-01 |
AU2021268845A1 (en) | 2023-01-05 |
CN115843297A (zh) | 2023-03-24 |
EP4146649A1 (en) | 2023-03-15 |
WO2021223736A1 (en) | 2021-11-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112022022608A2 (pt) | Compostos como inibidores de bcl-2 | |
BR112021024108A2 (pt) | Inibidores de tead e usos dos mesmos | |
BR112021024224A2 (pt) | Inibidores de tead e usos dos mesmos | |
BR112022011651A2 (pt) | Degradadores de irak e usos dos mesmos | |
CO2022003782A2 (es) | Inhibidores de kras g12d | |
CY1121418T1 (el) | Παρεμποδιστες ιου ηπατιτιδας c | |
BR112021019748A2 (pt) | Degradadores de stat e usos dos mesmos | |
BR112018003343A2 (pt) | compostos heteroarila como inibidores de irak e usos dos mesmos | |
BR112018003812A2 (pt) | compostos de heteroarila como inibidores de irak e usos dos mesmos | |
EA201391127A1 (ru) | C-17 и c-3 модифицированные тритерпеноиды с ингибиторной активностью созревания вич | |
EA201691726A1 (ru) | Новые 6-конденсированные гетероарилдигидропиримидины для лечения и профилактики заражения вирусом гепатита b | |
BR112015028171A8 (pt) | Inibidores de acc e seu uso | |
BR112018070123A2 (pt) | oxiesterós e métodos de uso dos mesmos | |
UY37645A (es) | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue | |
BR112012017382A2 (pt) | compostos inibidores de viroses flaviviridae, uso dos mesmos e composição farmacêutica | |
EA201591406A1 (ru) | C-19 модифицированные тритерпеноиды с ингибиторной активностью созревания вич | |
MX2020009234A (es) | Compuestos de heteroarilo como inhibidores de cinasas asociadas con receptores de interleucina-1 (irak) tipo ii y usos de los mismos. | |
UY37646A (es) | Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue | |
BR112017014970A2 (pt) | macrociclos de piridazinona como inibidores de irak e usos dos mesmos | |
GEP20227353B (en) | Tetracyclic heterocycle compounds useful as hiv integrase inhibitors | |
BR112022012410A2 (pt) | Degradadores smarca e usos dos mesmos | |
SA519410093B1 (ar) | مركبات بيريميدو بيريميدينون مفيدة كمثبطات دبليو إى إى-1 كيناز | |
BR112016002638A2 (pt) | novos aza-oxo-indóis para o tratamento e profilaxia de infecção pelo virus sincicial respiratório | |
BR112022018678A2 (pt) | Degradadores de mdm2 e usos dos mesmos | |
EA202091400A1 (ru) | Производные пиррола в качестве ингибиторов асс |