BR112022002375A2 - Compostos de 4,4a,5,7,8,8a-hexapirido[4,3-b][1,4]oxazin-3-ona como inibidores de magl - Google Patents
Compostos de 4,4a,5,7,8,8a-hexapirido[4,3-b][1,4]oxazin-3-ona como inibidores de maglInfo
- Publication number
- BR112022002375A2 BR112022002375A2 BR112022002375A BR112022002375A BR112022002375A2 BR 112022002375 A2 BR112022002375 A2 BR 112022002375A2 BR 112022002375 A BR112022002375 A BR 112022002375A BR 112022002375 A BR112022002375 A BR 112022002375A BR 112022002375 A2 BR112022002375 A2 BR 112022002375A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- hexapyrido
- oxazin
- ona
- magl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
Abstract
COMPOSTOS DE 4,4A,5,7,8,8A-HEXAPIRIDO[4,3- B][1,4]OXAZIN-3-ONA COMO INIBIDORES DE MAGL. A presente invenção refere-se a compostos heterocíclicos tendo a fórmula geral (I) em que A, B, L1, X, m, n, R1 a R7 são conforme descritos no presente documento, composições incluindo os compostos, processos para fabricar os compostos, métodos para usar os compostos como inibidores de monoacilglicerol lipase (MAGL).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19196879 | 2019-09-12 | ||
PCT/EP2020/075260 WO2021048242A1 (en) | 2019-09-12 | 2020-09-10 | 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022002375A2 true BR112022002375A2 (pt) | 2022-07-19 |
Family
ID=67953598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022002375A BR112022002375A2 (pt) | 2019-09-12 | 2020-09-10 | Compostos de 4,4a,5,7,8,8a-hexapirido[4,3-b][1,4]oxazin-3-ona como inibidores de magl |
Country Status (17)
Country | Link |
---|---|
US (1) | US11814375B2 (pt) |
EP (1) | EP4028403B1 (pt) |
JP (1) | JP2022548028A (pt) |
KR (1) | KR20220062515A (pt) |
CN (1) | CN114269755A (pt) |
AR (1) | AR119943A1 (pt) |
AU (1) | AU2020346350A1 (pt) |
BR (1) | BR112022002375A2 (pt) |
CA (1) | CA3151516A1 (pt) |
CL (1) | CL2022000556A1 (pt) |
CO (1) | CO2022001879A2 (pt) |
CR (1) | CR20220104A (pt) |
IL (1) | IL289186A (pt) |
MX (1) | MX2022002311A (pt) |
PE (1) | PE20220565A1 (pt) |
TW (1) | TW202128706A (pt) |
WO (1) | WO2021048242A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
AR114136A1 (es) | 2017-10-10 | 2020-07-29 | Hoffmann La Roche | Compuestos heterocíclicos |
EP3717477B1 (en) | 2017-11-28 | 2022-07-20 | F. Hoffmann-La Roche AG | New heterocyclic compounds |
WO2019134985A1 (en) | 2018-01-08 | 2019-07-11 | F. Hoffmann-La Roche Ag | Octahydropyrido[1,2-alpha]pyrazines as magl inhibitors |
EP3837263A1 (en) | 2018-08-13 | 2021-06-23 | F. Hoffmann-La Roche AG | New heterocyclic compounds as monoacylglycerol lipase inhibitors |
EP4028403B1 (en) | 2019-09-12 | 2023-11-22 | F. Hoffmann-La Roche AG | 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors |
CR20220325A (es) | 2019-12-20 | 2022-08-19 | Tenaya Therapeutics Inc | Fluoroalquil-oxadiazoles y sus usos |
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EP4028403B1 (en) | 2019-09-12 | 2023-11-22 | F. Hoffmann-La Roche AG | 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors |
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AR120029A1 (es) | 2019-09-24 | 2022-01-26 | Hoffmann La Roche | Compuestos heterocíclicos |
-
2020
- 2020-09-10 EP EP20774901.1A patent/EP4028403B1/en active Active
- 2020-09-10 MX MX2022002311A patent/MX2022002311A/es unknown
- 2020-09-10 BR BR112022002375A patent/BR112022002375A2/pt unknown
- 2020-09-10 PE PE2022000245A patent/PE20220565A1/es unknown
- 2020-09-10 CR CR20220104A patent/CR20220104A/es unknown
- 2020-09-10 CA CA3151516A patent/CA3151516A1/en active Pending
- 2020-09-10 KR KR1020227007925A patent/KR20220062515A/ko unknown
- 2020-09-10 JP JP2022516054A patent/JP2022548028A/ja active Pending
- 2020-09-10 US US17/017,200 patent/US11814375B2/en active Active
- 2020-09-10 WO PCT/EP2020/075260 patent/WO2021048242A1/en unknown
- 2020-09-10 CN CN202080059190.8A patent/CN114269755A/zh active Pending
- 2020-09-10 AU AU2020346350A patent/AU2020346350A1/en active Pending
- 2020-09-11 TW TW109131236A patent/TW202128706A/zh unknown
- 2020-09-11 AR ARP200102527A patent/AR119943A1/es unknown
-
2021
- 2021-12-20 IL IL289186A patent/IL289186A/en unknown
-
2022
- 2022-02-22 CO CONC2022/0001879A patent/CO2022001879A2/es unknown
- 2022-03-07 CL CL2022000556A patent/CL2022000556A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
MX2022002311A (es) | 2022-03-25 |
CR20220104A (es) | 2022-04-20 |
EP4028403C0 (en) | 2023-11-22 |
CA3151516A1 (en) | 2021-03-18 |
KR20220062515A (ko) | 2022-05-17 |
CO2022001879A2 (es) | 2022-03-29 |
WO2021048242A1 (en) | 2021-03-18 |
TW202128706A (zh) | 2021-08-01 |
PE20220565A1 (es) | 2022-04-13 |
EP4028403B1 (en) | 2023-11-22 |
US20210094943A1 (en) | 2021-04-01 |
AR119943A1 (es) | 2022-01-19 |
CL2022000556A1 (es) | 2022-10-21 |
US11814375B2 (en) | 2023-11-14 |
IL289186A (en) | 2022-02-01 |
AU2020346350A1 (en) | 2022-02-17 |
CN114269755A (zh) | 2022-04-01 |
JP2022548028A (ja) | 2022-11-16 |
EP4028403A1 (en) | 2022-07-20 |
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