BR112019008349A2 - composição de peptídeos, e, utilização de uma composição. - Google Patents

composição de peptídeos, e, utilização de uma composição.

Info

Publication number
BR112019008349A2
BR112019008349A2 BR112019008349A BR112019008349A BR112019008349A2 BR 112019008349 A2 BR112019008349 A2 BR 112019008349A2 BR 112019008349 A BR112019008349 A BR 112019008349A BR 112019008349 A BR112019008349 A BR 112019008349A BR 112019008349 A2 BR112019008349 A2 BR 112019008349A2
Authority
BR
Brazil
Prior art keywords
composition
amount
peptides
peptide
molecular weight
Prior art date
Application number
BR112019008349A
Other languages
English (en)
Inventor
Bruno-Bonnet Christelle
Jolimaitre-Robert Pascale
Corbille Patrice
Auffret Yannick
Original Assignee
Gelatines Weishardt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gelatines Weishardt filed Critical Gelatines Weishardt
Publication of BR112019008349A2 publication Critical patent/BR112019008349A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
    • A23J3/342—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of collagen; of gelatin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
    • A61K38/014—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/54—Proteins
    • A23V2250/542—Animal Protein
    • A23V2250/543—Fish protein
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2300/00—Processes
    • A23V2300/28—Hydrolysis, degree of hydrolysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)

Abstract

a invenção refere-se a uma composição de peptídeos com um aminograma em que: - a glicina, a hidroxiprolina e a prolina estão em quantidades molares tais que a razão de cada quantidade para a soma das quantidades molares dos aminoácidos na composição está compreendida, respectivamente, entre 20,0% e 24,5%, entre 6,0% e 12,0% e entre 10,6% e 14,6%; - a composição de peptídeos compreendendo uma quantidade de peptídeos de peso molecular inferior a 1400 da de modo que a razão desta quantidade para a quantidade de peptídeos da composição é inferior a 40%; o peso molecular e a quantidade dos peptídeos da composição sendo determinados por cromatografia de exclusão. a invenção refere-se, igualmente, a uma tal composição para sua utilização como medicamento. ela refere-se, igualmente, a uma tal composição para sua utilização como complemento alimentar.
BR112019008349A 2016-10-28 2017-10-24 composição de peptídeos, e, utilização de uma composição. BR112019008349A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1660521A FR3058142B1 (fr) 2016-10-28 2016-10-28 Composition de peptides de collagene de peau de poisson et son utilisation a titre de medicament
PCT/FR2017/052932 WO2018078276A1 (fr) 2016-10-28 2017-10-24 Composition de peptides de collagène de peau de poisson et son utilisation à titre de médicament

Publications (1)

Publication Number Publication Date
BR112019008349A2 true BR112019008349A2 (pt) 2019-07-09

Family

ID=59296872

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019008349A BR112019008349A2 (pt) 2016-10-28 2017-10-24 composição de peptídeos, e, utilização de uma composição.

Country Status (14)

Country Link
US (2) US11427626B2 (pt)
EP (1) EP3532491A1 (pt)
JP (1) JP7125198B2 (pt)
KR (2) KR20190072617A (pt)
CN (1) CN110072886B (pt)
AU (1) AU2017349311B2 (pt)
BR (1) BR112019008349A2 (pt)
CA (1) CA3039276A1 (pt)
FR (1) FR3058142B1 (pt)
MA (1) MA46622A (pt)
MY (1) MY194925A (pt)
RU (1) RU2751886C2 (pt)
TW (1) TWI790214B (pt)
WO (1) WO2018078276A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3058142B1 (fr) * 2016-10-28 2023-11-24 Gelatines Weishardt Composition de peptides de collagene de peau de poisson et son utilisation a titre de medicament
US11180541B2 (en) 2017-09-28 2021-11-23 Geltor, Inc. Recombinant collagen and elastin molecules and uses thereof
CN109602896A (zh) * 2019-01-11 2019-04-12 无限极（中国）有限公司 一种胶原蛋白肽和弹性蛋白肽的组合物及其制备方法和应用
CN113993885A (zh) 2019-04-12 2022-01-28 格尔托公司 重组弹性蛋白及其生产
CN111220720B (zh) * 2019-12-05 2022-07-22 上海上药第一生化药业有限公司 胰蛋白酶及其酶原的纯度检测方法
EP4093761A4 (en) 2020-01-24 2024-04-17 Geltor Inc FOOD COLLAGEN FREE OF ANIMAL SUBSTANCES
CN114053165B (zh) * 2020-08-06 2023-10-20 大江生医股份有限公司 生物活性物质用于制备改善皮肤状态的组合物的用途
CN114073756B (zh) * 2020-08-21 2024-04-16 大江生医股份有限公司 生物活性物质用于制备抗老化的组合物的用途
TWI743960B (zh) 2020-08-21 2021-10-21 大江生醫股份有限公司 生物活性物質用於製備提升細胞粒線體活性的組合物的用途
TWI788003B (zh) * 2020-08-21 2022-12-21 大江生醫股份有限公司 生物活性物質用於製備改善毛孔及皺紋的組合物的用途
CN114740105B (zh) * 2022-03-17 2023-11-07 重庆医药高等专科学校 一种脯氨酸和n-甲基脯氨酸的液相色谱分离检测方法及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2720067B1 (fr) * 1994-05-17 1996-08-02 Dielen Lab Hydrolysat de protéines d'animaux marins, procédé d'obtention et applications.
ES2288791B1 (es) * 2006-02-10 2008-12-01 Masterfarm, S.L. Procedimiento de obtencion de un hidrolizado de colageno. hidrolizado enzimatico de colageno obtenible por el procedimiento y usos del mismo.
JP5308619B2 (ja) 2006-06-05 2013-10-09 株式会社アドバンス 健康食品
KR101095698B1 (ko) 2006-11-15 2011-12-20 가부시키가이샤 메이지 콜라겐 펩티드 조성물 및 이것을 함유하는 음식품
DE102007002295A1 (de) * 2007-01-09 2008-07-10 Gelita Ag Nahrungsmittelprodukt auf Proteinbasis und Verfahren zur Herstellung
JP2009280508A (ja) * 2008-05-20 2009-12-03 Hikari Ishii 血管老化抑制剤および老化防止抑制製剤
MY160866A (en) * 2008-12-23 2017-03-31 Univ Putra Malaysia Collagen extraction from aquatic animals
SG10201401809RA (en) * 2009-04-28 2014-06-27 Meiji Co Ltd Collagen Peptide Composition Having Good Blood Transfer Properties, And Food And Drink Containing Same
EP2766383B1 (en) * 2011-10-14 2018-08-08 Council of Scientific and Industrial Research Peptides from fish gelatine
FR3058142B1 (fr) * 2016-10-28 2023-11-24 Gelatines Weishardt Composition de peptides de collagene de peau de poisson et son utilisation a titre de medicament

Also Published As

Publication number Publication date
US20190276515A1 (en) 2019-09-12
AU2017349311A1 (en) 2019-06-06
RU2019109793A (ru) 2020-11-30
KR20230104296A (ko) 2023-07-07
TWI790214B (zh) 2023-01-21
RU2751886C2 (ru) 2021-07-19
JP7125198B2 (ja) 2022-08-24
RU2019109793A3 (pt) 2020-12-22
MY194925A (en) 2022-12-23
JP2020511399A (ja) 2020-04-16
KR20190072617A (ko) 2019-06-25
CN110072886B (zh) 2023-05-12
FR3058142B1 (fr) 2023-11-24
WO2018078276A1 (fr) 2018-05-03
FR3058142A1 (fr) 2018-05-04
CN110072886A (zh) 2019-07-30
MA46622A (fr) 2019-09-04
US20230024455A1 (en) 2023-01-26
CA3039276A1 (fr) 2018-05-03
AU2017349311B2 (en) 2022-07-14
US11427626B2 (en) 2022-08-30
TW201827452A (zh) 2018-08-01
EP3532491A1 (fr) 2019-09-04

Similar Documents

Publication Publication Date Title
BR112019008349A2 (pt) composição de peptídeos, e, utilização de uma composição.
CL2017000201A1 (es) Composiciones y métodos de uso para tratar trastornos metabólicos
EA201792245A1 (ru) Биоконъюгаты и их применения
BR112018004536A2 (pt) peptídeos de endereçamento à cartilagem
BR112019023071A2 (pt) proteínas de fusão do receptor tgf-beta do tipo ii e uso das mesmas
BR112016014969A2 (pt) polipeptídeo, formulação farmacêutica e uso de um polipeptídeo
BR112017001940A2 (pt) proteínas de fusão de interleucina-2/receptor alfa de interleucina-2 e processos de uso
BR112016028520A2 (pt) métodos e composições para o tratamento de transtornos com polipeptídeos de folistatina
BR112015032875A2 (pt) derivados de peptídeos do tipo glp-1, e usos dos mesmos
BR112018000903A2 (pt) composições e métodos para o tratamento de câncer
BR112018001761A2 (pt) uso de variantes de peptídeo natriurético tipo c para tratar a displasia esquelética
BR112012031183A2 (pt) líquidos nutricionais substancialmente claros compreendendo proteína de cálcio hmb e solúvel
BR112015009037A2 (pt) composição farmacêutica para uso no tratamento de infarto do miocárdio e uso de um peptídeo de fragmento de hmgb1
UA117096C2 (uk) Поліпептид, що зв'язується з c5 комплементу людини
AR064555A1 (es) Peptido wt1 restringido a hla-a*1101 y composicion farmaceutica que comprende el mismo
AR120721A2 (es) Péptidos y composiciones para el tratamiento de daño articular
BR112019011462A2 (pt) peptídeo coagonista de gip/glp-1, e, peptídeo para uso no tratamento e/ou profilaxia da doença de alzheimer clínica.
AR112069A1 (es) Inmunoglobulinas que fijan aggrecan
PH12019501064A1 (en) Ras PROTIEIN DEGRADATION INDUCING MOLECULE AND PHARMACEUTICAL COMPOSITION
EA201590601A1 (ru) Применение pedf-производных полипептидов для лечения остеоартрита
BR112022023723A2 (pt) Polipeptídeo, composição, polinucleotídeo, vetor, célula hospedeira, métodos para prevenção e/ou tratamento de uma doença relacionada à excitotoxicidade e/ou dor neuropática e para fabricar o polipeptídeo, uso do polipeptídeo, da composição, do polinucleotídeo, do vetor ou da célula hospedeira, e, kit de peças
BR112018000656A2 (pt) peptídeos para uso na promoção do transporte de glicose
BR112014028130A2 (pt) Sal de cloridrato de um peptídeo, composição farmacêutica, uso de um sal de cloridrato, uso de uma composição farmacêutica, e, método para evitar ou tratar alergia a gatos
BR112021000899A2 (pt) Peptídeos de ligação a il-17a e usos médicos dos mesmos
CL2021002483A1 (es) Compuestos y composiciones como moduladores de la señalización tlr

Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]