CL2021002483A1 - Compuestos y composiciones como moduladores de la señalización tlr - Google Patents
Compuestos y composiciones como moduladores de la señalización tlrInfo
- Publication number
- CL2021002483A1 CL2021002483A1 CL2021002483A CL2021002483A CL2021002483A1 CL 2021002483 A1 CL2021002483 A1 CL 2021002483A1 CL 2021002483 A CL2021002483 A CL 2021002483A CL 2021002483 A CL2021002483 A CL 2021002483A CL 2021002483 A1 CL2021002483 A1 CL 2021002483A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- compositions
- modulators
- tlr signaling
- treatment
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
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- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
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- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
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- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
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- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
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- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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- C07D285/01—Five-membered rings
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- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
Abstract
La presente descripción se refiere a compuestos, composiciones farmacéuticas que comprenden dichos compuestos, y al uso de dichos compuestos en métodos de tratamiento o en medicamentos para el tratamiento de enfermedades inflamatorias y determinados trastornos neurológicos que están relacionados con procesos inflamatorios de señalización, que incluyen, de modo no taxativo, proteínas mal plegadas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201962824170P | 2019-03-26 | 2019-03-26 | |
US201962824189P | 2019-03-26 | 2019-03-26 |
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CL2021002483A1 true CL2021002483A1 (es) | 2022-06-24 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CL2021002483A CL2021002483A1 (es) | 2019-03-26 | 2021-09-24 | Compuestos y composiciones como moduladores de la señalización tlr |
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US (2) | US11299487B2 (es) |
EP (1) | EP3946599A1 (es) |
JP (1) | JP2022527294A (es) |
KR (1) | KR20220004982A (es) |
CN (1) | CN114025847A (es) |
AU (1) | AU2020245489A1 (es) |
BR (1) | BR112021018918A2 (es) |
CA (1) | CA3133825A1 (es) |
CL (1) | CL2021002483A1 (es) |
CO (1) | CO2021013171A2 (es) |
CR (1) | CR20210499A (es) |
IL (1) | IL286511A (es) |
MX (1) | MX2021011596A (es) |
PE (1) | PE20212177A1 (es) |
SG (1) | SG11202109936YA (es) |
WO (1) | WO2020198368A1 (es) |
Families Citing this family (2)
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US11345713B2 (en) | 2018-03-27 | 2022-05-31 | Neuropore Therapies, Inc. | Compounds as modulators of TLR2 signaling |
CA3193577A1 (en) * | 2020-09-25 | 2022-03-31 | Neuropore Therapies, Inc. | Compounds and compositions as modulators of tlr signaling |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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DE2821116A1 (de) | 1978-05-13 | 1979-11-15 | Bayer Ag | Benzofuranyl-benzimidazole |
EP1402887A1 (en) * | 2002-09-18 | 2004-03-31 | Jerini AG | New compounds for the inhibition of undesired cell proliferation and use thereof |
US7858666B2 (en) * | 2007-06-08 | 2010-12-28 | Mannkind Corporation | IRE-1α inhibitors |
WO2009002790A2 (en) | 2007-06-26 | 2008-12-31 | Bausch & Lomb Incorporated | Compositions and methods for treating, reducing, ameliorating, alleviating, or preventing dry eye |
BRPI0922135B1 (pt) | 2008-12-05 | 2021-07-13 | Astellas Pharma Inc | Composto de 2h-cromeno ou um sal do mesmo, composição farmacêutica compreendendo dito composto e uso do mesmo para prevenir ou tratar uma doença induzida por infiltração de linfócito indesejável associada com s1p1 |
CN101805338B (zh) | 2010-04-06 | 2014-10-15 | 沈阳药科大学 | 噁二唑基哌嗪衍生物及其用途 |
WO2013013504A1 (zh) | 2011-07-26 | 2013-01-31 | 山东亨利医药科技有限责任公司 | 替加环素衍生物 |
US8916705B2 (en) * | 2011-10-14 | 2014-12-23 | The Board of Trustees of The University of Illilnois | Procaspase-activating compounds and compositions |
EP3280256A4 (en) | 2015-04-06 | 2018-12-12 | University of Maryland, Baltimore | Small molecule inhibitors of tlr2 signaling |
JP2019524781A (ja) | 2016-08-03 | 2019-09-05 | ニューロポア セラピーズ インコーポレイテッド | Tlr2二量体化調節剤としての脂質置換アミノ1,2−ジオール化合物および脂質置換アミノ1,3−ジオール化合物 |
US11345713B2 (en) | 2018-03-27 | 2022-05-31 | Neuropore Therapies, Inc. | Compounds as modulators of TLR2 signaling |
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2020
- 2020-03-25 EP EP20720611.1A patent/EP3946599A1/en active Pending
- 2020-03-25 US US16/830,110 patent/US11299487B2/en active Active
- 2020-03-25 KR KR1020217034824A patent/KR20220004982A/ko active Search and Examination
- 2020-03-25 CR CR20210499A patent/CR20210499A/es unknown
- 2020-03-25 CA CA3133825A patent/CA3133825A1/en active Pending
- 2020-03-25 BR BR112021018918A patent/BR112021018918A2/pt unknown
- 2020-03-25 JP JP2021557609A patent/JP2022527294A/ja active Pending
- 2020-03-25 SG SG11202109936Y patent/SG11202109936YA/en unknown
- 2020-03-25 MX MX2021011596A patent/MX2021011596A/es unknown
- 2020-03-25 CN CN202080033739.6A patent/CN114025847A/zh active Pending
- 2020-03-25 WO PCT/US2020/024728 patent/WO2020198368A1/en unknown
- 2020-03-25 AU AU2020245489A patent/AU2020245489A1/en active Pending
- 2020-03-25 PE PE2021001584A patent/PE20212177A1/es unknown
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2021
- 2021-09-19 IL IL286511A patent/IL286511A/en unknown
- 2021-09-24 CL CL2021002483A patent/CL2021002483A1/es unknown
- 2021-09-30 CO CONC2021/0013171A patent/CO2021013171A2/es unknown
-
2022
- 2022-02-10 US US17/669,273 patent/US20220298155A1/en active Pending
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WO2020198368A1 (en) | 2020-10-01 |
AU2020245489A1 (en) | 2021-10-14 |
PE20212177A1 (es) | 2021-11-09 |
IL286511A (en) | 2021-12-01 |
JP2022527294A (ja) | 2022-06-01 |
KR20220004982A (ko) | 2022-01-12 |
CR20210499A (es) | 2021-12-17 |
US20200308163A1 (en) | 2020-10-01 |
BR112021018918A2 (pt) | 2021-12-07 |
US11299487B2 (en) | 2022-04-12 |
CN114025847A (zh) | 2022-02-08 |
CA3133825A1 (en) | 2020-10-01 |
SG11202109936YA (en) | 2021-10-28 |
EP3946599A1 (en) | 2022-02-09 |
CO2021013171A2 (es) | 2021-10-20 |
US20220298155A1 (en) | 2022-09-22 |
MX2021011596A (es) | 2021-10-13 |
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