BR112019002979A2 - método de cromatografia para quantificação de um tensoativo não iônico em uma composição compreen-dendo o tensoativo não iônico e um polipeptídeo - Google Patents

método de cromatografia para quantificação de um tensoativo não iônico em uma composição compreen-dendo o tensoativo não iônico e um polipeptídeo

Info

Publication number
BR112019002979A2
BR112019002979A2 BR112019002979A BR112019002979A BR112019002979A2 BR 112019002979 A2 BR112019002979 A2 BR 112019002979A2 BR 112019002979 A BR112019002979 A BR 112019002979A BR 112019002979 A BR112019002979 A BR 112019002979A BR 112019002979 A2 BR112019002979 A2 BR 112019002979A2
Authority
BR
Brazil
Prior art keywords
nonionic surfactant
polypeptide
composition
quantifying
chromatography method
Prior art date
Application number
BR112019002979A
Other languages
English (en)
Other versions
BR112019002979B1 (pt
Inventor
Montti Mary
S Chinn Michael
L Beardsley Richard
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BR112019002979A2 publication Critical patent/BR112019002979A2/pt
Publication of BR112019002979B1 publication Critical patent/BR112019002979B1/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3847—Multimodal interactions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/36—Control of physical parameters of the fluid carrier in high pressure liquid systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Abstract

a invenção fornece métodos para quantificação de um tensoativo não iônico em uma composição que compreende um polipeptí-deo e o tensoativo não iônico, em que a quantificação apresenta interferência reduzida entre o tensoativo não iônico e o polipeptídeo. são também fornecidos métodos em que a composição inclui ainda n-acetil-triptofano, e a quantificação apresenta uma interferência reduzida entre o tensoativo não iônico, o polipeptídeo e o n-acetil-triptofano.
BR112019002979-6A 2016-08-15 2017-08-14 Método de cromatografia para quantificação de um tensoativo não iônico em uma composição compreendendo o tensoativo não iônico e um polipeptídeo BR112019002979B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662375373P 2016-08-15 2016-08-15
US62/375,373 2016-08-15
PCT/US2017/046725 WO2018035025A1 (en) 2016-08-15 2017-08-14 Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptide

Publications (2)

Publication Number Publication Date
BR112019002979A2 true BR112019002979A2 (pt) 2019-07-09
BR112019002979B1 BR112019002979B1 (pt) 2023-10-03

Family

ID=59687053

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019002979-6A BR112019002979B1 (pt) 2016-08-15 2017-08-14 Método de cromatografia para quantificação de um tensoativo não iônico em uma composição compreendendo o tensoativo não iônico e um polipeptídeo

Country Status (14)

Country Link
US (2) US11333644B2 (pt)
EP (1) EP3497440A1 (pt)
JP (1) JP7286536B2 (pt)
KR (1) KR102617148B1 (pt)
CN (2) CN109716127B (pt)
AR (1) AR109343A1 (pt)
AU (2) AU2017312540B2 (pt)
BR (1) BR112019002979B1 (pt)
CA (1) CA3033737A1 (pt)
IL (1) IL264582B (pt)
MX (1) MX2019001572A (pt)
SG (1) SG11201901228QA (pt)
TW (1) TWI775770B (pt)
WO (1) WO2018035025A1 (pt)

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AU2017312540B2 (en) 2016-08-15 2023-02-02 Genentech, Inc. Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptide
TW202045927A (zh) * 2019-02-27 2020-12-16 法商賽諾菲公司 以具內標之lc-ms於樣品中進行聚山梨醇酯定量之方法
WO2020211584A1 (zh) * 2019-04-19 2020-10-22 海正生物制药有限公司 组合物中泊洛沙姆188的检测方法
KR20220002581A (ko) 2019-05-03 2022-01-06 제넨테크, 인크. 정제 플랫폼으로부터 수득된 조성물의 효소적 가수분해 활성 속도를 감소시키는 방법
WO2022094116A1 (en) 2020-10-30 2022-05-05 Genentech, Inc. Purification platforms for obtaining pharmaceutical compositions having a reduced hydrolytic enzyme activity rate
KR20230148413A (ko) 2021-02-24 2023-10-24 에프. 호프만-라 로슈 아게 심층 필터의 재생 및 다회 사용
KR102283871B1 (ko) * 2021-03-02 2021-08-02 한국원자력연구원 크로마토그래피를 이용한 무담체 홀뮴-166의 분리 방법, 분리 장치 및 이에 의하여 분리된 무담체 홀뮴-166
WO2023126903A2 (en) * 2021-12-31 2023-07-06 Kashiv Biosciences, Llc A process for separation and quantification of non-ionic surfactant

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Also Published As

Publication number Publication date
TWI775770B (zh) 2022-09-01
KR20190051977A (ko) 2019-05-15
CN109716127A (zh) 2019-05-03
BR112019002979B1 (pt) 2023-10-03
AU2017312540A1 (en) 2019-02-28
AU2022291517A1 (en) 2023-02-02
CN109716127B (zh) 2022-06-14
CN115598231A (zh) 2023-01-13
CA3033737A1 (en) 2018-02-22
SG11201901228QA (en) 2019-03-28
IL264582A (en) 2019-02-28
AR109343A1 (es) 2018-11-21
MX2019001572A (es) 2019-08-29
US11333644B2 (en) 2022-05-17
US11680931B2 (en) 2023-06-20
AU2017312540B2 (en) 2023-02-02
IL264582B (en) 2022-04-01
JP2019530857A (ja) 2019-10-24
TW201809658A (zh) 2018-03-16
WO2018035025A1 (en) 2018-02-22
US20190178859A1 (en) 2019-06-13
EP3497440A1 (en) 2019-06-19
KR102617148B1 (ko) 2023-12-26
US20230077255A1 (en) 2023-03-09
JP7286536B2 (ja) 2023-06-05

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