BR112018017117A2 - método de produção para derivados de fenoxietanol - Google Patents

método de produção para derivados de fenoxietanol

Info

Publication number
BR112018017117A2
BR112018017117A2 BR112018017117-4A BR112018017117A BR112018017117A2 BR 112018017117 A2 BR112018017117 A2 BR 112018017117A2 BR 112018017117 A BR112018017117 A BR 112018017117A BR 112018017117 A2 BR112018017117 A2 BR 112018017117A2
Authority
BR
Brazil
Prior art keywords
production method
phenoxyethanol
formula
derivatives
phenoxyethanol derivatives
Prior art date
Application number
BR112018017117-4A
Other languages
English (en)
Japanese (ja)
Other versions
BR112018017117B1 (pt
Inventor
Toyama Takayuki
miyake Naoki
Original Assignee
Shionogi & Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co., Ltd. filed Critical Shionogi & Co., Ltd.
Publication of BR112018017117A2 publication Critical patent/BR112018017117A2/pt
Publication of BR112018017117B1 publication Critical patent/BR112018017117B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/46—Use of additives, e.g. for stabilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

é fornecido um método de produção de um derivado de fenoxietanol. este método de produção de um composto representado pela fórmula (ii) é caracterizado pelo fato de que um composto representado pela fórmula (i) (na fórmula, r1 é uma alquila substituída ou não substituída) é reduzido na presença de boroidreto de lítio.
BR112018017117-4A 2016-03-15 2017-03-14 Metodo de produqao para derivados de fenoxietanol BR112018017117B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016050604 2016-03-15
JP2016-050604 2016-03-15
PCT/JP2017/010159 WO2017159669A1 (ja) 2016-03-15 2017-03-14 フェノキシエタノール誘導体の製造方法

Publications (2)

Publication Number Publication Date
BR112018017117A2 true BR112018017117A2 (pt) 2018-12-26
BR112018017117B1 BR112018017117B1 (pt) 2021-11-16

Family

ID=59851930

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018017117-4A BR112018017117B1 (pt) 2016-03-15 2017-03-14 Metodo de produqao para derivados de fenoxietanol

Country Status (14)

Country Link
US (1) US10472312B2 (pt)
EP (2) EP3415491B1 (pt)
JP (1) JPWO2017159669A1 (pt)
KR (1) KR102377433B1 (pt)
CN (1) CN108137457B (pt)
AU (1) AU2017232476B2 (pt)
BR (1) BR112018017117B1 (pt)
CA (1) CA3016545A1 (pt)
CL (1) CL2018002641A1 (pt)
CO (1) CO2018009436A2 (pt)
EA (1) EA039048B1 (pt)
HK (1) HK1256626A1 (pt)
MX (1) MX2018010466A (pt)
WO (1) WO2017159669A1 (pt)

Family Cites Families (28)

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JPS4839639B1 (pt) * 1963-04-15 1973-11-26
FR2162692A5 (pt) * 1971-09-09 1973-07-20 Rhone Poulenc Sa
BE788612A (fr) * 1971-09-09 1973-03-08 Rhone Poulenc Sa Nouveaux herbicides
DE3512179A1 (de) 1985-04-03 1986-12-04 Merck Patent Gmbh, 6100 Darmstadt Fotoinitiatoren fuer die fotopolymerisation in waessrigen systemen
US4982016A (en) * 1989-06-06 1991-01-01 Carter-Wallace, Inc. Conversion of diethyl phenylmalonate to 2-phenyl-1,3-propanediol
US5532416A (en) 1994-07-20 1996-07-02 Monsanto Company Benzoyl derivatives and synthesis thereof
JPH05271129A (ja) 1992-01-30 1993-10-19 Idemitsu Petrochem Co Ltd （ペルフルオロデカリン）アルコール体
DE4212628A1 (de) 1992-04-15 1993-10-21 Manfred Dr Metzler Neue Bis-phenyl-hexene
FR2706898B1 (pt) * 1993-06-25 1995-09-08 Union Pharma Scient Appl
JPH07316131A (ja) * 1994-05-27 1995-12-05 Mitsubishi Chem Corp ピロール誘導体の製造方法
US5808107A (en) * 1997-10-31 1998-09-15 Board Of Trustees Operating Michigan State University Process for the preparation of hydroxy substituted gamma butyrolactones
JP4079505B2 (ja) 1998-04-28 2008-04-23 田辺三菱製薬株式会社 ２−アミノ−２−［２−（４−オクチルフェニル）エチル］プロパン−１，３−ジオールの新規な製造法
TW593256B (en) 1999-11-16 2004-06-21 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
SI21655A (sl) 2003-12-29 2005-06-30 LEK farmacevtska dru�ba d.d. Sinteza optično čistega (R)-5-(2-aminopropil)-2-metoksibenzensulfonamida
EP2395005A1 (en) 2006-09-07 2011-12-14 Industrial Research Limited Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
CA2677861C (en) * 2007-02-14 2015-05-19 Hormos Medical Ltd. Method for the preparation of therapeutically valuable triphenylbutene derivatives
CA2707447C (en) 2007-12-26 2016-03-08 Banyu Pharmaceutical Co., Ltd. Sulfonyl-substituted 6-membered ring derivative
RS53353B (en) * 2010-01-19 2014-10-31 Cambrex Karlskoga Ab NEW PROCEDURES FOR THE PRODUCTION OF BENZOPHENONE DERIVATIVES
US8277699B2 (en) 2010-04-30 2012-10-02 Transistions Optical, Inc. Photochromic materials that include 6-amino substituted indeno-fused naphthopyrans
JP2013224263A (ja) * 2010-08-19 2013-10-31 Taisho Pharmaceutical Co Ltd ４−イソプロピルフェニルグルシトール化合物
WO2012089606A1 (en) * 2010-12-28 2012-07-05 Glaxo Group Limited Azabicyclo [4.1.0] hept - 4 - yl derivatives as human orexin receptor antagonists
WO2012089607A1 (en) * 2010-12-28 2012-07-05 Glaxo Group Limited Novel compounds with a 3a-azabicyclo [4.1.0] heptane core acting on orexin receptors
CN103242142A (zh) 2012-02-13 2013-08-14 天津药物研究院 欧司哌米芬及其中间体的制备方法
JP6174156B2 (ja) * 2012-10-19 2017-08-02 フェルミオン オサケ ユキチュア オスペミフェンの製造方法
EP2909163A1 (en) 2012-10-19 2015-08-26 Fermion Oy A process for the preparation of ospemifene
CN104030896A (zh) * 2013-03-07 2014-09-10 天津药物研究院 一种简易去除欧司哌米芬特异杂质的方法
WO2016043189A1 (ja) * 2014-09-16 2016-03-24 塩野義製薬株式会社 トリフェニルブテン誘導体の製造方法
US10138190B2 (en) * 2015-01-09 2018-11-27 Glenmark Pharmaceuticals Limited Process for preparation of ospemifene

Also Published As

Publication number Publication date
CN108137457A (zh) 2018-06-08
EP3415491A1 (en) 2018-12-19
EA039048B1 (ru) 2021-11-26
EP3835285A1 (en) 2021-06-16
JPWO2017159669A1 (ja) 2019-01-24
AU2017232476B2 (en) 2019-10-03
HK1256626A1 (zh) 2019-09-27
US20190084910A1 (en) 2019-03-21
BR112018017117B1 (pt) 2021-11-16
KR20180122330A (ko) 2018-11-12
KR102377433B1 (ko) 2022-03-23
EP3415491B1 (en) 2020-11-18
CO2018009436A2 (es) 2018-10-10
CA3016545A1 (en) 2017-09-21
AU2017232476A1 (en) 2018-10-04
CL2018002641A1 (es) 2019-01-18
CN108137457B (zh) 2022-09-06
EP3415491A4 (en) 2019-02-27
WO2017159669A1 (ja) 2017-09-21
US10472312B2 (en) 2019-11-12
EA201891918A1 (ru) 2019-02-28
MX2018010466A (es) 2019-01-14

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Legal Events

Date Code Title Description
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/03/2017, OBSERVADAS AS CONDICOES LEGAIS.