BR112017024773A2 - compostos depsipeptídeos anti-helmínticos - Google Patents
compostos depsipeptídeos anti-helmínticosInfo
- Publication number
- BR112017024773A2 BR112017024773A2 BR112017024773-9A BR112017024773A BR112017024773A2 BR 112017024773 A2 BR112017024773 A2 BR 112017024773A2 BR 112017024773 A BR112017024773 A BR 112017024773A BR 112017024773 A2 BR112017024773 A2 BR 112017024773A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- depsipeptide compounds
- birds
- mammals
- compositions
- Prior art date
Links
- OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical class O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 title abstract 2
- 230000000507 anthelmentic effect Effects 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 244000045947 parasite Species 0.000 abstract 2
- 108010002156 Depsipeptides Proteins 0.000 abstract 1
- 206010061217 Infestation Diseases 0.000 abstract 1
- 230000003071 parasitic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P17/00—Pest repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Medicinal Chemistry (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
a presente invenção proporciona compostos depsipeptídeos cíclicos de fórmula (i) e composições compreendendo os compostos que são eficazes contra parasitas que prejudicam animais. os compostos e composições podem ser utilizadas para combater parasitas em ou sobre mamíferos e aves. a invenção também fornece um método aprimorado para erradicar, controlar e prevenir a infestação parasitária em aves e mamíferos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562163997P | 2015-05-20 | 2015-05-20 | |
US62/163,997 | 2015-05-20 | ||
PCT/US2016/033522 WO2016187534A1 (en) | 2015-05-20 | 2016-05-20 | Anthelmintic depsipeptide compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017024773A2 true BR112017024773A2 (pt) | 2018-11-06 |
Family
ID=56322274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017024773-9A BR112017024773A2 (pt) | 2015-05-20 | 2016-05-20 | compostos depsipeptídeos anti-helmínticos |
Country Status (32)
Country | Link |
---|---|
US (3) | US10081656B2 (pt) |
EP (2) | EP3922639A1 (pt) |
JP (2) | JP7045191B2 (pt) |
KR (1) | KR20180002886A (pt) |
CN (2) | CN107835818B (pt) |
AR (1) | AR104714A1 (pt) |
AU (2) | AU2016264635B2 (pt) |
BR (1) | BR112017024773A2 (pt) |
CA (1) | CA2986478C (pt) |
CL (1) | CL2017002936A1 (pt) |
CO (1) | CO2017011738A2 (pt) |
CY (1) | CY1124370T1 (pt) |
DK (1) | DK3298027T3 (pt) |
ES (1) | ES2916216T3 (pt) |
HK (1) | HK1245285A1 (pt) |
HR (1) | HRP20211041T1 (pt) |
HU (1) | HUE055535T2 (pt) |
IL (1) | IL255735B (pt) |
LT (1) | LT3298027T (pt) |
MX (2) | MX2021001566A (pt) |
NZ (1) | NZ737610A (pt) |
PH (1) | PH12017502106A1 (pt) |
PL (1) | PL3298027T3 (pt) |
PT (1) | PT3298027T (pt) |
RS (1) | RS62130B1 (pt) |
RU (1) | RU2707298C2 (pt) |
SG (1) | SG10202103403SA (pt) |
SI (1) | SI3298027T1 (pt) |
TW (2) | TWI749509B (pt) |
UY (1) | UY36683A (pt) |
WO (1) | WO2016187534A1 (pt) |
ZA (2) | ZA201707806B (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2016380868B2 (en) * | 2015-12-28 | 2019-11-28 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
CN110167921A (zh) | 2016-11-16 | 2019-08-23 | 勃林格殷格翰动物保健美国公司 | 驱蠕虫缩肽化合物 |
DK3579696T3 (da) * | 2017-02-08 | 2023-09-18 | Boehringer Ingelheim Animal Health Usa Inc | In vivo-model til parasitisk ormeinfektion og fremgangsmåder til evaluering af antiparasitiske forbindelser, herunder forbindelser som er aktive over for hunde-hjerteorm |
GB201713633D0 (en) * | 2017-08-24 | 2017-10-11 | Walshe Nigel | Methods for production of emodepside from pf 1022a derivatives |
WO2019091975A1 (en) * | 2017-11-07 | 2019-05-16 | Bayer Animal Health Gmbh | Method for the synthesis of cyclic depsipeptides |
SG11202003832WA (en) * | 2017-11-29 | 2020-06-29 | Zoetis Services Llc | Endoparasitic depsipeptides |
US11583545B2 (en) | 2018-02-08 | 2023-02-21 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof |
KR20210005176A (ko) | 2018-05-10 | 2021-01-13 | 조에티스 서비시즈 엘엘씨 | 내부기생충성 뎁시펩타이드 |
AU2020205960B2 (en) | 2019-01-10 | 2024-04-18 | Zoetis Services Llc | Anthelmintic laboratory animal model for heartworm |
US11560388B2 (en) | 2019-03-19 | 2023-01-24 | Boehringer Ingelheim Vetmedica Gmbh | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
CN110343056B (zh) * | 2019-07-19 | 2022-01-07 | 爱斯特(成都)生物制药股份有限公司 | 一种n-叔丁氧羰基-n-甲基-2-氨基-4,4-二甲基戊酸的制备方法 |
KR20230028268A (ko) | 2020-05-29 | 2023-02-28 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 헤테로시클릭 화합물 |
WO2022140728A1 (en) | 2020-12-21 | 2022-06-30 | Boehringer Ingelheim Animam Health Usa Inc. | Parasiticidal collar comprising isoxazoline compounds |
WO2023156938A1 (en) | 2022-02-17 | 2023-08-24 | Boehringer Ingelheim Vetmedica Gmbh | Method and system for providing a fluid product mailer |
CN114920669A (zh) * | 2022-06-28 | 2022-08-19 | 吉尔多肽生物制药(大连市)有限公司 | 一种n-甲基-n-苄氧羰基-l-天门冬氨酸(4-叔丁酯)二环己胺盐的合成方法 |
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