BR112016029650A2 - roedor, polipeptídeo pd-1, célula isolada ou tecido de roedor, célula-tronco embrionária de roedor, métodos de produzir um roedor, de reduzir o crescimento de tumor em um roedor, de matar células tumorais em um roedor e de avaliar as propriedades farmacocinéticas de uma droga que direciona pd-1 humano, e, modelo de tumor de roedor? - Google Patents
roedor, polipeptídeo pd-1, célula isolada ou tecido de roedor, célula-tronco embrionária de roedor, métodos de produzir um roedor, de reduzir o crescimento de tumor em um roedor, de matar células tumorais em um roedor e de avaliar as propriedades farmacocinéticas de uma droga que direciona pd-1 humano, e, modelo de tumor de roedor?Info
- Publication number
- BR112016029650A2 BR112016029650A2 BR112016029650A BR112016029650A BR112016029650A2 BR 112016029650 A2 BR112016029650 A2 BR 112016029650A2 BR 112016029650 A BR112016029650 A BR 112016029650A BR 112016029650 A BR112016029650 A BR 112016029650A BR 112016029650 A2 BR112016029650 A2 BR 112016029650A2
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- BR
- Brazil
- Prior art keywords
- rodent
- polypeptide
- producing
- methods
- drug
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 241000283984 Rodentia Species 0.000 title 7
- 206010028980 Neoplasm Diseases 0.000 title 1
- 210000004027 cell Anatomy 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 210000001671 embryonic stem cell Anatomy 0.000 title 1
- 210000004881 tumor cell Anatomy 0.000 title 1
- 230000004614 tumor growth Effects 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000003782 apoptosis assay Methods 0.000 abstract 1
- 238000012239 gene modification Methods 0.000 abstract 1
- 230000005017 genetic modification Effects 0.000 abstract 1
- 235000013617 genetically modified food Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000005522 programmed cell death Effects 0.000 abstract 1
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- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
Abstract
animais não humanos e métodos e composições para produzir e usar os mesmos, são fornecidos, em que os referidos animais não humanos compreendem uma humanização de um gene de morte celular programada 1 (pdcd1). esses animais não humanos podem ser descritos, em algumas modalidades, como tendo uma modificação genética para um gene pdcd1 endógeno, de modo que os referidos animais não humanos expressam um polipeptídeo pd-1 que inclui uma porção humana e uma porção endógena (por exemplo, uma porção não humana).
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US201462086518P | 2014-12-02 | 2014-12-02 | |
US201562138221P | 2015-03-25 | 2015-03-25 | |
PCT/US2015/036649 WO2015196051A1 (en) | 2014-06-19 | 2015-06-19 | Non-human animals having a humanized programmed cell death 1 gene |
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BR112016029650A BR112016029650A2 (pt) | 2014-06-19 | 2015-06-19 | roedor, polipeptídeo pd-1, célula isolada ou tecido de roedor, célula-tronco embrionária de roedor, métodos de produzir um roedor, de reduzir o crescimento de tumor em um roedor, de matar células tumorais em um roedor e de avaliar as propriedades farmacocinéticas de uma droga que direciona pd-1 humano, e, modelo de tumor de roedor? |
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WO (1) | WO2015196051A1 (pt) |
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