SG11202011284RA - Non-human animal models of ditra disease and uses thereof - Google Patents
Non-human animal models of ditra disease and uses thereofInfo
- Publication number
- SG11202011284RA SG11202011284RA SG11202011284RA SG11202011284RA SG11202011284RA SG 11202011284R A SG11202011284R A SG 11202011284RA SG 11202011284R A SG11202011284R A SG 11202011284RA SG 11202011284R A SG11202011284R A SG 11202011284RA SG 11202011284R A SG11202011284R A SG 11202011284RA
- Authority
- SG
- Singapore
- Prior art keywords
- ditra
- disease
- animal models
- human animal
- models
- Prior art date
Links
- 238000010171 animal model Methods 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/545—IL-1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0368—Animal model for inflammation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Environmental Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862698459P | 2018-07-16 | 2018-07-16 | |
US201962867477P | 2019-06-27 | 2019-06-27 | |
PCT/US2019/041964 WO2020018511A1 (en) | 2018-07-16 | 2019-07-16 | Non-human animal models of ditra disease and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202011284RA true SG11202011284RA (en) | 2020-12-30 |
Family
ID=67544343
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202011284RA SG11202011284RA (en) | 2018-07-16 | 2019-07-16 | Non-human animal models of ditra disease and uses thereof |
Country Status (9)
Country | Link |
---|---|
US (2) | US11589562B2 (en) |
EP (1) | EP3823443B1 (en) |
JP (1) | JP2021530970A (en) |
KR (1) | KR20210031868A (en) |
CN (2) | CN112638154B (en) |
AU (1) | AU2019308205A1 (en) |
CA (1) | CA3098040A1 (en) |
SG (1) | SG11202011284RA (en) |
WO (1) | WO2020018511A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7139419B2 (en) | 2017-09-29 | 2022-09-20 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Non-Human Animals Containing Humanized TTR Loci and Methods of Use |
US11419318B2 (en) | 2017-11-30 | 2022-08-23 | Regeneran Pharmaceuticals, Inc. | Genetically modified rat comprising a humanized TRKB locus |
ES2966625T3 (en) | 2019-04-04 | 2024-04-23 | Regeneron Pharma | Rodents comprising a humanized coagulation factor 12 locus |
CA3137761A1 (en) | 2019-06-04 | 2020-12-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use |
EP3796776A1 (en) | 2019-06-07 | 2021-03-31 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized albumin locus |
KR20230038774A (en) * | 2020-07-17 | 2023-03-21 | 베링거 인겔하임 인터내셔날 게엠베하 | Anti-IL-36R antibody for treatment of neutrophilic dermatosis |
WO2023072052A1 (en) * | 2021-10-25 | 2023-05-04 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric genes |
Family Cites Families (41)
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US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US20070160576A1 (en) | 2001-06-05 | 2007-07-12 | Genentech, Inc. | IL-17A/F heterologous polypeptides and therapeutic uses thereof |
CN101031316A (en) * | 2004-07-29 | 2007-09-05 | 津莫吉尼蒂克斯公司 | Use of il-28 and il-29 to treat cancer and autoimmune disorders |
PT2767161T (en) | 2004-10-19 | 2018-04-20 | Regeneron Pharma | Method for generating an non-human animal homozygous for a genetic modification |
PT2769992T (en) * | 2006-10-02 | 2021-03-11 | Regeneron Pharma | High affinity human antibodies to human il-4 receptor |
RU2425880C2 (en) | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Method of producing transgene mice |
PT3417701T (en) | 2009-10-06 | 2022-03-16 | Univ Yale | Genetically modified mice and engraftment |
FI3375284T3 (en) | 2011-02-15 | 2023-06-15 | Regeneron Pharma | Humanized m-csf mice and uses thereof |
BR112014009941B1 (en) | 2011-10-28 | 2022-11-29 | Regeneron Pharmaceuticals, Inc | METHODS FOR PRODUCING A GENETICALLY MODIFIED RODENT EMBRYONIC STEM CELL(S) |
SG11201400945UA (en) | 2011-10-28 | 2014-04-28 | Regeneron Pharma | Humanized il-6 and il-6 receptor |
ES2741649T3 (en) | 2011-10-28 | 2020-02-11 | Regeneron Pharma | Mice with major genetically modified histocompatibility complex |
HUE047437T2 (en) * | 2011-11-16 | 2020-04-28 | Boehringer Ingelheim Int | Anti il-36r antibodies |
US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
KR20240045263A (en) | 2012-09-07 | 2024-04-05 | 예일 유니버시티 | Genetically modified non-human animals and methods of use thereof |
RU2673156C2 (en) | 2012-11-05 | 2018-11-22 | Ридженерон Фармасьютикалз, Инк. | Genetically modified non-human animals and methods for use thereof |
SG11201505968WA (en) | 2013-02-20 | 2015-08-28 | Regeneron Pharma | Genetic modification of rats |
EP3543253B1 (en) | 2013-02-20 | 2024-03-27 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized t-cell co-receptors |
US20150342163A1 (en) | 2013-02-22 | 2015-12-03 | Regeneron Pharmaceuticals, Inc. | Genetically modified major histocompatibility complex mice |
CN110192541B (en) | 2013-02-22 | 2022-02-18 | 瑞泽恩制药公司 | Mice expressing humanized major histocompatibility complex |
SG11201508028QA (en) | 2013-04-16 | 2015-10-29 | Regeneron Pharma | Targeted modification of rat genome |
IL297607B2 (en) | 2013-09-23 | 2024-01-01 | Regeneron Pharma | Non–human animals having a humanized signal–regulatory protein gene |
RS55472B1 (en) | 2013-10-15 | 2017-04-28 | Regeneron Pharma | Humanized il-15 animals |
CA2929846C (en) | 2013-11-19 | 2020-09-15 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
EP3071025B1 (en) | 2013-11-19 | 2018-10-10 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized a proliferation-inducing ligand gene |
US9474255B2 (en) | 2014-04-08 | 2016-10-25 | Regeneron Pharmaceuticals, Inc. | Non-human animals having humanized Fc-gamma receptors |
WO2015171523A1 (en) | 2014-05-05 | 2015-11-12 | Regeneron Pharmaceuticals, Inc. | Humanized c5 and c3 animals |
NO2785538T3 (en) * | 2014-05-07 | 2018-08-04 | ||
CN113045639A (en) | 2014-05-19 | 2021-06-29 | 再生元制药公司 | Genetically modified non-human animals expressing human EPO |
IL287519B2 (en) | 2014-06-19 | 2024-01-01 | Regeneron Pharma | Non-human animals having a humanized programmed cell death 1 gene |
CN113016720B (en) | 2014-11-24 | 2023-02-21 | 瑞泽恩制药公司 | Non-human animals expressing humanized CD3 complexes |
FI3850946T3 (en) | 2014-12-05 | 2023-12-28 | Regeneron Pharma | Non-human animals having a humanized cluster of differentiation 47 gene |
CN113412818B (en) | 2014-12-09 | 2022-11-04 | 瑞泽恩制药公司 | Non-human animal having humanized cluster of differentiation 274 gene |
SI3280257T1 (en) | 2015-04-06 | 2023-10-30 | Regeneron Pharmaceuticals, Inc., | Humanized t cell mediated immune responses in non-human animals |
SG11201708380WA (en) | 2015-04-13 | 2017-11-29 | Regeneron Pharma | Humanized sirpa-il15 knockin mice and methods of use thereof |
BR112018010158A2 (en) | 2015-11-20 | 2018-11-21 | Regeneron Pharma | rodent, humanized lag-3 polypeptide, cell or tissue, embryonic stem cell and rodent embryo, methods for producing a rodent to evaluate the antitumor efficacy and pharmacokinetic properties of a drug |
EP3411392B1 (en) | 2016-02-04 | 2021-12-29 | Regeneron Pharmaceuticals, Inc. | Non-human animals having an engineered angptl8 gene |
ES2886958T3 (en) | 2016-02-29 | 2021-12-21 | Regeneron Pharma | Rodents that have a humanized TMPRSS gene |
SG11201907606XA (en) | 2017-02-27 | 2019-09-27 | Regeneron Pharma | Humanized model of kidney and liver disorders |
JP7139419B2 (en) | 2017-09-29 | 2022-09-20 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Non-Human Animals Containing Humanized TTR Loci and Methods of Use |
US11419318B2 (en) | 2017-11-30 | 2022-08-23 | Regeneran Pharmaceuticals, Inc. | Genetically modified rat comprising a humanized TRKB locus |
US11576984B2 (en) | 2018-03-26 | 2023-02-14 | Regeneron Pharmaceuticals, Inc. | Genetically modified mouse with humanized immunoglobulin heavy chain constant region genes and method of using |
-
2019
- 2019-07-16 WO PCT/US2019/041964 patent/WO2020018511A1/en unknown
- 2019-07-16 JP JP2020571589A patent/JP2021530970A/en active Pending
- 2019-07-16 SG SG11202011284RA patent/SG11202011284RA/en unknown
- 2019-07-16 CA CA3098040A patent/CA3098040A1/en active Pending
- 2019-07-16 EP EP19749891.8A patent/EP3823443B1/en active Active
- 2019-07-16 AU AU2019308205A patent/AU2019308205A1/en active Pending
- 2019-07-16 US US16/512,949 patent/US11589562B2/en active Active
- 2019-07-16 KR KR1020207037963A patent/KR20210031868A/en active Search and Examination
- 2019-07-16 CN CN201980040953.1A patent/CN112638154B/en active Active
- 2019-07-16 CN CN202211224751.2A patent/CN116200426A/en active Pending
-
2023
- 2023-01-25 US US18/159,414 patent/US20230172172A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US11589562B2 (en) | 2023-02-28 |
CN112638154B (en) | 2022-10-18 |
US20230172172A1 (en) | 2023-06-08 |
JP2021530970A (en) | 2021-11-18 |
KR20210031868A (en) | 2021-03-23 |
CA3098040A1 (en) | 2020-01-23 |
EP3823443A1 (en) | 2021-05-26 |
US20200015462A1 (en) | 2020-01-16 |
CN116200426A (en) | 2023-06-02 |
CN112638154A (en) | 2021-04-09 |
AU2019308205A1 (en) | 2020-11-19 |
WO2020018511A1 (en) | 2020-01-23 |
EP3823443B1 (en) | 2024-05-22 |
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