BR112016015422A2 - formulações de vacina de frasco único - Google Patents
formulações de vacina de frasco únicoInfo
- Publication number
- BR112016015422A2 BR112016015422A2 BR112016015422A BR112016015422A BR112016015422A2 BR 112016015422 A2 BR112016015422 A2 BR 112016015422A2 BR 112016015422 A BR112016015422 A BR 112016015422A BR 112016015422 A BR112016015422 A BR 112016015422A BR 112016015422 A2 BR112016015422 A2 BR 112016015422A2
- Authority
- BR
- Brazil
- Prior art keywords
- single vial
- vaccine formulations
- vial vaccine
- lyophilized formulations
- formulations
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
resumo "formulações de vacina de frasco único" a presente invenção refere-se a formulações liofilizadas termoestáveis, incluindo vacinas e composições farmacêuticas para induzir ou intensificar uma resposta imune, e métodos de utilização das mesmas. as formulações liofilizadas geralmente compreendem um antígeno e/ou um adjuvante, um óleo metabolizável e um excipiente de formação de torta.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361922761P | 2013-12-31 | 2013-12-31 | |
PCT/US2014/072615 WO2015103167A2 (en) | 2013-12-31 | 2014-12-29 | Single vial vaccine formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016015422A2 true BR112016015422A2 (pt) | 2017-10-24 |
Family
ID=53494219
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016015422A BR112016015422A2 (pt) | 2013-12-31 | 2014-12-29 | formulações de vacina de frasco único |
Country Status (15)
Country | Link |
---|---|
US (2) | US11801223B2 (pt) |
EP (2) | EP3089754B1 (pt) |
JP (1) | JP6741580B2 (pt) |
KR (3) | KR20220100041A (pt) |
CN (1) | CN106163551A (pt) |
AU (2) | AU2014373928C1 (pt) |
BR (1) | BR112016015422A2 (pt) |
CA (1) | CA2935620A1 (pt) |
EA (1) | EA201691348A1 (pt) |
ES (1) | ES2880306T3 (pt) |
IL (2) | IL246456B2 (pt) |
MX (2) | MX2016008640A (pt) |
PT (1) | PT3089754T (pt) |
WO (1) | WO2015103167A2 (pt) |
ZA (1) | ZA201604498B (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
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JP6741580B2 (ja) | 2013-12-31 | 2020-08-19 | インフェクシャス ディズィーズ リサーチ インスティチュート | 単一バイアルのワクチン製剤 |
JP6893765B2 (ja) * | 2016-07-15 | 2021-06-23 | 森山 雅美 | 人以外の陸上動物用のウイルス感染症に対する抗体誘導剤とその補助剤 |
CN117752780A (zh) | 2017-12-07 | 2024-03-26 | 默沙东有限责任公司 | 登革病毒疫苗组合物的制剂 |
KR102154572B1 (ko) * | 2017-12-14 | 2020-09-10 | 연세대학교 산학협력단 | Rv3628/Rv0351을 포함하는 새로운 BCG prime booster 백신 조성물 |
CN108823232A (zh) * | 2018-04-20 | 2018-11-16 | 中国科学院广州生物医药与健康研究院 | 一种艾滋病疫苗及其制备方法 |
CN110787291A (zh) * | 2018-08-03 | 2020-02-14 | 王元涛 | 一种加强型佐剂 |
EP3867919A4 (en) | 2018-10-19 | 2022-08-31 | F. Hoffmann-La Roche AG | DEFECT DETECTION IN LYOPHILIZED MEDICINAL PRODUCTS USING NEURAL CONVOLUTIONAL NETWORKS |
WO2020109365A1 (en) * | 2018-11-29 | 2020-06-04 | Glaxosmithkline Biologicals Sa | Methods for manufacturing an adjuvant |
CA3141577A1 (en) | 2019-05-25 | 2020-12-03 | Infectious Disease Research Institute | Composition and method for spray drying an adjuvant vaccine emulsion |
US11679163B2 (en) | 2019-09-20 | 2023-06-20 | Hdt Bio Corp. | Compositions and methods for delivery of RNA |
CA3172489A1 (en) | 2020-03-23 | 2021-09-30 | Amit KHANDHAR | Nanoemulsion compositions and methods for delivery of nra |
US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
CA3173408A1 (en) | 2020-12-23 | 2022-06-30 | Access To Advanced Health Institute | Solanesol vaccine adjuvants and methods of preparing same |
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JP6741580B2 (ja) | 2020-08-19 |
MX2022002106A (es) | 2022-03-17 |
WO2015103167A3 (en) | 2015-11-12 |
MX2016008640A (es) | 2016-10-07 |
KR20160133413A (ko) | 2016-11-22 |
JP2017502962A (ja) | 2017-01-26 |
US11801223B2 (en) | 2023-10-31 |
IL246456B2 (en) | 2024-06-01 |
AU2014373928B2 (en) | 2020-07-16 |
AU2020227042B2 (en) | 2021-12-02 |
AU2014373928A1 (en) | 2016-07-21 |
US20230293440A1 (en) | 2023-09-21 |
US20160324783A1 (en) | 2016-11-10 |
IL246456A0 (en) | 2016-08-31 |
EP3089754B1 (en) | 2021-04-21 |
ZA201604498B (en) | 2019-10-30 |
EP3089754A4 (en) | 2017-08-02 |
CN106163551A (zh) | 2016-11-23 |
KR20220100041A (ko) | 2022-07-14 |
KR102411781B1 (ko) | 2022-06-22 |
EP3089754A2 (en) | 2016-11-09 |
EA201691348A1 (ru) | 2016-11-30 |
IL246456B1 (en) | 2024-02-01 |
KR20240023713A (ko) | 2024-02-22 |
CA2935620A1 (en) | 2015-07-09 |
IL310015A (en) | 2024-03-01 |
EP3915579A1 (en) | 2021-12-01 |
AU2014373928C1 (en) | 2020-12-17 |
PT3089754T (pt) | 2021-07-23 |
AU2020227042A1 (en) | 2020-09-17 |
ES2880306T3 (es) | 2021-11-24 |
WO2015103167A2 (en) | 2015-07-09 |
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