BR112015032736A2 - inibidores de bromodomínio cristalino - Google Patents

inibidores de bromodomínio cristalino

Info

Publication number
BR112015032736A2
BR112015032736A2 BR112015032736A BR112015032736A BR112015032736A2 BR 112015032736 A2 BR112015032736 A2 BR 112015032736A2 BR 112015032736 A BR112015032736 A BR 112015032736A BR 112015032736 A BR112015032736 A BR 112015032736A BR 112015032736 A2 BR112015032736 A2 BR 112015032736A2
Authority
BR
Brazil
Prior art keywords
crystalline
bromodomain inhibitors
bromodomain
inhibitors
ethanesulfonamide
Prior art date
Application number
BR112015032736A
Other languages
English (en)
Inventor
Gong Yuchuan
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of BR112015032736A2 publication Critical patent/BR112015032736A2/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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Abstract

resumo “inibidores de bromodomínio cristalino” n-[4-(2,4-difluorofenóxi)-3-(6-metil-7-oxo-6,7-di-hidro-1h-pirrolo[2,3-c]piridin-4-il)fenil]etanossulfonamida e suas formas cristalinas são ingredientes farmacêuti-cos adequados para as composições farmacêuticas úteis no tratamento de doença, por exemplo, câncer.
BR112015032736A 2013-06-28 2014-06-27 inibidores de bromodomínio cristalino BR112015032736A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361840777P 2013-06-28 2013-06-28
PCT/US2014/044513 WO2014210425A1 (en) 2013-06-28 2014-06-27 Crystalline bromodomain inhibitors

Publications (1)

Publication Number Publication Date
BR112015032736A2 true BR112015032736A2 (pt) 2017-07-25

Family

ID=51261220

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015032736A BR112015032736A2 (pt) 2013-06-28 2014-06-27 inibidores de bromodomínio cristalino

Country Status (33)

Country Link
US (3) US9321765B2 (pt)
EP (1) EP3013826B1 (pt)
JP (1) JP6423425B2 (pt)
KR (1) KR102323829B1 (pt)
CN (1) CN105473586B (pt)
AR (1) AR096758A1 (pt)
AU (2) AU2014302252B2 (pt)
BR (1) BR112015032736A2 (pt)
CA (1) CA2916221C (pt)
CL (1) CL2015003722A1 (pt)
CR (1) CR20160036A (pt)
CY (1) CY1119066T1 (pt)
DK (1) DK3013826T3 (pt)
DO (1) DOP2015000304A (pt)
ES (1) ES2636939T3 (pt)
HK (2) HK1223354A1 (pt)
HR (1) HRP20171154T1 (pt)
IL (1) IL243202B (pt)
LT (1) LT3013826T (pt)
ME (1) ME02801B (pt)
MX (1) MX360065B (pt)
NZ (1) NZ631112A (pt)
PE (1) PE20160287A1 (pt)
PH (1) PH12015502792A1 (pt)
PL (1) PL3013826T3 (pt)
PT (1) PT3013826T (pt)
RS (1) RS56318B1 (pt)
RU (1) RU2675268C2 (pt)
SG (1) SG11201510692TA (pt)
SI (1) SI3013826T1 (pt)
TW (1) TWI639594B (pt)
UY (1) UY35632A (pt)
WO (1) WO2014210425A1 (pt)

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CN109384784B (zh) * 2017-08-10 2021-01-12 浙江海正药业股份有限公司 磺酰胺类衍生物、其制备方法及其在医药上的用途
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US11633399B2 (en) 2018-12-25 2023-04-25 Sol-Gel Technologies Ltd. Treatment of skin disorders with compositions comprising an EGFR inhibitor
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MX2022005795A (es) * 2019-11-13 2022-06-08 Rapt Therapeutics Inc Formas cristalinas del antagonista del receptor de quimiocinas cc tipo 4 y usos de las mismas.
CN110964691B (zh) * 2019-12-31 2020-10-30 深圳新赛尔生物科技有限公司 子宫内膜干细胞的定向成脂分化培养
JP2023510610A (ja) * 2020-01-19 2023-03-14 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド ブロモドメインタンパク質阻害剤の結晶形、塩形態及びその製造方法
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AU2014302252B2 (en) 2018-03-22
SI3013826T1 (sl) 2017-10-30
TWI639594B (zh) 2018-11-01
ME02801B (me) 2018-01-20
PT3013826T (pt) 2017-08-11
HRP20171154T1 (hr) 2017-10-20
NZ631112A (en) 2018-03-23
CR20160036A (es) 2016-05-17
RU2675268C2 (ru) 2018-12-18
IL243202A0 (en) 2016-02-29
EP3013826A1 (en) 2016-05-04
HK1224298A1 (zh) 2017-08-18
AU2014302252A1 (en) 2015-12-24
CA2916221C (en) 2022-08-30
MX360065B (es) 2018-10-22
JP6423425B2 (ja) 2018-11-14
IL243202B (en) 2019-07-31
CA2916221A1 (en) 2014-12-31
RU2016102591A (ru) 2017-08-03
LT3013826T (lt) 2017-08-10
HK1223354A1 (zh) 2017-07-28
AR096758A1 (es) 2016-02-03
CL2015003722A1 (es) 2016-07-29
US20160237085A1 (en) 2016-08-18
JP2016525090A (ja) 2016-08-22
PH12015502792A1 (en) 2016-03-21
RS56318B1 (sr) 2017-12-29
MX2015017435A (es) 2016-08-12
DK3013826T3 (en) 2017-08-28
KR102323829B1 (ko) 2021-11-09
AU2018201986A1 (en) 2018-04-12
WO2014210425A1 (en) 2014-12-31
EP3013826B1 (en) 2017-05-10
CY1119066T1 (el) 2018-01-10
ES2636939T3 (es) 2017-10-10
PE20160287A1 (es) 2016-05-22
US9321765B2 (en) 2016-04-26
KR20160025021A (ko) 2016-03-07
SG11201510692TA (en) 2016-01-28
TW201534608A (zh) 2015-09-16
CN105473586B (zh) 2019-11-05
US20170066765A1 (en) 2017-03-09
RU2016102591A3 (pt) 2018-04-25
PL3013826T3 (pl) 2017-10-31
UY35632A (es) 2015-01-30
DOP2015000304A (es) 2016-02-29
CN105473586A (zh) 2016-04-06
US20150005340A1 (en) 2015-01-01

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