BR112015026055A2 - novos compostos de pirimidina condensados substituídos - Google Patents

novos compostos de pirimidina condensados substituídos

Info

Publication number
BR112015026055A2
BR112015026055A2 BR112015026055A BR112015026055A BR112015026055A2 BR 112015026055 A2 BR112015026055 A2 BR 112015026055A2 BR 112015026055 A BR112015026055 A BR 112015026055A BR 112015026055 A BR112015026055 A BR 112015026055A BR 112015026055 A2 BR112015026055 A2 BR 112015026055A2
Authority
BR
Brazil
Prior art keywords
pyrimidine compounds
substituted condensed
condensed pyrimidine
new substituted
medicaments
Prior art date
Application number
BR112015026055A
Other languages
English (en)
Inventor
Nardi Antonio
Hesslinger Christian
Jakob Florian
Konetzki Ingo
Ratcliffe Paul
Craan Tobias
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of BR112015026055A2 publication Critical patent/BR112015026055A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

resumo novos compostos de pirimidina condensados substituídos. a invenção está relacionada a novos compostos de pirimidina condensados substituídos de fórmula geral (i) na qual os agrupamentos químicos, substituintes e índices são como definido na descrição, e a seu uso como medicamentos, em particular como medicamentos para o tratamento de condições e doenças que podem ser tratadas pela inibição da enzima pde4. 1/1
BR112015026055A 2013-04-16 2014-04-15 novos compostos de pirimidina condensados substituídos BR112015026055A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13001993 2013-04-16
PCT/EP2014/001013 WO2014170020A1 (en) 2013-04-16 2014-04-15 Substituted condensed pyrimidine compounds

Publications (1)

Publication Number Publication Date
BR112015026055A2 true BR112015026055A2 (pt) 2017-07-25

Family

ID=48141722

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015026055A BR112015026055A2 (pt) 2013-04-16 2014-04-15 novos compostos de pirimidina condensados substituídos

Country Status (13)

Country Link
US (1) US9527832B2 (pt)
EP (1) EP2986600B1 (pt)
JP (1) JP2016516787A (pt)
AR (1) AR096040A1 (pt)
AU (1) AU2014253810A1 (pt)
BR (1) BR112015026055A2 (pt)
CA (1) CA2909464A1 (pt)
ES (1) ES2642822T3 (pt)
HU (1) HUE034254T2 (pt)
MX (1) MX2015013936A (pt)
PL (1) PL2986600T3 (pt)
TW (1) TW201512189A (pt)
WO (1) WO2014170020A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR101196A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Compuestos de pirimidina sustituidos
AR101198A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Pirimidinas 2,5-sustituidas como inhibidores de pde4b
AR101197A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Pirimidinas 2,5-sustituidas
AR107099A1 (es) * 2015-12-22 2018-03-21 Gruenenthal Gmbh Compuestos espiro-[indolin heterocicloalcano] como inhibidores de la fosfodiesterasa
JP2020506966A (ja) * 2017-01-25 2020-03-05 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 化合物
US20210130339A1 (en) * 2017-01-25 2021-05-06 Glaxosmithkline Intellectual Property Development Limited Compounds
CN109761809A (zh) * 2019-02-16 2019-05-17 安徽华胜医药科技有限公司 一种钯碳催化还原合成2-溴-2-(2-氟-3-甲氧基苯基)乙酸乙酯的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1238149A (en) 1984-10-30 1988-06-14 Jacynthe Cote Closed cell phenolic foams
CZ290266B6 (cs) 1993-07-02 2002-06-12 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituované benzamidy, způsob jejich výroby a farmaceutické prostředky s jejich obsahem
CN1894222A (zh) 2003-08-05 2007-01-10 沃泰克斯药物股份有限公司 作为电压门控离子通道抑制剂的稠合嘧啶化合物
TW200621257A (en) 2004-10-20 2006-07-01 Astellas Pharma Inc Pyrimidine derivative fused with nonaromatic ring
US20060293343A1 (en) 2005-05-18 2006-12-28 Asahi Kasei Pharma Corporation Pyrimidine derivatives
ATE537175T1 (de) * 2007-10-19 2011-12-15 Boehringer Ingelheim Int Neue piperazino-dihydrothienopyrimidin-derivate
BR112015018355A8 (pt) * 2013-02-04 2018-01-23 Gruenenthal Gmbh novos compostos de pirimidina condensados substituídos

Also Published As

Publication number Publication date
US20160031857A1 (en) 2016-02-04
HUE034254T2 (en) 2018-02-28
MX2015013936A (es) 2015-12-11
WO2014170020A1 (en) 2014-10-23
AU2014253810A1 (en) 2015-12-03
EP2986600A1 (en) 2016-02-24
EP2986600B1 (en) 2017-07-05
CA2909464A1 (en) 2014-10-23
US9527832B2 (en) 2016-12-27
ES2642822T3 (es) 2017-11-20
PL2986600T3 (pl) 2017-12-29
TW201512189A (zh) 2015-04-01
JP2016516787A (ja) 2016-06-09
AR096040A1 (es) 2015-12-02

Similar Documents

Publication Publication Date Title
BR112017000830A2 (pt) novas 2,5-piridinas substituídas
BR112017000821A2 (pt) novos compostos de pirimidina substituída.
BR112015026055A2 (pt) novos compostos de pirimidina condensados substituídos
BR112018069612A2 (pt) compostos de pirroltriazina como inibidores de tam
BR112017000826A2 (pt) novas 2,5-piridinas substituídas.
BR112017003442A2 (pt) compostos e métodos para inibir histona desmetilases
BR112015026023A2 (pt) derivados de 2- aminopirido[4,3-d]pirimidin-5-ona e seu uso como inibidores de wee-1
BR112015027951A2 (pt) arilquinazolinas
BR112015020650A2 (pt) inibidores de histona demetilases
BR112015011456A2 (pt) compostos de aminopirimidina como inibidores de egfr mutantes contendo t790m
BR112014005226A2 (pt) derivados de benzonitrila como inibidores de cinase
BR112017004741A2 (pt) compostos e composições como inibidores da raf quinase
BR112013000275A2 (pt) derivados de tetraidro-pirido-pirimidina
BR112015020795A2 (pt) derivados de pirazol novos
BR112015018547A2 (pt) microbiocidas
BR112013032758A2 (pt) derivados de n-oxi-pirazolo-triazepino-diona
BR112017009629A2 (pt) triazolo [4,5-d] pirimidinas como agonistas do receptor canabinoide 2
BR112018011525A2 (pt) inibidores da tirosina quinase de bruton e métodos de seu uso
BR112016002638A2 (pt) novos aza-oxo-indóis para o tratamento e profilaxia de infecção pelo virus sincicial respiratório
DOP2017000244A (es) Derivados de pirazol útiles como inhibidores de proteína activadora de 5-lipoxigenasa (flap)
DOP2015000176A (es) Compuestos de azetidiniloxifenilpirrolidina
BR112015021449A2 (pt) uso de acilsufonamidas para melhorar a produção da planta
BR112016001928A2 (pt) derivados de piperidina ureia
BR112012013005A2 (pt) compostos químicos e seu uso como pesticidas.
BR112015030824A2 (pt) novos derivados de tetrazolona

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired
B350 Update of information on the portal [chapter 15.35 patent gazette]