BR112015024907A2 - n-acil-(3-substituido)-(8-substituido)-5,6-dihidro-[1,2,4]triazol[4,3a]pirazinas como antagonistas receptores seletivos de nk-3, composição farmacêutica, métodos para uso em desordens mediadas por receptores de nk-3 - Google Patents

n-acil-(3-substituido)-(8-substituido)-5,6-dihidro-[1,2,4]triazol[4,3a]pirazinas como antagonistas receptores seletivos de nk-3, composição farmacêutica, métodos para uso em desordens mediadas por receptores de nk-3

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Publication number
BR112015024907A2
BR112015024907A2 BR112015024907A BR112015024907A BR112015024907A2 BR 112015024907 A2 BR112015024907 A2 BR 112015024907A2 BR 112015024907 A BR112015024907 A BR 112015024907A BR 112015024907 A BR112015024907 A BR 112015024907A BR 112015024907 A2 BR112015024907 A2 BR 112015024907A2
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Brazil
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substituted
pyrazines
dihydro
acyl
selective
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BR112015024907A
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English (en)
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BR112015024907B1 (pt
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Fraser Graeme
Dutheuil Guillaume
Hoveyda Hamid
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Euroscreen Sa
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Publication of BR112015024907B1 publication Critical patent/BR112015024907B1/pt

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Abstract

1/1 resumo “n-acil-(3-substituido)-(8-substituido)-5,6-dihidro-[1,2,4]triazol[4,3­a]pirazinas como antagonistas receptores seletivos de nk-3, composição farmacêutica, métodos para uso em desordens mediadas por receptores de nk-3” a presente invenção está relacionada a novos compostos de fórmula i r1 o r4 r2 * nn n n r3 r1' r2' x2 n x1 r5 e o seu uso em tratamentos terapêuticos.
BR112015024907-8A 2013-03-29 2014-03-28 N-acil-(3-substituido)-(8-substituido)-5,6-dihidro-[1,2,4]triazol[4,3- a] pirazinas como antagonistas para receptores seletivos de nk3, composição farmacêutica, métodos para uso em desordens mediadas por receptores de nk- 3 BR112015024907B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP13161863 2013-03-29
EP13161863.9 2013-03-29
EP13193025.7 2013-11-15
EP13193025 2013-11-15
EP14154303.3 2014-02-07
EP14154303 2014-02-07
PCT/EP2014/056367 WO2014154895A1 (en) 2013-03-29 2014-03-28 NOVEL N-ACYL-(3-SUBSTITUTED)-(8-SUBSTITUTED)-5,6-DIHYDRO- [1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR-MEDIATED DISORDERS

Publications (2)

Publication Number Publication Date
BR112015024907A2 true BR112015024907A2 (pt) 2017-07-18
BR112015024907B1 BR112015024907B1 (pt) 2023-05-09

Family

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Application Number Title Priority Date Filing Date
BR112015024907-8A BR112015024907B1 (pt) 2013-03-29 2014-03-28 N-acil-(3-substituido)-(8-substituido)-5,6-dihidro-[1,2,4]triazol[4,3- a] pirazinas como antagonistas para receptores seletivos de nk3, composição farmacêutica, métodos para uso em desordens mediadas por receptores de nk- 3

Country Status (27)

Country Link
US (3) US9422299B2 (pt)
EP (2) EP3219715A1 (pt)
JP (2) JP6316932B2 (pt)
KR (2) KR102364835B1 (pt)
CN (1) CN105229008B (pt)
AU (1) AU2014242906B2 (pt)
BR (1) BR112015024907B1 (pt)
CA (1) CA2907809C (pt)
CY (1) CY1119576T1 (pt)
DK (1) DK2948455T5 (pt)
EA (1) EA027570B1 (pt)
ES (1) ES2646488T3 (pt)
HK (2) HK1244273A1 (pt)
HR (1) HRP20171688T1 (pt)
HU (1) HUE035870T2 (pt)
IL (1) IL241473B (pt)
LT (1) LT2948455T (pt)
MX (1) MX370000B (pt)
NO (1) NO2948455T3 (pt)
NZ (1) NZ712802A (pt)
PL (1) PL2948455T3 (pt)
PT (1) PT2948455T (pt)
RS (1) RS56501B1 (pt)
SG (1) SG11201508005XA (pt)
SI (1) SI2948455T1 (pt)
WO (1) WO2014154895A1 (pt)
ZA (1) ZA201506234B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011234398B8 (en) 2010-04-02 2015-03-05 Ogeda Sa Novel NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders
KR102049534B1 (ko) 2011-10-03 2019-11-27 오게다 에스.에이. 선택적 NK-3 수용체 길항제로서의 신규한 키랄 N-아실-5,6,7,(8-치환된)-테트라히드로-[1,2,4]트리아졸로[4,3-a]피라진, 의약 조성물, NK-3 수용체 매개 질환에 사용하는 방법 및 그의 키랄 합성법
EP2989103B1 (en) 2013-03-29 2019-02-20 Ogeda Sa N-acyl-(3-substituted)-(8-methyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor-mediated disorders
US10183948B2 (en) 2013-03-29 2019-01-22 Ogeda Sa N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
CA2907809C (en) 2013-03-29 2021-05-04 Euroscreen Sa N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor-mediated disorders
EP2978766B1 (en) 2013-03-29 2018-12-19 Ogeda Sa N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor-mediated disorders
SG10201800162RA (en) 2014-09-25 2018-02-27 Ogeda Sa Novel chiral synthesis of n-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines
EA036709B1 (ru) * 2015-03-16 2020-12-10 Огеда Са Применение антагонистов рецептора нейрокинина-3 для терапевтического или косметологического лечения излишних жировых отложений на теле
KR102122470B1 (ko) * 2016-12-08 2020-06-12 주식회사 엘지화학 변성제 및 이로부터 유래된 작용기를 포함하는 변성 공액디엔계 중합체
EP3428168A1 (en) 2017-07-12 2019-01-16 Ogeda Sa Deuterated fezolinetant
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