TR201900662T4 - Cb2 reseptör antagonistleri olarak triazolo[4,5-d]pirimidin türevleri. - Google Patents
Cb2 reseptör antagonistleri olarak triazolo[4,5-d]pirimidin türevleri. Download PDFInfo
- Publication number
- TR201900662T4 TR201900662T4 TR2019/00662T TR201900662T TR201900662T4 TR 201900662 T4 TR201900662 T4 TR 201900662T4 TR 2019/00662 T TR2019/00662 T TR 2019/00662T TR 201900662 T TR201900662 T TR 201900662T TR 201900662 T4 TR201900662 T4 TR 201900662T4
- Authority
- TR
- Turkey
- Prior art keywords
- triazolo
- receptor antagonists
- pyrimidine derivatives
- compound
- formula
- Prior art date
Links
- GIIGHSIIKVOWKZ-UHFFFAOYSA-N 2h-triazolo[4,5-d]pyrimidine Chemical class N1=CN=CC2=NNN=C21 GIIGHSIIKVOWKZ-UHFFFAOYSA-N 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
Mevcut buluş, aşağıda gösterilen bir formül (I) bileşiği olup, burada R1 ila R4 tarifnamede ve istemlerde tanımlandığı şekildedir. Formül (I) bileşiği bir ilaç olarak kullanılabilir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13183385 | 2013-09-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201900662T4 true TR201900662T4 (tr) | 2019-02-21 |
Family
ID=49111076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/00662T TR201900662T4 (tr) | 2013-09-06 | 2014-09-03 | Cb2 reseptör antagonistleri olarak triazolo[4,5-d]pirimidin türevleri. |
Country Status (32)
Country | Link |
---|---|
US (1) | US9593123B2 (tr) |
EP (3) | EP3943497A1 (tr) |
JP (1) | JP6441356B2 (tr) |
KR (3) | KR102349567B1 (tr) |
CN (1) | CN105555788B (tr) |
AR (1) | AR097553A1 (tr) |
AU (1) | AU2014317229B2 (tr) |
CA (1) | CA2915766C (tr) |
CL (1) | CL2016000495A1 (tr) |
CR (1) | CR20160076A (tr) |
DK (2) | DK3483163T3 (tr) |
EA (1) | EA028335B1 (tr) |
ES (2) | ES2883923T3 (tr) |
HK (1) | HK1219277A1 (tr) |
HR (2) | HRP20190361T1 (tr) |
HU (2) | HUE041760T2 (tr) |
IL (1) | IL243092B (tr) |
LT (2) | LT3483163T (tr) |
MA (1) | MA38826B1 (tr) |
MX (2) | MX367084B (tr) |
MY (1) | MY191628A (tr) |
PE (2) | PE20160691A1 (tr) |
PH (1) | PH12016500250A1 (tr) |
PL (2) | PL3041843T3 (tr) |
PT (2) | PT3483163T (tr) |
RS (2) | RS58390B1 (tr) |
SG (1) | SG11201601714UA (tr) |
SI (2) | SI3041843T1 (tr) |
TR (1) | TR201900662T4 (tr) |
TW (1) | TWI705966B (tr) |
UA (1) | UA116395C2 (tr) |
WO (1) | WO2015032769A1 (tr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015162630A1 (en) * | 2014-04-25 | 2015-10-29 | Anlon Chemical Research Organization | Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis. |
WO2016071375A1 (en) | 2014-11-07 | 2016-05-12 | F. Hoffmann-La Roche Ag | Triazolo[4,5-d]pyrimidines as agonists of the cannabinoid receptor 2 |
WO2017004133A1 (en) * | 2015-06-29 | 2017-01-05 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
WO2017076266A1 (zh) * | 2015-11-06 | 2017-05-11 | 江苏恒瑞医药股份有限公司 | 制备坎格雷洛中间体的方法 |
CN109311886B (zh) | 2016-06-23 | 2021-11-09 | 豪夫迈·罗氏有限公司 | [1,2,3]***并[4,5-d]嘧啶衍生物 |
SG10202113286RA (en) * | 2016-06-23 | 2021-12-30 | Hoffmann La Roche | [1,2,3]triazolo[4,5-d]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor |
JP7090037B2 (ja) * | 2016-06-23 | 2022-06-23 | エフ.ホフマン-ラ ロシュ アーゲー | 新規な[1,2,3]トリアゾロ[4,5-d]ピリミジン誘導体 |
EP3475283B1 (en) | 2016-06-23 | 2021-08-11 | F. Hoffmann-La Roche AG | Novel[1,2,3]triazolo[4,5-d]pyrimidine derivatives |
CN106478639B (zh) * | 2016-09-05 | 2018-09-18 | 郑州大学 | 嘧啶并1,2,4–三氮唑类的lsd1抑制剂、其制备方法及应用 |
CN106432247B (zh) * | 2016-09-27 | 2018-06-29 | 郑州大学 | 含有腙键的嘧啶并三氮唑类化合物、制备方法及其应用 |
CN106432248B (zh) * | 2016-09-27 | 2018-11-27 | 郑州大学 | 含嘧啶并三氮唑类lsd1抑制剂、其制备方法及应用 |
CN106928296A (zh) * | 2017-02-06 | 2017-07-07 | 上海华升生物科技有限公司 | 一种2‑(3,3,3‑三氟丙硫基)腺苷的合成方法 |
CN106928235A (zh) * | 2017-05-03 | 2017-07-07 | 郑州大学 | 含嘧啶并三氮唑类lsd1抑制剂、其制备方法及应用 |
CN107033148B (zh) * | 2017-05-03 | 2018-10-26 | 郑州大学 | 含嘧啶并三氮唑—巯基四氮唑类lsd1抑制剂、其制备方法及应用 |
CN109516990B (zh) * | 2017-09-19 | 2021-06-01 | 天津药物研究院有限公司 | 嘧啶并三氮唑类化合物、其制备方法和用途 |
CN113582935A (zh) * | 2021-08-27 | 2021-11-02 | 中国医学科学院放射医学研究所 | 一种炎症小体核苷酸结合寡聚化结构域样受体蛋白3抑制剂及其制备方法和应用 |
CN115246832A (zh) * | 2022-06-15 | 2022-10-28 | 深圳湾实验室 | 一类去泛素化酶usp25和usp28靶向抑制剂及制备和应用 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1012151B1 (en) | 1997-09-02 | 2002-08-07 | Bristol-Myers Squibb Pharma Company | Heterocyclyl-substituted ring-fused pyridines and pyrimidines as corticotropin releasing hormone (crh) antagonists, useful for treating cns and stress-related disorders |
CA2399791A1 (en) | 2000-02-11 | 2001-08-16 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases |
JP2008503464A (ja) * | 2004-06-17 | 2008-02-07 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 習慣性行動の1つ以上の構成要素の改善のためのアデノシンa2aレセプターの拮抗 |
AR051596A1 (es) | 2004-10-26 | 2007-01-24 | Irm Llc | Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentarios |
WO2008141249A1 (en) | 2007-05-10 | 2008-11-20 | Acadia Pharmaceuticals Inc. | Imidazol (1,2-a)pyridines and related compounds with activity at cannabinoid cb2 receptors |
EP2219646A4 (en) * | 2007-12-21 | 2010-12-22 | Univ Rochester | METHOD FOR MODIFYING THE LIFETIME OF EUKARYOTIC ORGANISMS |
WO2009117444A1 (en) | 2008-03-17 | 2009-09-24 | Northeastern University | Inhibitors of fatty acid amide hydrolase and monoacylglycerol lipase for modulation of cannabinoid receptors |
WO2010120987A1 (en) | 2009-04-17 | 2010-10-21 | Wyeth Llc | Ring fused, ureidoaryl- and carbamoylaryl-bridged morpholino-pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
WO2013060837A1 (en) | 2011-10-27 | 2013-05-02 | Lek Pharmaceuticals D.D. | Synthesis of triazolopyrimidine compounds |
UA111640C2 (uk) * | 2011-11-08 | 2016-05-25 | Ф. Хоффманн-Ля Рош Аг | ПОХІДНІ [1,2,3]ТРИАЗОЛО[4,5-d]ПІРИМІДИНУ ЯК АГОНІСТИ КАНАБІНОЇДНОГО РЕЦЕПТОРА 2 |
US9067943B2 (en) * | 2011-11-25 | 2015-06-30 | Hoffmann-La Roche Inc. | [1,2,3]triazolo[4,5-D]pyrimidine derivatives |
CN104395290A (zh) | 2012-07-04 | 2015-03-04 | 霍夫曼-拉罗奇有限公司 | 作为***素受体2激动剂的新金刚烷基衍生物 |
US9303012B2 (en) | 2012-12-07 | 2016-04-05 | Hoffman-La Roche Inc. | Pyridine-2-amides useful as CB2 agonists |
CN104837831B (zh) | 2012-12-07 | 2017-10-31 | 霍夫曼-拉罗奇有限公司 | 新的吡啶衍生物 |
PE20151060A1 (es) | 2012-12-07 | 2015-07-25 | Hoffmann La Roche | Nuevos derivados de pirazina como agonistas del receptor cb2 |
MX2015007156A (es) | 2012-12-07 | 2015-10-14 | Hoffmann La Roche | Piridina-2-amidas utiles como agonistas receptores de canabinoides 2 (cb2). |
WO2014135507A1 (en) | 2013-03-07 | 2014-09-12 | F. Hoffmann-La Roche Ag | Novel pyrazol derivatives |
KR20210145303A (ko) | 2013-05-02 | 2021-12-01 | 에프. 호프만-라 로슈 아게 | Cb2 수용체 작용제로서의 퓨린 유도체 |
CA2907691A1 (en) | 2013-05-02 | 2014-11-06 | F. Hoffmann-La Roche Ag | Pyrrolo[2,3-d]pyrimidine derivatives as cb2 receptor agonists |
EP3008055B1 (en) | 2013-06-11 | 2017-07-19 | F. Hoffmann-La Roche AG | Tetrazolone derivatives |
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2014
- 2014-09-03 JP JP2016539509A patent/JP6441356B2/ja active Active
- 2014-09-03 CN CN201480048593.7A patent/CN105555788B/zh active Active
- 2014-09-03 AU AU2014317229A patent/AU2014317229B2/en active Active
- 2014-09-03 HU HUE14761320A patent/HUE041760T2/hu unknown
- 2014-09-03 PL PL14761320T patent/PL3041843T3/pl unknown
- 2014-09-03 KR KR1020167008516A patent/KR102349567B1/ko active IP Right Grant
- 2014-09-03 LT LTEP18206943.5T patent/LT3483163T/lt unknown
- 2014-09-03 TR TR2019/00662T patent/TR201900662T4/tr unknown
- 2014-09-03 SI SI201431099T patent/SI3041843T1/sl unknown
- 2014-09-03 KR KR1020227034655A patent/KR20220140651A/ko not_active Application Discontinuation
- 2014-09-03 SG SG11201601714UA patent/SG11201601714UA/en unknown
- 2014-09-03 ES ES18206943T patent/ES2883923T3/es active Active
- 2014-09-03 EP EP21179163.7A patent/EP3943497A1/en active Pending
- 2014-09-03 WO PCT/EP2014/068640 patent/WO2015032769A1/en active Application Filing
- 2014-09-03 HU HUE18206943A patent/HUE055201T2/hu unknown
- 2014-09-03 PT PT182069435T patent/PT3483163T/pt unknown
- 2014-09-03 DK DK18206943.5T patent/DK3483163T3/da active
- 2014-09-03 RS RS20190264A patent/RS58390B1/sr unknown
- 2014-09-03 ES ES14761320T patent/ES2714094T3/es active Active
- 2014-09-03 SI SI201431869T patent/SI3483163T1/sl unknown
- 2014-09-03 EA EA201690478A patent/EA028335B1/ru not_active IP Right Cessation
- 2014-09-03 UA UAA201603048A patent/UA116395C2/uk unknown
- 2014-09-03 PL PL18206943T patent/PL3483163T3/pl unknown
- 2014-09-03 MY MYPI2016700721A patent/MY191628A/en unknown
- 2014-09-03 EP EP14761320.2A patent/EP3041843B1/en active Active
- 2014-09-03 EP EP18206943.5A patent/EP3483163B1/en active Active
- 2014-09-03 PE PE2015002700A patent/PE20160691A1/es unknown
- 2014-09-03 KR KR1020217017887A patent/KR102454344B1/ko active Application Filing
- 2014-09-03 RS RS20211007A patent/RS62234B1/sr unknown
- 2014-09-03 PE PE2019001869A patent/PE20191528A1/es unknown
- 2014-09-03 DK DK14761320.2T patent/DK3041843T3/en active
- 2014-09-03 PT PT14761320T patent/PT3041843T/pt unknown
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- 2014-09-03 MX MX2016002117A patent/MX367084B/es active IP Right Grant
- 2014-09-03 CA CA2915766A patent/CA2915766C/en active Active
- 2014-09-04 AR ARP140103305A patent/AR097553A1/es active IP Right Grant
- 2014-09-04 TW TW103130651A patent/TWI705966B/zh active
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2015
- 2015-12-14 IL IL243092A patent/IL243092B/en active IP Right Grant
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2016
- 2016-02-04 MA MA38826A patent/MA38826B1/fr unknown
- 2016-02-04 PH PH12016500250A patent/PH12016500250A1/en unknown
- 2016-02-16 CR CR20160076A patent/CR20160076A/es unknown
- 2016-02-17 MX MX2019009100A patent/MX2019009100A/es unknown
- 2016-02-23 US US15/050,753 patent/US9593123B2/en active Active
- 2016-03-04 CL CL2016000495A patent/CL2016000495A1/es unknown
- 2016-06-23 HK HK16107348.6A patent/HK1219277A1/zh unknown
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2019
- 2019-02-25 HR HRP20190361TT patent/HRP20190361T1/hr unknown
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2021
- 2021-08-16 HR HRP20211322TT patent/HRP20211322T1/hr unknown
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