BR112015023187A2 - inibidores de pirrolo[2,3 - b] piridina cdk9 kinase - Google Patents

inibidores de pirrolo[2,3 - b] piridina cdk9 kinase

Info

Publication number
BR112015023187A2
BR112015023187A2 BR112015023187A BR112015023187A BR112015023187A2 BR 112015023187 A2 BR112015023187 A2 BR 112015023187A2 BR 112015023187 A BR112015023187 A BR 112015023187A BR 112015023187 A BR112015023187 A BR 112015023187A BR 112015023187 A2 BR112015023187 A2 BR 112015023187A2
Authority
BR
Brazil
Prior art keywords
pyrrolo
pyridine
kinase inhibitors
compounds
cdk9 kinase
Prior art date
Application number
BR112015023187A
Other languages
English (en)
Inventor
S Florjancic Alan
Mastracchio Anthony
Lai Chunqiu
Zhu Guidong
Gong Jianchun
Miyashiro Juliem
W Woods Keith
Babu Dabbeeru Madhu
L Curtin Michael
Michaelides Michael
Bruncko Milan
Reddy Iquturi Omprakash
Goswami Rajeev
F Clark Richard
M Risi Roberto
R Frey Robin
Penning Thomas
M Hansen Todd
Song Xiaohong
Tong Yunsong
Tao Zhi-Fu
Ji Zhiqin
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Priority claimed from PCT/CN2014/000265 external-priority patent/WO2014139328A1/en
Publication of BR112015023187A2 publication Critical patent/BR112015023187A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

resumo “inibidores de pirrolo[2,3 – b] piridina cdk9 kinase” são descritos compostos da formula (iia), em que r1, r2, r3a, r3b, r3c, r3d, r3e e r4 são definidos como no relatório descritivo e sais farmaceuticamente aceitáveis do mesmo. os compostos podem ser usados como agentes no tratamento de doenças, incluindo câncer. também são fornecidas composições farmacêuticas compreendendo um ou mais composto da formula (iia). fórmula (iia),
BR112015023187A 2013-03-14 2014-03-13 inibidores de pirrolo[2,3 - b] piridina cdk9 kinase BR112015023187A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN745DE2013 2013-03-14
US201361904842P 2013-11-15 2013-11-15
PCT/CN2014/000265 WO2014139328A1 (en) 2013-03-14 2014-03-13 Pyrrolo[2,3-b]pyridine cdk9 kinase inhibitors

Publications (1)

Publication Number Publication Date
BR112015023187A2 true BR112015023187A2 (pt) 2017-07-18

Family

ID=54249678

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112015023356A BR112015023356A2 (pt) 2013-03-14 2014-03-13 inibidores de quinase pirrol[2,3-b]piridina cdk9
BR112015023187A BR112015023187A2 (pt) 2013-03-14 2014-03-13 inibidores de pirrolo[2,3 - b] piridina cdk9 kinase

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR112015023356A BR112015023356A2 (pt) 2013-03-14 2014-03-13 inibidores de quinase pirrol[2,3-b]piridina cdk9

Country Status (9)

Country Link
US (1) US9796708B2 (pt)
EP (2) EP2970278A4 (pt)
JP (2) JP2016514113A (pt)
CN (2) CN105324380A (pt)
AR (1) AR101528A1 (pt)
AU (2) AU2014234077A1 (pt)
BR (2) BR112015023356A2 (pt)
CA (2) CA2905530A1 (pt)
MX (2) MX2015012896A (pt)

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WO2019057123A1 (zh) * 2017-09-20 2019-03-28 杭州英创医药科技有限公司 作为ido抑制剂和/或ido-hdac双重抑制剂的多环化合物
CA3076714C (en) * 2019-09-29 2021-06-15 Mabplex International, Ltd. Method for producing antibody-drug conjugate intermediate by addition of acid and use thereof
MA57379B1 (fr) * 2019-10-18 2024-02-29 Lead Pharma Holding Bv Modulateurs du recepteur alpha associe aux oestrogenes (err-alpha)
CN116249701A (zh) * 2020-10-12 2023-06-09 上海海雁医药科技有限公司 取代的二（吡啶-2-基）胺衍生物、其组合物及医药上的用途
WO2022135580A1 (zh) * 2020-12-25 2022-06-30 南京明德新药研发有限公司 吡啶并吡咯类化合物的晶型、制备方法及其应用
CN112852874B (zh) * 2021-02-04 2023-05-23 中国农业科学院兰州兽医研究所 Hdac5基因敲除的bhk-21细胞系及其构建方法和应用
CN113248496B (zh) * 2021-05-06 2022-02-11 东南大学 吡咯并吡啶类化合物及其盐及其用途
CN113666934B (zh) * 2021-07-28 2023-06-23 北京深度制耀科技有限公司 Cdk9激酶抑制剂

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Also Published As

Publication number Publication date
AU2014234077A1 (en) 2015-10-01
CA2905530A1 (en) 2014-09-18
CN105324380A (zh) 2016-02-10
AU2014231567A1 (en) 2015-10-01
BR112015023356A2 (pt) 2017-07-18
CN105246890A (zh) 2016-01-13
CA2905935A1 (en) 2014-09-25
AR101528A1 (es) 2016-12-28
MX2015012899A (es) 2016-06-02
JP2016516713A (ja) 2016-06-09
EP2970264A1 (en) 2016-01-20
US20160060257A1 (en) 2016-03-03
EP2970278A4 (en) 2016-12-07
JP2016514113A (ja) 2016-05-19
MX2015012896A (es) 2016-06-02
US9796708B2 (en) 2017-10-24
EP2970278A1 (en) 2016-01-20

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B07D Technical examination (opinion) related to article 229 of industrial property law
B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
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B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2505 DE 08-01-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.