BR112015018089A2 - moduladores de receptor de nmda de espiro-lactama e usos dos mesmos - Google Patents

moduladores de receptor de nmda de espiro-lactama e usos dos mesmos

Info

Publication number
BR112015018089A2
BR112015018089A2 BR112015018089A BR112015018089A BR112015018089A2 BR 112015018089 A2 BR112015018089 A2 BR 112015018089A2 BR 112015018089 A BR112015018089 A BR 112015018089A BR 112015018089 A BR112015018089 A BR 112015018089A BR 112015018089 A2 BR112015018089 A2 BR 112015018089A2
Authority
BR
Brazil
Prior art keywords
nmda receptor
spiro
receptor modulators
compounds
lactam
Prior art date
Application number
BR112015018089A
Other languages
English (en)
Other versions
BR112015018089B1 (pt
Inventor
A Lowe John Iii
Amin Khan M
Original Assignee
Naurex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Naurex Inc filed Critical Naurex Inc
Publication of BR112015018089A2 publication Critical patent/BR112015018089A2/pt
Publication of BR112015018089B1 publication Critical patent/BR112015018089B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

resumo moduladores de receptor de nmda de espiro-lactama e usos dos mesmos são divulgados compostos tendo potência intensificada na modulação da atividade de receptor de nmda. tais compostos são contemplados para uso no tratamento de condições tais como depressão e distúrbios relacionados. formulações oralmente disponíveis e outras formas de distribuição farmaceuticamente aceitáveis dos compostos, incluindo formulações intravenosas, são também descritas.
BR112015018089-2A 2013-01-29 2014-01-29 Compostos moduladores de receptor de nmda de espiro-lactama, composição farmacêutica os compreendendo e uso dos mesmos BR112015018089B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361757920P 2013-01-29 2013-01-29
US61/757,920 2013-01-29
PCT/US2014/013621 WO2014120784A1 (en) 2013-01-29 2014-01-29 Spiro-lactam nmda receptor modulators and uses thereof

Publications (2)

Publication Number Publication Date
BR112015018089A2 true BR112015018089A2 (pt) 2017-07-18
BR112015018089B1 BR112015018089B1 (pt) 2022-09-20

Family

ID=50069346

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015018089-2A BR112015018089B1 (pt) 2013-01-29 2014-01-29 Compostos moduladores de receptor de nmda de espiro-lactama, composição farmacêutica os compreendendo e uso dos mesmos

Country Status (17)

Country Link
US (5) US9828384B2 (pt)
EP (1) EP2951182B1 (pt)
JP (1) JP6531042B2 (pt)
KR (1) KR102410989B1 (pt)
CN (1) CN105408336B (pt)
AU (1) AU2014212485C1 (pt)
BR (1) BR112015018089B1 (pt)
CA (1) CA2898774C (pt)
CL (1) CL2015002122A1 (pt)
EA (1) EA032153B1 (pt)
HK (1) HK1218418A1 (pt)
IL (1) IL240162B (pt)
MX (1) MX2015009772A (pt)
PE (1) PE20151427A1 (pt)
PH (1) PH12015501596A1 (pt)
SG (1) SG11201505942YA (pt)
WO (1) WO2014120784A1 (pt)

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CN109415372B (zh) 2016-05-19 2021-01-15 阿普廷伊克斯股份有限公司 螺-内酰胺nmda受体调节剂及其用途
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WO2018026798A1 (en) 2016-08-01 2018-02-08 Aptinyx Inc. Spiro-lactam nmda modulators and methods of using same
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WO2019152685A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and methods of using same
US11578072B2 (en) * 2018-01-31 2023-02-14 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
WO2019152688A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
WO2019152696A1 (en) * 2018-01-31 2019-08-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
PE20211455A1 (es) * 2018-01-31 2021-08-05 Aptinyx Inc Moduladores del receptor nmda espiro-lactama y usos de los mismos
WO2021228123A1 (zh) * 2020-05-12 2021-11-18 北京广为医药科技有限公司 调节nmda受体活性的化合物、其药物组合物及用途

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Also Published As

Publication number Publication date
KR102410989B1 (ko) 2022-06-17
NZ709872A (en) 2020-09-25
AU2014212485B2 (en) 2018-04-19
KR20150110788A (ko) 2015-10-02
PE20151427A1 (es) 2015-10-10
US20180179218A1 (en) 2018-06-28
EP2951182B1 (en) 2020-03-18
EA201591402A1 (ru) 2015-12-30
CN105408336B (zh) 2018-06-26
US20180215767A1 (en) 2018-08-02
CN105408336A (zh) 2016-03-16
MX2015009772A (es) 2016-05-31
AU2014212485A1 (en) 2015-07-30
CA2898774A1 (en) 2014-08-07
SG11201505942YA (en) 2015-08-28
CA2898774C (en) 2021-07-13
HK1218418A1 (zh) 2017-02-17
CL2015002122A1 (es) 2015-12-18
US20210155632A1 (en) 2021-05-27
AU2014212485C1 (en) 2018-10-25
PH12015501596A1 (en) 2015-10-19
IL240162A0 (en) 2015-09-24
EP2951182A1 (en) 2015-12-09
IL240162B (en) 2020-08-31
WO2014120784A1 (en) 2014-08-07
US20180244680A1 (en) 2018-08-30
BR112015018089B1 (pt) 2022-09-20
US9828384B2 (en) 2017-11-28
EA032153B1 (ru) 2019-04-30
JP6531042B2 (ja) 2019-06-12
JP2016506959A (ja) 2016-03-07
US20150368252A1 (en) 2015-12-24

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