BR112015011897A2 - novos moduladores seletivos do receptor de andrógeno - Google Patents

novos moduladores seletivos do receptor de andrógeno

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Publication number
BR112015011897A2
BR112015011897A2 BR112015011897A BR112015011897A BR112015011897A2 BR 112015011897 A2 BR112015011897 A2 BR 112015011897A2 BR 112015011897 A BR112015011897 A BR 112015011897A BR 112015011897 A BR112015011897 A BR 112015011897A BR 112015011897 A2 BR112015011897 A2 BR 112015011897A2
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BR
Brazil
Prior art keywords
branched alkyl
straight chain
hydrogen
androgen receptor
chain
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Application number
BR112015011897A
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English (en)
Other versions
BR112015011897B1 (pt
Inventor
Matthew Gilbert Adam
P Ricketts Anthony
Kipp Erickson Bruce
P Thompson David
L Ellsworth Edmund
Lvovich Piatnitski Chekler Eugene
Thomas Anderson James
Robert Verhoest Patrick
Jal Unwalla Rayomand
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Pfizer
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Application filed by Pfizer filed Critical Pfizer
Publication of BR112015011897A2 publication Critical patent/BR112015011897A2/pt
Publication of BR112015011897B1 publication Critical patent/BR112015011897B1/pt

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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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Abstract

resumo “novos moduladores seletivos do receptor de andrógeno” a presente invenção se refere a um composto da fórmula 1, 2 ou 3: em que a é n ou -cr0--, onde r0 é hidrogênio, alquila de cadeia linear ou ramificada c1-c6, etc., z é -cre -- ou -n--, onde re é hidrogênio, alquila de cadeia linear ou ramificada c1-c6, etc.; r1 é hidrogênio, alquila de cadeia linear ou ramificada c1-c6, etc.; r2 é, independentemente, hidrogênio ou alquila de cadeia linear ou ramificada c1-c6; r3 e r4 são, independentemente, hidrogênio, alquila de cadeia linear ou ramificada c1-c6, etc;. r5 e r6 são, independentemente, hidrogênio ou alquila de cadeia linear ou ramificada c1-c6, etc; r8 é hidrogênio, alquila de cadeia linear ou ramificada c1-c6, etc.; r9 e r10 são, independentemente, hidrogênio ou alquila de cadeia linear ou ramificada c1-c6, etc.; q é --co--, --(ch2)q--, --(chrs)q-- ou -(crsrt)q--, onde rs e rt são, independentemente, alquila de cadeia linear ou ramificada c1-c6, arila, alquillarila, heteroarila ou alquil-heteroarila; onde q é 0, 1, 2 ou 3; e, onde n é 0, 1, 2, 3, 4 ou 5; ou, um sal farmaceuticamente aceitável do mesmo, às composições contendo tais compostos; e aos usos de tais compostos no tratamento de várias doenças, particularmente, aquelas afetadas ou mediadas pelo receptor de andrógeno.
BR112015011897-6A 2012-12-03 2013-11-25 Compostos moduladores seletivos do receptor de andrógeno e seu uso BR112015011897B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261732617P 2012-12-03 2012-12-03
US61/732.617 2012-12-03
PCT/IB2013/060381 WO2014087298A1 (en) 2012-12-03 2013-11-25 Novel selective androgen receptor modulators

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BR112015011897A2 true BR112015011897A2 (pt) 2017-07-11
BR112015011897B1 BR112015011897B1 (pt) 2021-11-03

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EP (1) EP2925725B1 (pt)
JP (1) JP6039100B2 (pt)
KR (1) KR101745225B1 (pt)
CN (1) CN104854093B (pt)
AP (1) AP2015008444A0 (pt)
AR (1) AR093697A1 (pt)
AU (1) AU2013353723B2 (pt)
BR (1) BR112015011897B1 (pt)
CA (1) CA2891234C (pt)
CL (1) CL2015001495A1 (pt)
CO (1) CO7400864A2 (pt)
CR (1) CR20150290A (pt)
CU (1) CU20150054A7 (pt)
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PH (1) PH12015501215A1 (pt)
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US10328082B2 (en) 2014-05-30 2019-06-25 Pfizer Inc. Methods of use and combinations
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
CN107573270B (zh) * 2017-09-29 2019-11-29 河南师范大学 一种α-甲酰基吡咯烷类化合物的合成方法
CN110372628B (zh) * 2019-07-09 2021-04-02 武汉大学 内磺酰胺类化合物及其制备方法
US20220315568A1 (en) * 2019-09-12 2022-10-06 Disarm Therapeutics, Inc. Inhibitors of sarm1
WO2023275715A1 (en) * 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

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US20140155390A1 (en) 2014-06-05
CL2015001495A1 (es) 2015-10-02
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CO7400864A2 (es) 2015-09-30
TN2015000237A1 (fr) 2016-10-03
IL239076B (en) 2018-10-31
WO2014087298A4 (en) 2014-08-21
CR20150290A (es) 2015-07-09
IL239076A0 (en) 2015-07-30
BR112015011897B1 (pt) 2021-11-03
ZA201503517B (en) 2017-11-29
PH12015501215B1 (en) 2015-08-17
HK1209744A1 (en) 2016-04-08
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CA2891234C (en) 2017-03-07
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EA026562B1 (ru) 2017-04-28
PH12015501215A1 (en) 2015-08-17
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