CO6890101A2 - Inhibidores de pde10 de pirimidina - Google Patents

Inhibidores de pde10 de pirimidina

Info

Publication number
CO6890101A2
CO6890101A2 CO14042266A CO14042266A CO6890101A2 CO 6890101 A2 CO6890101 A2 CO 6890101A2 CO 14042266 A CO14042266 A CO 14042266A CO 14042266 A CO14042266 A CO 14042266A CO 6890101 A2 CO6890101 A2 CO 6890101A2
Authority
CO
Colombia
Prior art keywords
pde10 inhibitors
pyrimidine
pyrimidine pde10
inhibitors
pde10
Prior art date
Application number
CO14042266A
Other languages
English (en)
Inventor
Christopher D Cox
Vadim Dudkin
Jeffrey Kern
Mark E Layton
Izzat T Raheem
Original Assignee
Merk Sharp & Dohme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merk Sharp & Dohme Corp filed Critical Merk Sharp & Dohme Corp
Publication of CO6890101A2 publication Critical patent/CO6890101A2/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
CO14042266A 2011-08-25 2014-02-27 Inhibidores de pde10 de pirimidina CO6890101A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161527392P 2011-08-25 2011-08-25

Publications (1)

Publication Number Publication Date
CO6890101A2 true CO6890101A2 (es) 2014-03-10

Family

ID=47746797

Family Applications (1)

Application Number Title Priority Date Filing Date
CO14042266A CO6890101A2 (es) 2011-08-25 2014-02-27 Inhibidores de pde10 de pirimidina

Country Status (36)

Country Link
US (1) US9062059B2 (es)
EP (1) EP2748151B1 (es)
JP (1) JP5648147B2 (es)
KR (1) KR101655635B1 (es)
CN (1) CN103917528B (es)
AR (1) AR087628A1 (es)
AU (1) AU2012299080B2 (es)
BR (1) BR112014004310B8 (es)
CA (1) CA2845578C (es)
CL (1) CL2014000450A1 (es)
CO (1) CO6890101A2 (es)
CR (1) CR20140085A (es)
CY (1) CY1117622T1 (es)
DK (1) DK2748151T3 (es)
DO (1) DOP2014000039A (es)
EA (1) EA023685B1 (es)
ES (1) ES2572527T3 (es)
HK (1) HK1193410A1 (es)
HR (1) HRP20160635T1 (es)
HU (1) HUE028451T2 (es)
IL (1) IL230997A (es)
MA (1) MA35508B1 (es)
ME (1) ME02419B (es)
MX (1) MX357241B (es)
MY (1) MY157301A (es)
NI (1) NI201400014A (es)
PE (1) PE20141535A1 (es)
PL (1) PL2748151T3 (es)
RS (1) RS54788B1 (es)
SG (1) SG2014013536A (es)
SI (1) SI2748151T1 (es)
TN (1) TN2014000070A1 (es)
TW (1) TWI450895B (es)
UA (1) UA109735C2 (es)
WO (1) WO2013028590A1 (es)
ZA (1) ZA201401272B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013052526A1 (en) 2011-10-06 2013-04-11 Merck Sharp & Dohme Corp. Triazolyl pde10 inhibitors
AU2012318874A1 (en) 2011-10-06 2014-05-15 Merck Sharp & Dohme Corp. 1,3-substituted azetidine PDE10 inhibitors
EP2919783B1 (en) 2012-11-15 2018-01-31 Merck Sharp & Dohme Corp. Cyclopropyl imidazopyridine pde10 inhibitors
TW201422610A (zh) * 2012-11-15 2014-06-16 Merck Sharp & Dohme 作爲pde10抑制劑之經二級醇取代之***
US9284302B2 (en) 2012-11-15 2016-03-15 Merck Sharp & Dohme Corp. Cyclobutyl benzimidazoles as PDE 10 inhibitors
WO2014081617A1 (en) 2012-11-20 2014-05-30 Merck Sharp & Dohme Corp. Substituted pyridone derivatives as pde10 inhibitors
US9663513B2 (en) 2012-11-20 2017-05-30 Merck Sharp & Dohme Corp. Pyrimidine PDE10 inhibitors
WO2014139150A1 (en) 2013-03-15 2014-09-18 Merck Sharp & Dohme Corp. Substituted pyridizinone derivatives as pde10 inhibitors
ES2862203T3 (es) 2014-03-24 2021-10-07 Novartis Ag Compuestos orgánicos de monobactam para el tratamiento de infecciones bacterianas
US10125101B2 (en) 2016-11-28 2018-11-13 Boehringer Ingelheim International Gmbh Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
CA3212082A1 (en) * 2021-03-17 2022-09-22 Merck Sharp & Dohme Llc Pro drugs of pde10 compounds
WO2023184486A1 (en) * 2022-04-01 2023-10-05 Merck Sharp & Dohme Llc Process for preparing ( (1s, 2s) -2- (5-methylpyridin-2-yl) cyclopropyl) -methanol
CN115403527B (zh) * 2022-07-20 2024-03-29 西安近代化学研究所 一种还原胺化法合成杀菌剂乙嘧酚的方法
WO2024049721A1 (en) * 2022-08-31 2024-03-07 Merck Sharp & Dohme Llc Sustained release delivery of a pde10 inhibitor

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1755611A1 (en) 2004-06-07 2007-02-28 Pfizer Products Inc. Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions
JP4874983B2 (ja) 2004-10-12 2012-02-15 マックスリニアー,インコーポレイティド デジタル発生中間周波を有する受信器アーキテクチャ
RS51385B (en) 2005-01-07 2011-02-28 Pfizer Products Inc. HETEROAROMATIC COMPOUNDS OF HINOLINE AND THEIR USE AS PDE10 INHIBITORS
WO2006106307A1 (en) 2005-04-05 2006-10-12 Astrazeneca Ab Pyrimidine derivatives for use as anticancer agents
GB0506883D0 (en) * 2005-04-05 2005-05-11 Astrazeneca Ab Chemical compounds
NL2000397C2 (nl) * 2006-01-05 2007-10-30 Pfizer Prod Inc Bicyclische heteroarylverbindingen als PDE10 inhibitoren.
WO2007129183A2 (en) 2006-05-02 2007-11-15 Pfizer Products Inc. Bicyclic heteroaryl compounds as pde10 inhibitors
JPWO2010024258A1 (ja) * 2008-08-29 2012-01-26 塩野義製薬株式会社 Pi3k阻害活性を有する縮環アゾール誘導体
EP2350027A1 (en) 2008-09-04 2011-08-03 Mitsubishi Tanabe Pharma Corporation Tri-substituted pyrimidine compounds and their use as pde10 inhibitors
WO2010030027A1 (en) * 2008-09-10 2010-03-18 Mitsubishi Tanabe Pharma Corporation Aromatic nitrogen-containing 6-membered ring compounds and their use
AR074343A1 (es) * 2008-11-14 2011-01-12 Amgen Inc Derivados de piridina y pirimidina como inhibidores de la fosfodiesterasa 10
CA2746307C (en) * 2008-12-17 2013-11-19 Amgen Inc. Aminopyridine and carboxypyridine compounds as phosphodiesterase 10 inhibitors
WO2011008931A2 (en) * 2009-07-15 2011-01-20 Cystic Fibrosis Foundation Therapeutics, Inc. Arylpyrimidine compounds and combination therapy comprising same for treating cystic fibrosis & related disorders
TWI481607B (zh) * 2009-12-17 2015-04-21 Lundbeck & Co As H 作為pde10a酵素抑制劑的2-芳基咪唑衍生物
US8470820B2 (en) * 2010-01-22 2013-06-25 Hoffman-La Roche Inc. Nitrogen-containing heteroaryl derivatives
WO2012044561A2 (en) 2010-09-30 2012-04-05 Merck Sharp & Dohme Corp. 2-alkoxy pyrimidine pde10 inhibitors
US8957077B2 (en) * 2010-09-30 2015-02-17 Merck Sharp & Dohme Corp. Pyrazolopyrimidine PDE 10 inhibitors

Also Published As

Publication number Publication date
BR112014004310B1 (pt) 2022-03-03
BR112014004310B8 (pt) 2023-04-18
MX357241B (es) 2018-06-29
ME02419B (me) 2016-09-20
AR087628A1 (es) 2014-04-09
NI201400014A (es) 2014-07-25
NZ621245A (en) 2014-12-24
RS54788B1 (sr) 2016-10-31
HRP20160635T1 (hr) 2016-07-01
SI2748151T1 (sl) 2016-06-30
DOP2014000039A (es) 2014-06-01
EP2748151A4 (en) 2015-01-07
EP2748151A1 (en) 2014-07-02
IL230997A0 (en) 2014-03-31
BR112014004310A2 (pt) 2017-03-28
CN103917528A (zh) 2014-07-09
CY1117622T1 (el) 2017-04-26
PE20141535A1 (es) 2014-11-06
HUE028451T2 (en) 2016-12-28
AU2012299080A1 (en) 2014-03-06
EA201490492A1 (ru) 2014-06-30
KR20140053356A (ko) 2014-05-07
KR101655635B1 (ko) 2016-09-07
IL230997A (en) 2015-08-31
WO2013028590A1 (en) 2013-02-28
US9062059B2 (en) 2015-06-23
ZA201401272B (en) 2017-09-27
EA023685B1 (ru) 2016-06-30
EP2748151B1 (en) 2016-03-16
MY157301A (en) 2016-05-31
JP2014524471A (ja) 2014-09-22
TW201313699A (zh) 2013-04-01
UA109735C2 (xx) 2015-09-25
CN103917528B (zh) 2016-04-20
JP5648147B2 (ja) 2015-01-07
SG2014013536A (en) 2014-07-30
CA2845578A1 (en) 2013-02-28
MA35508B1 (fr) 2014-10-02
CR20140085A (es) 2014-05-02
TWI450895B (zh) 2014-09-01
CL2014000450A1 (es) 2014-08-22
DK2748151T3 (en) 2016-07-04
HK1193410A1 (zh) 2014-09-19
MX2014002178A (es) 2014-05-01
CA2845578C (en) 2016-02-16
PL2748151T3 (pl) 2016-09-30
ES2572527T3 (es) 2016-06-01
AU2012299080B2 (en) 2016-03-17
US20140228368A1 (en) 2014-08-14
TN2014000070A1 (en) 2015-07-01

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